OOIR: Observatory of International Research

Papers

(The TQCC of Organic Process Research & Development is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	173
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	94
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	65
Issue Editorial Masthead	62
Issue Editorial Masthead	61
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	54
Issue Editorial Masthead	52
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	51
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	51
Issue Publication Information	50
Issue Editorial Masthead	47
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	46
Issue Publication Information	45
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	45
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	44
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	43
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	43
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	42
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	40
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	39
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	39
Issue Publication Information	38
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	37
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	36
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	36

Issue Editorial Masthead	36
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	35
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	35
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	35
Application of an Interdisciplinary Approach to Form Selection in Drug Development	31
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	30
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	29
Issue Publication Information	28
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	28
Excellence in Industrial Organic Synthesis 2021	28
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	28
Issue Publication Information	27
Some Items of Interest to Process R&D Chemists and Engineers	27
Issue Publication Information	27
Issue Editorial Masthead	26
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	26
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	26
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	26
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	26
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction	26
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation	25
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	25
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	25
Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification	25
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	24
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	24
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	24
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	24
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	23
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	23
Highly Selective Hydrogenation of Phenols to Cyclohexanone Derivatives Using a Palladium@N-Doped Carbon/SiO₂ Catalyst	22
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	22
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	22
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	22
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	22
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	21
Regulatory Highlights	21
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	21
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	21
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	21
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	21
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	21
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	21
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	21
Practical Kilogram Synthesis of (S)-1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine	21
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	20
Evaluation, Method Development, and Validation for Content Determination of Potential Genotoxic Impurities (PGIs) at the TTC Level in Telmisartan API	20
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	20
Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan	20
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	19

Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	19
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	19
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	19
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	18
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	18
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	18
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	18
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	18
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	18
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	18
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	18
Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis	18
Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters	18
Characterization, Solubility, and Hygroscopicity of BMS-817399	17
Issue Publication Information	17
Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations	17
Low-Level Quantification of tert-Butyl Nitrite in a Pharmaceutical Intermediate	17
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	17
Some Items of Interest to Process R&D Chemists and Engineers	17
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	16
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	16
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	16
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	16
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	16
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	16
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	16
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	16
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	16
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	15
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	15
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	15
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	15
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	15
Safe Scale-Up of anN-Bromosuccinimide Involved Bromination Reaction	15
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	15
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	15
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	15
Issue Publication Information	14
Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases	14
Issue Editorial Masthead	14
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	14
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	14
Issue Publication Information	14
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	14
Issue Publication Information	14
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	14
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	14
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	14
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	14
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	13
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	13
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	13
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	13
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	13
Recent Advances in Nonprecious Metal Catalysis	13
Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRAS^G12C Inhibitors	13
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	13
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	13
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	13
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	13
Nitrosamine Risk Assessments in Oligonucleotides	12
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	12
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	12
Some Items of Interest to Process R&D Chemists and Engineers	12
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	12
Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles	12
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	12
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	12
Issue Publication Information	12
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	12
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	12
Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process	12
Practical and Scalable Synthesis of 1,3-Adamantanediol	12
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	12
Some Items of Interest to Process R&D Chemists and Engineers	11
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	11
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	11
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	11
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	11
Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient	11

Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	11
Green Chemistry Articles of Interest to the Pharmaceutical Industry	11
Issue Editorial Masthead	11
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	11
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	11
Optimization and Development of a Scalable Palladium-Catalyzed C–H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator	11
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	11
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	11
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	11
Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation	11
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	11
Regulatory Highlights	11
Issue Publication Information	11
Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	11
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	11
Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst	10
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	10
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	10
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	10
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	10
Issue Publication Information	10
Issue Editorial Masthead	10
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	10
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	10
Ketoprofen Solubility in Pure Organic Solvents Using In Situ FTIR and UV–Vis and Analysis of Solution Thermodynamics	10
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	10
Hybrid Flow-Batch Model for the Efficient Synthesis of 2-(Dimethylamino)-6-methylpyridin-4-ol	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	10
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	10
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	10
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	10
Study on the Safety Design of 3-Amino-6-Bromo-1,2,4-Triazine Drying Process Based on Thermal Analysis Technology	10
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	9
A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Issue Publication Information	9
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	9
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	9
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	9
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	9
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	9
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	9
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	9
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	9
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	9
Issue Editorial Masthead	9
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	9
Issue Editorial Masthead	9
Green Chemistry Articles of Interest to the Pharmaceutical Industry	9
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	9
Efficient Synthesis of a Key Intermediate for Baloxavir Marboxil from a Greener Starting Material: Ethylene Glycol	9
Quantification of Nitrite in Excipients and Chemicals: A Versatile and Highly Sensitive Method Using Headspace Gas Chromatography Coupled to Mass Spectrometry	9
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	9
Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development	9
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	9
Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation	9
Development of a Continuous Flow Synthesis of Lorazepam	9
Issue Editorial Masthead	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	9
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	9
Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology	9
Technology Transfer and Process Development of Danicopan to Enable Process Validation	9
Issue Publication Information	8
Scalable Synthesis of CVN424, an Inverse Agonist of the GPR6 Receptor	8
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	8
Recent Advances in Nonprecious Metal Catalysis	8
A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC	8
Issue Publication Information	8
Some Items of Interest to Process R&D Chemists and Engineers	8
A Scalable Solution to Constant-Potential Flow Electrochemistry	8
Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550)	8
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization	8
Scalable and Safe Transformation of 3-Hydroxypropionitrile to Its Amidoxime	8
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm	8
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	8
Recent Highlights in Micellar Catalysis: An Industrial Outlook	8
Development of an Intrinsically Safer Methanolysis/Aromatic Nitro Group Reduction for Step 1 and 2 of Talazoparib Tosylate	8
Review on Synthetic Approaches toward the Synthesis of Clozapine, an Antipsychotic Drug	8
Development of a Safe and Scalable Method to Prepare 3-Bromo-N-alkyl-1,6-naphthyridones via Enamine Cyclization	8
Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594	8
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	8
Acetonitrile Regeneration from Oligonucleotide Production Waste Streams	8
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	8
Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction	8