OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	196
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	114
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	71
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	69
Application of an Interdisciplinary Approach to Form Selection in Drug Development	65
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	60
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	59
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	58
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	57
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	57
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	57
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	55
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	53
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	48
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	46
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	42
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	41
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	39
Issue Editorial Masthead	38
Issue Publication Information	36
Issue Publication Information	35
Issue Editorial Masthead	34
Issue Editorial Masthead	34
Issue Publication Information	33
Issue Editorial Masthead	32

Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	32
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	32
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	30
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	30
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	30