Journal of Biomedical Optics

Article	Citations
Terahertz radiation and the skin: a review	92
Deep learning in photoacoustic tomography: current approaches and future directions	90
Beer–Lambert law for optical tissue diagnostics: current state of the art and the main limitations	68
Comprehensive review of surgical microscopes: technology development and medical applications	65
Automatic detection of oral cancer in smartphone-based images using deep learning for early diagnosis	58
Photogrammetry-based stereoscopic optode registration method for functional near-infrared spectroscopy	56
Cellular effects of terahertz waves	54
Smartphone-based imaging systems for medical applications: a critical review	53
Diffuse correlation spectroscopy measurements of blood flow using 1064 nm light	45
Deep learning in photoacoustic imaging: a review	45
Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography	36
Toward accurate quantitative photoacoustic imaging: learning vascular blood oxygen saturation in three dimensions	35
Interpretable deep learning approach for oral cancer classification using guided attention inference network	33
Recent innovations in fluorescence lifetime imaging microscopy for biology and medicine	32
Laparoscopic system for simultaneous high-resolution video and rapid hyperspectral imaging in the visible and near-infrared spectral range	29
Surface-enhanced Raman spectroscopy of tears: toward a diagnostic tool for neurodegenerative disease identification	29
Kernel Flow: a high channel count scalable time-domain functional near-infrared spectroscopy system	27
Perspective on fast-evolving photoacoustic tomography	26
Saliva-based detection of COVID-19 infection in a real-world setting using reagent-free Raman spectroscopy and machine learning	26
Optical manipulation: advances for biophotonics in the 21st century	26
Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy	25
Mobile-based oral cancer classification for point-of-care screening	25
Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients	24
Characterization of Mueller matrix elements for classifying human skin cancer utilizing random forest algorithm	24
HRVCam: robust camera-based measurement of heart rate variability	23

Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings	23
MCX Cloud—a modern, scalable, high-performance and in-browser Monte Carlo simulation platform with cloud computing	22
Heartbeat optical coherence elastography: corneal biomechanics in vivo	22
Interferometric diffuse correlation spectroscopy improves measurements at long source–detector separation and low photon count rate	21
Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy	21
Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond	20
Deep feature loss to denoise OCT images using deep neural networks	20
Hemoglobin quantification in red blood cells via dry mass mapping based on UV absorption	20
Compact and ultracompact spectral imagers: technology and applications in biomedical imaging	19
Review of successful pathways for regulatory approvals in open-field fluorescence-guided surgery	19
Automatic detection and characterization of quantitative phase images of thalassemic red blood cells using a mask region-based convolutional neural network	19
Automatic diagnosis of macular diseases from OCT volume based on its two-dimensional feature map and convolutional neural network with attention mechanism	18
Characterizing reduced scattering coefficient of normal human skin across different anatomic locations and Fitzpatrick skin types using spatial frequency domain imaging	18
Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment	17
High signal-to-noise ratio reconstruction of low bit-depth optical coherence tomography using deep learning	17
Open-sourced Raman spectroscopy data processing package implementing a baseline removal algorithm validated from multiple datasets acquired in human tissue and biofluids	17
Classification of imbalanced oral cancer image data from high-risk population	16
Measuring hemoglobin spectra: searching for carbamino-hemoglobin	16
Aptamer-based surface-enhanced resonance Raman scattering assay on a paper fluidic platform for detection of cardiac troponin I	16
Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine	16
Machine learning to extract physiological parameters from multispectral diffuse reflectance spectroscopy	16
Hyperspectral and multispectral image processing for gross-level tumor detection in skin lesions: a systematic review	16
Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography	16
SIMPA: an open-source toolkit for simulation and image processing for photonics and acoustics	15
Deep learning methods hold promise for light fluence compensation in three-dimensional optoacoustic imaging	15
Diagnosing 12 prostate needle cores within an hour of biopsy via open-top light-sheet microscopy	15
Effects of lipid composition on photothermal optical coherence tomography signals	15
Deep learning in macroscopic diffuse optical imaging	15
Clinical evaluation of fever-screening thermography: impact of consensus guidelines and facial measurement location	15
Wavelength- and irradiance-dependent changes in intracellular nitric oxide level	15
Handheld macroscopic Raman spectroscopy imaging instrument for machine-learning-based molecular tissue margins characterization	15
Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy	15
Characterization of retinal biomechanical properties using Brillouin microscopy	15
Binary photoacoustic tomography for improved vasculature imaging	15
Image-guided Raman spectroscopy probe-tracking for tumor margin delineation	15
Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response	14
Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva	14
Design and implementation of a portable colposcope Mueller matrix polarimeter	14
Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure	14
Separation of color channels from conventional colonoscopy images improves deep neural network detection of polyps	14
Photoacoustics resolves species-specific differences in hemoglobin concentration and oxygenation	14
Virtual scale function of gastrointestinal endoscopy for accurate polyp size estimation in real-time: a preliminary study	14
Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study	14
Multiresolution nondestructive 3D pathology of whole lymph nodes for breast cancer staging	13
Photoacoustic image improvement based on a combination of sparse coding and filtering	13
Rapid tissue oxygenation mapping from snapshot structured-light images with adversarial deep learning	13
Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications	13
Estimation of skin microcirculatory hemoglobin oxygen saturation and red blood cell tissue fraction using a multispectral snapshot imaging system: a validation study	13
Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images	13
In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment	13

Detection of hypoxia by near-infrared spectroscopy and pulse oximetry: a comparative study	13
Deep-learning approach for automated thickness measurement of epithelial tissue and scab using optical coherence tomography	13
Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties	13
Detection of live breast cancer cells in bright-field microscopy images containing white blood cells by image analysis and deep learning	12
Label-free imaging of lipid-rich biological tissues by mid-infrared photoacoustic microscopy	12
Intraoperative molecular imaging: 3rd biennial clinical trials update	12
Rapid assessment of breast tumor margins using deep ultraviolet fluorescence scanning microscopy	12
Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis	12
Automated classification of coronary plaque calcification in OCT pullbacks with 3D deep neural networks	12
Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise	12
Effect of curvature correction on parameters extracted from hyperspectral images	11
Anthropomorphic optical phantom of the neonatal thorax: a key tool for pulmonary studies in preterm infants	11
Extracellular pH affects the fluorescence lifetimes of metabolic co-factors	11
Accurate and early prediction of the wound healing outcome of burn injuries using the wavelet Shannon entropy of terahertz time-domain waveforms	11
Development of a Monte Carlo-wave model to simulate time domain diffuse correlation spectroscopy measurements from first principles	11
Review of in vivo optical molecular imaging and sensing from x-ray excitation	11
Unbiased corneal tissue analysis using Gabor-domain optical coherence microscopy and machine learning for automatic segmentation of corneal endothelial cells	11
Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology	11
Deep learning-level melanoma detection by interpretable machine learning and imaging biomarker cues	11
Constructing a portable optical polarimetry probe for in-vivo skin cancer detection	11
Dynamic SWIR imaging near the 1950-nm water absorption band for caries lesion diagnosis	10
Domain adaptation for robust workload level alignment between sessions and subjects using fNIRS	10
Advantages of Fresnel biprism-based digital holographic microscopy in quantitative phase imaging	10
Sub-millimeter endoscope demonstrates feasibility of in vivo reflectance imaging, fluorescence imaging, and cell collection in the fallopian tubes	10
High-speed axially swept light sheet microscopy using a linear MEMS phased array for isotropic resolution	10
Hyperspectral imaging for tumor segmentation on pigmented skin lesions	10
Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies	10
History of Monte Carlo modeling of light transport in tissues using mcml.c	10
Neural network model assisted Fourier ptychography with Zernike aberration recovery and total variation constraint	10
Graphics-processing-unit-accelerated Monte Carlo simulation of polarized light in complex three-dimensional media	10
Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart	10
Human embryonic stem cell classification: random network with autoencoded feature extractor	10
Non-invasive blood glucose sensing by machine learning of optic fiber-based speckle pattern variation	10
Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE	10
Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast	10
Looking deep inside tissue with photoacoustic molecular probes: a review	10
In situ Raman spectroscopy and machine learning unveil biomolecular alterations in invasive breast cancer	10
Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography	9
Research on the combination of color channels in heart rate measurement based on photoplethysmography imaging	9
MCCL: an open-source software application for Monte Carlo simulations of radiative transport	9
Real-time video-rate perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning	9
Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor	9
Polarimetric imaging for cervical pre-cancer screening aided by machine learning: ex vivo studies	9
Small molecule kinase inhibitors enhance aminolevulinic acid-mediated protoporphyrin IX fluorescence and PDT response in triple negative breast cancer cell lines	9
MCDataset: a public reference dataset of Monte Carlo simulated quantities for multilayered and voxelated tissues computed by massively parallel PyXOpto Python package	9
Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom	9
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 1: Raman spectroscopy fiber-optics system and in situ tissue characterization	9
Photoacoustic imaging of posterior periodontal pocket using a commercial hockey-stick transducer	9
Real-time visualization of renal microperfusion using laser speckle contrast imaging	9
Systematic stability testing of insulins as representative biopharmaceuticals using ATR FTIR-spectroscopy with focus on quality assurance	9
Deep learning on reflectance confocal microscopy improves Raman spectral diagnosis of basal cell carcinoma	9
Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review	9
Multimodal 3D photoacoustic remote sensing and confocal fluorescence microscopy imaging	8
Imaging of enthesitis by an LED-based photoacoustic system	8
Reproducibility of identical solid phantoms	8
Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets	8
Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array	8
High frame rate (∼3 Hz) circular photoacoustic tomography using single-element ultrasound transducer aided with deep learning	8
Quantifying tissue optical properties of human heads in vivo using continuous-wave near-infrared spectroscopy and subject-specific three-dimensional Monte Carlo models	8
In situ terahertz monitoring of an ice ball formation during tissue cryosurgery: a feasibility test	8
Terahertz spectroscopy analysis of human corneal sublayers	8
Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging	8
Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data	8
Label-free detection of brain tumors in a 9L gliosarcoma rat model using stimulated Raman scattering-spectroscopic optical coherence tomography	8
Enhancement of in vivo cardiac photoacoustic signal specificity using spatiotemporal singular value decomposition	8
BlenderPhotonics: an integrated open-source software environment for three-dimensional meshing and photon simulations in complex tissues	8
Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology	8
Evaluating clinical near-infrared surgical camera systems with a view to optimizing operator and computational signal analysis	8
Monte Carlo-based data generation for efficient deep learning reconstruction of macroscopic diffuse optical tomography and topography applications	8
Near-infrared diffuse in vivo flow cytometry	8
Multiple illumination learned spectral decoloring for quantitative optoacoustic oximetry imaging	8
High-throughput label-free cell detection and counting from diffraction patterns with deep fully convolutional neural networks	8
Registration of polarimetric images for in vivo skin diagnostics	8
Perspective on the integration of optical sensing into orthopedic surgical devices	8
Skin optical properties in the obese and their relation to body mass index: a review	8
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 2: in-vivo tumor-targeting using a classification model combining spectral and MRI-radiomics	8
First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett’s-related neoplasia	8
Deep learning-based method to accurately estimate breast tissue optical properties in the presence of the chest wall	8
Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance	8
Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes	7

Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgery	7
Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis	7
Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement	7
Depth distributions of bacteria for the Pseudomonas aeruginosa-infected burn wounds treated by methylene blue-mediated photodynamic therapy in rats: effects of additives to photosensitizer	7
Modeling toolchain for realistic simulation of photoacoustic data acquisition	7
Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO2 during radiotherapy	7
Virtual organelle self-coding for fluorescence imaging via adversarial learning	7
Quantifying optical anisotropy in soft tissue membranes using Mueller matrix imaging	7
Automatic detection of head and neck squamous cell carcinoma on histologic slides using hyperspectral microscopic imaging	7
Multispectral snapshot imaging of skin microcirculatory hemoglobin oxygen saturation using artificial neural networks trained on in vivo data	7
Dual-emissive, oxygen-sensing boron nanoparticles quantify oxygen consumption rate in breast cancer cells	7
Dual short wavelength infrared transillumination/reflectance mode imaging for caries detection	7
Comparison of preprocessing techniques to reduce nontissue-related variations in hyperspectral reflectance imaging	7
Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties	7
Incorporating early and late-arriving photons to improve the reconstruction of cerebral hemodynamic responses acquired by time-resolved near-infrared spectroscopy	7
Prediction of optimal contrast times post-imaging agent administration to inform personalized fluorescence-guided surgery	7
Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation	7
CNN-based CP-OCT sensor integrated with a subretinal injector for retinal boundary tracking and injection guidance	7
High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging	7
Investigation of photoacoustic tomography reconstruction with a limited view from linear array	7
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence	7
Coherent Raman scattering microscopy: capable solution in search of a larger audience	7
Special Section Guest Editorial: Advances in Terahertz Biomedical Science and Applications	7
Development of a drug–device combination for fluorescence-guided surgery in neuroendocrine tumors	7
Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography	7
Signal and measurement considerations for human translation of diffuse in vivo flow cytometry	7
Experimental validation of a recently developed model for single-fiber reflectance spectroscopy	7
Perspectives on interstitial photodynamic therapy for malignant tumors	7
Signal-carrying speckle in optical coherence tomography: a methodological review on biomedical applications	7
Transcutaneous monitoring of hemoglobin derivatives during methemoglobinemia in rats using spectral diffuse reflectance	7
Assessing corneal cross-linking with reverberant 3D optical coherence elastography	7
Multiwavelength tissue-mimicking phantoms with tunable vessel pulsation	7
Large field-of-view short-wave infrared metalens for scanning fiber endoscopy	7
Applications of compressive sensing in spatial frequency domain imaging	7
Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: a comparison of colorimetry with spatial frequency domain imaging	7
Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content	7
Methods and applications of full-filed optical coherence tomography: a review	7
Comparison of different spectral cameras for image-guided organ transplantation	7
Using Fourier ptychography microscopy to achieve high-resolution chromosome imaging: an initial evaluation	7
Optical fibers for endoscopic high-power Er:YAG laserosteotomy	6
Globally deployed COVID-19 fever screening devices using infrared thermographs consistently normalize high readings to afebrile range	6
Focused x-ray luminescence imaging system for small animals based on a rotary gantry	6
Two-step verification method for Monte Carlo codes in biomedical optics applications	6
Label-free multimodal nonlinear optical imaging of needle biopsy cores for intraoperative cancer diagnosis	6
In vivo skin optical clearing efficacy quantification of clinically compatible agents using line-field confocal optical coherence tomography	6
Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography	6
Characterization and identification of cell death dynamics by quantitative phase imaging	6
Handheld multispectral imager for quantitative skin assessment in low-resource settings	6
Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models	6
Evaluation of a pipeline for simulation, reconstruction, and classification in ultrasound-aided diffuse optical tomography of breast tumors	6
Noise-robust phase-space deconvolution for light-field microscopy	6
Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice	6
Imaging performance of microscopy adaptive-optics system using scene-based wavefront sensing	6
Three-dimensional vascular and metabolic imaging using inverted autofluorescence	6
Bimodal multispectral imaging system with cloud-based machine learning algorithm for real-time screening and detection of oral potentially malignant lesions and biopsy guidance	6
Imaging sub-diffuse optical properties of cancerous and normal skin tissue using machine learning-aided spatial frequency domain imaging	6
Functional imaging with dynamic quantitative oblique back-illumination microscopy	6
Protoporphyrin IX delayed fluorescence imaging: a modality for hypoxia-based surgical guidance	6
Mid-infrared absorption by soft tissue sarcoma and cell ablation utilizing a mid-infrared interband cascade laser	6
Terahertz high-resolution spectroscopy of thermal decomposition gas products of diabetic and non-diabetic blood plasma and kidney tissue pellets	6
Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies	6
Deep learning-based optical approach for skin analysis of melanin and hemoglobin distribution	6
Adaptive correction method of hybrid aberrations in Fourier ptychographic microscopy	6
Analysis of structural effects of sickle cell disease on brain vasculature of mice using three-dimensional quantitative phase imaging	6
Estimation of diffuse Cherenkov optical emission from external beam radiation build-up in tissue	6
Empirical method for rapid quantification of intrinsic fluorescence signals of key metabolic probes from optical spectra measured on tissue-mimicking turbid medium	6
High-speed mosaic imaging using scanner-synchronized stage position sampling	6
Analyzing the influence of oblique incidence on quantitative backscattering tissue polarimetry: a pilot ex vivo study	6
Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation	5
Large volume holographic imaging for biological sample analysis	5
Dimensional reduction based on peak fitting of Raman micro spectroscopy data improves detection of prostate cancer in tissue specimens	5
USB capsule endoscope for retrograde imaging of the esophagus	5
Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector	5
In vivo photoacoustic assessment of the oxygen saturation changes in the human radial artery: a preliminary study associated with age	5
High-sensitivity dynamic diffuse fluorescence tomography system for fluorescence pharmacokinetics	5
Discrimination of cancerous from benign pigmented skin lesions based on multispectral autofluorescence lifetime imaging dermoscopy and machine learning	5
Ultrasmall compact CMOS imaging system for bioluminescence reporter-based live gene expression analysis	5
Preclinical evaluation of molecularly targeted fluorescent probes in perfused amputated human limbs	5
Objective determination of peripheral edema in heart failure patients using short-wave infrared molecular chemical imaging	5
Spatial frequency domain imager based on a compact multiaperture camera: testing and feasibility for noninvasive burn severity assessment	5
Photobiomodulation in 3D tissue engineering	5
Automating reflectance confocal microscopy image analysis for dermatological research: a review	5
Stochastic three-dimensional numerical phantoms to enable computational studies in quantitative optoacoustic computed tomography of breast cancer	5
Two-photon scanned light sheet fluorescence microscopy with axicon imaging for fast volumetric imaging	5
Minimally invasive intrathecal spinal cord imaging with optical coherence tomography	5
Dual division of focal plane polarimeters-based collinear reflection Mueller matrix fast imaging microscope	5
Reflection-mode acousto-optic imaging using a one-dimensional ultrasound array with electronically scanned focus	5
Evaluation of standardized performance test methods for biomedical Raman spectroscopy	5
Automated interpretation of time-lapse quantitative phase image by machine learning to study cellular dynamics during epithelial–mesenchymal transition	5
Multichromatic near-infrared imaging to assess interstitial lymphatic and venous uptake in vivo	5
Birefringence effect studies of collagen formed by nonenzymatic glycation using dual-retarder Mueller polarimetry	5
Accelerating 3D single-molecule localization microscopy using blind sparse inpainting	5
Development and characterization of phasor-based analysis for FLIM to evaluate the metabolic and epigenetic impact of HER2 inhibition on squamous cell carcinoma cultures	5
Skin chromophore mapping by smartphone RGB camera under spectral band and spectral line illumination	5
Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy	5