OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	212
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	122
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	76
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	73
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	73
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	67
Issue Editorial Masthead	63
Issue Publication Information	62
Issue Editorial Masthead	61
Issue Publication Information	61
Issue Publication Information	58
Issue Editorial Masthead	58
Issue Editorial Masthead	57
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	52
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	49
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	47
Application of an Interdisciplinary Approach to Form Selection in Drug Development	43
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	42
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	41
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	40
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	40
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	40
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	38
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	36
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	34

Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	34
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	34
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	34
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	34
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	33
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	32
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	31
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	31