Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2050
A genetic test to predict adverse drug reactions	1730
LLMs get a medical education	1564
Liquid biopsies and tumor mutational burden: the cutoff conundrum	829
In vivo gene editing for inherited vision loss	739
Recapitulating sensory feedback in artificial skin	701
Telemonitoring for complicated pregnancies	695
Rise in ambient temperature is associated with increased mortality in Latin America	682
Easing the pain of endometriosis	616
SCOTUS v. reproductive health in United States	609
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	606
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	560
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	535
Can an implanted minipump deliver for diabetes patients?	530
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	529
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	514
The inconvenient reality of AI-assisted embryo selection in IVF	509
The capacity of brain circuits to enhance psychiatry	498
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	475
Combating vaccine revisionism	473
A global metric of immune health	468
HIPAA is a misunderstood and inadequate tool for protecting medical data	464
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	454
First tumor-agnostic approval for an ADC	453
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	434

Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	428
The effect of geopolitical flux on antimicrobial resistance	424
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	414
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	410
Ending the taboo on periods and period problems	403
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	396
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	385
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	379
How virtual reality therapy is shaping mental health	378
The WHO genomics program of work for equitable implementation of human genomics for global health	376
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	373
AI as a new paradigm for risk-based screening for breast cancer	369
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	365
Estimating the total effect of anthropogenic climate change on human health and wellbeing	365
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	364
Concerns about the Burden of Proof studies	362
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	358
Anemia in women — an intractable problem that requires innovative solutions	356
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	356
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	356
Solving medicine’s data bottleneck: Nightingale Open Science	356
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	355
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	344
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	344
An explainable foundation model for drug repurposing	336
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	336
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	336
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	333
Integrated image-based deep learning and language models for primary diabetes care	332
HIV prevention through PrEP in cisgender women	330
PD-L1 and the dawn of modern cancer immunotherapy	328
In utero origin of myelofibrosis presenting in adult monozygotic twins	327
An AI chatbot for talking therapy referrals	326
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	325
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	324
Supported decision-making can advance clinical research participation for people with disabilities	319
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	316
Gene-edited pig liver successfully transplanted into human	314
The role of research in China’s successful elimination of malaria	311
Author Correction: Digital consults in heart failure care: a randomized controlled trial	306
FDA approves first drug to delay type 1 diabetes	303
The uncertain science of preimplantation and prenatal genetic testing	299
Author Correction: Unexplained post-acute infection syndromes	293
Targeted therapy for osteoarthritis: progress and pitfalls	292
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	290
Integrating the environmental and genetic architectures of aging and mortality	287
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	286
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	282
Hippocampal network activity forecasts epileptic seizures	280
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	279

Continuous glucose monitoring and intrapersonal variability in fasting glucose	279
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	278
Will ChatGPT transform healthcare?	275
The landscape of mRNA nanomedicine	275
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	272
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	272
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	270
Rethinking aspirin for heart health	269
Health in the Amazon	269
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	269
An outdated loophole is letting faulty lab tests hit the market	267
An anti-obesity drug from the diabetes toolbox	266
WHO sets research agenda for refugee and migrant health	265
The Yearbook	262
Mapping the cellular landscape of the brain	258
How patient advocates influence health policy	254
Using genetics to predict toxicity of cancer immunotherapy	253
The effect of embryonic genome imbalances on pregnancy	252
Brain pathology of COVID-19	251
Advancing global antibiotic research, development and access	250
Menstrual health without stigma	248
Air pollution interventions for health	246
Peace in Colombia requires healing the scars of conflict on the mind and brain	245
Microbes convert plastic waste into paracetamol	240
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	240
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	237
An international treaty to regulate misuse of alcohol and cannabis	234
Familial confounding in the associations between maternal health and autism	234
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	233
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	232
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	231
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	229
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	229
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	227
Strategies for shortening tuberculosis therapy	227
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	227
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	226
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	226
A gene-by-sex interaction contributes to liver disease susceptibility in women	223
Health benefits of calorie restriction	221
An African One Health network for antimicrobial resistance and neglected tropical diseases	220
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	219
Steps to prevent and respond to an H5N1 epidemic in the USA	218
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	217
The visible and hidden mortality caused by flooding	217
siRNA therapy lowers triglycerides in patients with rare condition	216
Prenatal exposure to famine affects lifelong health	212
Machine learning improves prediction of clinical outcomes for invasive breast cancers	212
Coproducing health research with Indigenous peoples	211
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	209
Overcoming zero-sum thinking to advance US population health	209
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	208
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	208
Using unlabeled data to enhance fairness of medical AI	207
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	205
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	205
A benchmarking crisis in biomedical machine learning	205
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	204
Self-improving generative foundation model for synthetic medical image generation and clinical applications	202
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	202
Mpox continues to spread in Africa and threatens global health security	201
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	200
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	199
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	199
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	198
Meningioma risk stratification with a targeted gene-expression biomarker	197
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	196
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	195
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	194
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	193
Geographical shifting of cholera burden in Africa and its implications for disease control	192
Use of mobile diagnostics and digital clinical trials in cardiology	191
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	191
The economics of investing in women and health	191
Clinical AI tools must convey predictive uncertainty for each individual patient	191
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	189
AI-generated text may have a role in evidence-based medicine	188
Genome-wide polygenic score to predict chronic kidney disease across ancestries	188
An integrated cell atlas of the lung in health and disease	187
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	187

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	187
The limits of fair medical imaging AI in real-world generalization	186
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	185
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	185
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	184
Emerging diagnostics and therapeutics for Alzheimer disease	184
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	183
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	180
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	179
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	179
Gene therapy for alcohol-use disorder	179
Could video games be good for your health?	178
A human brain circuit for addiction remission	176
A smart solution for detecting ear problems	175
Determinants and inequities in healthy working life expectancy in China	174
Pig-to-human transplants inch closer to reality	174
The unseen climate health risks of antimicrobial resistance in urban informal settlements	174
ALS therapy hits molecular mark but misses clinical one	174
AI-guided precision parenteral nutrition for neonatal intensive care units	172
A federated learning system for precision oncology in Europe: DigiONE	171
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	170
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	169
Human embryo models offer glimpse into early development	169
A framework to assess the effects of genetic risk factors on disability-adjusted life years	169
Deciphering the heritability of human height	168
A neural stem-cell treatment for progressive multiple sclerosis	167
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	165
Permissive gun laws in the USA linked to thousands of child deaths	164
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	164
Challenges with benchmarking of MDMA-assisted psychotherapy	163
Hibernation science harnessed to treat obesity and modify metabolism	162
Cities, communities and clinics can be testbeds for human exposome and aging research	161
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	159
New neurons are born in the adult human brain	157
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	157
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	157
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	156
Gene-editing breakthrough for a rare hereditary disorder	155
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	154
Imatinib and the dawn of precision cancer therapy	154
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	153
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	153
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	153
Concern for the validity of short-term dietary crossover trials	152
Adequate information about clinical trial results must be given to participants	152
Countering the impact of the climate crisis on health will require data	151
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	151
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	151
The economic value of reducing avoidable mortality	150
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	149
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	149
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	149
Hope for patients facing deadly infections	148
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	147
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	147
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	145
Caution at psychiatry’s psychedelic frontier	144
The impact of school opening model on SARS-CoV-2 community incidence and mortality	143
Bacterial SNPs in the human gut microbiome associate with host BMI	143
Multi-ancestry polygenic mechanisms of type 2 diabetes	142
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	142
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	142
COVID-19 vaccination gives hope to eradicate polio	141
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	141
A H3K27M-targeted vaccine in adults with diffuse midline glioma	140
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	140
Using implementation science to navigate the complexity of integrating genomics into healthcare	140
Targeted radiation adds precision to cancer therapy	140
City-level impact of extreme temperatures and mortality in Latin America	137
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	136
Why paying individual people for their health data is a bad idea	136
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	135
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	135
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	135
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	135
Targeting KRAS in cancer	133
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	133
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	132
Mapping the mediators of Alzheimer’s disease	132
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	132
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	131
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	130
The role of placebo control in clinical trials for neurodegenerative diseases	130
Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance	130
Balancing the risks of HIV transmission at low viral load	129
Boosting the efficacy of emergency contraception	129
11 clinical trials that will shape medicine in 2022	128
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	128
‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease	125
Biological and health effects of fire smoke exposure	124
Publisher Correction: Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial	124
Education does not affect memory decline or brain aging	124
Location matters for brain gene therapy in lysosomal disorders	124
Information is a determinant of health	124
Surge in endometriosis research after decades of underfunding could herald new era for women’s health	124