OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes	88
Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review	81
Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures	77
Potential for the Formation of N-Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water	75
Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply	75
Integrated Continuous Pharmaceutical Technologies—A Review	72
Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond	64
Heterogeneous Catalysis for Cross-Coupling Reactions: An Underutilized Powerful and Sustainable Tool in the Fine Chemical Industry?	62
Organolithium Bases in Flow Chemistry: A Review	60
Applications of Flow Chemistry in the Pharmaceutical Industry—Highlights of the Recent Patent Literature	54
Potential Safety Hazards Associated with Using N,N-Dimethylformamide in Chemical Reactions	53
Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO)	51
Multikilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy	50
Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir	50
Continuous Production of Five Active Pharmaceutical Ingredients in Flexible Plug-and-Play Modules: A Demonstration Campaign	50
Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination	49
Fully Automated Chemical Synthesis: Toward the Universal Synthesizer	48
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	46
Strategies to Tackle the Waste Water from α-Tocopherol-Derived Surfactant Chemistry	44
A Structured Approach To Cope with Impurities during Industrial Crystallization Development	44
Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor	42
Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs	42
A General Kilogram Scale Protocol for Suzuki–Miyaura Cross-Coupling in Water with TPGS-750-M Surfactant	41
Comparison of the Thermal Stabilities of Diazonium Salts and Their Corresponding Triazenes	39
Progress and Opportunities for Utilizing Seeding Techniques in Crystallization Processes	38

Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction	38
Optimization of a Decatungstate-Catalyzed C(sp³)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor	36
Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels	34
Pilot-Scale Production of Peroxygenase from Agrocybe aegerita	34
Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions	33
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study	33
Ranitidine—Investigations into the Root Cause for the Presence of N-Nitroso-N,N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products	32
Recent Advances in Enzyme Immobilization Utilizing Nanotechnology for Biocatalysis	32
Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition	32