Organic Process Research & Development

Article	Citations
Where Does the Fluorine Come From? A Review on the Challenges Associated with the Synthesis of Organofluorine Compounds	152
Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes	82
Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures	76
Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review	76
Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply	75
Potential for the Formation of N-Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water	75
Integrated Continuous Pharmaceutical Technologies—A Review	70
Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond	64
Heterogeneous Catalysis for Cross-Coupling Reactions: An Underutilized Powerful and Sustainable Tool in the Fine Chemical Industry?	60
Organolithium Bases in Flow Chemistry: A Review	56
Applications of Flow Chemistry in the Pharmaceutical Industry—Highlights of the Recent Patent Literature	54
Potential Safety Hazards Associated with Using N,N-Dimethylformamide in Chemical Reactions	51
Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir	50
Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy	49
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO)	49
Continuous Production of Five Active Pharmaceutical Ingredients in Flexible Plug-and-Play Modules: A Demonstration Campaign	49
Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination	47
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	45
Fully Automated Chemical Synthesis: Toward the Universal Synthesizer	45
A Structured Approach To Cope with Impurities during Industrial Crystallization Development	43
Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs	41
Strategies to Tackle the Waste Water from α-Tocopherol-Derived Surfactant Chemistry	41
Comparison of the Thermal Stabilities of Diazonium Salts and Their Corresponding Triazenes	39
Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor	39
A General Kilogram Scale Protocol for Suzuki–Miyaura Cross-Coupling in Water with TPGS-750-M Surfactant	38

Optimization of a Decatungstate-Catalyzed C(sp3)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor	36
Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction	35
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	34
Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels	33
Progress and Opportunities for Utilizing Seeding Techniques in Crystallization Processes	33
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study	33
Ranitidine—Investigations into the Root Cause for the Presence of N-Nitroso-N,N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products	32
Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions	31
Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition	31
Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis	30
Supporting-Electrolyte-Free and Scalable Flow Process for the Electrochemical Synthesis of 3,3′,5,5′-Tetramethyl-2,2′-biphenol	30
A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation	29
Continuous Flow C-Glycosylation via Metal–Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir	29
The Effect of Dissolved Oxygen on Kinetics during Continuous Biocatalytic Oxidations	28
Recent Advances in Enzyme Immobilization Utilizing Nanotechnology for Biocatalysis	28
Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material	26
Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification	26
High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective	26
Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam	26
Development and Execution of an Ni(II)-Catalyzed Reductive Cross-Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate	26
Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis	25
Applications of Quantum Chemistry in Pharmaceutical Process Development: Current State and Opportunities	25
Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib	25
Recent Advances in High-Throughput Automated Powder Dispensing Platforms for Pharmaceutical Applications	25
Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir	25
Improvement of the C-glycosylation Step for the Synthesis of Remdesivir	25
Recent Advances in Photobiocatalysis for Selective Organic Synthesis	25
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation	25
PAT Implementation on a Mobile Continuous Pharmaceutical Manufacturing System: Real-Time Process Monitoring with In-Line FTIR and Raman Spectroscopy	25
Scale-Up of a Heterogeneous Photocatalytic Degradation Using a Photochemical Rotor–Stator Spinning Disk Reactor	25
High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry	24
Seeding Techniques and Optimization of Solution Crystallization Processes	24
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	24
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview	24
Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process	24
From Bench to Plant: An Opportunity for Transition Metal Paired Electrocatalysis	24
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis	24
A Comment on Continuous Flow Technologies within the Agrochemical Industry	23
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	23
Design and Characterization of a Scaled-up Ultrasonic Flow Reactor	23
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration	22
Predicting Performance of Photochemical Transformations for Scaling Up in Different Platforms by Combining High-Throughput Experimentation with Computational Modeling	22
Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia	22
Organosilanes in Metal-Catalyzed, Enantioselective Reductions	21
Development of Scalable Routes to 1-Bicyclo[1.1.1]pentylpyrazoles	21
Recent Advances in Nonprecious Metal Catalysis	21
Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M	21
Use of High-Throughput Tools for Telescoped Continuous Flow Synthesis of an Alkynylnaphthyridine Anticancer Agent, HSN608	21
Efficient Kinetic Data Acquisition and Model Prediction: Continuous Flow Microreactors, Inline Fourier Transform Infrared Spectroscopy, and Self-Modeling Curve Resolution	21
Upscaling Photoredox Cross-Coupling Reactions in Batch Using Immersion-Well Reactors	21

3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow	21
In Situ Imaging Combined with Deep Learning for Crystallization Process Monitoring: Application to Cephalexin Production	21
Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?	21
Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF3I Gas	20
Recent Advances in Nonprecious Metal Catalysis	20
Insights into Fast Amide Couplings in Aqueous Nanomicelles	20
Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution	20
API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing	20
Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques	20
Minimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions	20
Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction	19
A Digital Workflow Supporting the Selection of Solvents for Optimizing the Crystallizability of p-Aminobenzoic Acid	18
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production	18
Development of an Efficient Synthetic Process for Broflanilide	18
Decarboxylative Bromination of Sterically Hindered Carboxylic Acids with Hypervalent Iodine(III) Reagents	18
Pd-Catalyzed Cross-Couplings: On the Importance of the Catalyst Quantity Descriptors, mol % and ppm	18
Efficient Asymmetric Synthesis of Ethyl (S)-4-Chloro-3-hydroxybutyrate Using Alcohol Dehydrogenase SmADH31 with High Tolerance of Substrate and Product in a Monophasic Aqueous System	18
Electrochemical Cyclobutane Synthesis in Flow: Scale-Up of a Promising Melt-Castable Energetic Intermediate	18
Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib	18
Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids	18
Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor	18
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process	18
A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug	18
Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead	18
Green Chemistry: A Framework for a Sustainable Future	18
Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control	18
Heterogeneous Crystallization as a Process Intensification Technology in an Integrated Continuous Manufacturing Process for Pharmaceuticals	18
Recent Advances in Nonprecious Metal Catalysis	17
Development and Production of an Enantioselective Tetrahydroisoquinoline Synthesis Enabled by Continuous Cryogenic Lithium–Halogen Exchange	17
Controlling a Cohort: Use of Mirabilis-Based Purge Calculations to Understand Nitrosamine-Related Risk and Control Strategy Options	17
Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran	17
Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients	17
Multigram Synthesis of Pure HMF and BHMF	17
Evaluation and Screening of Spherical Pd/C for Use as a Catalyst in Pharmaceutical-Scale Continuous Hydrogenations	17
Drug Development through Modification of Small Molecular Drugs with Monodisperse Poly(ethylene glycol)s	17
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	17
Integrating Continuous-Flow Electrochemistry and Photochemistry for the Synthesis of Acridinium Photocatalysts Via Site-Selective C–H Alkylation	17
A Continuous-Flow Electrochemical Taylor Vortex Reactor: A Laboratory-Scale High-Throughput Flow Reactor with Enhanced Mixing for Scalable Electrosynthesis	16
Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation	16
High-Throughput Classical Chiral Resolution Screening of Synthetic Intermediates: Effects of Resolving Agents, Crystallization Solvents, and Other Factors	16
Development of a Commercial Manufacturing Route to 2-Fluoroadenine, The Key Unnatural Nucleobase of Islatravir	16
Ruthenium-Catalyzed Ester Reductions Applied to Pharmaceutical Intermediates	16
Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow	16
Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib	16
Ketone Reductase Biocatalysis in the Synthesis of Chiral Intermediates Toward Generic Active Pharmaceutical Ingredients	16
Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow	16
Toward a Scalable Synthesis and Process for EMA401, Part III: Using an Engineered Phenylalanine Ammonia Lyase Enzyme to Synthesize a Non-natural Phenylalanine Derivative	15
Developing a Batch Isolation Procedure and Running It in an Automated Semicontinuous Unit: AWL CFD25 Case Study	15
Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation	15
Explosive Hazard Identification in Pharmaceutical Process Development: A Novel Screening Method and Workflow for Shipping Potentially Explosive Materials	15
Continuous and Selective Hydrogenation of Heterocyclic Nitroaromatics in a Micropacked Bed Reactor	15
Synthesis of a Crizotinib Intermediate via Highly Efficient Catalytic Hydrogenation in Continuous Flow	15
Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis	15
Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics	15
High-Throughput Salt Screening of Synthetic Intermediates: Effects of Solvents, Counterions, and Counterion Solubility	14
Styrene Oxide Isomerase Catalyzed Meinwald Rearrangement Reaction: Discovery and Application in Single-Step and One-Pot Cascade Reactions	14
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Development of a Highly Efficient Synthesis for Ciprofloxacin	14
Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate	14
An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines	14
Biocompatible Catalysts for Lactide Polymerization—Catalyst Activity, Racemization Effect, and Optimization of the Polymerization Based On Design of Experiments	14
High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades	14
Two Scalable Syntheses of 3-(Trifluoromethyl)cyclobutane-1-carboxylic Acid	14
Antibody–Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology	14
Synthesis Development of the Selective Estrogen Receptor Degrader (SERD) LSZ102 from a Suzuki Coupling to a C–H Activation Strategy	14
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis	14
Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective	14
A Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesis	14
Cost-Effective Flow Peptide Synthesis: Metamorphosis of HPLC	14
Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts	14
Taming Troublesome Suzuki–Miyaura Reactions in Water Solution of Surfactants by the Use of Lecithin: A Step beyond the Micellar Model	14
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor	14
Process Intensification for Obtaining a Cannabidiol Intermediate by Photo-oxygenation of Limonene under Continuous-Flow Conditions	13
Recent Advances in Nonprecious Metal Catalysis	13
Scale-Up of Ozonolysis using Inherently Safer Technology in Continuous Flow under Pressure: Case Study on β-Pinene	13
Development of a Commercial Process for Deucravacitinib, a Deuterated API for TYK2 Inhibition	13
Development of the Convergent, Kilogram-Scale Synthesis of an Antibacterial Clinical Candidate Using Enantioselective Hydrogenation	13
Recent Advances in Nonprecious Metal Catalysis	13
Synthesis and Applications of Periodate for Fine Chemicals and Important Pharmaceuticals	13
Investigation of On-Resin Disulfide Formation for Large-Scale Manufacturing of Cyclic Peptides: A Case Study	13
Diethanolamine Boronic Esters: Development of a Simple and Standard Process for Boronic Ester Synthesis	13

Scalable Aerobic Oxidation of Alcohols Using Catalytic DDQ/HNO3	13
Quest for a Cure: Potential Small-Molecule Treatments for COVID-19, Part 2	13
Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated On Demand	13
Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates	13
Effective Control of Crystal Size via an Integrated Crystallization, Wet Milling, and Annealing Recirculation System	13
Development of a Large-Scale Route to Glecaprevir: Synthesis of the Side Chain and Final Assembly	13
Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles	13
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	13
Novel Si(II)+ and Ge(II)+ Compounds as Efficient Catalysts in Organosilicon Chemistry: Siloxane Coupling Reaction	13
Kinetics of Polycondensation of Citric Acid with Glycerol Based on a Genetic Algorithm	13
Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029	12
Application of the New 400 MHz High-Temperature Superconducting (HTS) Power-Driven Magnet NMR Technology for Online Reaction Monitoring: Proof of Concept with a Ring-Closing Metathesis (RCM) Reaction	12
Reaction Calorimetry in Continuous Flow Mode: A New Approach for the Thermal Characterization of High Energetic and Fast Reactions	12
A Novel Integrated Workflow for Isolation Solvent Selection Using Prediction and Modeling	12
Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process	12
Heat Loss in Accelerating Rate Calorimetry Analysis and Thermal Lag for High Self-Heat Rates	12
Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction	12
Characterization of a Modular Continuous Vacuum Screw Filter for Small-Scale Solid–Liquid Separation of Suspensions	12
Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes	12
Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream	12
Solvent Selection for Mitsunobu Reaction Driven by an Active Learning Surrogate Model	12
Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone	12
Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor	12
Selective Oxidation of Benzylic sp3 C–H Bonds using Molecular Oxygen in a Continuous-Flow Microreactor	12
Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRASG12C Inhibitors	12
Nitrosamine Reactivity: A Survey of Reactions and Purge Processes	12
Seeking for Selectivity and Efficiency: New Approaches in the Synthesis of Raltegravir	12
Polymer-Supported Chiral Cis-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems	11
Bromine–Lithium Exchange on a gem-Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers	11
Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine	11
Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate	11
Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach	11
Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor	11
Highlights of the Recent Patent Literature─Focus on Biocatalysis Innovation	11
Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib	11
Scale-Up and Development of Synthesis 2-Ethylhexyl Nitrate in Microreactor Using the Box–Behnken Design	11
Mini-Monoplant Technology for Pharmaceutical Manufacturing	11
Understanding API Static Drying with Hot Gas Flow: Design and Test of a Drying Rig Prototype and Drying Modeling Development	11
Recent Advances in Nonprecious Metal Catalysis	11
Identification and Screening of Potential Organic Solvents for the Liquid–Liquid Extraction of Aromatics	11
Two-Phase Flow in a Coiled Flow Inverter: Process Development from Batch to Continuous Flow	11
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	11
Development of a Practical, Biocatalytic Synthesis of tert-Butyl (R)-3-Hydroxyl-5-hexenoate: A Key Intermediate to the Statin Side Chain	11
Highly Productive α-Alkylation of Ketones with Alcohols Mediated by an Ir–Oxalamidato/Solid Base Catalyst System	11
Development and Scale-Up of a Novel Photochemical C–N Oxidative Coupling	11
Developing a Multistep Continuous Manufacturing Process for (1R,2R)-2-Amino-1-methylcyclopentan-1-ol	11
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis	11
Peroxygenase-Driven Ethylbenzene Hydroxylation in a Rotating Bed Reactor	11
Recent Advances in Non-Precious Metal Catalysis	11
Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)	11
Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation	11
Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H)2] and Improved Synthesis of the ICHF2 Precursor	11
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process	11
An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly	11
Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions	11
Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate	11
High-Throughput Synthesis of (S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions	10
Semicontinuous Process for GMP Manufacture of a Carbapenem Intermediate via Carbene Insertion Using an Immobilized Rhodium Catalyst	10
Multigram Synthesis of Trioxanes Enabled by a Supercritical CO2 Integrated Flow Process	10
Process Development of a Sonogashira Cross-Coupling Reaction as the Key Step of Tirasemtiv Synthesis Using Design of Experiments	10
Recent Advances in the Solid- and Solution-Phase Synthesis of Peptides and Proteins Using Microflow Technology	10
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	10
Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity	10
Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology	10
Prediction of N-Nitrosamine Partition Coefficients for Derisking Drug Substance Manufacturing Processes	10
Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification	10
Continuous Flow Process for the Synthesis of Betahistine via Aza-Michael-Type Reaction in Water	10
Air-Stable Iron-Based Precatalysts for Suzuki–Miyaura Cross-Coupling Reactions between Alkyl Halides and Aryl Boronic Esters	10
Application of C–H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib	10
Automation Technologies to Enable Data-Rich Experimentation: Beyond Design of Experiments for Process Modeling in Late-Stage Process Development	10
“One-Pot” Synthesis of Molnupiravir from Cytidine	10
One-Pot Enzymatic Synthesis of Enantiopure 1,3-Oxathiolanes Using Trichosporon laibachii Lipase and the Kinetic Model	10
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19	10
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass	10
Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process	10
Flow Photocleavage for Automated Glycan Assembly (AGA)	10
Large-Scale Production of C9 Aromatic Hydrocarbon Resin from the Cracked-Petroleum-Derived C9 Fraction: Chemistry, Scalability, and Techno-economic Analysis	10
A Versatile Electrochemical Batch Reactor for Synthetic Organic and Inorganic Transformations and Analytical Electrochemistry	10
The Nitrosamine “Saga”: Lessons Learned from Five Years of Scrutiny	10
New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones	10
Kinetics of Polycondensation of Sebacic Acid with Glycerol	9
Performance Analysis and Model-Free Design of Deracemization via Temperature Cycles	9
Enzymatic Cascade in a Simultaneous, One-Pot Approach with In Situ Product Separation for the Asymmetric Production of (4S,5S)-Octanediol	9
Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging	9
Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor	9
Stirring Peptide Synthesis to a New Level of Efficiency	9
Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene	9
Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids	9
Six-Step Gram-Scale Synthesis of the Human Immunodeficiency Virus Integrase Inhibitor Dolutegravir Sodium	9
Application of Continuous Flow in Tazobactam Synthesis	9
Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation	9
Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes	9
Investigating Process Variables and Additive Selection To Optimize Polymorphic Control of Carbamazepine in a CO2 Antisolvent Crystallization Process	9
Formation of Dialkyl-N-nitrosamines in Aqueous Solution: An Experimental Validation of a Conservative Predictive Model and a Comparison of the Rates of Dialkyl and Trialkylamine Nitrosation	9
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1	9