Pharmaceutical Development and Technology

Article	Citations
Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration	57
Nanotechnologies for intranasal drug delivery: an update of literature	42
Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma	34
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery	31
Mucoadhesive polymeric films comprising polyvinyl alcohol, polyvinylpyrrolidone, and poloxamer 407 for pharmaceutical applications	26
An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization	22
Application of plant-derived exosome-like nanoparticles in drug delivery	22
Gelatin-methacryloyl hydrogel based in vitro blood–brain barrier model for studying breast cancer-associated brain metastasis	21
Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres	20
The use of electronic tongue and sensory panel on taste evaluation of pediatric medicines: a systematic review	20
pH-sensitive chitosan-deoxycholic acid/alginate nanoparticles for oral insulin delivery	20
Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy	19
Recent advances in targeting malaria with nanotechnology-based drug carriers	19
Chitosan caged liposomes for improving oral bioavailability of rivaroxaban: in vitro and in vivo evaluation	19
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M® membrane and excised human skin	18
Dry powder inhalation formulation of chitosan nanoparticles for co-administration of isoniazid and pyrazinamide	17
Acriflavine-loaded solid lipid nanoparticles: preparation, physicochemical characterization, and anti-proliferative properties	16
Anti-ageing peptides and proteins for topical applications: a review	15
Simvastatin nanosuspensions prepared using a combination of pH-sensitive and timed-release approaches for potential treatment of colorectal cancer	15
Tabletability and compactibility of α-lactose monohydrate powders of different particle size. I. Experimental comparison	15
Preparation and functional evaluation of electrospun polymeric nanofibers as a new system for sustained topical ocular delivery of itraconazole	15
Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery	14
Electrospun orally disintegrating film formulation of telmisartan	14
In vitro and in vivo evaluation of an ionic sensitive in situ gel containing nanotransfersomes for aripiprazole nasal delivery	14
Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line	14

Formulation optimization of solid self-microemulsifying pellets for enhanced oral bioavailability of curcumin	13
Preparation and optimization of silibinin-loaded chitosan–fucoidan hydrogel: an in vivo evaluation of skin protection against UVB	13
Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: formulation, characterization, in vitro-ex vivo evaluation	13
Cilnidipine loaded poly (ε-caprolactone) nanoparticles for enhanced oral delivery: optimization using DoE, physical characterization, pharmacokinetic, and pharmacodynamic evaluation	13
A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of folate–apoferritin-conjugated cationic solid lipid nanoparticles	13
Microemulsion-thermosensitive gel composites as in situ-forming drug reservoir for periodontitis tissue repair through alveolar bone and collagen regeneration strategy	12
Glutamate-urea-based PSMA-targeted PLGA nanoparticles for prostate cancer delivery of docetaxel	11
Feasibility of developing hospital preparation by semisolid extrusion 3D printing: personalized amlodipine besylate chewable tablets	11
Targeted drug delivery via folate decorated nanocarriers based on linear polymer for treatment of breast cancer	11
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles	11
Ocular microemulsion of brinzolamide: Formulation, physicochemical characterization, and in vitro irritation studies based on EpiOcular™ eye irritation assay	11
Pharmaceutical, biomedical and ophthalmic applications of biodegradable polymers (BDPs): literature and patent review	11
Development of a microencapsulated probiotic delivery system for New Zealand black-footed abalone (Haliotis iris)	10
Loading Pistacia atlantica essential oil in solid lipid nanoparticles and its effect on apoptosis of breast cancer cell line MDA-MB-231	10
In vitro and in vivo evaluations on nanoparticle and phospholipid hybrid nanoparticles with absorption enhancers for oral insulin delivery	10
PLA-coated Imwitor® 900 K-based herbal colloidal carriers as novel candidates for the intra-articular treatment of arthritis	10
Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone	10
Chitosan-bovine serum albumin-Carbopol 940 nanogels for mupirocin dermal delivery: ex-vivo permeation and evaluation of cellular binding capacity via radiolabeling	10
Investigations into the use of machine learning to predict drug dosage form design to obtain desired release profiles for 3D printed oral medicines	10
Emulsions with alkyl polyglucosides as carriers for off-label topical spironolactone – safety and stability evaluation	10
Influence of process temperature and residence time on the manufacturing of amorphous solid dispersions in hot melt extrusion	9
Spray freeze-drying for inhalation application: process and formulation variables	9
Co-delivery of CPP decorated doxorubicin and CPP decorated siRNA by NGR-modified nanobubbles for improving anticancer therapy	9
An overview on the advantages and limitations of 3D printing of microneedles	9
Brain targeting of agomelatine egg lecithin based chitosan coated nanoemulsion	9
Calcitonin-loaded octamaleimic acid–silsesquioxane nanoparticles in hydrogel scaffold support osteoinductivity in bone regeneration	9
Rivaroxaban-loaded SLNs with treatment potential of deep vein thrombosis: in-vitro, in-vivo, and toxicity evaluation	9
Formulation of solid dispersion to improve dissolution and oral bioavailability of poorly soluble dexibuprofen	9
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity	8
Combating hematopoietic and hepatocellular abnormalities resulting from administration of cisplatin: role of liver targeted glycyrrhetinic acid nanoliposomes loaded with amino acids	8
Cholecalciferol complexation with hydroxypropyl-β-cyclodextrin (HPBCD) and its molecular dynamics simulation	8
pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin	8
3D printing and enteric coating of a hollow capsular device with controlled drug release characteristics prepared using extruded Eudragit® filaments	8
Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug	8
Medicinal cannabis pharmacokinetics and potential methods of delivery	8
Alternatives to titanium dioxide in tablet coating	8
Insightful exploring of advanced nanocarriers for the topical/transdermal treatment of skin diseases	8
In vitro galactose-targeted study of RSPP050-loaded micelles against liver hepatocellular carcinoma	8
Chitosan functionalized PCL nanoparticles bearing tyrosine kinase inhibitor osimertinib mesylate for effective lung cancer therapy	7
Dual-modified PCL-PEG nanoparticles for improved targeting and therapeutic efficacy of docetaxel against colorectal cancer	7
Microfluidics in drug delivery: review of methods and applications	7
Promising nanogels loaded with usnic acid for oral ulcer treatment: development, characterization, and in vivo evaluation in rabbits	7
An overview of polyallylamine applications in gene delivery	7
Oridonin-loaded lipid-coated calcium phosphate nanoparticles: preparation, characterization, and application in A549 lung cancer	7
Bile acids as novel enhancers of CNS targeting antitumor drugs: a comprehensive review	7
Development and characterization of lyophilized cefpodoxime proxetil-Pluronic® F127/polyvinylpyrrolidone K30 solid dispersions with improved dissolution and enhanced antibacterial activity	7
Different applications of temperature responsive nanogels as a new drug delivery system mini review	7
Preparation and characterization of dexamethasone lipid nanoparticles by membrane emulsification technique, use of self-emulsifying lipids as a carrier and stabilizer	7
Preparation and characterization of dicarboxylic acids salt of aripiprazole with enhanced physicochemical properties	7
A multivariate data analysis approach to tablet sticking on an industrial scale: a qualitative case study of an ibuprofen-based formulation	7

Development of ACE2 loaded decoy liposomes and their effect on SARS-CoV-2 for Covid-19 treatment	7
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system	7
Investigation of propellant-free aqueous foams as pharmaceutical carrier systems	7
Exploiting synergistic effects of brittle and plastic excipients in directly compressible formulations of sitagliptin phosphate and sitagliptin hydrochloride	6
Exploring the use of niosomes in cosmetics for efficient dermal drug delivery	6
Drug delivery to the intestinal lymph by oral formulations	6
Surface modifications of gold nanoparticles: stabilization and recent applications in cancer therapy	6
Self-assembled micelles enhance the oral delivery of curcumin for the management of alcohol-induced tissue injury	6
Impact of highly phospholipid-containing lipid nanocarriers on oral bioavailability and pharmacodynamics performance of genistein	6
Evaluation of antitumor efficacy of folate-poly(2-ethyl-2-oxazoline)-distearoyl phosphatidyl ethanolamine based liposome	6
The effect of some acrylic polymers on dissolution of celecoxib solid dispersion formulations	6
Development of rebamipide-loaded spray-dried microsphere using distilled water and meglumine: physicochemical characterization and pharmacokinetics in rats	6
Chitosan as a potential biomaterial for the management of oral mucositis, a common complication of cancer treatment	6
Development and characterization of an amorphous curcumin-Eudragit®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties	6
In-vitro evaluation of dendrimeric formulation of oxaliplatin	6
Covalently coupling doxorubicin to polymeric nanoparticles as potential inhaler therapy:in vitrostudies	6
Hyperoside-loaded TPGs/mPEG-PDLLA self-assembled polymeric micelles: preparation, characterization and in vitro/in vivo evaluation	6
Ethanol-assisted kneading of apigenin with arginine for enhanced dissolution rate of apigenin: development of rapidly disintegrating tablets	6
Preparation, characterization, and anti-colon cancer activity of oridonin-loaded long-circulating liposomes	6
Preparation and evaluation of fast-dissolving films of etilefrine hydrochloride for practical buccal dosing	5
Impact of nanosizing on the formation and characteristics of polymethacrylate films: micro- versus nano-suspensions	5
Rheological and in vitro release measurements of manufactured acyclovir 5% creams: confirming sensitivity of the in vitro release	5
Sucrose acetate isobutyrate (SAIB) and glyceryl monooleate (GMO) hybrid nanoparticles for bioavailability enhancement of rivaroxaban: an optimization study	5
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers	5
Spray drying of naproxen and naproxen sodium for improved tableting and dissolution – physicochemical characterization and compression performance	5
Inhalable spray-dried polycaprolactone-based microparticles of Sorafenib Tosylate with promising efficacy on A549 cells	5
Diltiazem-loaded electrospun nanofibers as a new wound dressing: fabrication, characterization, and experimental wound healing	5
Nanonized carbamazepine for nose-to-brain delivery: pharmaceutical formulation development	5
Development and optimization of oral nanoemulsion of rutin for enhancing its dissolution rate, permeability, and oral bioavailability	5
Major difference in particle size, minor difference in release profile: a case study of solid lipid nanoparticles	5
Sublingual insulin administration: application of hydroxypropyl beta-cyclodextrin and poloxamer188 as permeation enhancers	5
Mechanistic modelling of targeted pulmonary delivery of dactinomycin iron oxide-loaded nanoparticles for lung cancer therapy	5
Formulation and performance evaluation of emulgel platform for combined skin delivery of curcumin and propolis	5
QbD approach to downstream processing of spray-dried amorphous solid dispersions – a case study	5
mPEG-Cholic acid/TPGS mixed micelles for combined delivery of paclitaxel and bufalin to treat hepatocellular carcinoma	4
Emerging nanotechnology based combination therapies of taxanes for multiple drug-resistant cancers	4
Drying behavior of a horizontal vibrated fluidized bed dryer for continuous manufacturing	4
Acetaminophen and tramadol hydrochloride-loaded soft gelatin capsule: preparation, dissolution and pharmacokinetics in beagle dogs	4
Comparative study on the performance of monoolein cubic nanoparticles and trimyristin solid lipid nanoparticles as carriers for docetaxel	4
Bilayer nanofibrous wound dressing prepared by electrospinning containing gallic acid and quercetin with improved biocompatibility, antibacterial, and antioxidant effects	4
The challenge of flavonoid/cyclodextrin complexation in a complex matrix of the quercetin, luteolin, and 3-O-methylquercetin	4
Chrysin–phospholipid complex-based solid dispersion for improved anti-aging and neuroprotective effects in mice	4
Optimization of taste-masked dapoxetine oral thin films using factorial design: in vitro and in vivo evaluation	4
Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d-panthenyl triacetate as combinational treatment	4
Permeation, stability and acute dermal irritation of miroestrol and deoxymiroestrol from Pueraria candollei var. mirifica crude extract loaded transdermal gels	4
Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy	4
The impact of solid-state form, water content and surface area of magnesium stearate on lubrication efficiency, tabletability, and dissolution	4
Catechol-modified chitosan hydrogel containing PLGA microspheres loaded with triclosan and chlorhexidine: a sustained-release antibacterial system for urinary catheters	4
Improved uptake and bioavailability of cinnamaldehyde via solid lipid nanoparticles for oral delivery	4
Development of cyclosporine A nanosuspension: cytotoxicity and permeability on Caco-2 cell lines	4
Multi-dimensional population balance model development using a breakage mode probability kernel for prediction of multiple granule attributes	4
Novel dapagliflozin di-L-proline cocrystal-loaded tablet: preparation, physicochemical characterization, and pharmacokinetics in beagle dogs and mini-pigs	4
Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment	4
Development of a novel oral complex lipid emulsion containing triptolide for targeting pancreatic cancer	4
Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation,in vitro, andin vivoevaluation	3
Recent advances in freeze-drying: variables, cycle optimization, and innovative techniques	3
Fabrication of gastro-floating sustained-release etoricoxib and famotidine tablets: design, optimization , in-vitro , and in-vivo evaluati	3
Erlotinib complexation with randomly methylated β-cyclodextrin improves drug solubility, intestinal permeability, and therapeutic efficacy in non-small cell lung cancer	3
Pharmaceutical suspensions of ursodeoxycholic acid for pediatric patients:in vitroandin vivostudies	3
Stability screening of pharmaceutical cocrystals	3
Mannosylation of pH-sensitive liposomes promoted cytoplasmic delivery of protein to macrophages: green fluorescent protein (GFP) performed as an endosomal escape tracer	3
Quality by design enabled the development of stable and effective oil-in-water emulsions at compounding pharmacy: the case of a sunscreen formulation	3
Preparation of an isorhamnetin phospholipid complex for improving solubility and anti-hyperuricemia activity	3
Development of ezetimibe eutectic with improved biopharmaceutical and mechanical properties to design an optimized oral solid dosage formulation	3
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations	3
Sustained-release of erythropoietin using a novel injectable thermosensitive hydrogel:in vitrostudies, biological activity, and efficacy in rats	3
Physicochemical, pharmacokinetic, and pharmacodynamic characterization of isradipine tablets for controlled release	3
Preparation and in vitro–in vivo evaluation of QbD based acemetacin loaded transdermal patch formulations for rheumatic diseases	3
Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method	3
Topical delivery of Bruton’s tyrosine kinase inhibitor and curcumin-loaded nanostructured lipid carrier gel: Repurposing strategy for the psoriasis management	3
Menthol augmented niosomes for enhanced intestinal absorption of lopinavir	3
Accelerated shelf life modeling of appearance change in drug products using ASAPprime®	3
Preparation and evaluation of vancomycin spray-dried powders for pulmonary delivery	3
Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel	3
Stability of trastuzumab during nanomedicine formulation using SEC-HPLC coupled with polyacrylamide gel electrophoresis	3
Co-delivery of docetaxel and p53 gene from cationic nanoparticles based on poly ( l -lactide) and low-molecular-weight polyethyleneimine (PEA)	3
Pirfenidone as a potential antifibrotic injectable for Dupuytren’s disease	3
In vitro evaluation of enteral tube administration of lansoprazole orally disintegrating tablets	3
Application of a novel multicomponent nanoemulsion to tumor therapy Based on the theory of “unification of drugs and excipients”	3
In-line monitoring of solid dispersion preparation in small scale extrusion based on UV–vis spectroscopy	3

Newly developed nano-biocomposite embedded hydrogel to enhance drug loading and modulated release of anti-inflammatory drug	3
Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis	3
Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer	3
Microneedles enable the development of skin-targeted vaccines against coronaviruses and influenza viruses	3
Compression–decompression modulus (CDM) – an alternative/complementary approach to Heckel’s analysis	3
Effect of Soluplus® on γ-cyclodextrin solubilization of irbesartan and candesartan and their nanoaggregates formation	3
Oxybutynin nanosuspension gel for enhanced transdermal treatment for overactive bladder syndrome	3
Docetaxel liposomes for lung targeted delivery: development and evaluation	3
Experimental design, development and evaluation of extended release subcutaneous thermo-responsive in situ gels for small molecules in drug discovery	3
Engineered PLGA microspheres for extended-release of naltrexone: in vitro, in vivo , and IVIVR	2
Nanoparticle-containing lyophilized dry powder inhaler formulations optimized using central composite design with improved aerodynamic parameters and redispersibility	2
In-silico, in-vitro and ex-vivo evidence of combining silymarin phytopharmaceutical with piperine, and fulvic acid for enhancing its solubility and permeability	2
In vitro evaluation and in vivo efficacy studies of a liposomal doxorubicin-loaded glycyrretinic acid formulation for the treatment of hepatocellular	2
Effect of functional excipients on the dissolution and membrane permeation of furosemide formulated into multiple-unit pellet system (MUPS) tablets	2
Hydrolysis kinetics of the prodrug myristyl nicotinate	2
Extrusion-based technologies for 3D printing: a comparative study of the processability of thermoplastic polyurethane-based formulations	2
Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route	2
Ivermectin: recent approaches in the design of novel veterinary and human medicines	2
Fabrication and in vitro characterization of zinc oxide nanoparticles and hyaluronic acid-containing carboxymethylcellulose gel for wound healing application	2
Profiling gene expression dynamics underpinning conventional testing approaches to better inform pre-clinical evaluation of an age appropriate spironolactone formulation	2
Nanoparticle-based chewable gels of praziquantel	2
Effect of PEGylation on drug uptake, biodistribution, and tissue toxicity of efavirenz–ritonavir loaded PAMAM G4 dendrimers	2
Development of a nanotechnological hydrogel containing desonide nanocapsules in association with acai oil: design and in vivo evaluation	2
Formulation of smokeless tobacco products with a wide range of pH to study nicotine pharmacokinetics and pharmacodynamics	2
Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser	2
Enhancement of the dissolution and in-vitro activity of a new antineoplastic agent	2
Preparation of a novel tacrolimus ion sensitive ocular in situ gel and in vivo evaluation of curative effect of immune conjunctivitis	2
Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model	2
Optimization of nanovesicular carriers of a poorly soluble drug using factorial design methodology and artificial neural network by applying quality by design approach	2
Solid dispersions based on chitosan/hypromellose phthalate blends to modulate pharmaceutical properties of zidovudine	2
Formulation and characterization studies of inclusion complexes of voriconazole for possible ocular application	2
Controlled release of bioactive IL-2 from visible light photocured biodegradable elastomers for cancer immunotherapy applications	2
Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with tribasic calcium phosphate	2
Remdesivir powders manufactured by jet milling for potential pulmonary treatment of COVID-19	2
Supercritical CO 2 versus water as an antisolvent in the crystallization process to enhance dissolution rate of curcumin	2
Niosomal formulation of hydroxytyrosol, a polyphenolic antioxidant, for enhancing transdermal delivery across human cadaver skin	2
Characterization of co-amorphous carvedilol–maleic acid system prepared by solvent evaporation	2
Optimizing formulation parameters for the development of carvedilol injectable in situ forming depots	2
Pueraria flavones-loaded bile salt liposomes with improved intestinal absorption and oral bioavailability: in vitro and in vivo evaluation	2
Development of an enhanced formulation to minimize pharmacokinetic variabilities of a weakly basic drug compound	2
Effect of drug load and lipid–wax blends on drug release and stability from spray-congealed microparticles	2
A systematic review of emerging technologies to enhance the treatment of ovarian cancer	2
Hexagonal liquid crystalline system containing cinnamaldehyde for enhancement of skin permeation of sinomenine hydrochloride	2
Optimization of topical curcumin spanlastics for melanoma treatment	2
Sustained release of curcumin self-emulsifying drug delivery system (SEDDS) from solvent-cast Soluplus® films	2
A study on distribution and stability of drugs at the interface of a scutellarin-loaded emulsion	2
Design of a vertical Loss-in-Weight feeder prototype with experimental proof of concept validation	2
A novel technique to evaluate nail softening effects of different urea formulations	2
Pharmaceutical tablet compression: measuring temporal and radial concentration profiles to better assess segregation	2
Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials throughout the supply chain	2
Improved direct compression properties of Gardeniae fructus water extract powders via fluid bed-mediated surface engineering	2
The efficiency and mechanism of a new absorption enhancer, malic acid, for enhancing the oral bioavailability of docetaxel	2
Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: formulation, in vitro and in vivo evaluation	2
Chondroitin Sulphate-Chitosan polyelectrolyte complexes for etorocoxib transdermal delivery: in silico , in vitro and in vi	2