OOIR: Observatory of International Research

Papers

(The TQCC of Nature Medicine is 130. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome	2251
High-performance medicine: the convergence of human and artificial intelligence	2006
Chronic inflammation in the etiology of disease across the life span	1363
A guide to deep learning in healthcare	1290
Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network	1172
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study	930
Clinical-grade computational pathology using weakly supervised deep learning on whole slide images	871
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease	797
End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography	759
Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids	729
The practical implementation of artificial intelligence technologies in medicine	703
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction	692
Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus	676
Clonal replacement of tumor-specific T cells following PD-1 blockade	667
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma	663
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer	529
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer	526
The microbiome, cancer, and cancer therapy	515
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer	501
A cellular census of human lungs identifies novel cell states in health and in asthma	488
The pros, cons, and many unknowns of probiotics	481
Identification of preexisting adaptive immunity to Cas9 proteins in humans	480
Screening for cardiac contractile dysfunction using an artificial intelligence–enabled electrocardiogram	457
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease	440
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma	430
The vaginal microbiome and preterm birth	423
Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial	416
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation	409
Single-cell immune landscape of human atherosclerotic plaques	377
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10	374
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants	373
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models	372
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade	370
Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma	364
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma	362
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	360
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein	358
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer	357
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma	353
Biomimetic 3D-printed scaffolds for spinal cord injury repair	351
Privacy in the age of medical big data	349
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity	347
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism	341
Identifying facial phenotypes of genetic disorders using deep learning	326
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study	325
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis	325
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy	320
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers	315
Undulating changes in human plasma proteome profiles across the lifespan	306
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR	292
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery	287
Do no harm: a roadmap for responsible machine learning for health care	285
Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence	284
Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial	279
Genomic correlates of response to immune checkpoint blockade	277
Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial	274
Clinical lessons learned from the first leg of the CAR T cell journey	272
The landscape of cancer cell line metabolism	264
Highly efficient therapeutic gene editing of human hematopoietic stem cells	255
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency	255
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers	255
A longitudinal big data approach for precision health	251
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy	248
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States	248
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy	248
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity	245
Programmable bacteria induce durable tumor regression and systemic antitumor immunity	243
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome	243
A safe and potent anti-CD19 CAR T cell therapy	238
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring	235
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice	235
A rectal cancer organoid platform to study individual responses to chemoradiation	234
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination	231
High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population	230
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer	226
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report	225
Spinal cord repair: advances in biology and technology	221
Healthy infants harbor intestinal bacteria that protect against food allergy	220
Deep learning-based classification of mesothelioma improves prediction of patient outcome	216
Microbial network disturbances in relapsing refractory Crohn’s disease	203
Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma	201
Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma	198
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1	197
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation	195
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research	193
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes	192
Immunogenic neoantigens derived from gene fusions stimulate T cell responses	191
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids	189
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer	180
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy	177
T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant	171
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss	171
Farm-like indoor microbiota in non-farm homes protects children from asthma development	167
Plasma protein patterns as comprehensive indicators of health	167
An immune-cell signature of bacterial sepsis	166
Sex differences in cardiometabolic disorders	165
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma	165
Modeling shield immunity to reduce COVID-19 epidemic spread	163
Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study	162
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts	154
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic	153
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques	153
Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children	153
ApoE attenuates unresolvable inflammation by complex formation with activated C1q	152
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients	151
Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect	150
Methionine is a metabolic dependency of tumor-initiating cells	148
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy	146
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer	145
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia	144
Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults	143
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy	142
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study	141
A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate	141
IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure	138
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions	138
Translation control of the immune checkpoint in cancer and its therapeutic targeting	135
Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants	133
Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level	133
Rational design of anti-GITR-based combination immunotherapy	132
Vaginal microbiome transplantation in women with intractable bacterial vaginosis	130