OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	227
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	129
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	82
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	81
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	75
Issue Editorial Masthead	74
Issue Publication Information	65
Issue Publication Information	64
Issue Editorial Masthead	62
Issue Publication Information	61
Issue Editorial Masthead	61
Issue Editorial Masthead	61
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	59
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	57
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	51
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	48
Application of an Interdisciplinary Approach to Form Selection in Drug Development	47
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	46
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	42
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	41
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	37
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	37
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	36
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	36
Model Aided Scale-up for Wet Milling	34

Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	34
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	33
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	33
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	32
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	31
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	31