OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Interferon and Cytokine Research is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Topical Effects of N-Acetyl Cysteine and Doxycycline on Inflammatory and Angiogenic Factors in the Rat Model of Alkali-Burned Cornea	76
Sorting Out the SOCS Genes and Their Role in Macrophage Activation	60
Differential Expression of Th17-Related Cytokines in Patients of Chronic Kidney Disease with and Without Systemic Lupus Erythematosus	26
Counteracting Interleukin-15 to Elucidate Its Modes of Action in Physiology and Pathology	22
Serum Cytokine Profiles in Patients with Rheumatoid Arthritis Before and After Treatment with Methotrexate	21
Research Hotspots of Interferon Gamma in the Treatment of Lung Cancer: A Bibliometric Analysis Based on CiteSpace	20
DNA-Dependent Interferon Induction and Lung Inflammation in Bordetella pertussis Infection	20
Investigating Causal Associations Between Circulating Cytokines and Vestibular Disorders Using Mendelian Randomization: Insights from Large-Scale Genome-Wide Association Studies Data in European Popul	19
RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway	17
The Discovery of Hepatitis C	16
Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer	14
Call for Special Issue Papers: Basic and Clinical Aspects of Cytokine Storms in Infectious Diseases	13
IL-4 Downregulates PD-L1 Level Via SOCS1 Upregulation-Induced JNK Deactivation to Enhance Antitumor Immunity in In Vitro Colorectal Cancer	12
Acknowledgment of Reviewers 2023	12
A Conversation with Wanjun Chen	12
Cytokine Profile Response of Human Peripheral Blood Mononuclear Cells Stimulated by Bartonella bacilliformis	11
The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination	10
Transplantation of Graft Anti-Host Cytotoxic T Lymphocytes Along with Allogeneic Bone Marrow Skips Macrophage-Induced Graft-Versus-Host Disease	10
Autoantibodies Neutralizing Type III Interferons Are Uncommon in Patients with Severe Coronavirus Disease 2019 Pneumonia	9
The Role of Different Circulating T Follicular Helper Cell Markers in Rheumatoid Arthritis	9
Remote Ischemic Conditioning Relieves Necrotizing Enterocolitis Through Regulation of Redox and Inflammation	9
Stimulator of Interferon Genes Signal in Lung Cancer Regulates Differentiation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Via the Interferon Regulatory Factor 3/NF-κB Pathway	9
Plasma Markers for Early Prediction of Radiation-Induced Myocardial Damage	9
Experts Speak: A Conversation with Professor Susan Kaech	9
Interleukin 10 -1082 G/AGene Polymorphism and Susceptibility to Bronchial Asthma in Children: A Single-Center Study	8

Prolonged Interferon-Stimulated Gene and Protein Signatures in Multiple Sclerosis Induced by PEGylated IFN-β-1a Compared to Non-PEGylated IFN-β-1a	8
Acknowledgment of Reviewers 2021	8
Pharmacodynamic of Recombinant Human Interferon Alpha-2b Nasal Drops and Effective Prophylaxis Against SARS-COV-2 Infection	8
Prognostic Significance of Cytokine Release Syndrome in B Cell Hematological Malignancies Patients After Chimeric Antigen Receptor T Cell Therapy	8
Unexpected Need of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity for Signaling by Intracellular Pattern Recognition Receptors of Nucleic Acids	8
Cytokines as Prognostic Biomarkers in Osteosarcoma Patients: A Systematic Review and Meta-analysis	8
Effect of Bone-Marrow-Derived Mesenchymal Stem Cells on the Healing of Bone Fractures	8
Regulation of Glucose Transport in Adipocytes by Interleukin-4	7
Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and Sequelae	7
Sequence Diversity in the 3′ Untranslated Region of Alphavirus Modulates IFIT2-Dependent Restriction in a Cell Type-Dependent Manner	7
Aqueous Humor Factors' Predictive Effects in Treating Refractor Macular Edema: An Overview	7
The Many Faces of Oligoadenylate Synthetases	7
An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation	7
Exposing the Two Contrasting Faces of STAT2 in Inflammation	7
Role of Proinflammatory Cytokines and Genetic Factors Related to Metabolic Alterations in People Living with HIV/AIDS	7
C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing	7
Analysis of Immune and Inflammatory Microenvironment Characteristics of Noncancer End-Stage Liver Disease	7
Targeting Tregs in Tumors	6
A Conversation with Dr. Jenny Ting	6
A Message from Editor-in-Chief David L. Woodland	6
Hydrocortisone Long-term Treatment Effect on Immunomodulatory Properties of Human Adipose-Derived Mesenchymal Stromal/Stem Cells	6
Striving for Truly Inclusive Collaborations: An Interview with Industry Scientist Cherié Butts, PhD	6
Thomas J. Braciale, MD, PhD1946–2023	6
Darren P. Baker, PhD A Pioneer in the Development of Pegylated Interferon-β for Clinical Use	6
A Conversation with Ralph A. Tripp	6
HDAC9 in the Injury of Vascular Endothelial Cell Mediated by P38 MAPK Pathway	6
Acknowledgment of Reviewers 2024	6
Altered Tumor Necrosis Factor Response in Neurologic Postacute SARS-CoV-2 Syndrome	6
The Association of Serum Midkine Level with Invasion in Placenta Previa: A Case–Control Study from a Tertiary Reference Center	6
Activated and Naïve Allogenic Human Placental Mesenchymal Stromal Cells Exert an Immunomodulatory Effect on Hidradenitis Suppurativa Patient Peripheral Blood Mononuclear Cells	5
Synthetic RIG-I-Agonist RNA Induces Death of Hepatocellular Carcinoma Cells	5
Roles of IL-4, IL-13, and Their Receptors in Lung Cancer	5
Lienal Polypeptide Decreases Immune Thrombocytopenia in a Mouse Model by Upregulating Cytokine Production and Increasing the Levels of CD4⁺, CD8⁺, and T Regulatory Cells	5
Correlation Between MicroRNA by Extracellular Vesicle Mediated and Antiviral Effects of Interferon Omega in Feline Peripheral Blood	5
Alternative Splicing in Multiple Sclerosis: A Promising Biomarker of Therapeutic Response to Interferon-β	5
A Comprehensive Network Map of Interleukin-26 Signaling Pathway	5
The “Yin-Yang” Activities of Tumor-Induced Inflammatory Cytokines for Cancer Immunotherapy, Detection, and Prognosis	5
The Role and Potential Regulatory Mechanism of STING Modulated Macrophage Apoptosis and Differentiation in Severe Acute Pancreatitis-Associated Lung Injury	5
Dr. Howard Young: A Unique NCI Investigator	4
Cytokines 2024: 12th Annual Meeting of the International Cytokine and Interferon Society	4
Insights into the Crosstalk Between miR-200a/lncRNA H-19 and IL-6/SIRT-1 Axis in Breast Cancer	4
Ponatinib and STAT5 Inhibitor Pimozide Combined Synergistic Treatment Applications Potentially Overcome Drug Resistance via Regulating the Cytokine Expressional Network in Chronic Myeloid Leukemia Cel	4
Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus	4
Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines?	4
Types of Interferons and Their Expression in Plant Systems	4
Early Diagnosis of Coronary Artery Disease by Inflammatory Biomarkers of Atherosclerosis in Patients with Angina	4
A Protease Activatable Interleukin-2 Fusion Protein Engenders Antitumor Immune Responses by Interferon Gamma-Dependent and Interferon Gamma-Independent Mechanisms	4
A Conversation with Dr. Ludmila Prokunina-Olsson	4
Friendly Fire in the War Against Pathogens: On the Harmful Effects of Cytokines and the Origins of Cytokine Storms in Infectious Diseases	4
Multifarious Aspect of Cytokines as an Immuno-Therapeutic for Various Diseases	4

Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19