Organic Process Research & Development

Article	Citations
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	147
Issue Editorial Masthead	94
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	79
Deracemization via Periodic and Non-periodic Temperature Cycles: Rationalization and Experimental Validation of a Simplified Process Design Approach	76
Issue Publication Information	57
Green Chemistry Articles of Interest to the Pharmaceutical Industry	53
Three-Step One-Pot Process of 3-Methyl-5-Benzofuranol from Amine, Aldehydes, and p-Benzoquinone	52
Binary Solvent Swap Processing in a Bubble Column in Batch and Continuous Modes	48
Importance of Thermal Stability Data to Avoid Dangerous Reagents: Temozolomide Case Study	44
Issue Editorial Masthead	42
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	42
Development of a Practical and Scalable Synthetic Route for the Adenosine Monophosphate-Activated Protein Kinase Activator, ASP4132	40
Development of an Optimized Synthetic Process for an Antiobesity Drug Candidate (S-234462) Featuring Mild Chlorination of Benzoxazolone and In Situ IR Monitoring of a Mitsunobu Reaction	39
Scaling up a C–H Borylation: Addressing the Safety Concerns of an Iridium-Catalyzed Process for Multikilo Scale Manufacture	38
Issue Publication Information	35
Consolidating and Managing Data for Drug Development within a Pharmaceutical Laboratory: Comparing the Mapping and Reporting Tools from Software Applications	34
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	34
Issue Publication Information	33
In Support of Early-Career Researchers	32
Reduction in the Thermal Stability of Nitro-Containing Compounds due to Cross-Catalyzed Autocatalytic Decomposition Caused by Nitro-Containing Impurities	32
Issue Publication Information	31
Synthesis of BACE1 Inhibitors E2609/E2071 via Oxime–Olefin Cycloaddition Following a Process Risk Mitigation Strategy	30
Process Development of Tacalcitol	30
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	30
Some Items of Interest to Process R&D Chemists and Engineers	30

Implementation of MSMPR Crystallization to Avoid Liquid–Liquid Phase Separation	30
Biocatalysis: Improving Enzymatic Processes through Protein and Reaction Engineering	30
Issue Editorial Masthead	29
Issue Publication Information	29
Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor	28
Practical Manufacturing Process for Baloxavir Marboxil: Efficient Route to a Tricyclic Triazinanone Scaffold	28
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm	28
Citation Bias in Organic Chemistry Research: Are Industry-Affiliated Papers Cited Less Often?	27
Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates	27
Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols	26
Catalyst-Free and Scalable Process for Synthesis of Novel MAP4K4 Inhibitor DMX-5804 and Its Glyco-Conjugates	26
Hydroformylation and Late-Stage Diversification on Densely Functionalized Cores of Influenza Endonuclease Inhibitors	25
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	25
Acetonitrile Regeneration from Oligonucleotide Production Waste Streams	25
Method to Rapidly Identify Potential Solvent Systems for Crystallization of Cocrystals	25
Issue Editorial Masthead	24
Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594	23
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	22
Development of a Continuous Flow Synthesis of Lorazepam	22
Issue Editorial Masthead	22
Issue Editorial Masthead	22
High-Yielding Process for the Synthesis of Hydroxychloroquine under Concentrated Conditions: Nucleophilic Amination of Chloropyridines Promoted by Dimethyl Sulfoxide or Catalyzed by 3,5-Bis(trifluorom	22
Process Safety from Bench to Pilot to Plant	22
Simple Methods to Predict Particle Size for Growth-Only Systems Undergoing One or More Temperature Cycles	21
A Novel and Practical Synthesis of Mavorixafor	21
Thermal Risk Assessment and Optimization of Hazard Ranking for Aromatic Nitro Compounds: Multiparameterization and Quantitative Structure–Property Relationship Modeling	21
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	20
Efficient, Scalable Synthesis of Functionalized Pyrrolo[2,1-f][1,2,4]triazines	20
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	20
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	19
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	19
Process Intensification via End-to-End Continuous Manufacturing of Atorvastatin Calcium Using an Integrated, Modular Reaction-Crystallization-Spherical Agglomeration-Filtration-Drying Process	19
Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir	19
Development of a Cryogenic Flow Reactor to Optimize Glycosylation Reactions Based on the Active Donor Intermediate	19
Continuous Crystallization Kinetics of Cefradine in a Mixed Suspension Mixed Product Removal System	18
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	18
Proprietary Synthesis of the C27–C35 Fragment of Eribulin and Its Elaboration toward the C14–C35 Subunit	18
Development of the Late-Phase Manufacturing Process of ZPL389: Control of Process Impurities by Enhanced Process Knowledge	18
Regulatory Highlights	18
Solvent Switching in Continuous Multistep Chemoenzymatic Synthesis: Telescoping Enzymatic Synthesis of Chiral, Pyridine-Containing Amines with Cross-Coupling as a Case Study	18
Some Items of Interest to Process R&D Chemists and Engineers	18
Issue Editorial Masthead	18
Synthesis of Fingolimod Employing Regioselective Aziridine Ring-Opening Reaction as a Key Step	17
Understanding and Controlling the Formation of an N-Alkyl Impurity in Olmesartan Medoxomil: A Derivative via Michael-Type Addition between Tetrazole and Mesityl Oxide In Situ Generated from Ace	17
Issue Editorial Masthead	17
Risk Assessment of the Leachables’ Profile for Small-Molecule Pharmaceutical Drug Substances	17
Highly Efficient Production of Optically Active (R)-Tetrahydrothiophene-3-ol in Batch and Continuous Flow by Using Immobilized Ketoreductase	16
Removal of Alkyl Sulfonates Using DABCO	16
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	16
Synthesis of Rovafovir Etalafenamide (Part IV): Evolution of the Synthetic Process to the Fluorinated Nucleoside Fragment	16

Discovery of New Fe(II)/α-Ketoglutarate-Dependent Dioxygenases for Oxidation of l-Proline	16
Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient	16
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	16
Some Items of Interest to Process R&D Chemists and Engineers	16
Continuous-Flow Synthesis of syn-2-Amino-1,3-diol via Catalytic Hydrogenation: A Vital Intermediate of (+)-Thiamphenicol and (+)-Florfenicol	15
Some Items of Interest to Process R&D Chemists and Engineers	15
Correction to “Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow”	15
Corrections to “An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer”	15
A Scalable Solution to Constant-Potential Flow Electrochemistry	15
Six-Step Gram-Scale Synthesis of the Human Immunodeficiency Virus Integrase Inhibitor Dolutegravir Sodium	15
Palladium-Catalyzed C–O Cross-Coupling as a Replacement for a Mitsunobu Reaction in the Development of an Androgen Receptor Antagonist	15
Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study	15
Some Items of Interest to Process R&D Chemists and Engineers	15
Issue Publication Information	15
Efficient Synthesis of (S)-Nornicotine using Co-Immobilized IRED and GDH in Batch and Continuous Flow Reaction Systems	15
Some Items of Interest to Process R&D Chemists and Engineers	15
Issue Publication Information	15
Thermal Runaway Inhibition of Adipic Acid Green Synthesis Based on a Radical Chain Reaction Mechanism	14
Energetic Material Synthesis: Scale-up Using a Novel Modular Microflow Reactor Setup	14
Stereoselective Nickel(II)-Catalyzed Addition of Aryl Grignards to Diphenylacetylene in the Synthesis of Zuclomiphene	14
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	14
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1	14
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	14
High-Throughput Experimentation Enabling Rapid Process Optimization of an RSV Drug Candidate	14
Identification of Kinetics and Autocatalytic Behavior in Acetic Anhydride Hydrolysis Reaction via Reaction Calorimetry	14
Side-Chain Unprotected Fmoc-Arg/His/Tyr-OH Couplings and Their Application in Solid-Phase Peptide Synthesis through a Minimal-Protection/Green Chemistry Strategy	14
Some Items of Interest to Process R&D Chemists and Engineers	14
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	14
Optimized Synthesis of the Key Intermediate of Telmisartan via the Cyclization of 2-Bromoarylamine with n-Butyronitrile	14
Strategy to Assess and Control Nitrosamine Formation in API during Storage: A Sitagliptin Case Study	13
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization	13
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	13
Continuous Flow Synthesis of tert-Butyl Nitrite and Its Applications as Nitrating Agent	13
Optimized Synthesis of a Key Intermediate of Nirmatrelvir	13
Analysis of the Change in Molecular Complexity of Reaction Products in Process Development Activities at AstraZeneca Over Time	13
Some Items of Interest to Process R&D Chemists and Engineers	13
Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture	13
Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group	13
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	13
Synthetic Process Development of (R)-(+)-1,2-Epoxy-5-hexene: An Important Chiral Building Block	13
Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir	13
Preparation of Enantiopure 3-Aminopiperidine and 3-Aminoazepane Derivatives from Ornithine and Lysine. Consecutive Syntheses of Pharmacologically Active Analogs, Such as Besifloxacin	13
Scalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet	13
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	12
Improved Synthetic Process of Baloxavir Marboxil Intermediate 3-Benzyloxy-4-oxo-4H-pyran-2-carboxylic Acid	12
First Multikilogram Synthesis of the Next-Generation Oral Selective ERα Degrader Camizestrant	12
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO) III: Investigations Regarding the Main Decomposition	12
Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy	12
Some Items of Interest to Process R&D Chemists and Engineers	12
Development of a Scalable Synthetic Route to BMS-986251, Part 2: Synthesis of the Tricyclic Core and the API	12
Early Process Development of CH7057288, a Benzofuran-Containing Selective NTRK Inhibitor	12
Refractive Index to Monitor Solid-Phase Oligonucleotide Synthesis	12
Application of Continuous Flow in Tazobactam Synthesis	12
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	12
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	12
Early Process Development of Two Vanin-1 Inhibitors: Solid Form Challenges and Control of Ambident Reactivity	12
Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183	12
Optimized Process and Quality Evaluation for Ketamine Hydrochloride	12
A Journey through Process Development Enhanced by Kinetic Modeling: An Efficient Manufacturing Route to Balcinrenone	11
Issue Editorial Masthead	11
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	11
Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction	11
Robust Liquid Chromatography–Mass Spectrometry Determination of Deuterium Isotopologues for Quality Control of Deucravacitinib Using Nominal Mass Instrumentation	11
Process Development for the Manufacture of a Topical Pan-Trk Inhibitor Incorporating Decarboxylative sp2–sp3 Cross-Coupling	11
A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug	11
Practical Synthesis of Tenofovir Alafenamide Fumarate Inspired by New Retrosynthetic Disconnection Featuring a Novel Carbon–Phosphorus Bond Construction Methodology	11
Issue Publication Information	11
Atom-Economical and Environmentally Friendly Bts-Based Purine PNA Monomers without Base-Protecting Groups	11
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	11
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	11
Development of a Scalable Method for the Synthesis of Ethoxy(pentafluoro)cyclotriphosphazene	11
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	10
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	10
A Consideration of the Extent That Tertiary Amines Can Form N-Nitroso Dialkylamines in Pharmaceutical Products	10
Synthesis of N-Bromo and N-Iodo Imides: A Rapid Redox-Neutral and Bench Stable Process	10
Pd-Catalyzed Cyanation of a Bromoaryl Carboxylate En Route to Etrumadenant: Robust Process with Low Catalyst Loading Enabled by Preactivation	10
Synthesis of 5-Substituted Tetrazoles: Reaction of Azide Salts with Organonitriles Catalyzed by Trialkylammonium Salts in Non-polar Media	10
An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer	10
Quantification of Nitrite in Excipients and Chemicals: A Versatile and Highly Sensitive Method Using Headspace Gas Chromatography Coupled to Mass Spectrometry	10
Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation	10

Development of a Telescoped Alkylation/Reduction Reaction Sequence and an Asymmetric Hydrogenation to Enable the Kilogram Synthesis of ABBV-3748	10
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture	10
Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam	10
Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272	10
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Development of a Highly Efficient Synthesis for Ciprofloxacin	10
Use of Bayesian Modeling for Risk Assessment and Robustness Evaluation	10
Regulatory Highlights	10
Development of a Scalable Process for the Synthesis of Cyclopropyl-Methyl-Proline with Complex Stereochemistry: A Key Building Block of Factor D Inhibitors	10
Development of Scalable Processes with Underutilized Biocatalyst Classes	10
How to Develop Organometallic Catalytic Reactions in the Pharmaceutical Industry	10
Application of a Statistical Approach to Process Development of Futibatinib by Employing Quality-by-Design Principles. Part 1: Identification of Critical Process Parameters for Impurities	9
Oligonucleotide Purification by Ion Exchange Chromatography: A Step-by-Step Guide to Process Understanding, Modeling, and Simulation	9
Issue Publication Information	9
Industrial-Scale Organic Solvent Nanofiltration for Dimer Impurity Removal: Enhancing Vitamin D3 Production	9
Insights into Large-Scale Synthesis of Benfotiamine	9
Development of a Commercial Process for Odalasvir	9
Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?	9
Continuous Flow Chemistry with Solids: A Review	9
Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379	9
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	9
Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow	9
High-Throughput Crystallization Screening Technique with Transmission PXRD Analysis	9
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis	9
Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)	9
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	9
Catalytic Activity of Triphenylphosphine for Electrophilic Aromatic Bromination Using N-Bromosuccinimide and Process Safety Evaluation	9
Co-immobilized Multienzyme System for the Cofactor-Driven Cascade Synthesis of (R)-2-Amino-3-(2-bromophenyl)propanoic Acid: A Model Reaction	9
Platform Strategies for Synthetic Oligonucleotide Drug Substances	9
Antibody–Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology	9
Issue Editorial Masthead	9
Opportunities for Machine Learning and Artificial Intelligence to Advance Synthetic Drug Substance Process Development	9
Integrated Continuous Pharmaceutical Technologies—A Review	9
PAT Implementation on a Mobile Continuous Pharmaceutical Manufacturing System: Real-Time Process Monitoring with In-Line FTIR and Raman Spectroscopy	9
Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran	9
Improved Purification of GalNAc-Conjugated Antisense Oligonucleotides Using Boronic Acids	9
Temperature-Controlled Photoreactors and ChemBeads as Key Technologies for Robust and Practical Photochemical HTE	9
pH-Switchable Phase-Transfer Agents for Host Cell Protein Rejection in the Cascaded Biocatalytic Synthesis of an Active Pharmaceutical Ingredient	9
Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 2: Synthesis of the Payload, Linker, and Drug Linker	9
Recent Advances in Nonprecious Metal Catalysis	9
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	9
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	9
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	9
Recommendations for Effective and Defendable Implementation of Quality by Design	9
Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations	9
Novel Analytical Approach to Quantify Reactive Potentially Mutagenic Sulfonate Ester Impurities in Pharmaceutical Compounds and Its Application in the Development of a Control Strategy for Nonaflate I	9
Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir	9
Novel, Practical, and Scalable Approach for the Synthesis of Eldecalcitol	8
Application of an Interdisciplinary Approach to Form Selection in Drug Development	8
When Safety Data Sheets are a Safety Hazard	8
Pd-Catalyzed Miyaura Borylations Mediated by Potassium Pivalate with Alcohol Cosolvents	8
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	8
Thermal Stability, OREOS+ Explosive Hazard Assessment, and Maximum Safe Storage Temperature of Cyclic Hypervalent Iodine (λ-3-Iodane)-Based Reagents	8
Rediscovery of an Old Named Reaction: From Micellar Catalysis to Unusual Schotten–Baumann Conditions	8
Predicting the Fire and Explosion Properties of Early-Phase Active Pharmaceutical Ingredients	8
Practical Synthesis of (+)-Biotin Key Intermediate by Calcium Borohydride Reduction and Temperature-Dependent Purity Upgrade during Crystallization	8
Selective Thermal Deprotection of N-Boc Protected Amines in Continuous Flow	8
OPR&D: An Exceptional Legacy and Exciting Opportunities for the Future of Process Chemistry	8
Scalable and Safe Transformation of 3-Hydroxypropionitrile to Its Amidoxime	8
Optimization and Thermal Risk Analysis of 3,4-bis(4-Aminofurazano-3-yl) Furoxan Synthesis Process Based on Reaction Mechanism	8
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	8
The ReactALL Platform: Experimental Data and Case Studies	8
Stereoselective Synthesis of a Tubulysin Core for Antibody–Drug Conjugate Studies	8
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl2-BINOL	8
New Bench-Scale Method To Elucidate Active Pharmaceutical Ingredient Drying Mechanisms	8
Process Development and Optimization of Linagliptin Aided by the Design of Experiments (DoE)	8
Exploration for Chemical Filter Cartridges that Can Reduce Nitrogen Oxides, a Common Factor in the Formation of Nitrosamines	8
Recent Highlights in Micellar Catalysis: An Industrial Outlook	8
Trace-Level Determination of Acrylonitrile Generated in the Manufacturing Process of Oligonucleotides by Static Headspace Gas Chromatography with an Electron Impact(+) Mass Detector	8
The Identification of Naloxone-Related Drug Product Degradants	8
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	8
Issue Publication Information	8
Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid A	8
Issue Publication Information	7
Issue Editorial Masthead	7
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	7
Strategies for UF/DF-Based Impurity Removal in the Post-conjugation Purification of Antibody–Drug Conjugates	7
Some Items of Interest to Process R&D Chemists and Engineers	7
Application of Imine Reductase in Bioactive Chiral Amine Synthesis	7
Addition Reaction of Alcohol to Isocyanate Catalyzed by Copper Present in Tap Water: Robust Manufacturing Process of Naldemedine Tosylate	7
Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction	7
Issue Editorial Masthead	7
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	7
Practical and Scalable Synthesis of 5,6-Dichlorofurazano[3,4-b]pyrazine	7
Some Items of Interest to Process R&D Chemists and Engineers	7
Risk Assessment and Control of N-Nitrosamines in Antibody–Drug Conjugates: Current Industry Practices	7
Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation	7
On-Demand Production of Two Commercial Plant Activators, Tiadinil and Methiadinil, under an Integrated Continuous Flow System	7
Early Development, Scale-Up, and Reverse-Phase Purification of a Highly Potent Pyrrolobenzodiazepine Dimer, SG3259, for Use in Antibody–Drug Conjugates	7
Issue Publication Information	7
Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550)	7
Alternative Approach to the Large-Scale Synthesis of the Densely Functionalized Pyrrolidone BMT-415200	7
Process Development and Scale-Up of the SOS1 Inhibitor MRTX0902	7
Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies	7
Issue Publication Information	7
Excellence in Industrial Organic Synthesis 2021	7