OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Receptors and Signal Transduction is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
The cannabinoid CB ₂ receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro	25
Endothelial progenitor cells promote neural stem cell proliferation in hypoxic conditions through VEGF via the PI3K/AKT pathway	24
Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation	20
TPX2 knockdown mediates p53 activation to induce autophagy and apoptosis for anti-colorectal cancer effects	15
The route of autophagy regulation by osteopontin: a review on the linking mechanisms	12
Investigating the causal relationship between immune cells and colorectal cancer risk using bidirectional and multivariable Mendelian randomization analysis	12
Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy	10
Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against tr	10
Regulation of elevated expression of Mcl-1 in hepatocellular carcinoma – a review	9
An overview of the molecular and clinical significance of the angiopoietin system in leukemia	8
Identification of novel mycocompounds as inhibitors of PI3K/AKT/mTOR pathway against RCC	8
Can calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX-3) be useful in diagnosing acute migraine attack?	7
XIST/miR-34a-5p/PDL1 axis regulated the development of lung cancer cells and the immune function of CD8⁺ T cells	6
Quest for discovering novel CDK12 inhibitor	6
Determination of cytokine profile and associated genes of the signaling pathway in HNSCC	6
Sepsis modulates aortic AT1 and P₂Y₆ receptors to produce vascular hyporeactivity in mice	5
Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway	5
Deciphering the involvement of norepinephrine and β-adrenergic receptor subtypes in glucose induced insulin secretion: an integrated in silico and in vitr	5
Lycopene induces antiproliferative effects through apoptosis, autophagy, and oxidative DNA damage in the HeLa cells	5
Bortezomib suppresses TGF-β1-mediated LOXL4 reduction through the inhibition of MEK/ERK pathways in MDA-MB-231 cells	5
Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposure	4
Design and molecular mechanism investigation of ALK inhibitors based on virtual screening and structural descriptor modeling	4
MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3	4
Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE)	4
Protective role of selenium on MPP⁺ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells	4

QSAR study of indole derivatives as active agents against Candida albicans: a DFT calculation	3
Crosstalk between kisspeptin and gonadotropin-inhibitory hormone in the silence of puberty: preclinical evidence from a calcium signaling study	3
Protective effects of salvianolic acid B on intestinal ischemia/reperfusion injury in rats by regulating the AhR/IL-22/STAT6 axis	3
Understanding the association of cell-surface proteins (ACE2 and GRP78) facilitating pathogen recognition: a computational approach	3
CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN	3
DFT based QSAR study on quinolone-triazole derivatives as antibacterial agents	3
Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario	2
Orphan G-protein coupled receptor 75 (GPR75), a unique and controversial potential therapeutic target	2
Focusing on Keap1, IKKβ, and Bcl2 proteins: predicted targets of stigmasterol in neurodegeneration	2
QSAR study of antituberculosis activity of oxadiazole derivatives using DFT calculations	2
An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer’s disease	2
The influence of senescent associated secretory phenotype on glucose homeostasis in C2C12 muscle cells: insights into potential p38 inhibitor interventions	2
The role of G protein-coupled receptor 4 in inflammatory diseases and its potential clinical significance	2
Selective thyroid hormone receptor beta agonist, GC-1, is capable to reduce growth of colorectal tumor in syngeneic mouse models	1
4-octyl itaconate inhibits high glucose induced renal tubular epithelial cell fibrosis through TGF-β-ROS pathway	1
The vasodilator effect of Eugenol on uterine artery – potential therapeutic applications in pregnancy-associated hypertension	1
Molecular docking study of britannin binding to PD-L1 and related anticancer pseudoguaianolide sesquiterpene lactones	1
Evaluation of the effect of Helicobacter pylori -derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-β/	1
Interaction of sex hormone receptors and calcium handling proteins in the left ventricle of patients with heart failure	1
MFAP2 promotes the malignant progression of gastric cancer via activating the PI3K/AKT signaling pathway	1
Long-term spontaneous membrane currents in DRG neurons	1
cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies	1
Target-based in-silico screening of basil polysaccharides against different epigenetic targets responsible for breast cancer	1
Novel therapeutic approaches targeting 5-HT7 receptors outside the central nervous system	1
Allosteric covalent inhibition of TOE1 as potential unexplored anti-cancer target: structure-based virtual screening and covalent molecular dynamics analysis	1
UBE2C, targeted by miR-140-3p, promotes the progression of osteosarcoma via PI3K/AKT signaling pathway	1
The combined use of thymoquinone and metformin provides more effective neuroprotection in a mouse model of MPTP-induced Parkinson’s disease	1
Identifying potent Janus kinase 3 inhibitors using structure-guided virtual screening for inflammatory and neoplastic disease therapy	1
MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons	1
Estrogen receptors as potential therapeutic target in endometrial cancer	1
Integrated computational approach for in silico design of new purinyl pyridine derivatives as B-Raf kinase inhibitors	1
Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study	1
Targeting ubiquitin-specific peptidase 22 (USP22) as a nexus for drug repurposing in anticancer therapeutic development	1