OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	151
Issue Editorial Masthead	105
Issue Publication Information	104
Issue Publication Information	94
Issue Editorial Masthead	92
Issue Editorial Masthead	88
Issue Editorial Masthead	78
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	75
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	63
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	60
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	55
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	55
Model Aided Scale-up for Wet Milling	55
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	52
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	47
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	46
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	45
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	45
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	42
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	42
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	41
Development of a Flow Process to tert -Butyl 4-(6-Chloropyridin-2-yl)piperidine-1-carboxylate	41
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	40
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	40
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	38

Advancing Arsenazo III Synthesis by Batch-to-Flow Translation and Additive Reactor Manufacturing	37
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	35
Application of an Interdisciplinary Approach to Form Selection in Drug Development	34
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	34
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	34
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	33
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	32
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	32
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	32
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	32