OOIR: Observatory of International Research

Papers

(The TQCC of Preparative Biochemistry & Biotechnology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Development of an attenuated glutamine synthetase (GS) selection system for the stable expression of tissue plasminogen activator in CHO-K1 cells	34
Bioconversion of mustard oil cake for production of lipase, optimization and direct immobilization from solid-state fermentation extract	32
The potential of Streptococcus pyogenes and Escherichia coli bacteriocins in synergistic control of Staphylococcus aureus	25
Changes in the structure and composition of pineapple leaf fiber after alkali and ionic surfactant pretreatments and their impact on enzymatic hydrolysis	24
Subcritical water extraction of polysaccharides from Gastrodiae Rhizoma : optimization, characterization and in vitro hepatoprotective activity	22
Maximizing polyphenol yield: ultrasound-assisted extraction and antimicrobial potential of mango peel	20
First report of collagenase production by Trichosporon sp. strain isolated from pollen of Amazonian bee (Melipona seminigra seminigra)	19
A novel pretreatment biotechnology for increasing methane yield from lipid-rich wastewater based on combination of hydrolytic enzymes with Candida rugosa fungus	15
Hyaluronic acid production and purification techniques: a review	15
GFP fusion promotes the soluble and active expression of a pea actin isoform (PEAc1) in Escherichia coli	15
The influence of UV light on the course of fluorescent enzyme assays	15
Kinetic modeling and statistical optimization of submerged production of anti-Parkinson’s prodrug L-DOPA by Pseudomonas fluorescens	14
Statistical optimization of medium components for biosurfactant production by Pseudomonas guguanensis D30	13
Quantification of human intravenous immunoglobulin from plasma and in process samples by affinity chromatography	13
Research on soft sensing method of photosynthetic bacteria fermentation process based on ant colony algorithm and least squares support vector machine	13
New application of gelatin and starch as biocarriers for the biodegradation of reactive blue azo dye using immobilized mixed cells	12
Purification of chitosanases produced by Bacillus toyonensis CCT 7899 and functional oligosaccharides production	12
Synthesis of cellulosic and nano-cellulosic aerogel from lignocellulosic materials for diverse sustainable applications: a review	12
Study on covalent coupling process and flow characteristics of antibody on the surface of immunoassay microfluidic chip	12
Deep eutectic solvent assisted recovery of high molecular weight levan from an isolated Neobacillus pocheonensis BPSCM4	12
Analysis of microalgal growth kinetic model and carbohydrate biosynthesis cultivated using agro-industrial waste residuals as carbon source	12
Optimization of cryoprotectant formulation to enhance the viability of Lactiplantibacillus plantarum NBC99 isolated from human origin	11
Coproduction of inulinase and invertase by Galactomyces geotrichum in whey-based medium and evaluation of additional nutrients	11
Bacteriocin production and inhibition of Bacillus subtilis by Lactobacillus paracasei HD1.7 in an indirect coculture system	10
Direct and cost-effective method for histone isolation from cultured mammalian cells	10

UV mutagenesis for lipase overproduction from Bacillus cereus ATA179, nutritional optimization, characterization and its usability in the detergent industry	10
Evaluation of nutritional and medicinal potential of defatted Sapindus mukorossi seed kernel	10
Increasing lipid production from Zygosaccharomyces siamensis AP1 in molasses substrate using sequencing batch method	9
Characterization of a novel marine microbial uricase from Priestia flexa and evaluation of the effects of CMCS conjugation on its enzymatic properties	9
Purification of total flavonoids from Ginkgo biloba flowers with resin column chromatography and evaluation of antioxidant activities in vitro	9
Optimization of process parameters for specific pathogen-free chicken embryonic fibroblast cultivation for yellow fever vaccine production	8
Microbased biorefinery for gold nanoparticle production: recent advancements, applications and future aspects	8
The response surface optimization of exopolysaccharide produced by Saccharomyces cerevisiae Y3 and its partial characterization	8
A novel strategy to construct multi-strain starter cultures: an insight to evolve from natural to directed fermentation	8
Microbial fermentation technology for degradation of saponins from peony seed meal	8
Biochemical characteristics of Myceliophthora thermophila recombinant β -glucosidase (MtBgl3c) applicable in cellulose bioconversion	8
The effects of different extraction methods on the structure and antioxidant properties of Bletilla striata polysaccharide	8
A soft sensor model of Pichia pastoris cell concentration based on IBDA-RELM	8
Review of LC techniques for determination of methadone and its metabolite in the biological samples	8
Development of HPV58 type-specific antibodies and detection kit	8
Screening and stability verification of reference genes in Botrytis cinerea ZX2 fermentation	8
Antimicrobial activity of the recombinant peptide Melittin-Thanatin with three glycine to tryptophan mutations	8
A sustainable process for co-production of xylooligosaccharides and ethanol from alkali treated sugarcane bagasse: A strategy towards waste management	7
Biosurfactants produced from corncob: a bibliometric perspective of a renewable and promising substrate	7
Chaperone-assisted soluble expression and characterization of chitinase chiZJ408 in Escherichia coli BL21 and the chitin degradation by recombinant enzyme	7
Recent advancements in soluble expression of recombinant antibody fragments in microbial host systems	7
Regulatory considerations in biosimilars: Middle East and Africa regions	7
Optimization of extraction and bioactivity detection of celery leaf flavonoids using BP neural network combined with genetic algorithm and response	7
Evaluation of antioxidation, regulation of glycolipid metabolism and potential as food additives of exopolysaccharide from Sporidiobolus pararoseus PFY-Z1	7
Isolation and identification of an osmotolerant Bacillus amyloliquefaciens strain T4 for 2, 3-butanediol production with tobacco waste	7
Intracellular-to-extracellular localization switch of acidic lipase in Enterobacter cloacae: evaluation of production kinetics and enantioselective esterification potential for pharmaceutical a	7
Microbial conversion of lignin rich biomass hydrolysates to medium chain length polyhydroxyalkanoates (mcl-PHA) using Pseudomonas putida KT2440	7
Optimization of exopolysaccharide production from the novel Enterococcus species, using statistical design of experiment	7
Extraction of total antioxidants from Azadirachta indica (neem) using three phase partitioning and its process intensification using ultrasound	7
Effects of pyruvate decarboxylase (pdc1, pdc5) gene knockout on the production of metabolites in two haploid Saccharomyces cerevisiae strains	7
Comparative bioreactor studies of different process enhancement methods in B. licheniformis for enzyme co-production	7
Effect of temperature on synthesis of clavulanic acid and impurity substance G during fermentation by Streptomyces clavuligerus	7
Effect of precursor feeding, dietary supplementation, chemical elicitors and co-culturing on resveratrol production by Arcopilus aureus	7
L-asparaginase production in solid-state fermentation using Aspergillus niger: process modeling by artificial neural network approach	7
Production of bioactive recombinant monoclonal antibody fragment in periplasm of Escherichia coli expression system	7
Microbial consortia adaptation to substrate changes in anaerobic digestion	6
Unraveling the biological potential of chicken viscera proteins: a study based on their enzymatic hydrolysis to obtain hydrolysates with antioxidant properties	6
Recovery and separation of glycyrrhizic acid from Natural Deep Eutectic Solvent (NADES) extract by macroporous resin: adsorption kinetics and isotherm studies	6
2,3-Butanediol plus acetoin obtention by Enterobacter aerogenes ATCC 13048: inhibition by target products and cells reuse during fed-batch cultivation	6
Development of a strategy for a quick process for separation of volatile compounds in counter-current chromatography: purification of cinnamaldehyde from Cinnamomum cassia by high performance c	6
Antimicrobial peptides (AMPs) from microalgae as an alternative to conventional antibiotics in aquaculture	6
New wheat straw fermentation feed: recombinant Schizosaccharomyces pombe efficient degradation of lignocellulose and increase feed protein	6
Expression and characterization of cholesterol oxidase with high thermal and pH stability from Janthinobacterium agaricidamnosum	6
Disposable glutamate biosensor based on platinum nanoparticles, carbon quantum dots and poly-L-aspartic acid	6
Choice of gDNA isolation method has a significant impact on average murine Telomere Length estimates	6
Fractional mixture design: a novel design and methodology for analyzing and optimizing mixtures of several ingredients	6
Optimization of ultrasound-assisted deep eutectic solvent extraction, characterization, and bioactivities of polysaccharide from Plantaginis Semen	6
Optimization of media components for enhanced carotenoid production by Paracoccus marcusii RSPO1 and assessment of their cytotoxicity against A549 and vero cells	5
Transcriptome analysis revealing molecular mechanisms of enhanced pigment yield by succinic acid and fluconazole	5
Tyrosinase from the pulps of local cultivars of Musa spp: Purification, characterization, immobilization, and application in the batch production of l-3,4-dihydroxypheny	5

Chitinase induction in Trichoderma harzianum : a solid-state fermentation approach using shrimp waste and wheat bran/commercial chitin for chitooligosaccharides synthesi	5
Comparative analysis of biodesulfurization of dibenzothiophene (DBT) and 4,6-dimethyl dibenzothiophene (4,6-DMDBT) by 4S pathway using molecular simulations	5
Study on the use of bovine blood protein hydrolysate as a peptone in microbial culture media	5
Production, characterization, and bio-ethanologenic potential of a novel tripartite raw starch-digesting amylase from Priestia flexa UCCM 00132	5
Development of a novel Pichia pastoris expression platform via genomic integration of lipase gene for sustained release of methanol from methyloleate	5
Engineered Saccharomyces cerevisiae harbors xylose isomerase and xylose transporter improves co-fermentation of xylose and glucose for ethanol production	5
2,3-Butanediol production using soy-based nitrogen source and fermentation process evaluation by a novel isolate of Bacillus licheniformis BL1	5
Utilization of the sugar fraction from Arabica coffee pulp as a carbon source for bacteria producing cellulose and cytotoxicity with human keratinocyte	5
Recombinant expression and purification of phenylalanyl-tRNA synthetase from wheat: a long-lasting poly(U)-dependent poly(Phe) synthesis system	5
Improving the production of recombinant L-Asparaginase-II in Escherichia coli by co-expressing catabolite repressor activator ( cra ) gene	5
The multiple-response modeling of heat-assisted, microwave-assisted and subcritical water extraction on selected phenolics from traditional plant speciesTeucrium montanum	4
Optimizing the extraction of active components from Salvia miltiorrhiza by combination of machine learning models and intelligent optimization algorithms and its correla	4
Engineering Trichoderma reesei for the hyperproduction of cellulose induced protein 1 (Cip1) on a sophorose-containing inducer to efficiently saccharify alkali-pretreated corn stover	4
Cloning, overexpression, and structural characterization of a novel archaeal thermostable neopullulanase from Desulfurococcus mucosus DSM 2162	4
Potential of silver nanoparticles synthesized using low active mosquitocidal Lysinibacillus sphaericus as novel antimicrobial agents	4
Antimicrobial, antibiofilm, and anticancer potential of silver nanoparticles synthesized using pigment-producing Micromonospora sp. SH121	4
PEGylation versus glycosylation: effect on the thermodynamics and thermostability of crisantaspase	4
Kinetics of dye decolorization using heterogeneous catalytic system with immobilized Achromobacter xylosoxidans DDB6	4
Production of milk-coagulating protease by fungus Pleurotus djamor through solid state fermentation using wheat bran as the low-cost substrate	4
Modeling and evaluation of the sucrose-degrading activity of recombinantly produced oligo-1,6-glucosidase from A. gonensis	4
Optimization of asymmetric bioreduction conditions of 1-(thiophen-2-yl)ethanone by Weissella cibaria N9 using a desirability function-embedded face-centered optimization	4
Effect of culture medium optimization on the secondary metabolites activity ofLysobacter antibioticus13-6	4
Efficient production of ε-poly-l-lysine using cassava starch and fish meal by Streptomyces albulus FQC-24	4
Effect of nutritional parameters on microbial production of L-Asparaginase by novel Brevibacillus borstelensis ML12	4
Detoxification of areca nut acid hydrolysate and production of xylitol by Candida tropicalis (MTCC 6192)	4
Lovastatin production by Aspergillus terreus in membrane gradostat bioreactor with two-stage feeding strategy	4
Enhancement in T1 lipase purification recovery using the novel construct pGEX4T1/His-T1	4
Novel extracellular synthesized silver nanoparticles using thermophilic Anoxybacillus flavithermus and Geobacillus stearothermophilus and	4
Kinetic modeling and quasi-economic analysis of fermentative glycolipopeptide biosurfactant production in a medium co-optimized by statistical and neural network approaches	4
High-level production of poly-γ-glutamic acid by a newly isolated Bacillus sp. YJY-8 and potential use in increasing the production of tomato	4
Synthesize and characterization of CaOx crystals against various citrus waste peel extracts: an in vitro study	4
Valorization of rice biomass by a green approach to release phenolic compounds and their antioxidant activities	4
Potential utility of callus proteases as a milk clotting alternative to naturally propagated Wrightia tinctoria proteases	4
Insight into the pilot‐scale fed-batch fermentation for production of Enterococcus faecium CW3801 using molasses-based medium	4
Efficient three phase partitioning of actinidin from kiwifruit ( Actinidia deliciosa) and its characterization	4
Biosorption of arsenite (As[III]) using Saccharomyces cerevisiae SRCM 501804 isolated from Korean turbid rice wine	4
Statistical optimization of process variables for agarase production using Microbacterium sp. SS5 strain from non-marine sources	4
Advanced temperature control in ethanol fermentation using a PSO-PID controller with split-range control strategy	4