Organic Process Research & Development

Article	Citations
Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes	138
Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review	103
Integrated Continuous Pharmaceutical Technologies—A Review	94
Heterogeneous Catalysis for Cross-Coupling Reactions: An Underutilized Powerful and Sustainable Tool in the Fine Chemical Industry?	79
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	74
Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination	57
Progress and Opportunities for Utilizing Seeding Techniques in Crystallization Processes	53
Strategies to Tackle the Waste Water from α-Tocopherol-Derived Surfactant Chemistry	52
Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs	49
Recent Advances in Enzyme Immobilization Utilizing Nanotechnology for Biocatalysis	44
Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis	42
Scale-Up of a Heterogeneous Photocatalytic Degradation Using a Photochemical Rotor–Stator Spinning Disk Reactor	42
Green Chemistry: A Framework for a Sustainable Future	41
Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction	41
Ranitidine—Investigations into the Root Cause for the Presence of N-Nitroso-N,N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products	41
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	40
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	38
Recent Advances in Photobiocatalysis for Selective Organic Synthesis	34
PAT Implementation on a Mobile Continuous Pharmaceutical Manufacturing System: Real-Time Process Monitoring with In-Line FTIR and Raman Spectroscopy	34
Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam	33
High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective	33
A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation	33
Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?	32
Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification	32
Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis	31

In Situ Imaging Combined with Deep Learning for Crystallization Process Monitoring: Application to Cephalexin Production	30
Organosilanes in Metal-Catalyzed, Enantioselective Reductions	30
Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran	30
Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution	30
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	30
Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir	28
Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material	28
Pd-Catalyzed Cross-Couplings: On the Importance of the Catalyst Quantity Descriptors, mol % and ppm	28
Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis	27
A Comment on Continuous Flow Technologies within the Agrochemical Industry	27
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	27
Antibody–Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology	26
Formation of N-Nitrosamine Drug Substance Related Impurities in Medicines: A Regulatory Perspective on Risk Factors and Mitigation Strategies	26
Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process	26
The Nitrosamine “Saga”: Lessons Learned from Five Years of Scrutiny	25
API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing	25
Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis	25
From Bench to Plant: An Opportunity for Transition Metal Paired Electrocatalysis	25
Insights into Fast Amide Couplings in Aqueous Nanomicelles	24
Development of Scalable Routes to 1-Bicyclo[1.1.1]pentylpyrazoles	24
Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia	23
Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF3I Gas	22
Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor	22
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production	22
Multigram Synthesis of Pure HMF and BHMF	22
Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow	22
Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib	22
Development of a Commercial Process for Deucravacitinib, a Deuterated API for TYK2 Inhibition	22
A Review on Synthetic Advances toward the Synthesis of Apremilast, an Anti-inflammatory Drug	22
Recent Advances in Nonprecious Metal Catalysis	21
Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients	21
Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective	21
Explosive Hazard Identification in Pharmaceutical Process Development: A Novel Screening Method and Workflow for Shipping Potentially Explosive Materials	20
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	20
Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction	20
Heterogeneous Crystallization as a Process Intensification Technology in an Integrated Continuous Manufacturing Process for Pharmaceuticals	20
Continuous and Selective Hydrogenation of Heterocyclic Nitroaromatics in a Micropacked Bed Reactor	19
On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Development of a Highly Efficient Synthesis for Ciprofloxacin	19
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor	19
Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control	19
Cost-Effective Flow Peptide Synthesis: Metamorphosis of HPLC	19
A Continuous-Flow Electrochemical Taylor Vortex Reactor: A Laboratory-Scale High-Throughput Flow Reactor with Enhanced Mixing for Scalable Electrosynthesis	19
Ruthenium-Catalyzed Ester Reductions Applied to Pharmaceutical Intermediates	19
Synthesis and Applications of Periodate for Fine Chemicals and Important Pharmaceuticals	18
Scale-Up of Ozonolysis using Inherently Safer Technology in Continuous Flow under Pressure: Case Study on β-Pinene	18
Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation	18
Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation	18
Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles	18
High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades	18
Styrene Oxide Isomerase Catalyzed Meinwald Rearrangement Reaction: Discovery and Application in Single-Step and One-Pot Cascade Reactions	18

Palladium Extraction Following Metal-Catalyzed Reactions: Recent Advances and Applications in the Pharmaceutical Industry	18
Integrating Continuous-Flow Electrochemistry and Photochemistry for the Synthesis of Acridinium Photocatalysts Via Site-Selective C–H Alkylation	18
Peroxygenase-Driven Ethylbenzene Hydroxylation in a Rotating Bed Reactor	18
Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor	18
Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts	17
Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics	17
Selective Oxidation of Benzylic sp3 C–H Bonds using Molecular Oxygen in a Continuous-Flow Microreactor	17
Two Scalable Syntheses of 3-(Trifluoromethyl)cyclobutane-1-carboxylic Acid	17
Nitrosamine Reactivity: A Survey of Reactions and Purge Processes	17
Automation Technologies to Enable Data-Rich Experimentation: Beyond Design of Experiments for Process Modeling in Late-Stage Process Development	16
Scale-Up and Development of Synthesis 2-Ethylhexyl Nitrate in Microreactor Using the Box–Behnken Design	16
A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry	16
Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)	16
A Novel Integrated Workflow for Isolation Solvent Selection Using Prediction and Modeling	16
Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction	16
Heat Loss in Accelerating Rate Calorimetry Analysis and Thermal Lag for High Self-Heat Rates	16
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	16
Highlights of the Recent Patent Literature─Focus on Biocatalysis Innovation	16
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	16
The Cost of Quantum Yield	15
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	15
High-Productivity Single-Pass Electrochemical Birch Reduction of Naphthalenes in a Continuous Flow Electrochemical Taylor Vortex Reactor	15
Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates	15
Drawing a Line: Where Might the Cohort of Concern End?	15
Photoredox Iridium–Nickel Dual Catalyzed Cross-Electrophile Coupling: From a Batch to a Continuous Stirred-Tank Reactor via an Automated Segmented Flow Reactor	15
Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations	15
Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations	15
Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach	15
Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate	15
Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib	15
Recent Advances in Non-Precious Metal Catalysis	15
Recent Advances in Nonprecious Metal Catalysis	15
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	14
Characterization of a Modular Continuous Vacuum Screw Filter for Small-Scale Solid–Liquid Separation of Suspensions	14
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19	14
Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions	14
Quest for a Cure: Potential Small-Molecule Treatments for COVID-19, Part 2	14
Advances in Continuous Flow Calorimetry	14
Highlights of the Recent Patent Literature: Focus on Asymmetric Organocatalysis	14
Recent Advances in Nonprecious Metal Catalysis	14
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O	14
Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone	14
New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones	14
Prediction of N-Nitrosamine Partition Coefficients for Derisking Drug Substance Manufacturing Processes	14
Development and Scale-Up of a Novel Photochemical C–N Oxidative Coupling	14
Recent Advances in Nonprecious Metal Catalysis	14
Kinetics of Polycondensation of Citric Acid with Glycerol Based on a Genetic Algorithm	14
“One-Pot” Synthesis of Molnupiravir from Cytidine	13
Solvent Selection for Mitsunobu Reaction Driven by an Active Learning Surrogate Model	13
Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine	13
Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029	13
Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes	13
Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRASG12C Inhibitors	13
Air-Stable Iron-Based Precatalysts for Suzuki–Miyaura Cross-Coupling Reactions between Alkyl Halides and Aryl Boronic Esters	13
Formation of Dialkyl-N-nitrosamines in Aqueous Solution: An Experimental Validation of a Conservative Predictive Model and a Comparison of the Rates of Dialkyl and Trialkylamine Nitrosation	13
Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction	13
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation–Cyclization as a Flow–Batch Process Leads to Significant Improvements in Process Mass	13
Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream	13
Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate	13
Development of a Commercial Process for Odalasvir	13
How to Develop Organometallic Catalytic Reactions in the Pharmaceutical Industry	12
Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology	12
Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol–Ene/Cyclization Sequence in Continuous Flow	12
Targeting Particle Size Specification in Pharmaceutical Crystallization: A Review on Recent Process Design and Development Strategies and Particle Size Measurements	12
Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process	12
Optimization of Metal Affinity Ketoreductase Immobilization for Application in Batch and Flow Processes	12
Application of Continuous Flow in Tazobactam Synthesis	12
Development of Adagrasib’s Commercial Manufacturing Route	12
Process Development and Protein Engineering Enhanced Nitroreductase-Catalyzed Reduction of 2-Methyl-5-nitro-pyridine	12
Metal Catalyst and Hydrogen Gas-Free Selective Reduction of Biomass-Derived Substituted Furfuraldehyde to Alkyl Furan as a Key Biofuel Additive	12
Identification and Screening of Potential Organic Solvents for the Liquid–Liquid Extraction of Aromatics	12
Recent Advances in the Solid- and Solution-Phase Synthesis of Peptides and Proteins Using Microflow Technology	12
Scaling-up Electroorganic Synthesis Using a Spinning Electrode Electrochemical Reactor in Batch and Flow Mode	12
Direct Synthesis of Methylchlorosilanes: Catalysts, Mechanisms, Reaction Conditions, and Reactor Designs	12
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis	12
Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst	12
Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity	11
High-Throughput Synthesis of (S)-α-Phellandrene through Three-Step Sequential Continuous-Flow Reactions	11
Continuous Flow Process for the Synthesis of Betahistine via Aza-Michael-Type Reaction in Water	11
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	11

Application of C–H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib	11
Control of Mutagenic Impurities: Survey of Pharmaceutical Company Practices and a Proposed Framework for Industry Alignment	11
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	11
Loss on Drying Using Halogen Moisture Analyzer: An Orthogonal Technique for Monitoring Volatile Content for In-Process Control Samples during Pharmaceutical Manufacturing	11
Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on a Multigram Scale	11
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	11
From Screening to Scale-Up: The DoE-Based Optimization of Electrochemical Reduction of l-Cystine at Metal Cathodes	11
Easy Removal of Triphenylphosphine Oxide from Reaction Mixtures by Precipitation with CaBr2	11
Stirring Peptide Synthesis to a New Level of Efficiency	11
Process Development of a Sonogashira Cross-Coupling Reaction as the Key Step of Tirasemtiv Synthesis Using Design of Experiments	11
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	11
The Impact of Solvent Quality on the Heck Reaction: Detection of Hydroperoxide in 1-Methyl-2-pyrrolidinone (NMP)	11
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1	10
Mechanistic Insights into the Aerobic Oxidation of Aldehydes: Evidence of Multiple Reaction Pathways during the Liquid Phase Oxidation of 2-Ethylhexanal	10
Designing Chemical Reaction Arrays Using Phactor and ChatGPT	10
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	10
Di-tert-butyl Phosphonate Route to the Antiviral Drug Tenofovir	10
Enzymatic Cascade in a Simultaneous, One-Pot Approach with In Situ Product Separation for the Asymmetric Production of (4S,5S)-Octanediol	10
Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin	10
Large-Scale Production of C9 Aromatic Hydrocarbon Resin from the Cracked-Petroleum-Derived C9 Fraction: Chemistry, Scalability, and Techno-economic Analysis	10
An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide	10
Temperature-Controlled Photoreactors and ChemBeads as Key Technologies for Robust and Practical Photochemical HTE	10
Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug	10
Safe and Expeditious Preparation of Ni(cod)2for Same-Day High-Throughput Screening	10
Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation	10
Multigram Synthesis of Trioxanes Enabled by a Supercritical CO2 Integrated Flow Process	10
Synthesis of Rovafovir Etalafenamide (Part III): Evolution of the Synthetic Process to the Phosphonamidate Fragment	10
Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation	10
Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction	10
Discovery of New Fe(II)/α-Ketoglutarate-Dependent Dioxygenases for Oxidation of l-Proline	10
Multigram Electrochemical Hofmann Rearrangement Using a Spinning Three-Dimensional Anode	10
Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient	10
Development of a Continuous Photochemical Bromination/Alkylation Sequence En Route to AMG 423	10
tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure	10
Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene	10
Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging	10
Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379	10
Mathematical Modeling and Optimization to Inform Impurity Control in an Industrial Active Pharmaceutical Ingredient Manufacturing Process	9
Process Intensification Enabling Continuous Manufacturing Processes Using Modular Continuous Vacuum Screw Filter	9
When Safety Data Sheets are a Safety Hazard	9
Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone	9
Six-Step Gram-Scale Synthesis of the Human Immunodeficiency Virus Integrase Inhibitor Dolutegravir Sodium	9
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	9
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	9
Ketoprofen Solubility in Pure Organic Solvents Using In Situ FTIR and UV–Vis and Analysis of Solution Thermodynamics	9
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 3─Development of a Scalable Enzymatic Oxidation Process	9
Enzyme Optimization and Process Development for a Scalable Synthesis of (R)-2-Methoxymandelic Acid	9
Process Intensive Synthesis of Propofol Enabled by Continuous Flow Chemistry	9
Large-Scale Synthesis of Eldecalcitol	9
Reactor Design for the Direct Electrosynthesis of Periodate	9
Generation of Tosyl Azide in Continuous Flow Using an Azide Resin, and Telescoping with Diazo Transfer and Rhodium Acetate-Catalyzed O–H Insertion	9
Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction	9
Advances and Applications in Catalysis with Earth-Abundant Metals	9
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO) III: Investigations Regarding the Main Decomposition	9
Scale-Up of a Continuous Manufacturing Process of Edaravone	9
A Consideration of the Extent That Tertiary Amines Can Form N-Nitroso Dialkylamines in Pharmaceutical Products	9
Preparation of Carbamates, Esters, Amides, and Unsymmetrical Ureas via Brønsted Acid-Activated N-Acyl Imidazoliums	9
Co-Crystallization-Induced Spontaneous Deracemization: An Optimization Study	9
Risk-Based Operation of a Continuous Mixed-Suspension-Mixed-Product-Removal Antisolvent Crystallization Process for Polymorphic Control	9
Additive Manufacturing as a Rapid Prototyping and Fabrication Tool for Laboratory Crystallizers─A Proof-of-Concept Study	9
Determination of Purge Factors for Use in Oligonucleotide Control Strategies	9
Copper-Catalyzed, Aerobic Oxidation of Hydrazone in a Three-Phase Packed Bed Reactor	9
Activation of Aryl Chlorides in the Suzuki-Miyaura Reaction by “Ligand-Free” Pd Species through a Homogeneous Catalytic Mechanism: Distinguishing between Homogeneous and Heterogeneous Catalytic Mechan	9
Enhancement of Continuous Crystallization of Lysozyme through Ultrasound	9
Readily Reconfigurable Continuous-Stirred Tank Photochemical Reactor Platform	9
Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation	9
Payloads for Antibody–Drug Conjugates	9
75 Years of Vitamin A Production: A Historical and Scientific Overview of the Development of New Methodologies in Chemistry, Formulation, and Biotechnology	9
Recommendations for Effective and Defendable Implementation of Quality by Design	9
Development of a Safe Continuous Process to Sodium Nitrotetrazolate via Solid Phase “Catch and Release”	9
Highly Efficient Production of Optically Active (R)-Tetrahydrothiophene-3-ol in Batch and Continuous Flow by Using Immobilized Ketoreductase	9
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	9
Refractive Index: The Ultimate Tool for Real-Time Monitoring of Solid-Phase Peptide Synthesis. Greening the Process	9
Coprecipitated Amorphous Dispersions as Drug Substance: Opportunities and Challenges	9
Importance of Green and Sustainable Chemistry in the Chemical Industry	9
Efficient Biocatalytic Synthesis of (R)-2-Chloro-1-(3,4-difluorophenyl)ethanol by the Short-Chain Dehydrogenase PpKR8 from Paraburkholderia phymatum STM815	9
Hazard Evaluation and Safety Considerations for Scale-Up of a Fuming Nitric Acid Mediated Nitration of Aryl Boronic Acids	9
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	9
Synthesis of Rovafovir Etalafenamide (Part I): Active Pharmaceutical Ingredient Process Development, Scale-Up, and Impurity Control Strategy	9
Automated End-to-End Workflow for Volumetric Mass-Transfer Coefficient (kLa) Characterization in Small-Molecule Pharmaceutical Development	8
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	8
Development of a Practical and Greener Process for the Dual Leucine Zipper Kinase Inhibitor GDC-0134 Comprising Two SNAr Reactions, Oxidation and Suzuki Coupling	8
Comparison of One-Dimensional and Two-Dimensional Population Balance Models for Optimization of a Crystallization Process for a Needle-Shaped Active Pharmaceutical Ingredient	8
Efficient Synthesis of (S)-1-Boc-3-aminopiperidine in a Continuous Flow System Using ω-Transaminase-Immobilized Amino-Ethylenediamine-Modified Epoxide Supports	8
Optimized Synthesis of a Key Intermediate of Nirmatrelvir	8
Thermal Stability Evaluation of Nitroalkanes with Differential Scanning Calorimetry	8
Development and Scale-Up of an Asymmetric Synthesis Process for Alogliptin	8
Scalable Synthesis of (R,R)-N,N-Dibenzyl-2-fluorocyclohexan-1-amine with CsF under Hydrogen Bonding Phase-Transfer Catalysis	8
Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid	8
Application of a Statistical Approach to Process Development of Futibatinib by Employing Quality-by-Design Principles. Part 1: Identification of Critical Process Parameters for Impurities	8
Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis	8
Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inv	8
In-line Monitoring of Microgel Synthesis: Flow versus Batch Reactor	8
Development of an Ene Reductase-Based Biocatalytic Process for the Production of Flavor Compounds	8
Determining Phase Separation Dynamics with an Automated Image Processing Algorithm	8