OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	173
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	94
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	65
Issue Editorial Masthead	62
Issue Editorial Masthead	61
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	54
Issue Editorial Masthead	52
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	51
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	51
Issue Publication Information	50
Issue Editorial Masthead	47
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	46
Issue Publication Information	45
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	45
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	44
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	43
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	43
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	42
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	40
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	39
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	39
Issue Publication Information	38
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	37
Issue Editorial Masthead	36
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	36

Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	36
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	35
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	35
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	35
Application of an Interdisciplinary Approach to Form Selection in Drug Development	31
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	30