Journal of Biomedical Optics

Article	Citations
Terahertz radiation and the skin: a review	99
Beer–Lambert law for optical tissue diagnostics: current state of the art and the main limitations	91
Comprehensive review of surgical microscopes: technology development and medical applications	74
Automatic detection of oral cancer in smartphone-based images using deep learning for early diagnosis	69
Smartphone-based imaging systems for medical applications: a critical review	59
Cellular effects of terahertz waves	58
Deep learning in photoacoustic imaging: a review	49
Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography	39
Interpretable deep learning approach for oral cancer classification using guided attention inference network	37
Recent innovations in fluorescence lifetime imaging microscopy for biology and medicine	34
Kernel Flow: a high channel count scalable time-domain functional near-infrared spectroscopy system	30
Perspective on fast-evolving photoacoustic tomography	29
Optical manipulation: advances for biophotonics in the 21st century	28
Mobile-based oral cancer classification for point-of-care screening	28
Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients	26
HRVCam: robust camera-based measurement of heart rate variability	26
Saliva-based detection of COVID-19 infection in a real-world setting using reagent-free Raman spectroscopy and machine learning	26
Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy	26
Characterization of Mueller matrix elements for classifying human skin cancer utilizing random forest algorithm	24
Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings	23
MCX Cloud—a modern, scalable, high-performance and in-browser Monte Carlo simulation platform with cloud computing	22
Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy	22
Heartbeat optical coherence elastography: corneal biomechanics in vivo	22
Open-sourced Raman spectroscopy data processing package implementing a baseline removal algorithm validated from multiple datasets acquired in human tissue and biofluids	22
Compact and ultracompact spectral imagers: technology and applications in biomedical imaging	21

Deep feature loss to denoise OCT images using deep neural networks	21
Review of successful pathways for regulatory approvals in open-field fluorescence-guided surgery	20
Automatic detection and characterization of quantitative phase images of thalassemic red blood cells using a mask region-based convolutional neural network	20
Hemoglobin quantification in red blood cells via dry mass mapping based on UV absorption	20
Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment	19
Characterizing reduced scattering coefficient of normal human skin across different anatomic locations and Fitzpatrick skin types using spatial frequency domain imaging	19
High signal-to-noise ratio reconstruction of low bit-depth optical coherence tomography using deep learning	19
Hyperspectral and multispectral image processing for gross-level tumor detection in skin lesions: a systematic review	19
Deep learning in macroscopic diffuse optical imaging	18
Machine learning to extract physiological parameters from multispectral diffuse reflectance spectroscopy	18
Deep learning methods hold promise for light fluence compensation in three-dimensional optoacoustic imaging	17
Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy	17
Classification of imbalanced oral cancer image data from high-risk population	16
Diagnosing 12 prostate needle cores within an hour of biopsy via open-top light-sheet microscopy	16
Virtual scale function of gastrointestinal endoscopy for accurate polyp size estimation in real-time: a preliminary study	16
Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography	16
Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response	16
SIMPA: an open-source toolkit for simulation and image processing for photonics and acoustics	16
Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine	16
Multiresolution nondestructive 3D pathology of whole lymph nodes for breast cancer staging	15
Handheld macroscopic Raman spectroscopy imaging instrument for machine-learning-based molecular tissue margins characterization	15
Effects of lipid composition on photothermal optical coherence tomography signals	15
Effect of curvature correction on parameters extracted from hyperspectral images	15
Binary photoacoustic tomography for improved vasculature imaging	15
Deep-learning approach for automated thickness measurement of epithelial tissue and scab using optical coherence tomography	15
Image-guided Raman spectroscopy probe-tracking for tumor margin delineation	15
Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure	14
Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study	14
Design and implementation of a portable colposcope Mueller matrix polarimeter	14
Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva	14
Separation of color channels from conventional colonoscopy images improves deep neural network detection of polyps	14
In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment	14
Detection of hypoxia by near-infrared spectroscopy and pulse oximetry: a comparative study	14
Rapid tissue oxygenation mapping from snapshot structured-light images with adversarial deep learning	14
Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise	14
Intraoperative molecular imaging: 3rd biennial clinical trials update	13
Rapid assessment of breast tumor margins using deep ultraviolet fluorescence scanning microscopy	13
Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties	13
Detection of live breast cancer cells in bright-field microscopy images containing white blood cells by image analysis and deep learning	13
Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images	13
Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications	13
Estimation of skin microcirculatory hemoglobin oxygen saturation and red blood cell tissue fraction using a multispectral snapshot imaging system: a validation study	13
Deep learning-level melanoma detection by interpretable machine learning and imaging biomarker cues	12
Hyperspectral imaging for tumor segmentation on pigmented skin lesions	12
Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis	12
Graphics-processing-unit-accelerated Monte Carlo simulation of polarized light in complex three-dimensional media	12
Accurate and early prediction of the wound healing outcome of burn injuries using the wavelet Shannon entropy of terahertz time-domain waveforms	12
Extracellular pH affects the fluorescence lifetimes of metabolic co-factors	12
Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology	11
Development of a Monte Carlo-wave model to simulate time domain diffuse correlation spectroscopy measurements from first principles	11

In situ Raman spectroscopy and machine learning unveil biomolecular alterations in invasive breast cancer	11
Review of in vivo optical molecular imaging and sensing from x-ray excitation	11
Non-invasive blood glucose sensing by machine learning of optic fiber-based speckle pattern variation	11
Anthropomorphic optical phantom of the neonatal thorax: a key tool for pulmonary studies in preterm infants	11
Looking deep inside tissue with photoacoustic molecular probes: a review	11
Comparison of preprocessing techniques to reduce nontissue-related variations in hyperspectral reflectance imaging	11
History of Monte Carlo modeling of light transport in tissues using mcml.c	11
Constructing a portable optical polarimetry probe for in-vivo skin cancer detection	11
Sub-millimeter endoscope demonstrates feasibility of in vivo reflectance imaging, fluorescence imaging, and cell collection in the fallopian tubes	11
Dynamic SWIR imaging near the 1950-nm water absorption band for caries lesion diagnosis	11
Photoacoustic imaging of posterior periodontal pocket using a commercial hockey-stick transducer	10
Neural network model assisted Fourier ptychography with Zernike aberration recovery and total variation constraint	10
Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom	10
Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies	10
Domain adaptation for robust workload level alignment between sessions and subjects using fNIRS	10
Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast	10
Real-time visualization of renal microperfusion using laser speckle contrast imaging	10
Human embryonic stem cell classification: random network with autoencoded feature extractor	10
Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE	10
Polarimetric imaging for cervical pre-cancer screening aided by machine learning: ex vivo studies	10
Small molecule kinase inhibitors enhance aminolevulinic acid-mediated protoporphyrin IX fluorescence and PDT response in triple negative breast cancer cell lines	10
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 1: Raman spectroscopy fiber-optics system and in situ tissue characterization	10
Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography	9
Research on the combination of color channels in heart rate measurement based on photoplethysmography imaging	9
MCCL: an open-source software application for Monte Carlo simulations of radiative transport	9
Deep learning-based method to accurately estimate breast tissue optical properties in the presence of the chest wall	9
Imaging of enthesitis by an LED-based photoacoustic system	9
In vivo quantitative photoacoustic monitoring of corticosteroid-induced vasoconstriction	9
Systematic stability testing of insulins as representative biopharmaceuticals using ATR FTIR-spectroscopy with focus on quality assurance	9
MCDataset: a public reference dataset of Monte Carlo simulated quantities for multilayered and voxelated tissues computed by massively parallel PyXOpto Python package	9
Real-time video-rate perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning	9
Registration of polarimetric images for in vivo skin diagnostics	9
High frame rate (∼3 Hz) circular photoacoustic tomography using single-element ultrasound transducer aided with deep learning	9
Deep learning on reflectance confocal microscopy improves Raman spectral diagnosis of basal cell carcinoma	9
Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor	9
Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review	9
First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett’s-related neoplasia	8
Quantifying tissue optical properties of human heads in vivo using continuous-wave near-infrared spectroscopy and subject-specific three-dimensional Monte Carlo models	8
Coherent Raman scattering microscopy: capable solution in search of a larger audience	8
In situ terahertz monitoring of an ice ball formation during tissue cryosurgery: a feasibility test	8
Terahertz spectroscopy analysis of human corneal sublayers	8
Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation	8
High-throughput label-free cell detection and counting from diffraction patterns with deep fully convolutional neural networks	8
Dual short wavelength infrared transillumination/reflectance mode imaging for caries detection	8
BlenderPhotonics: an integrated open-source software environment for three-dimensional meshing and photon simulations in complex tissues	8
Perspective on the integration of optical sensing into orthopedic surgical devices	8
Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology	8
Evaluating clinical near-infrared surgical camera systems with a view to optimizing operator and computational signal analysis	8
Large field-of-view short-wave infrared metalens for scanning fiber endoscopy	8
Monte Carlo-based data generation for efficient deep learning reconstruction of macroscopic diffuse optical tomography and topography applications	8
Near-infrared diffuse in vivo flow cytometry	8
Multiple illumination learned spectral decoloring for quantitative optoacoustic oximetry imaging	8
Methods and applications of full-filed optical coherence tomography: a review	8
Label-free detection of brain tumors in a 9L gliosarcoma rat model using stimulated Raman scattering-spectroscopic optical coherence tomography	8
Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets	8
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence	8
Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array	8
CNN-based CP-OCT sensor integrated with a subretinal injector for retinal boundary tracking and injection guidance	8
High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging	8
Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies	8
Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance	8
Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgery	8
Multimodal 3D photoacoustic remote sensing and confocal fluorescence microscopy imaging	8
Skin chromophore mapping by smartphone RGB camera under spectral band and spectral line illumination	8
Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data	8
Enhancement of in vivo cardiac photoacoustic signal specificity using spatiotemporal singular value decomposition	8
Reproducibility of identical solid phantoms	8
Skin optical properties in the obese and their relation to body mass index: a review	8
Depth distributions of bacteria for the Pseudomonas aeruginosa-infected burn wounds treated by methylene blue-mediated photodynamic therapy in rats: effects of additives to photosensitizer	8
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 2: in-vivo tumor-targeting using a classification model combining spectral and MRI-radiomics	8
Automatic detection of head and neck squamous cell carcinoma on histologic slides using hyperspectral microscopic imaging	7
Dual-emissive, oxygen-sensing boron nanoparticles quantify oxygen consumption rate in breast cancer cells	7
Computational multifocus fluorescence microscopy for three-dimensional visualization of multicellular tumor spheroids	7
Incorporating early and late-arriving photons to improve the reconstruction of cerebral hemodynamic responses acquired by time-resolved near-infrared spectroscopy	7
Approaching closed spherical, full-view detection for photoacoustic tomography	7
Modeling toolchain for realistic simulation of photoacoustic data acquisition	7
Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography	7
Protoporphyrin IX delayed fluorescence imaging: a modality for hypoxia-based surgical guidance	7
Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content	7
Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes	7

Multiwavelength tissue-mimicking phantoms with tunable vessel pulsation	7
Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: a comparison of colorimetry with spatial frequency domain imaging	7
Signal and measurement considerations for human translation of diffuse in vivo flow cytometry	7
Applications of compressive sensing in spatial frequency domain imaging	7
Using Fourier ptychography microscopy to achieve high-resolution chromosome imaging: an initial evaluation	7
Analyzing the influence of oblique incidence on quantitative backscattering tissue polarimetry: a pilot ex vivo study	7
Deep learning-based optical approach for skin analysis of melanin and hemoglobin distribution	7
Bimodal multispectral imaging system with cloud-based machine learning algorithm for real-time screening and detection of oral potentially malignant lesions and biopsy guidance	7
Transcutaneous monitoring of hemoglobin derivatives during methemoglobinemia in rats using spectral diffuse reflectance	7
Experimental validation of a recently developed model for single-fiber reflectance spectroscopy	7
Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis	7
Multispectral snapshot imaging of skin microcirculatory hemoglobin oxygen saturation using artificial neural networks trained on in vivo data	7
Assessing corneal cross-linking with reverberant 3D optical coherence elastography	7
Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO2 during radiotherapy	7
Imaging performance of microscopy adaptive-optics system using scene-based wavefront sensing	7
Focused x-ray luminescence imaging system for small animals based on a rotary gantry	7
Quantifying optical anisotropy in soft tissue membranes using Mueller matrix imaging	7
Development of a drug–device combination for fluorescence-guided surgery in neuroendocrine tumors	7
Comparison of different spectral cameras for image-guided organ transplantation	7
Functional imaging with dynamic quantitative oblique back-illumination microscopy	7
Perspectives on interstitial photodynamic therapy for malignant tumors	7
Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties	7
Prediction of optimal contrast times post-imaging agent administration to inform personalized fluorescence-guided surgery	7
Special Section Guest Editorial: Advances in Terahertz Biomedical Science and Applications	7
Signal-carrying speckle in optical coherence tomography: a methodological review on biomedical applications	7
Investigation of photoacoustic tomography reconstruction with a limited view from linear array	7
Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors	6
Characterization and identification of cell death dynamics by quantitative phase imaging	6
Imaging of the skin microvascularization using spatially depolarized dynamic speckle	6
Evaluation of standardized performance test methods for biomedical Raman spectroscopy	6
Optical fibers for endoscopic high-power Er:YAG laserosteotomy	6
Mid-infrared absorption by soft tissue sarcoma and cell ablation utilizing a mid-infrared interband cascade laser	6
Noise-robust phase-space deconvolution for light-field microscopy	6
Two-step verification method for Monte Carlo codes in biomedical optics applications	6
Three-dimensional vascular and metabolic imaging using inverted autofluorescence	6
Estimation of diffuse Cherenkov optical emission from external beam radiation build-up in tissue	6
Empirical method for rapid quantification of intrinsic fluorescence signals of key metabolic probes from optical spectra measured on tissue-mimicking turbid medium	6
Minimizing scattering-induced phase errors in differential interference contrast microscopy	6
Adaptive stochastic Gauss–Newton method with optical Monte Carlo for quantitative photoacoustic tomography	6
Birefringence effect studies of collagen formed by nonenzymatic glycation using dual-retarder Mueller polarimetry	6
Evaluation of a pipeline for simulation, reconstruction, and classification in ultrasound-aided diffuse optical tomography of breast tumors	6
Analysis of structural effects of sickle cell disease on brain vasculature of mice using three-dimensional quantitative phase imaging	6
Adaptive correction method of hybrid aberrations in Fourier ptychographic microscopy	6
Dual division of focal plane polarimeters-based collinear reflection Mueller matrix fast imaging microscope	6
Imaging sub-diffuse optical properties of cancerous and normal skin tissue using machine learning-aided spatial frequency domain imaging	6
Minimally invasive intrathecal spinal cord imaging with optical coherence tomography	6
High-speed mosaic imaging using scanner-synchronized stage position sampling	6
Terahertz high-resolution spectroscopy of thermal decomposition gas products of diabetic and non-diabetic blood plasma and kidney tissue pellets	6
Photobiomodulation in 3D tissue engineering	6
Globally deployed COVID-19 fever screening devices using infrared thermographs consistently normalize high readings to afebrile range	6
Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice	6
Label-free multimodal nonlinear optical imaging of needle biopsy cores for intraoperative cancer diagnosis	6
In vivo skin optical clearing efficacy quantification of clinically compatible agents using line-field confocal optical coherence tomography	6
Stochastic three-dimensional numerical phantoms to enable computational studies in quantitative optoacoustic computed tomography of breast cancer	5
Two-photon scanned light sheet fluorescence microscopy with axicon imaging for fast volumetric imaging	5
Multimode optical fiber specklegram smart bed sensor array	5
Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy	5
In vivo spectroscopic evaluation of human tissue optical properties and hemodynamics during HPPH-mediated photodynamic therapy of pleural malignancies	5
Mapping variation of extracellular matrix in human keloid scar by label-free multiphoton imaging and machine learning	5
Large volume holographic imaging for biological sample analysis	5
In vivo tissue optical clearing assisted through-skull targeted photothrombotic ischemic stroke model in mice	5
Dimensional reduction based on peak fitting of Raman micro spectroscopy data improves detection of prostate cancer in tissue specimens	5
Spatial frequency domain imager based on a compact multiaperture camera: testing and feasibility for noninvasive burn severity assessment	5
Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector	5
Monte Carlo method for assessment of a multimodal insertable biosensor	5
Development and characterization of phasor-based analysis for FLIM to evaluate the metabolic and epigenetic impact of HER2 inhibition on squamous cell carcinoma cultures	5
Dermoscopy and skin imaging light sources: a comparison and review of spectral power distribution and color consistency	5
Aberration-free digital holographic phase imaging using the derivative-based principal component analysis	5
Ultrasmall compact CMOS imaging system for bioluminescence reporter-based live gene expression analysis	5
Visualization of superficial vein dynamics in dorsal hand by near-infrared imaging in response to elevated local temperature	5
Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation	5
Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe	5
Objective determination of peripheral edema in heart failure patients using short-wave infrared molecular chemical imaging	5
Effects of skin tone on photoacoustic imaging and oximetry	5
Scalable, modular continuous wave functional near-infrared spectroscopy system (Spotlight)	5
In vivo photoacoustic assessment of the oxygen saturation changes in the human radial artery: a preliminary study associated with age	5
Broadband diffuse optical spectroscopy of absolute methemoglobin concentration can distinguish benign and malignant breast lesions	5
High-sensitivity dynamic diffuse fluorescence tomography system for fluorescence pharmacokinetics	5
Hybrid motion artifact detection and correction approach for functional near-infrared spectroscopy measurements	5
Robustness of tissue oxygenation estimates by continuous wave space-resolved near infrared spectroscopy	5
COVID-19 classification using thermal images	5
Discrimination of cancerous from benign pigmented skin lesions based on multispectral autofluorescence lifetime imaging dermoscopy and machine learning	5
Monitoring the skin structure during edema in vivo with spatially resolved diffuse reflectance spectroscopy	5
Preclinical evaluation of molecularly targeted fluorescent probes in perfused amputated human limbs	5
Spectral characterization of liquid hemoglobin phantoms with varying oxygenation states	5
Preclinical evaluation of a clinical prototype transrectal diffuse optical tomography system for monitoring photothermal therapy of focal prostate cancer	5
Multichromatic near-infrared imaging to assess interstitial lymphatic and venous uptake in vivo	5
Accelerating 3D single-molecule localization microscopy using blind sparse inpainting	5
Automating reflectance confocal microscopy image analysis for dermatological research: a review	5
Absolute retinal blood flowmeter using a laser Doppler velocimeter combined with adaptive optics	4
Investigation of image plane for image reconstruction of objects through diffusers via deep learning	4
Optimization of in vivo Cherenkov imaging dosimetry via spectral choices for ambient background lights and filtering	4
Fiber-based photoacoustic remote sensing microscopy and spectral-domain optical coherence tomography with a dual-function 1050-nm interrogation source	4
Exploring the feasibility of wavelength modulated near-infrared spectroscopy	4
Segmentation of the urothelium in optical coherence tomography images with dynamic contrast	4