Journal of Investigative Medicine

Article	Citations
The scientific value of medical student research: The experience at the Arrow Program for Medical Research Education	169
Basic Fibroblast Growth Factor Inhibits Aortic Valvular Interstitial Cells Calcification via Notch1 Pathway	146
CIAP1/2 can regulate the inflammatory response and lung injury induced by apoptosis in septic rats	55
CircZFR involves propofol-triggered ferroptosis in lung cancer cells through the IGF2BP2/GPX4 axis	46
Diagnostic role of multislice spiral computed tomography combined with clinical manifestations and laboratory tests in acute appendicitis subtypes	46
The Data Error Criteria (DEC) for retrospective studies: development and preliminary application	45
Telomere Length in Patients with Alcohol-Associated Liver Disease: A Brief Report	35
Stem bark of Fraxinus rhynchophylla ameliorates the severity of pancreatic fibrosis by regulating the TGF-β/Smad signaling pathway	25
The prevalence and characteristics of misinformation on “TikTok” related to cirrhosis and liver disease: A comparative analysis of accurate and misleading content	23
Colonoscopy in the young: Rethinking the yield	22
Does anticoagulation in combination with immunosuppressive therapy prevent recurrent thrombosis in Behçet’s disease?	22
COVID-19 Pneumonia in Patients with Impaired Fasting Glucose, Newly Diagnosed Diabetes and Pre-Existing Diabetes: A Tertiary Center Experience	21
Evaluation of Glycemic Control in Critically ill Patients with Bacteremia: A Retrospective, Single-Center Cohort Study	21
The role of pentraxin 3 and oxidative status in the prognosis of multiple myeloma	20
Serum Talin-1 and Pentraxin-3 levels as biomarkers for vulnerable plaques in STEMI: Correlation with SYNTAX and Gensini scores	20
Unveiling sarcopenia in Sjögren’s syndrome: A hidden comorbidity	19
EXPRESS: CD38 Expression on CD8⁺ T Cells as a Marker of Immune Activation and ART Efficacy in HIV	17
Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension	16
COVID-19-related mortality in Texas border counties vs non-border counties	16
Hyperbilirubinemia in hospitalized patients: Etiology and outcomes	15
Magnesium intake is associated with the metabolically healthy obese phenotype	15
Gender-specific effects of appendectomy on inflammatory bowel disease: Increased odds of Crohn’s disease, and decreased odds of ulcerative colitis in women—An analysis using the National Inpatient Sam	15
Discovery of rare and novel variants in inherited retinal disorders: Exome sequencing analysis of six Iranian families	15
FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease	15
Tocilizumab in Patients Hospitalized with COVID-19 Pneumonia: Systematic Review and Meta-Analysis of Randomized Controlled Trials	14

Analysis of risk factors for abdominal aortic calcification in dialysis patients and its influence on long-term recovery	14
EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus	14
Human microglia polarization following infection with the Lyme disease spirochete	13
Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway	13
L-Shaped association of fasting serum total bile acids with atrial fibrillation risk in the elderly	12
Introduction of 2024 International Conference on Advances in Biological Science and Technology, September 28-30, 2024, Online Video Conference	12
2025 8th International Conference on Advances in Biological Science and Technology Selected Meeting Abstracts Supplement	12
EXPRESS: Association of C-reactive Protein-to-Lymphocyte Ratio with Depression: A Mediating Effect of Weight-adjusted Waist Index	12
Deferasirox Combination with Eltrombopag Shows Anti-Myelodysplastic Syndrome Effects by Enhancing iron Deprivation–Related Apoptosis	12
2022 Southern Medical Research Conference	12
Yet Another Amyloidosis	12
Bronchodilatory Effect of Higenamine as Antiallergic Asthma Treatment	11
COVID-19 in the intensive care unit: Unmasking the critical factors impacting patient survival	11
Combined treatment with ruxolitinib and MK-2206 inhibits ERα activity by inhibiting MAPK signaling in BT474 breast cancer cells	11
Historical view of medical Spanish instruction in a medical school at the US–Mexico border region	11
Inhaled corticosteroids on mortality in COVID-19: A systematic review and meta-analysis of randomized controlled trials	11
Cancer Immunotherapy in Adult Patients with HIV	11
Response to: Faculty should be cautiously optimistic about the role of generative AI in medical education	11
Patient perception of voxelotor treatment benefit in sickle cell disease	10
Predictors of misperceptions, risk perceptions, and personal risk perceptions about COVID-19 by country, education and income	10
An innovative approach to comprehensive communication skills training for residents: A resident-led communication curriculum	10
Beyond age and family history: Symptoms as predictors in colorectal cancer screening	10
LECT-2 Amyloidosis: What do we Know?	10
Latin Americans and US Hispanics show Differences in IBD Phenotype: A Systematic Review with Meta-Analysis	10
Silent damage, early signals: A narrative review of the evolving role of cardiac biomarkers in oncology-driven cardiotoxicity	10
Clinical characteristics, prognostic factors, and outcomes of ventricular septal rupture in patients with acute myocardial infarction	10
Serum liver enzymes and metabolic syndrome from the Rafsanjan Cohort Study	10
MEF2A restrains cisplatin resistance in gastric cancer cells by modulating NFKBIA/NF-κB signaling pathway	10
Clinical differences in symptomology, characteristics, and risk factors in patients with post-acute sequelae of COVID-19: an experience from a tertiary-care academic center	9
Epidemiology, diagnosis, and management of cardiac amyloidosis	9
Trends and Demographic Patterns in Biologic and Corticosteroid Prescriptions for Inflammatory Bowel Disease: Findings from Electronic Medical Records, 2011–2020	9
Normal saline vs balanced intravenous fluids in acute ischemic stroke: A retrospective study	9
Mitochondria Signaling Pathways in Allergic Asthma	9
Study of antibiotic resistance and virulence genes in Escherichia coli isolated from urinary tract infection patients in Tanta University Hospitals	8
Evaluation of thiol–disulfide homeostasis and oxidative stress parameters in newborns receiving phototherapy	8
Comparing the Effects of Twice-Daily Exenatide and Insulin on Renal Function in Patients with Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Controlled Trial	8
Applicant essays and recommendation letters in residency selection:How generative artificial intelligence is changing them	8
Comparison of outcome among type 2 vs type 1 myocardial infarction: a systematic review and meta-analysis	8
Liver fibrosis prediction models in a population of Latina and White women	8
Large language model content detectors: Effects of human editing and ChatGPT mimicking individual style—A preliminary study	8
Network analysis of genes associated with esophageal squamous cell carcinoma progression	8
Depressive Symptomatology in Adults during the COVID-19 Pandemic	8
Venous Capacitance and Venous Return in Young Adults with Typical Vasovagal Syncope: A Cross-Sectional Study	8
Current status of novel weight loss interventions	8
Management of deep neck infections in adults and importance of clinical and laboratory findings	8
Expanded hemodialysis: a new concept of renal replacement therapy	8
EXPRESS: Association of Pan-immune Inflammation Values with Chronic Kidney Disease: Evidence from NHANES 1999-2018	7
Wegovy (Semaglutide): A New Weight Loss Drug for Chronic Weight Management	7
Peripheral ICOS+CD4 T cell frequency: An indicator for short-term progression in resectable advanced gastric cancer following platinum-based chemotherapy	7
Metabolic Derangement in Patients with Vitiligo: A Cross-Sectional Study	7

The role of immune activation and antigen persistence in acute and long COVID	7
The association of systemic lupus erythematosus with short-term mortality in sepsis: a population-level analysis	7
Bleeding Ectopic Varices: Clinical Presentation, Natural History, and Outcomes	7
Health insurance prevalence and acute pancreatitis mortality: a cross-sectional analysis	7
Clinical characteristics and social determinants of health associated with 30-day hospital readmissions of patients with COVID-19	7
The effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with decompensated heart failure	6
Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: An analysis of the National Health and Nutrition Examination Survey 2013–2014	6
COVID-19’s immuno-pathology and cardiovascular diseases	6
American Federation for Medical Research 2025 Southeastern Regional Meeting	6
Patterns and seasonality in pediatric referrals for functional somatic symptoms	6
Cholesterol deficiency as a mechanism for autism: A valproic acid model	6
Bispecific T-cell engagers for relapsed/refractory multiple myeloma after solid organ transplantation: A case series	6
Translational science and related disciplines	6
Incidence and Risk Factors for Mucormycosis in Renal Transplant Patients	6
Glucose ingestion does not lower testosterone concentrations in men on testosterone therapy	6
Response to: Correspondence on ‘Prospective Predictive Performance Comparison between Clinical Gestalt and Validated COVID-19 Mortality Scores’ by Meza-Comparán	6
Screening for presence of primary Sjogren’s syndrome in patients with autoimmune thyroid diseases	6
Association of intermittent versus continuous hemodialysis modalities with mortality in the setting of acute stroke among patients with end-stage renal disease	6
Response to: Applicant essays and recommendation letters in residency selection: How generative artificial intelligence is changing them	6
Nasopharyngeal airway-assisted sedation enhances oxygenation and reduces perioperative adverse events in pediatric dental surgery: A comparative clinical study	6
Evaluating Trends In Rumination Syndrome: A Retrospective Analysis	6
Effect of Bisphosphonate on Hip Fracture in Patients with Osteoporosis or Osteopenia According to age: A Meta-Analysis and Systematic Review	6
Direct-to-patient telemedicine: Expanding access to regional pediatric specialty care	6
Prediction of overall survival after radical gastrectomy using nomograms created by tumor markers	6
Retrospective Evaluation of Patients with and without 14-Day Readmissions following Hospitalization for COVID-19	5
Specific Changes of Erythroid Regulators and Hepcidin in Patients Infected by SARS-COV-2	5
Correspondence on ‘Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma’ by Radovanovic et al	5
Construction and validation of an autophagy-related long non-coding RNA signature to predict the prognosis of kidney renal papillary cell carcinoma	5
Implementation of telepsychiatry in an urban pediatric satellite emergency department	5
Association between Blood Carboxyhemoglobin Level and Bronchopulmonary Dysplasia in Extremely Low Birthweight Infants	5
Author Index	5
Cannabinoid hyperemesis syndrome: prevalence and management in an era of cannabis legalization	5
Polymorphism of Angiotensin-Converting Enzyme 2 Gene ( rs 2285666 ) and its susceptibility to COVID-19 infection and severity of the disea	5
Assessing the causal relationship between obesity and hypothyroidism using Mendelian randomization	5
Spexin as a potential biomarker for autoimmune inflammation in Graves’ disease	5
The long-term outcomes of combining pyloroplasty with gastric electrical stimulation in drug-refractory gastroparesis: A prospective single-arm trial	5
Outcomes of beta-blocker therapy in methamphetamine users with cardiovascular conditions	5
Semaglutide 2.4 Mg: The Latest GLP-1RA Approved for Obesity	5
Natriuretic Peptides, Extracellular Volume, and Subclinical Cardiovascular Changes in Chronic Kidney Disease Stages 1–3: A Pilot Study	5
Challenging biological samples and strategies for DNA extraction	5
Serum Levels of IL-37 and Correlation with Inflammatory Cytokines and Clinical Outcomes in Patients with Coronary Artery Disease	5
Effects of prehabilitation resistance training in mild to moderate clinically frail patients awaiting coronary artery bypass graft surgery	5
Clinical predictions of COVID-19 patients using deep stacking neural networks	5
Rapid qPCR-based quantitative immune cell phenotyping in mouse tissues	5
Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways	5
In-vivo Skeletal Muscle Mitochondrial Function in Klinefelter Syndrome	5
Correspondence on “Prognostic significance of complement factors in severely ill patients with COVID-19”	5
A novel predictive model based on pericarotid adipose tissue and lumen stenosis for stroke risk in patients with asymptomatic carotid stenosis	4
Public health initiatives: Addressing social vulnerability in research and practice	4
Severe COVID-19-associated hyperinflammatory syndrome versus classic hemophagocytic lymphohistiocytosis: similarities, differences, and the way forward	4
Methotrexate effects on adenosine receptor expression in peripheral monocytes of persons with type 2 diabetes and cardiovascular disease	4
State of the art: Alternative overlap syndrome—asthma and obstructive sleep apnea	4
Introduction of 2024 International Conference on Advances in Biological Science and Technology, September 28-30, 2024, Online Video Conference	4
Pharmacokinetic advantages of lipophilic statins over rosuvastatin in COVID-19 management	4
Sequential administration of pemetrexed and cisplatin reprograms tumor immune microenvironment and potentiates PD-1/PD-L1 treatment in a lung cancer model	4
Comparison of clinicopathological characteristics and response to neoadjuvant systemic therapy in patients with HER2-low-positive and HER2-zero breast cancer	4
Single-center outcomes of artificial intelligence in management of pulmonary embolism and pulmonary embolism response team activation	4
Association of exposure to nonpersistent endocrine disruptors with sex hormones and metabolic health in US females	4
Study of role of melanoma-associated antigen D1 (MAGE-D1) in hepatocellular carcinoma	4
Cohen's d and Physicians’ Opinion on Effect Size: A Questionnaire on Anemia Treatment	4
Reflections on my presidency of American Federation of Medical Research (AFMR)	4
AFMR Southeastern Regional Meeting Supplement	4
A new therapeutic perspective: Erastin inhibits tumor progression by driving ferroptosis in myelodysplastic syndromes	4
Effects of magnesium and potassium on insulin resistance and blood sugar level among insomniac patients with diabetes mellitus—A randomized controlled trial	4
Understanding the association between admission source and in-hospital delirium: A cross-sectional study	4
Hematological ratios in coronavirus disease 2019 patients with and without invasive mechanical ventilation	4
GANT61, an inhibitor of Gli1, inhibits the proliferation and migration of hepatocellular carcinoma cells	4
Butylphthalide protects against ischemia-reperfusion injury in rats via reducing neuron ferroptosis and oxidative stress	4
The incidence and characteristics of giant cell arteritis in Hispanics and the associated outcomes of ischemic ocular events and stroke	4
Trends of Sources of Clinical Research Funding from 1990 to 2020: A Meta-Epidemiological Study	4
Treatment and Outcomes among Patients ≥85 Years Hospitalized with Community-Acquired Pneumonia	4
Timing of convalescent plasma administration and 28-day mortality in COVID-19 pneumonia	4
Strengthening research capacity of early-mid career researchers: Implementation and evaluation of the Excellence in Non-COmmunicable disease REsearch (ENCORE) program	4
Corrigendum to “GDF11 Level and Its Effect on Prognosis in Patients with Acute Myeloid Leukemia”	4
Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis	4
Effect of intramuscular depot betamethasone injection in patients with fibromyalgia and elevated C-reactive protein levels	4
Assessment of serum level of galectin-9 in systemic lupus erythematosus patients in Tanta University hospitals, case-control research	4
Abstracts	4
EXPRESS: Impact of GLP-1 Receptor Agonists on Cardiovascular Outcomes in Patients with Peripheral Artery Disease without Diabetes: A Propensity Score-Matched Analysis	4
Prevalence, outcomes, and complications of vitamin D deficiency among patients with multiple myeloma: Nationwide burden of disease	4

N-Terminal Pro-Brain Natriuretic Peptide is an Independent Predictor of Mortality in Patients with Sepsis

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