Journal of Biomedical Optics

Article	Citations
Intraoperative characterization of cardiac tissue: the potential of light scattering spectroscopy	66
Comparative analysis of intraoperative thermal and optical imaging for identification of the human primary sensory cortex	62
Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues	55
ALA-based photodynamic priming in murine skin increases blood flow and oxygenation	49
Phasor-based FLIM analysis of NAD(P)H and FAD autofluorescence for label-free bacterial classification	42
Dual division of focal plane polarimeters-based collinear reflection Mueller matrix fast imaging microscope	42
Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery	35
Introduction to Special Issue on Metabolic Imaging and Spectroscopy, 2025	34
Er:YAG laser biofilm removal from zero-gap periodontal/peri-implant model system mimicking clinical attachment loss	34
Imaging lymphatic function and inflammation response through hypoxia via endogenous biomarker	33
Assessment of nonalcoholic fatty liver function by photoacoustic imaging	32
In vivo hamster cheek pouch subepithelial ablation, biomaterial injection, and localization: pilot study	29
Deep-learning–based optical coherence tomography reconstruction for high-speed and contrast morphology and vasculature imaging	29
Generalized 3D registration algorithm for enhancing retinal optical coherence tomography images	29
Polarized hyperspectral and polarized light microscopic imaging for enhanced visualization of white blood cells	28
Remote and low-cost intraocular pressure monitoring by deep learning of speckle patterns	28
Approaching closed spherical, full-view detection for photoacoustic tomography	28
Monte Carlo simulation of the effect of melanin concentration on light–tissue interactions for transmittance pulse oximetry measurement	27
Effects of phantom microstructure on their optical properties	27
Characterization of vascular patterns in endometrial cancer via optical resolution photoacoustic microscopy	26
Blood component analysis using mid-infrared photoacoustic spectroscopy based on ultrasound detection: glucose analysis trial	26
Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging	24
Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating birefringence-related image artifacts	23
Meshless Monte Carlo radiation transfer method for curved geometries using signed distance functions	23
Improved spatial speckle contrast model for tissue blood flow imaging: effects of spatial correlation among neighboring camera pixels	23

Spectral correction of light emitting diodes enables accurate hydration ratio calculation using narrowband diffuse reflectance spectroscopy	22
Hyperspectral imaging of 4T1 mammary carcinomas grown in dorsal skinfold window chambers: spectral renormalization and fluorescence modeling	22
Tissue harvest with a laser microbiopsy (Erratum)	22
Difference imaging from single measurements in diffuse optical tomography: a deep learning approach	22
Solid optical tissue phantom tools based on upconverting nanoparticles for biomedical applications	22
Minimizing near-infrared autofluorescence in preclinical imaging with diet and wavelength selection	21
Impact of signal-to-noise ratio and contrast definition on the sensitivity assessment and benchmarking of fluorescence molecular imaging systems	21
All-reflective tethered capsule endoscope for multimodal optical coherence tomography in the esophagus	20
Enhanced resolution optoacoustic microscopy using a picosecond high repetition rate Q-switched microchip laser	20
Assessing spectral effectiveness in color fundus photography for deep learning classification of retinopathy of prematurity	19
Multimodal microscope for optical coherence microscopy, tomography, vibrometry, and two-photon microscopy in the living mouse cochlea	19
Influence of optical aberrations on depth-specific spatial frequency domain techniques	19
Stain-free enucleation of mouse and human oocytes with a 1033 nm femtosecond laser	19
Deep learning-based optical approach for skin analysis of melanin and hemoglobin distribution	18
Spatial analysis of polarimetric images to enhance near-surface sampling sensitivity: feasibility in demineralized teeth and other tissue-like media	18
Special Section Guest Editorial: Introduction to the Special Section Celebrating 30 years of Open Source Monte Carlo Codes in Biomedical Optics	18
3D-motion mapping of the malleus–incus complex using a robot-mounted optical coherence tomography vibrometry system	18
Depolarization diagrams for circularly polarized light scattering for biological particle monitoring	17
Noninvasive assessment of skin barrier function: evaluating ceramide-based moisturizer using confocal Raman spectroscopy	17
Photoacoustic imaging plus X: a review	17
Multiplexed optical fiber cell temperature sensing system with high sensitivity and accuracy	17
Scattering angle resolved optical coherence tomography measures morphological changes in Bacillus subtilis colonies	16
CellSNAP: a fast, accurate algorithm for 3D cell segmentation in quantitative phase imaging	16
Deep structural brain imaging via computational three-photon microscopy	16
Automatic granular and spinous epidermal cell identification and analysis on in vivo reflectance confocal microscopy images using cell morphological features	16
Structure of tendon causes highly optical anisotropic properties and transport	15
Retrieval of chromophore concentration changes in a digital human head model using analytical mean partial pathlengths of photons	15
Multi-exposure speckle imaging through an optical fiber bundle	15
Hybrid CNN–transformer demosaicing for bioinspired single-chip color-near-infrared fluorescence imaging in oncologic surgery	15
Short-wave infrared (SWIR) spectroscopy and imaging of biological tissues: a decade of advancements (2016-2025)	15
Noise insensitive volumetric fusion method for enhanced photoacoustic microscopy	15
Development of a statistically standardized optical digital wrist model through integrated MRI-diffuse optical imaging methodology	15
Laser absorption spectroscopy measurements of different pulmonary oxygen gas concentrations in transmittance and remittance geometry: phantom study	15
Automated three-dimensional image registration for longitudinal photoacoustic imaging	15
Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities	15
Evaluating backscattering polarized light imaging microstructural mapping capabilities through neural tissue and analogous phantom imaging	14
Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine	14
Evaluating clinical near-infrared surgical camera systems with a view to optimizing operator and computational signal analysis	14
LED-based multicolor extended resolution transmission fluorescence microscopy	14
Noise-robust phase-space deconvolution for light-field microscopy	14
Development of a shortwave infrared sinuscope for the detection of cerebrospinal fluid leaks	14
Direct three-dimensional segmentation of prostate glands with nnU-Net	14
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study	14
Characterization of bacteria swarming effect under plasmonic optical fiber illumination	14
Impact of sample handling protocols on soft tissue attenuation coefficient and morphology	13
Intravital photoacoustic brain stimulation with high-precision	13
Optical coherence tomography–enabled classification of the human venoatrial junction	13
Reflective optical imaging for scattering medium using chaotic laser	13
Circularly polarized light scattering imaging of a cancerous layer creeping under a healthy layer for the diagnosis of early-stage cervical cancer	13
Beyond light scattering: the effects of intralipid on benzoporphyrin derivative-sensitized photodynamic treatment in ovarian cancer cells	13

Deep learning-based spectroscopic single-molecule localization microscopy	13
Two-step regression analysis approach to assess burn wound severity using spatial frequency domain imaging	13
Perspective on the optics of medical imaging	12
Label-free imaging flow cytometry for cell classification based directly on multiple off-axis holographic projections	12
Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array	12
Flexible catheter optical coherence tomography of the porcine middle ear via the Eustachian tube using a 3D-printed reflective objective	12
Toward fluorescence digital twins: multi-parameter experimental validation of fluorescence Monte Carlo simulations using solid phantoms	12
Lightweight and precise cell classification based on holographic tomography-derived refractive index point cloud	12
Assessment of open-field fluorescence guided surgery systems: implementing a standardized method for characterization and comparison	12
New Year, New JBO Editor-in-Chief	12
Development of breast-mimicking phantoms for use in optical coherence elastography	12
Design and validation of a high-speed hyperspectral laparoscopic imaging system	12
Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy	12
Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics	12
Non-invasive assessment of sublingual microcirculation using flow derived from green light PPG: evaluation and reference values	11
Hyperspectral dark-field microscopy of human breast lumpectomy samples for tumor margin detection in breast-conserving surgery	11
Comparison of diffuse correlation spectroscopy analytical models for measuring cerebral blood flow in adults	11
Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling	11
Motion-artifact-free single shot two-beam optical coherence elastography system	11
Polarimetric analysis of the Alzheimer’s pathology in excised mouse brain tissue	11
Imaging the ex-vivo human cochlea using 1.3-μm and 1.7-μm optical coherence tomography	11
Improved 3D image reconstruction via deep-learning-based fusion of light-field microscopy and Fourier light-field microscopy images	11
Monte Carlo simulation platform for laser Doppler flowmetry	11
Restoration of metabolic functional metrics from label-free, two-photon human tissue images using multiscale deep-learning-based denoising algorithms	11
Two-stage classification strategy for breast cancer diagnosis using ultrasound-guided diffuse optical tomography and deep learning	11
Wavefront shaping improves the transparency of the scattering media: a review (Publisher’s Note)	11
Enhanced neuroimaging with a calcium sensor in ex-vivo Drosophila melanogaster brains using closed-loop adaptive optics light-sheet fluorescence microscopy	11
Two-stage diffuse fluorescence tomography for monitoring of drug distribution in photodynamic therapy of tumors	11
Utilizing convolutional neural networks for discriminating cancer and stromal cells in three-dimensional cell culture images with nuclei counterstain	11
Depth-dependent fluence compensation without a priori knowledge of tissue composition for quantitative ultrasound-guided photoacoustic imaging	11
Scaling down the dimensions of a Fabry–Perot polymer film acoustic sensor for photoacoustic endoscopy	11
Motion-resistant three-wavelength spatial frequency domain imaging system with ambient light suppression using an 8-tap CMOS image sensor	11
Detection of live breast cancer cells in bright-field microscopy images containing white blood cells by image analysis and deep learning	10
Quantitative estimation of optical properties in bilayer media within the subdiffusive regime using a tilted fiber-optic probe in diffuse reflectance spectroscopy, part 1: a theoretical framework for	10
Noninvasive continuous blood pressure prediction using FlexNIRS and machine learning during carotid endarterectomy	10
Two-color fluorescence-guided surgery for head and neck cancer resections	10
Terahertz Mie scattering in tissue: diffuse polarimetric imaging and Monte Carlo validation in highly attenuating media models	10
Incremental residual polarization caused by aging in human skin	10
Honoring Lihong V. Wang, a pioneer in biomedical optics	10
Hardware-software co-design of an open-source automatic multimodal whole slide histopathology imaging system	10
Exploring near-infrared autofluorescence properties in parathyroid tissue: an analysis of fresh and paraffin-embedded thyroidectomy specimens	10
Asynchronous optical coherence elastography and directional phase gradient analysis	10
Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review	10
Mouthwash as a non-invasive method of indocyanine green delivery for near-infrared fluorescence dental imaging	10
Perspective on the use of fluorescence molecular imaging for peripheral and deep en face margin assessment	10
Structurally constrained and pathology-aware convolutional transformer generative adversarial network for virtual histology staining of human coronary optical coherence tomography images	9
HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation	9
Off-axis digital lensless holographic microscopy based on spatially multiplexed interferometry	9
Age-related changes in diffuse optical tomography sensitivity profiles from childhood to adulthood	9
Transmission infrared micro-spectroscopic study of individual human hair	9
Mapping functional hemodynamic and metabolic responses to dementia: a broadband spectroscopy pilot study	9
Noninvasive holographic sensor system for measuring stiffness of soft micro samples	9
Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue	9
Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage	9
Photoplethysmographic imaging and analysis of pulsatile pressure wave in palmar artery at 10 wavelengths	9
Field programmable gate array compression for large array multispeckle diffuse correlation spectroscopy	9
Quantitative evaluation of the site-dependent cell viability in three-dimensional hepatocyte spheroids based on dynamic optical coherence tomography	9
Light sources and detectors: applications in nanoscale imaging, sensing, and actuation	9
Evaluating blue light impact on reconstructed human epidermis using laser speckle imaging	9
Photoacoustic and fluorescence dual-modality imaging of cerebral biomarkers in Alzheimer’s disease rodent model	9
Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy	8
3D photogrammetry quantifies the size of basal cell carcinoma lesions with submillimeter accuracy: high correlation with lesion response to photodynamic therapy	8
Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics	8
NIRFASTerFF: an accessible, cross-platform Python package for fast photon modeling	8
Patient-specific arterial input function for accurate perfusion assessment in intraoperative fluorescence imaging	8
Development and preclinical evaluation of an endonasal Raman spectroscopy probe for transsphenoidal pituitary adenoma surgery	8
AI-powered remote monitoring of brain responses to clear and incomprehensible speech via speckle pattern analysis	8
Evaluation of analytical models to estimate depth of fluorescence objects in biological media	8
Femtosecond laser-assisted selective holding with ultra-low power for direct manipulation of biological species	8
Real-time identification of life-threatening necrotizing soft-tissue infections using indocyanine green fluorescence imaging	8
Near-infrared light-induced transcranial photobiomodulation enhances the visual pathway’s function in healthy volunteers	8
Impact of image preprocessing on dermatological OCTA vessel segmentation: a DERMA-OCTA study	8
Wavefront shaping improves the transparency of the scattering media: a review	8
Förster resonance energy transfer efficiency measurements on vinculin tension sensors at focal adhesions using a simple and cost-effective setup	8
Monte Carlo simulation of spatial frequency domain imaging for breast tumors during compression	8
Fast and robust Fourier ptychographic microscopy with position misalignment correction	8
Deep-learning approach to stratified reconstructions of tissue absorption and scattering in time-domain spatial frequency domain imaging	8
Depth detection limit of a fluorescent object in tissue-like medium with background emission in continuous-wave measurements: a phantom study	8
Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers	8
Radiometric and spectral characterization of multipanel planar light-emitting devices: a generalizable irradiance mapping approach for dose estimation	8

Comprehensive framework of GPU-accelerated image reconstruction for photoacoustic computed tomography	8
Remote sensing of alcohol consumption using machine learning speckle pattern analysis	8
Deep learning segmentation of periarterial and perivenous capillary-free zones in optical coherence tomography angiography	8
Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading	8
DOT-AE-GAN: a hybrid autoencoder–GAN model for enhanced ultrasound-guided diffuse optical tomography reconstruction	8
Improved U-net-based leukocyte segmentation method	7
Impact of corpus callosum fiber tract crossing on polarimetric images of human brain histological sections: ex vivo studies in transmission configuration	7
Efficient quality control of platelet-rich plasma preparation using computer vision and deep learning	7
Local protein detection with lateral flow assay read through tissue using X-ray excited luminescence chemical imaging	7
Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity	7
Cherenkov light emission in external beam radiation therapy of the larynx	7
Effective transfer of tumor annotations from hematoxylin and eosin to fluorescence images of breast and lung tissues	7
Basis function model to extract the combined confocal and fall-off function from multiple optical coherence tomography A-scans	7
Optical intensity changes under static load and their dependence on dental implant design around bone-mimicking material	7
Convolutional neural network-based regression analysis to predict subnuclear chromatin organization from two-dimensional optical scattering signals	7
Adaptive correction method of hybrid aberrations in Fourier ptychographic microscopy	7
Improved in vivo optical coherence tomography imaging of animal peripheral nerves using a prism nerve holder	7
Deep-learning-based cross-modality translation from Stokes image to bright-field contrast	7
Detection of breast cancer using machine learning on time-series diffuse optical transillumination data	7
Convolutional neural network advances in demosaicing for fluorescent cancer imaging with color–near-infrared sensors	7
Compact and cost-effective laser-powered speckle contrast optical spectroscopy fiber-free device for measuring cerebral blood flow	7
Elucidating the effect of tumor and background region-of-interest selection on the performance metrics used to assess fluorescence imaging	7
Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer’s disease	7
Model for the diffuse reflectance in spatial frequency domain imaging (Erratum)	7
Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review—part I	7
Combined optical-electromechanical wearable sensors for cardiac health monitoring	7
Quantitative estimation of optical properties in bilayer media within the subdiffusive regime using tilted fiber-optic probe diffuse reflectance spectroscopy, part 2: probe design, realization, and ex	7
Optimizing optical coherence tomography to detect occult spermatozoa in rat testis after induced non-obstructive azoospermia	7
Compact and ultracompact spectral imagers: technology and applications in biomedical imaging	7
Targeted multispectral filter array design for the optimization of endoscopic cancer detection in the gastrointestinal tract	7
In vivo tumor imaging of pre-clinical models via reflection-mode measurements of circular degree of polarization	7
Collagen microarchitecture from polarized light imaging: a biomechanics perspective	7
Ninety years of pulse oximetry: history, current status, and outlook	7
Rolling shutter-resistant confocal endomicroscopy image stitching via dual-path Gaussian U-Net	7
Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise	7
Detection properties of indium-111 and IRDye800CW for intraoperative molecular imaging use across tissue phantom models	7
Hyperspectral imaging in neurosurgery: a review of systems, computational methods, and clinical applications	7