OOIR: Observatory of International Research

Papers

(The median citation count of Organic Process Research & Development is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	196
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	114
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	71
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	69
Application of an Interdisciplinary Approach to Form Selection in Drug Development	65
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	60
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	59
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	58
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	57
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	57
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	57
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	55
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	53
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	48
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	46
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	42
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	41
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	39
Issue Editorial Masthead	38
Issue Publication Information	36
Issue Publication Information	35
Issue Editorial Masthead	34
Issue Editorial Masthead	34
Issue Publication Information	33
Issue Editorial Masthead	32

Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	32
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	32
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	30
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	30
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	30
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	29
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	29
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	29
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	28
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	28
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	28
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	27
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	27
Excellence in Industrial Organic Synthesis 2021	26
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	26
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	26
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	25
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	25
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	25
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	25
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	24
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	24
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	24
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	24
Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production	23
Design Space Visualization and Technoeconomic Evaluation of a Batch Manufacturing Process for the Green Production of an Anti-cancer Drug (Adavosertib) Precursor	23
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	23
Highly Selective Hydrogenation of Phenols to Cyclohexanone Derivatives Using a Palladium@N-Doped Carbon/SiO₂ Catalyst	23
Process Development for Continuous Manufacturing of Baloxavir Marboxil. Part 2: Step 2 Synthesis	23
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	22
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	22
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	22
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	21
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	21
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation	21
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	21
Regulatory Highlights	21
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	21
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction	21
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	20
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	20
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	19
Issue Editorial Masthead	19
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	19
Issue Publication Information	19
Issue Publication Information	19
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	19
Issue Publication Information	19
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	19
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	18

Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	18
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	18
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	18
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	18
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	18
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	18
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	18
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	18
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	17
Low-Level Quantification of tert-Butyl Nitrite in a Pharmaceutical Intermediate	17
Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan	17
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	17
Some Items of Interest to Process R&D Chemists and Engineers	17
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	17
Characterization, Solubility, and Hygroscopicity of BMS-817399	17
Practical Kilogram Synthesis of (S)-1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine	17
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	16
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	16
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	16
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	16
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	16
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	16
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	15
Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters	15
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	15
New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization	15
Co-Catalyst Enabled Biotransformation of Polyunsaturated Fatty Acids for Biobased Monomers	15
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	15
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	15
Discovery of Oxazole Byproduct Formation in the Modified Dakin–West Reaction and Efficient Synthesis of Diastereomeric α-Ketoamide Cysteine Protease Inhibitors	15
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	15
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278	15
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	15
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	15
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	15
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	15
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	15
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	15
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	14
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	14
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	14
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	14
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	14
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	14
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	14
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	14
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	14
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	14
Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases	14
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	13
Some Items of Interest to Process R&D Chemists and Engineers	13
Issue Publication Information	13
Recent Advances in Nonprecious Metal Catalysis	13
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	13
Issue Publication Information	13
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	13
Issue Editorial Masthead	13
Nitrosamine Risk Assessments in Oligonucleotides	13
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	12
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	12
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	12
Issue Publication Information	12
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	12
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	12
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	12
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	12
Issue Publication Information	12
Expeditious and Automated Dispensing of ChemBeads for High-Throughput Experimentation in 384-Well Microtiter Plates	12
Issue Publication Information	12
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	12
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	12
Development of a Reliable Low-Loading Palladium-Catalyzed Monoamination Process for the Large-Scale Synthesis of 3-Bromo-2,5-difluoroaniline	12
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	12
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	12
Optimization and Development of a Scalable Palladium-Catalyzed C–H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator	12
Issue Editorial Masthead	12
Ketoprofen Solubility in Pure Organic Solvents Using In Situ FTIR and UV–Vis and Analysis of Solution Thermodynamics	12
Hybrid Flow-Batch Model for the Efficient Synthesis of 2-(Dimethylamino)-6-methylpyridin-4-ol	12
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	12
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	11

Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	11
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	11
Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	11
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	11
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	11
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	11
Some Items of Interest to Process R&D Chemists and Engineers	11
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	11
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	11
Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst	11
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	11
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	11
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	11
Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation	11
Regulatory Highlights	11
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	10
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient	10
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons	10
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	10
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	10
Green Chemistry Articles of Interest to the Pharmaceutical Industry	10
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	10
Practical and Scalable Synthesis of 1,3-Adamantanediol	10
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	10
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	10
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	10
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	10
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	10
Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control	10
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	9
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	9
Study on the Safety Design of 3-Amino-6-Bromo-1,2,4-Triazine Drying Process Based on Thermal Analysis Technology	9
Technology Transfer and Process Development of Danicopan to Enable Process Validation	9
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	9
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	9
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	9
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	9
Issue Publication Information	9
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP)	9
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	9
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Optimization of a Parham Cyclization Aided by In Situ FTIR for an Enabling Synthesis of Tricyclo[6.2.0.0^3,6]deca-1,3(6),7-trien-2-amine	9
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	9
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	9
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	9
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	9
Green Chemistry Articles of Interest to the Pharmaceutical Industry	9
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	9
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	9
Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development	9
Efficient Synthesis of a Key Intermediate for Baloxavir Marboxil from a Greener Starting Material: Ethylene Glycol	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	9
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	9
Issue Editorial Masthead	9
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	9
Correction to “Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: A Key Interme	8
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	8
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	8
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	8
Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols	8
An Ultrafast Production of Imidazoles at Low Temperature with a 3D-Printed Microflow Reactor	8
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	8
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	8
Issue Editorial Masthead	8
Issue Publication Information	8
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture	8
Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol Hydrochloride	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Process Safety from Bench to Pilot to Plant	8
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	8
Scalable and Safe Transformation of 3-Hydroxypropionitrile to Its Amidoxime	8
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	8
Issue Publication Information	8
Issue Editorial Masthead	8
Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594	8
Risk Assessment of the Leachables’ Profile for Small-Molecule Pharmaceutical Drug Substances	8
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B₁	8
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	8
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization	8
Opportunities for Machine Learning and Artificial Intelligence to Advance Synthetic Drug Substance Process Development	8
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	8
Stereoselective Nickel(II)-Catalyzed Addition of Aryl Grignards to Diphenylacetylene in the Synthesis of Zuclomiphene	8
Quantification of Nitrite in Excipients and Chemicals: A Versatile and Highly Sensitive Method Using Headspace Gas Chromatography Coupled to Mass Spectrometry	8
Issue Editorial Masthead	8
A Scalable Solution to Constant-Potential Flow Electrochemistry	8