OOIR: Observatory of International Research

Papers

(The TQCC of Nature Medicine is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
AI to expand the reach of oncology trials	3406
Tocilizumab for the treatment of severe COVID-19	1416
Oligonucleotides get triglycerides under control	1324
Gene therapy helps children with immunodeficiency	1312
An implant to treat cluster headaches	938
A genetic test to predict adverse drug reactions	774
Digital intervention improves tuberculosis treatment outcomes	753
Combination treatment for immune-mediated HIV remission	714
MRI decoders translate thoughts into words	675
Precision medicine for advanced breast cancer	623
siRNA against anti-thrombin reduces bleeding in hemophilia	615
International transmission complicates HCV elimination	593
Questionable role of new techniques in IVF embryo culture	589
Global health engagement strengthens US security, prosperity and leadership	580
Diabetes risk after COVID-19	580
Why banning words in medical research is bad news for everyone	559
Sustainable, low-cost cancer diagnostics	545
Task-sharing and telemedicine delivery of psychotherapy to treat perinatal depression: a pragmatic, noninferiority randomized trial	531
Surgery versus no surgery in platinum-sensitive relapsed ovarian cancer: final overall survival analysis of the SOC-1 randomized phase 3 trial	526
Solving medicine’s data bottleneck: Nightingale Open Science	516
Mpox is a public health emergency — what happens now?	508
Sexual and reproductive health and rights must be enshrined in universal healthcare	507
In vivo gene editing for inherited vision loss	503
Tissue perfusion pressure enables continuous hemodynamic evaluation and risk prediction in the intensive care unit	500
Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial	497

A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma	484
Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction	471
RET inhibitors go tumor-agnostic	467
Repurposing a diabetes drug to treat Parkinson’s disease	437
CAR-T cell therapies for large B cell lymphoma	413
How a medical mystery led to a cure for viral hepatitis	411
Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial	407
Author Correction: Ferric carboxymaltose for anemia in late pregnancy: a randomized controlled trial	407
The expanding repertoire of brain–computer interfaces	407
Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial	406
Author Correction: Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission	405
Psychiatry goes psychedelic	397
Vaccine development needs a boost	393
Cracking the code of the Y chromosome	383
LLMs get a medical education	381
Immunotherapy for esophageal cancer	372
Recapitulating sensory feedback in artificial skin	370
Deciphering the genetic architecture of pain intensity	364
“I had to be with bodyguards with guns”—attacks on scientists during the pandemic	364
FDA approves first drug to delay type 1 diabetes	360
A call to invest in emergency, critical and operative care for universal health coverage	357
Hitting the right notes for pain relief	353
Every baby deserves access to genetic screening	353
Mapping peripartum brain changes in women	351
Easing the pain of endometriosis	351
Predicting breast cancer risk in women of African ancestry	345
Sex-specific genetic architecture of blood pressure	343
A common framework for health data governance standards	341
The uncertain science of preimplantation and prenatal genetic testing	340
Comparison of two diagnostic intervention packages for community-based active case finding for tuberculosis: an open-label randomized controlled trial	334
New and emerging approaches to treat psychiatric disorders	329
Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial	328
The inconvenient reality of AI-assisted embryo selection in IVF	327
The role of research in China’s successful elimination of malaria	324
A foundation model for clinician-centered drug repurposing	324
Continuous glucose monitoring and intrapersonal variability in fasting glucose	323
Transmission dynamics of the 2022 mpox epidemic in New York City	322
Innovative approaches from recent conflicts can aid the health crisis in Ukraine	320
SCOTUS v. reproductive health in United States	313
Renewed action on hypertension to improve health and reduce global inequalities	312
JAK inhibitor reinvigorates cancer immunotherapy	305
A little knowledge can be a dangerous thing	300
Improving the FITness of colorectal cancer screening	299
Tackling under-reporting of violence against women	298
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	294
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	294
The poorest and most vulnerable communities should be the first to be vaccinated	293
Base editors in the clinic	290
A blood test for prenatal genetic diagnosis	288
Telemedicine for abortion access	287

Epigenomic dysregulation correlates with arachnoid cyst formation and neurodevelopmental symptoms	287
Persistent mutations render cancer cells susceptible to immunotherapy	283
Telemonitoring for complicated pregnancies	279
Putting the brakes on Alzheimer’s disease	278
Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk	276
AI as a new paradigm for risk-based screening for breast cancer	276
Concerns about the Burden of Proof studies	275
Evidence-based COVID-19 policy-making in schools	272
Long-term health risks linked to childbirth	269
Author Correction: Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial	268
A global initiative to deliver precision health in diabetes	267
The WHO genomics program of work for equitable implementation of human genomics for global health	266
Author Correction: Durability of neutralizing RSV antibodies following nirsevimab administration and elicitation of the natural immune response to RSV infection in infants	265
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	263
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial	261
Subclassification of obesity for precision prediction of cardiometabolic diseases	260
What will it take to make precision health a global reality	259
Impact of cancer immunotherapy on female fertility	259
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma	259
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	257
Five award-winning researchers share their tips for inclusive health research	256
Monitoring metabolic changes during the menstrual cycle	253
Rise in ambient temperature is associated with increased mortality in Latin America	252
Gene editing advances on all fronts	250
Genetic testing in the neonatal ICU	248
Prescription for a healthy diet	244
Phthalate exposure linked to adverse pregnancy outcomes	244
Immunotherapy boosts responses in hormone receptor-positive breast cancers	241
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	241
Evaluating generalizability of oncology trial results to real-world patients using machine learning-based trial emulations	238
Visualizing the effects and causes of caregiver deaths on children in the USA	238
High-efficiency base editing in the retina in primates and human tissues	237
Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses	235
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	233
Dementia research needs a global approach	233
Epidemiological and genomic evolution of the ongoing outbreak of clade Ib mpox virus in the eastern Democratic Republic of the Congo	232
How virtual reality therapy is shaping mental health	228
A B7H3-targeting antibody–drug conjugate in advanced solid tumors: a phase 1/1b trial	228
Urgent call to close the gap in medical oxygen access	226
A new way to tackle bacterial vaginosis	225
Cancer immunotherapy gets personal	223
The German Network for Personalized Medicine to enhance patient care and translational research	221
Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial	221
Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial	220
Uncovering the role of sleep on human health	220
Our Future Health: a unique global resource for discovery and translational research	220
Endothelial cell-mediated risk of CAD could be used to target lipid-lowering therapy	220
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing	219
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma	218
Author Correction: Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial	216
Finding the right target for drug-resistant inflammatory bowel disease	213
One Health interprofessional stewardship to combat antimicrobial resistance	212
Clinical trials assess a precision-medicine approach to cancer screening	206
Semaglutide and risk of suicidal ideations	205
HIV prevention through PrEP in cisgender women	205
HIV-1 remission following stem cell transplant without CCR5Δ32 mutation	204
Aiming for equitable precision medicine in diabetes	203
Computational brain models map diversity embedded in aging and dementia	203
Sustained behavior change is key to preventing and tackling future pandemics	202
Hippocampal network activity forecasts epileptic seizures	202
Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation	200
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	199
The European Health Data Space can be a boost for research beyond borders	198
Single-cell profiling of the human endometrium in polycystic ovary syndrome	197
A shared neural basis underlying psychiatric comorbidity	196
Long COVID includes breathing and reproductive problems and has a range of risk factors	193
Diagnostic classification of childhood cancer using multiscale transcriptomics	192
Unmasking the elusive erythropoietin-producing ‘Norn’ cell	190
HIPAA is a misunderstood and inadequate tool for protecting medical data	189
Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes	189
Author Correction: High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial	186
The international Unity study for antivirals against mpox is a blueprint for future epidemics	185
Accurate diagnosis of pediatric brain cancers	185
Health nationalism in Aotearoa New Zealand during COVID-19: problems for global health equity	184
Balancing human and AI roles in clinical imaging	184
Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial	182
Author Correction: A shared neural basis underlying psychiatric comorbidity	182
How publishers can fight misinformation in and about science and medicine	182
Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution	181
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	181

Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial	180
Dynamics and durability of HIV-1 neutralization are determined by viral replication	180
Post-acute neurological consequences of COVID-19: an unequal burden	180
Polygenic embryo testing: understated ethics, unclear utility	179
Point-of-care testing for sepsis in remote Australia and for First Nations peoples	178
Building trust and transparency in biomedical sciences through data walks	177
The capacity of brain circuits to enhance psychiatry	177
CAR T cells reach clinical milestone in prostate cancer	177
Navigating the health frontiers of Africa’s climate challenge	177
Tracing the origins of antibiotic resistance	176
Microbiome research in Africa must be based on equitable partnerships	174
Author Correction: IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	174
Estimating the total effect of anthropogenic climate change on human health and wellbeing	174
Key components of successful digital remote monitoring in oncology	174
Publisher Correction: APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease	174
Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial	173
A life-course multisectoral approach to precision health in LMICs	173
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist	172
A randomized controlled trial to test financial incentives for COVID-19 vaccination in Ghana	171
Brain aging patterns in a large and diverse cohort of 49,482 individuals	171
Author Correction: Clinical surveillance systems obscure the true cholera infection burden in an endemic region	169
Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition	169
A brain cell atlas integrating single-cell transcriptomes across human brain regions	168
Author Correction: Unexplained post-acute infection syndromes	168
The centuries long pursuit to map the human lymphatic system	166
Author Correction: Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma	165
A global metric of immune health	165
Author Correction: Diversity, equity and inclusion actions from the NCATS Clinical and Translational Science awarded programs	165
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	164
Liquid biopsies and tumor mutational burden: the cutoff conundrum	164
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial	162
Author Correction: Not all AI health tools with regulatory authorization are clinically validated	161
Author Correction: Targeting the HIF2–VEGF axis in renal cell carcinoma	161
Lingering cardiac involvement in previously well people after mild COVID-19	160
Echocardiographic screening for heart failure and optimization of the care pathway for individuals with pacemakers: a randomized controlled trial	159
Publisher Correction: A T cell resilience model associated with response to immunotherapy in multiple tumor types	157
Reply to: Concerns about the Burden of Proof studies	157
Pembrolizumab in brain metastases of diverse histologies: phase 2 trial results	156
Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial	155
Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial	153
Author Correction: Digital consults in heart failure care: a randomized controlled trial	153
Targeted therapy for osteoarthritis: progress and pitfalls	153
Author Correction: Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial	153
Supported decision-making can advance clinical research participation for people with disabilities	151
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	151
Publisher Correction: Allogeneic BCMA-targeting CAR T cells in relapsed/refractory multiple myeloma: phase 1 UNIVERSAL trial interim results	150
Disruptions to the hearing health sector	149
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer	148
Trialing precision medicine for type 2 diabetes	148
Viral and host mediators of non-suppressible HIV-1 viremia	145
Publisher Correction: Altered perivascular fibroblast activity precedes ALS disease onset	145
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer	145
Retrieval of vector integration sites from cell-free DNA	144
HIV drug resistance to integrase inhibitors in low- and middle-income countries	143
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	143
Evidence for iatrogenic transmission of Alzheimer’s disease	142
Author Correction: Health effects associated with exposure to secondhand smoke: a Burden of Proof study	142
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	141
Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain	141
An AI chatbot for talking therapy referrals	141
Delivering high-quality childbirth care	141
Clinical decisions using AI must consider patient values	140
Can an implanted minipump deliver for diabetes patients?	138
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	138
A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide	137
Telehealth enables safe medication abortion in shifting health and legal contexts	135
Author Correction: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland	135
Disparities in healthy working life expectancy in different Chinese populations	134
A solid start for gene therapy in Tay–Sachs disease	134
Are GLP-1 drugs really for everybody?	134
The unknown efficacy of tecovirimat against monkeypox	133
GPT-4 assistance for improvement of physician performance on patient care tasks: a randomized controlled trial	133
A deep learning system for predicting time to progression of diabetic retinopathy	132
Autoimmune disease is the next frontier for CAR T cell therapy	131
Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial	131
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	131
Health benefits of fermented foods	129
Predatory journals: what can we do to protect their prey?	129
Sick as a dog: how understanding canine diseases will save human lives	128
Secrets of microbiota drug metabolism	128
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	128
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	128
Telehealth is here to stay	128
A decision-making tree for policy responses to a pathogen with pandemic potential	127
The future of brain–computer interfaces in medicine	125
Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells	124
Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells	123
Author Correction: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma	122
Identification of genetic correlates of coronary artery disease in diverse ancestral populations	122
Internet use linked to better mental health in older adults	121
11 clinical trials that will shape medicine in 2023	121
Obesity predisposes to specific cancer driver mutations	121
The need for a new strategy for Ebola vaccination	121
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas	120
A new phase of the Cancer Moonshot to end cancer as we know it	120