OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes	138
Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review	103
Integrated Continuous Pharmaceutical Technologies—A Review	94
Heterogeneous Catalysis for Cross-Coupling Reactions: An Underutilized Powerful and Sustainable Tool in the Fine Chemical Industry?	79
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	74
Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination	57
Progress and Opportunities for Utilizing Seeding Techniques in Crystallization Processes	53
Strategies to Tackle the Waste Water from α-Tocopherol-Derived Surfactant Chemistry	52
Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs	49
Recent Advances in Enzyme Immobilization Utilizing Nanotechnology for Biocatalysis	44
Scale-Up of a Heterogeneous Photocatalytic Degradation Using a Photochemical Rotor–Stator Spinning Disk Reactor	42
Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis	42
Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction	41
Ranitidine—Investigations into the Root Cause for the Presence of N-Nitroso-N,N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products	41
Green Chemistry: A Framework for a Sustainable Future	41
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	40
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	38
Recent Advances in Photobiocatalysis for Selective Organic Synthesis	34
PAT Implementation on a Mobile Continuous Pharmaceutical Manufacturing System: Real-Time Process Monitoring with In-Line FTIR and Raman Spectroscopy	34
A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation	33
Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam	33
High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective	33
Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification	32
Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?	32
Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis	31

Organosilanes in Metal-Catalyzed, Enantioselective Reductions	30
Unconventional Ethereal Solvents in Organic Chemistry: A Perspective on Applications of 2-Methyltetrahydrofuran, Cyclopentyl Methyl Ether, and 4-Methyltetrahydropyran	30
Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution	30
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	30
In Situ Imaging Combined with Deep Learning for Crystallization Process Monitoring: Application to Cephalexin Production	30