Nature Medicine

Papers
(The TQCC of Nature Medicine is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
SCOTUS v. reproductive health in United States3423
Rise in ambient temperature is associated with increased mortality in Latin America1438
Telemonitoring for complicated pregnancies1436
How virtual reality therapy is shaping mental health1396
LLMs get a medical education944
Questionable role of new techniques in IVF embryo culture780
A genetic test to predict adverse drug reactions775
Easing the pain of endometriosis738
Liquid biopsies and tumor mutational burden: the cutoff conundrum697
A global metric of immune health650
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology626
Solving medicine’s data bottleneck: Nightingale Open Science600
In vivo gene editing for inherited vision loss597
Recapitulating sensory feedback in artificial skin597
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease574
Concerns about the Burden of Proof studies557
First tumor-agnostic approval for an ADC553
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial547
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids542
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters516
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade512
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial508
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial487
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes483
An AI chatbot for talking therapy referrals473
Can an implanted minipump deliver for diabetes patients?450
The capacity of brain circuits to enhance psychiatry429
Author Correction: Digital consults in heart failure care: a randomized controlled trial417
AI as a new paradigm for risk-based screening for breast cancer416
HIV prevention through PrEP in cisgender women416
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial411
The role of research in China’s successful elimination of malaria411
Estimating the total effect of anthropogenic climate change on human health and wellbeing409
Promoting gender equity in the scientific and health workforce is essential to improve women’s health408
Pregnant and lactating women should be included in clinical trials for cardiovascular disease404
Combating vaccine revisionism402
Gene-edited pig liver successfully transplanted into human396
HIPAA is a misunderstood and inadequate tool for protecting medical data389
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial380
FDA approves first drug to delay type 1 diabetes375
The WHO genomics program of work for equitable implementation of human genomics for global health373
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma370
Hippocampal network activity forecasts epileptic seizures370
An explainable foundation model for drug repurposing368
The uncertain science of preimplantation and prenatal genetic testing364
Targeted therapy for osteoarthritis: progress and pitfalls359
Continuous glucose monitoring and intrapersonal variability in fasting glucose356
The inconvenient reality of AI-assisted embryo selection in IVF356
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites356
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities353
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus350
In utero origin of myelofibrosis presenting in adult monozygotic twins346
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19345
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs336
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease335
Supported decision-making can advance clinical research participation for people with disabilities333
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial331
Author Correction: Unexplained post-acute infection syndromes330
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial325
Integrated image-based deep learning and language models for primary diabetes care320
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy318
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial316
Changing climate and socioeconomic factors contribute to global antimicrobial resistance316
Anemia in women — an intractable problem that requires innovative solutions312
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial310
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants305
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing304
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial303
The landscape of mRNA nanomedicine299
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease298
Will ChatGPT transform healthcare?296
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses292
Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial291
Integrating the environmental and genetic architectures of aging and mortality288
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial284
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality282
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial282
WHO sets research agenda for refugee and migrant health281
The Yearbook280
Machine learning improves prediction of clinical outcomes for invasive breast cancers280
An anti-obesity drug from the diabetes toolbox276
An outdated loophole is letting faulty lab tests hit the market275
Handwriting with a brain implant270
High COVID-19 death toll in Africa269
Rethinking aspirin for heart health269
Health in the Amazon268
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts267
The visible and hidden mortality caused by flooding264
Using unlabeled data to enhance fairness of medical AI263
Mapping the cellular landscape of the brain261
Acquired blood mutations cause acute kidney injury via dysregulated inflammation260
Author Correction: Identification of a new orthonairovirus associated with human febrile illness in China259
Familial confounding in the associations between maternal health and autism257
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes256
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial255
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050253
Steps to prevent and respond to an H5N1 epidemic in the USA252
A benchmarking crisis in biomedical machine learning251
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs249
Anti-amyloid could help prevent genetic form of Alzheimer’s disease246
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial245
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders244
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection242
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial240
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection240
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial239
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates239
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.237
Open Letter to G7 and G20 leaders: resolve global crises to secure our future237
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer237
Use of mobile diagnostics and digital clinical trials in cardiology236
An African One Health network for antimicrobial resistance and neglected tropical diseases234
Coproducing health research with Indigenous peoples234
The expanding universe of checkpoint inhibitors for nasopharyngeal cancer233
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV230
A gene-by-sex interaction contributes to liver disease susceptibility in women229
Health benefits of calorie restriction227
Prenatal exposure to famine affects lifelong health225
How patient advocates influence health policy224
Meningioma risk stratification with a targeted gene-expression biomarker223
siRNA therapy lowers triglycerides in patients with rare condition223
Brain pathology of COVID-19220
The effect of embryonic genome imbalances on pregnancy220
Using genetics to predict toxicity of cancer immunotherapy216
Menstrual health without stigma215
Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination214
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment214
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults212
Partial recovery of visual function in a blind patient after optogenetic therapy211
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial209
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis207
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans205
Mpox continues to spread in Africa and threatens global health security203
Artificial intelligence–enabled electrocardiograms for identification of patients with low ejection fraction: a pragmatic, randomized clinical trial201
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial201
Genome-wide polygenic score to predict chronic kidney disease across ancestries200
Advancing global antibiotic research, development and access200
The limits of fair medical imaging AI in real-world generalization199
Emerging diagnostics and therapeutics for Alzheimer disease198
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer196
Clinical AI tools must convey predictive uncertainty for each individual patient194
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial194
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety192
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial190
AI-generated text may have a role in evidence-based medicine189
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial188
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial186
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer186
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations186
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity186
Determinants of COVID-19 vaccination status and hesitancy among older adults in China186
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure185
Self-improving generative foundation model for synthetic medical image generation and clinical applications185
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury185
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials184
An integrated cell atlas of the lung in health and disease183
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia183
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy183
Could video games be good for your health?181
Pig-to-human transplants inch closer to reality181
Gene therapy for alcohol-use disorder181
ALS therapy hits molecular mark but misses clinical one181
A human brain circuit for addiction remission179
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year179
A pinch of salt for heart disease179
A smart solution for detecting ear problems179
AI-guided precision parenteral nutrition for neonatal intensive care units178
Challenges with benchmarking of MDMA-assisted psychotherapy177
Reduction in life expectancy in Brazil after COVID-19175
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial175
Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial174
Cities, communities and clinics can be testbeds for human exposome and aging research174
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology173
The economic value of reducing avoidable mortality173
Why paying individual people for their health data is a bad idea172
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry170
A federated learning system for precision oncology in Europe: DigiONE169
Multi-ancestry polygenic mechanisms of type 2 diabetes168
Wearable sensors enable personalized predictions of clinical laboratory measurements168
The impact of school opening model on SARS-CoV-2 community incidence and mortality167
City-level impact of extreme temperatures and mortality in Latin America165
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution165
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial163
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial162
A H3K27M-targeted vaccine in adults with diffuse midline glioma162
The unseen climate health risks of antimicrobial resistance in urban informal settlements161
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans161
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research159
Targeted radiation adds precision to cancer therapy159
Deciphering the heritability of human height159
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection157
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma156
A framework to assess the effects of genetic risk factors on disability-adjusted life years155
Human embryo models offer glimpse into early development155
Gene-editing breakthrough for a rare hereditary disorder154
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery154
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers154
Determinants and inequities in healthy working life expectancy in China154
Using implementation science to navigate the complexity of integrating genomics into healthcare153
Advancing clinical genomics with Middle Eastern and South Asian pangenomes151
Imatinib and the dawn of precision cancer therapy151
New neurons are born in the adult human brain150
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial150
Countering the impact of the climate crisis on health will require data149
Adequate information about clinical trial results must be given to participants149
COVID-19 vaccination gives hope to eradicate polio148
Author Correction: Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis147
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality147
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants146
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial146
A neural stem-cell treatment for progressive multiple sclerosis145
Hibernation science harnessed to treat obesity and modify metabolism144
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine143
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster140
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial139
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial139
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination139
Caution at psychiatry’s psychedelic frontier138
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma138
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases138
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma137
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial137
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans136
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease136
Bacterial SNPs in the human gut microbiome associate with host BMI136
Targeting KRAS in cancer133
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial132
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination132
Mapping the mediators of Alzheimer’s disease131
Balancing the risks of HIV transmission at low viral load130
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries130
‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease129
Boosting the efficacy of emergency contraception129
Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering129
Tumor infiltrating lymphocyte approval heralds new era for precision cancer immunotherapy128
The role of placebo control in clinical trials for neurodegenerative diseases127
It’s time to send children back to school126
Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial126
11 clinical trials that will shape medicine in 2022125
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk124
Large floods drive changes in cause-specific mortality in the United States124
Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis124
Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality123
Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases122
Facilitating limb movement after stroke122
Pakistan is failing in maternal and neonatal tetanus elimination122
Building resilience in heatwaves122
Evolution, genetic diversity, and health121
Gene therapies should be for all121
Monitoring key epidemiological parameters of SARS-CoV-2 transmission121
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