OOIR: Observatory of International Research

Papers

(The TQCC of Organic Process Research & Development is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	212
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	122
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	76
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	73
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	73
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	67
Issue Editorial Masthead	63
Issue Publication Information	62
Issue Publication Information	61
Issue Editorial Masthead	61
Issue Editorial Masthead	58
Issue Publication Information	58
Issue Editorial Masthead	57
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	52
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	49
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	47
Application of an Interdisciplinary Approach to Form Selection in Drug Development	43
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	42
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	41
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	40
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	40
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	40
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	38
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	36
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	34

Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	34
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	34
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	34
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	34
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	33
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	32
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	31
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	31
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	30
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	29
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	28
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	28
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	28
Issue Publication Information	27
Issue Editorial Masthead	27
Issue Publication Information	27
Issue Publication Information	27
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	26
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	26
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	26
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	26
Regulatory Highlights	25
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	25
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	25
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	24
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	24
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	24
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	24
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction	24
Excellence in Industrial Organic Synthesis 2021	24
Process Development for Continuous Manufacturing of Baloxavir Marboxil. Part 2: Step 2 Synthesis	23
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	23
Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production	23
Bulk Mixing in a Milligram-Scale Solid Phase Batch Reactor	23
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	23
Design Space Visualization and Technoeconomic Evaluation of a Batch Manufacturing Process for the Green Production of an Anti-cancer Drug (Adavosertib) Precursor	22
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	22
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	22
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	22
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	22
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation	21
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	21
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	21
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	21
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	21
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	21
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	20
Tetramethylchloroformamidinium Hexafluorophosphate– N -Methylimidazole Amidation in Water: Successes, Limitations, and a Regression Model for Prediction	20
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	20
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	20

Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	20
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	20
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	20
New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization	19
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	19
Continuous Reduction of an Ester to Aldehyde in CSTR: From Laboratory to Industrial Plant	19
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	19
Co-Catalyst Enabled Biotransformation of Polyunsaturated Fatty Acids for Biobased Monomers	19
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	19
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278	19
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	18
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	18
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	18
Characterization, Solubility, and Hygroscopicity of BMS-817399	17
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	17
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	17
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	17
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	17
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	17
Some Items of Interest to Process R&D Chemists and Engineers	16
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	16
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	16
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	16
Discovery of Oxazole Byproduct Formation in the Modified Dakin–West Reaction and Efficient Synthesis of Diastereomeric α-Ketoamide Cysteine Protease Inhibitors	16
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	16
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	16
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	15
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	15
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	15
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	15
Thermal Hazard Evaluation and Safety Considerations for the Use of O-Benzoyl-N-alkyl Hydroxylamines as Synthetic Reagents	15
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	15
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	15
Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan	15
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	15
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	15
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	15
Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters	15
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	14
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	14
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	14
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	14
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	14
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	14
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	14
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	14
Some Items of Interest to Process R&D Chemists and Engineers	14
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	14
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	14
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	14
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	14
Development and Optimization of a Scalable Enzymatic Cascade-Carbamate Formation Telescope Process for the Synthesis of CDK2 Selective Candidate Tegtociclib (PF-07104091)	14
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	13
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	13
Issue Publication Information	13
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	13
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	13
Solid Acid-Enabled N-Boc Deprotection and Acetal Hydrolysis in the Synthesis of Vepdegestrant	13
Development of a Reliable Low-Loading Palladium-Catalyzed Monoamination Process for the Large-Scale Synthesis of 3-Bromo-2,5-difluoroaniline	13
Nitrosamine Risk Assessments in Oligonucleotides	13
Issue Publication Information	13
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	13
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	13
Issue Publication Information	13
Recent Advances in Nonprecious Metal Catalysis	13
Issue Publication Information	12
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	12
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	12
Issue Publication Information	12
Integrating Process Safety Consideration to Enhance Route Development and Optimization	12
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	12
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	12
Issue Editorial Masthead	12
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	12
Expeditious and Automated Dispensing of ChemBeads for High-Throughput Experimentation in 384-Well Microtiter Plates	12
Process Development of the Novel LpxC Inhibitor T-1228. Part 1: Synthesis of the Diol Fragment	12
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	12
Continuous Manufacturing of Rocuronium Bromide Part 2: Step 2 Process Development	12
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	11
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	11

Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	11
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	11
Some Items of Interest to Process R&D Chemists and Engineers	11
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	11
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	11
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	11
Regulatory Highlights	11
Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control	11
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	11
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	11
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	11
Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst	11
Some Items of Interest to Process R&D Chemists and Engineers	11
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons	11
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	10
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	10
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	10
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	10
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	10
Practical and Scalable Synthesis of 1,3-Adamantanediol	10
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	10
Issue Publication Information	10
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	10
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	10
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	10
Optimization of a Parham Cyclization Aided by In Situ FTIR for an Enabling Synthesis of Tricyclo[6.2.0.0^3,6]deca-1,3(6),7-trien-2-amine	10
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	10
A Sustainable Approach to ε-Lys Branched GLP-1 Analogs: Integrating Green SPPS, Metal-free Alloc Removal, Waste Minimization and TFA/PFAS-free Resin Cleavage	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	10
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	10
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	10
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	10
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	10
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	10
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	10
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	10
Issue Editorial Masthead	10
Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation	10
Some Items of Interest to Process R&D Chemists and Engineers	9
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP)	9
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	9
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	9
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	9
Continuous Manufacturing of Rocuronium Bromide. Part 1: Step 1 Process Development	9
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	9
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	9
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	9
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	9
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	9
Green Chemistry Articles of Interest to the Pharmaceutical Industry	9
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	9
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	9
Study on the Safety Design of 3-Amino-6-Bromo-1,2,4-Triazine Drying Process Based on Thermal Analysis Technology	9
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	9
Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development	9
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	9
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	9
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	9
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	9
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	9
Technology Transfer and Process Development of Danicopan to Enable Process Validation	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol Hydrochloride	8
Development of a Continuous Flow Synthesis of Lorazepam	8
Correction to “Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: A Key Interme	8
Issue Editorial Masthead	8
Issue Editorial Masthead	8
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	8
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm	8
Issue Publication Information	8
An Ultrafast Production of Imidazoles at Low Temperature with a 3D-Printed Microflow Reactor	8
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	8
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	8
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	8
Issue Editorial Masthead	8
Issue Publication Information	8
Acetonitrile Regeneration from Oligonucleotide Production Waste Streams	8
Quantification of Nitrite in Excipients and Chemicals: A Versatile and Highly Sensitive Method Using Headspace Gas Chromatography Coupled to Mass Spectrometry	8
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	8
Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594	8
Process Safety from Bench to Pilot to Plant	8
Risk Assessment of the Leachables’ Profile for Small-Molecule Pharmaceutical Drug Substances	8
Stereoselective Nickel(II)-Catalyzed Addition of Aryl Grignards to Diphenylacetylene in the Synthesis of Zuclomiphene	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture	8
Accurate Quantitation of N-Nitrosodimethylamine in Pharmaceutical Products with High Levels of N,N-Dimethylformamide by HPLC-MS	8
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	8
Scalable and Safe Transformation of 3-Hydroxypropionitrile to Its Amidoxime	8
Issue Editorial Masthead	8
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	8
Methanol Steam Reforming Controls the Selective Transfer Hydrogenation vs N-Methylation of Nitrobenzene Using a PVP-Stabilized IrO₂ Nanoparticle Catalyst	8