OOIR: Observatory of International Research

Papers

(The median citation count of Organic Process Research & Development is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	266
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	145
Issue Editorial Masthead	103
Issue Publication Information	100
Issue Publication Information	91
Issue Editorial Masthead	90
Issue Editorial Masthead	82
Issue Editorial Masthead	74
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	73
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	62
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	58
Advancing Arsenazo III Synthesis by Batch-to-Flow Translation and Additive Reactor Manufacturing	55
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	53
Application of an Interdisciplinary Approach to Form Selection in Drug Development	48
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	47
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	45
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	45
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	44
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	43
Model Aided Scale-up for Wet Milling	40
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	39
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	39
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	39
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	39
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	36

Development of a Flow Process to tert -Butyl 4-(6-Chloropyridin-2-yl)piperidine-1-carboxylate	36
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	36
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	35
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	33
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	33
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	32
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	32
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	31
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	31
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	31
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	31
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	30
Issue Publication Information	29
Issue Publication Information	29
Issue Publication Information	28
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	27
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	27
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	27
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	27
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	27
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	26
Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production	26
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	26
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	26
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	25
Process Development of the Novel LpxC Inhibitor T-1228. Part 4: Control of Mutagenic Impurities during API Synthesis	24
Design Space Visualization and Technoeconomic Evaluation of a Batch Manufacturing Process for the Green Production of an Anti-cancer Drug (Adavosertib) Precursor	24
Accelerating Process Innovation through Communications and Technical Notes	24
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	23
Aqueous S _N Ar Reactions without a Surfactant: A Scalable Method That Uses Only Water from Start to Finish	23
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	23
Correction to “Evolution of the Synthesis Route for CC-99677: From Discovery Towards Commercialization”	23
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	22
Tetramethylchloroformamidinium Hexafluorophosphate– N -Methylimidazole Amidation in Water: Successes, Limitations, and a Regression Model for Prediction	22
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	21
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	21
Bulk Mixing in a Milligram-Scale Solid Phase Batch Reactor	21
Process Development for Continuous Manufacturing of Baloxavir Marboxil. Part 2: Step 2 Synthesis	21
Scalable Synthesis of 6-Functionalized 1,4-Oxazepanes	20
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	20
Towards the Development of a Commercial Process To Produce Muvalaplin. Part I: Preparation of a Key Intermediate by an Evans Auxiliary-Assisted Asymmetric Alkylation	20
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	20
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	20
The Recombinant 3-Ketosteroid Δ ¹ -Dehydrogenase Catalyzed Δ ¹ -Dehydrogenation toward Total Synth	20
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	20
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	19
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	19
Yoshida-Type Equations: Perspectives from Thermal Analysis and Energetic Materials Research	19
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	19
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	19

Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	18
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	18
Continuous Reduction of an Ester to Aldehyde in CSTR: From Laboratory to Industrial Plant	18
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	18
New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization	18
Co-Catalyst Enabled Biotransformation of Polyunsaturated Fatty Acids for Biobased Monomers	17
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	17
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	17
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	17
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	17
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278	17
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	17
Stereoselective and Enantioselective Strategies for the Commercial-Scale Synthesis of Dorzolamide Hydrochloride	17
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	16
Some Items of Interest to Process R&D Chemists and Engineers	16
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	16
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	16
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	16
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	16
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	16
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	16
Characterization, Solubility, and Hygroscopicity of BMS-817399	16
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	15
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	15
Discovery of Oxazole Byproduct Formation in the Modified Dakin–West Reaction and Efficient Synthesis of Diastereomeric α-Ketoamide Cysteine Protease Inhibitors	15
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	15
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	15
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	15
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	15
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	14
Thermal Hazard Evaluation and Safety Considerations for the Use of O-Benzoyl-N-alkyl Hydroxylamines as Synthetic Reagents	14
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	14
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	14
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	14
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	14
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	13
Decoding Reactions in Process Chemistry: A Quarter-Century Analysis of Trends and Transformations in OPR&D	13
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	13
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	13
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	13
Automatic Design of Wet-Milling-Integrated Batch Crystallization Processes by Process Analytical Technology-Based Split-Range Direct Nucleation Control	13
Solid Acid-Enabled N -Boc Deprotection and Acetal Hydrolysis in the Synthesis of Vepdegestrant	13
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	13
Major Progress in the Liquid-Phase Synthesis of N -Alkyl-Rich Cyclic Peptides: Kilogram-Scale GMP Production of the KRAS Inhibitor LUNA18	13
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	13
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	13
Expeditious and Automated Dispensing of ChemBeads for High-Throughput Experimentation in 384-Well Microtiter Plates	12
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	12
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	12
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	12
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	12
Some Items of Interest to Process R&D Chemists and Engineers	12
Issue Publication Information	12
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	12
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	12
Process Development of the Novel LpxC Inhibitor T-1228. Part 1: Synthesis of the Diol Fragment	12
Scalable Process for Reduction of Aromatic Carboxylic Acids to Aldehydes via Pinacolborane	12
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	12
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	12
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	12
Issue Publication Information	12
Recent Advances in Nonprecious Metal Catalysis	12
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	12
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	12
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	12
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	12
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	12
Issue Publication Information	12
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	12
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	11
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	11
Development of a Reliable Low-Loading Palladium-Catalyzed Monoamination Process for the Large-Scale Synthesis of 3-Bromo-2,5-difluoroaniline	11
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	11
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	11
Integrating Process Safety Consideration to Enhance Route Development and Optimization	11
A Chemoenzymatic Synthesis of STING Agonist MK-2118	11
Nitrosamine Risk Assessments in Oligonucleotides	11
Early Process Development of a Heterobifunctional Protein Degrader	11
Issue Editorial Masthead	11
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	11

Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	11
Toward Agile, Distributed Pharmaceutical Manufacturing: Continuous End-to-End Integration of Reaction, Purification, and Formulation for Lomustine via the MiniPharm Platform	11
Development and Optimization of a Scalable Enzymatic Cascade-Carbamate Formation Telescope Process for the Synthesis of CDK2 Selective Candidate Tegtociclib (PF-07104091)	11
Issue Publication Information	11
Scalable Hydrophobic Tag-Assisted Convergent Synthesis of Cetrorelix Acetate	11
Issue Publication Information	11
Practical and Scalable Synthesis of 1,3-Adamantanediol	11
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	10
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	10
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	10
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	10
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	10
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	10
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	10
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	10
Scalable Continuous Flow Hydrogenation of Isoquinoline in Trickle-Bed Reactors	10
Efficient and Scalable Synthesis of a Novel Selective PI3Kα Inhibitor XJTU-L453	10
A Sustainable Approach to ε-Lys Branched GLP-1 Analogs: Integrating Green SPPS, Metal-free Alloc Removal, Waste Minimization and TFA/PFAS-free Resin Cleavage	10
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	10
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	10
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons	10
Continuous Manufacturing of Rocuronium Bromide Part 2: Step 2 Process Development	10
Regulatory Highlights	10
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	10
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	10
Overcoming PAT Challenges in Automated Process Validation for Continuous Liquid–Gas Biphasic Processes	10
Structure Determination of Synthesized Nitrosamine Drug Substance-Related Impurities (NDSRIs) Using 3D ED/MicroED	10
Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control	10
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	9
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	9
Issue Publication Information	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	9
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	9
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	9
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	9
Issue Editorial Masthead	9
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	9
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP)	9
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	9
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	9
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	9
Optimization of a Parham Cyclization Aided by In Situ FTIR for an Enabling Synthesis of Tricyclo[6.2.0.0^3,6]deca-1,3(6),7-trien-2-amine	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Continuous Manufacturing of Rocuronium Bromide. Part 1: Step 1 Process Development	9
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	9
Issue Editorial Masthead	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Issue Publication Information	8
Opportunities for Machine Learning and Artificial Intelligence to Advance Synthetic Drug Substance Process Development	8
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	8
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	8
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	8
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	8
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	8
Issue Editorial Masthead	8
Methanol Steam Reforming Controls the Selective Transfer Hydrogenation vs N-Methylation of Nitrobenzene Using a PVP-Stabilized IrO₂ Nanoparticle Catalyst	8
Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol Hydrochloride	8
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	8
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	8
Scalable Flow Synthesis of Genetically Encodable Tetrazine Amino Acids	8
Technology Transfer and Process Development of Danicopan to Enable Process Validation	8
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	8
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	8
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	8
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	8
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	8
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	8
Correction to “Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: A Key Interme	8
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	8
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	8
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	8
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	8
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	8
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	7
Development of Lab-Scale Continuous Stirred-Tank Reactor as Flow Process Tool for Oxidation Reactions Using Molecular Oxygen	7
Practical Synthesis Strategy for NIR-II Cyanine Fluorophores: Laboratory-Scale Development and Structural Characterization of IR 1048	7
Oxygen-, Nitrogen-, and Sulfur-Containing Heterocycles: Recent Advances in De Novo Synthesis and Prospect	7
Issue Publication Information	7
Some Items of Interest to Process R&D Chemists and Engineers	7
Formation of N-Nitrosamine Drug Substance Related Impurities in Medicines: A Regulatory Perspective on Risk Factors and Mitigation Strategies	7
Organic Solvent Nanofiltration in Pharmaceutical Applications	7
Three-Pronged Approach (Active Pharmaceutical Ingredients, Excipients, and NOx-Free Air) Successfully Suppressed the Formation of Nitroso-atomoxetine to 0.097 ppm	7
Scalable Synthesis of CVN424, an Inverse Agonist of the GPR6 Receptor	7
Kinetic Modeling of Solid-Phase Oligonucleotide Synthesis: Mechanistic Insights and Reaction Dynamics	7
Access to Cyclopropanol via Supply-Centered Synthesis	7
N-Nitrosodimethylamine Formation in Metformin Drug Products by the Reaction of Dimethylamine and Atmospheric NO₂	7