Nature Medicine

Article	Citations
SCOTUS v. reproductive health in United States	1928
Rise in ambient temperature is associated with increased mortality in Latin America	1644
Telemonitoring for complicated pregnancies	1535
LLMs get a medical education	980
Questionable role of new techniques in IVF embryo culture	814
A genetic test to predict adverse drug reactions	711
Easing the pain of endometriosis	671
Liquid biopsies and tumor mutational burden: the cutoff conundrum	668
A global metric of immune health	663
Recapitulating sensory feedback in artificial skin	607
In vivo gene editing for inherited vision loss	603
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	598
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	532
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	530
The inconvenient reality of AI-assisted embryo selection in IVF	510
The capacity of brain circuits to enhance psychiatry	509
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	491
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	483
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	478
Can an implanted minipump deliver for diabetes patients?	461
HIV prevention through PrEP in cisgender women	458
The uncertain science of preimplantation and prenatal genetic testing	455
An AI chatbot for talking therapy referrals	446
Estimating the total effect of anthropogenic climate change on human health and wellbeing	443
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	441

Gene-edited pig liver successfully transplanted into human	437
Supported decision-making can advance clinical research participation for people with disabilities	430
FDA approves first drug to delay type 1 diabetes	430
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	428
The role of research in China’s successful elimination of malaria	418
Author Correction: Digital consults in heart failure care: a randomized controlled trial	418
Author Correction: Unexplained post-acute infection syndromes	402
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	394
AI as a new paradigm for risk-based screening for breast cancer	394
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	393
First tumor-agnostic approval for an ADC	382
Anemia in women — an intractable problem that requires innovative solutions	369
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	367
Combating vaccine revisionism	364
Concerns about the Burden of Proof studies	364
How virtual reality therapy is shaping mental health	360
An explainable foundation model for drug repurposing	356
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	355
The effect of geopolitical flux on antimicrobial resistance	354
Solving medicine’s data bottleneck: Nightingale Open Science	354
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	351
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	345
Ending the taboo on periods and period problems	344
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	342
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	341
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	339
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	339
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	336
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	332
Targeted therapy for osteoarthritis: progress and pitfalls	331
PD-L1 and the dawn of modern cancer immunotherapy	327
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	324
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	324
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	324
HIPAA is a misunderstood and inadequate tool for protecting medical data	320
Hippocampal network activity forecasts epileptic seizures	316
Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial	312
Integrating the environmental and genetic architectures of aging and mortality	308
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	307
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	306
Integrated image-based deep learning and language models for primary diabetes care	305
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	300
Will ChatGPT transform healthcare?	295
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	292
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	290
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	290
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	287
Continuous glucose monitoring and intrapersonal variability in fasting glucose	280
In utero origin of myelofibrosis presenting in adult monozygotic twins	277
The WHO genomics program of work for equitable implementation of human genomics for global health	276

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	274
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	271
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	271
The landscape of mRNA nanomedicine	271
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	270
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	269
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	269
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	268
The Yearbook	265
WHO sets research agenda for refugee and migrant health	265
An anti-obesity drug from the diabetes toolbox	264
An outdated loophole is letting faulty lab tests hit the market	264
Rethinking aspirin for heart health	263
The visible and hidden mortality caused by flooding	261
Health in the Amazon	261
Mapping the cellular landscape of the brain	258
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	257
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	256
Steps to prevent and respond to an H5N1 epidemic in the USA	251
Clinical AI tools must convey predictive uncertainty for each individual patient	251
The expanding universe of checkpoint inhibitors for nasopharyngeal cancer	251
An international treaty to regulate misuse of alcohol and cannabis	246
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	245
The economics of investing in women and health	240
AI-generated text may have a role in evidence-based medicine	239
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	239
Strategies for shortening tuberculosis therapy	238
Air pollution interventions for health	237
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	233
Mpox continues to spread in Africa and threatens global health security	232
Overcoming zero-sum thinking to advance US population health	231
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	230
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	228
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	226
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	225
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	224
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	223
Advancing global antibiotic research, development and access	222
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	221
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	220
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	217
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	216
Health benefits of calorie restriction	215
A gene-by-sex interaction contributes to liver disease susceptibility in women	215
Prenatal exposure to famine affects lifelong health	214
How patient advocates influence health policy	212
siRNA therapy lowers triglycerides in patients with rare condition	211
Meningioma risk stratification with a targeted gene-expression biomarker	210
The effect of embryonic genome imbalances on pregnancy	209
Brain pathology of COVID-19	207
Using genetics to predict toxicity of cancer immunotherapy	205
Menstrual health without stigma	204
Use of mobile diagnostics and digital clinical trials in cardiology	203
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	203
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	203
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	202
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	202
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	202
Using unlabeled data to enhance fairness of medical AI	201
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	200
Peace in Colombia requires healing the scars of conflict on the mind and brain	200
Familial confounding in the associations between maternal health and autism	199
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	197
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	196
Geographical shifting of cholera burden in Africa and its implications for disease control	196
Microbes convert plastic waste into paracetamol	196
Machine learning improves prediction of clinical outcomes for invasive breast cancers	196
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	195
A benchmarking crisis in biomedical machine learning	194
Coproducing health research with Indigenous peoples	192
The limits of fair medical imaging AI in real-world generalization	192
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	191
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	190
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	188
Genome-wide polygenic score to predict chronic kidney disease across ancestries	187
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	186
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	186
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	186
An African One Health network for antimicrobial resistance and neglected tropical diseases	186
An integrated cell atlas of the lung in health and disease	185

D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	184
Self-improving generative foundation model for synthetic medical image generation and clinical applications	184
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	184
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	183
Emerging diagnostics and therapeutics for Alzheimer disease	183
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	183
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	182
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	182
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	182
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	182
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	181
Gene therapy for alcohol-use disorder	174
Could video games be good for your health?	174
ALS therapy hits molecular mark but misses clinical one	173
Pig-to-human transplants inch closer to reality	171
A human brain circuit for addiction remission	171
A smart solution for detecting ear problems	169
A pinch of salt for heart disease	169
Using implementation science to navigate the complexity of integrating genomics into healthcare	168
The unseen climate health risks of antimicrobial resistance in urban informal settlements	167
Deciphering the heritability of human height	166
Targeted radiation adds precision to cancer therapy	165
A framework to assess the effects of genetic risk factors on disability-adjusted life years	164
Human embryo models offer glimpse into early development	163
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	163
Gene-editing breakthrough for a rare hereditary disorder	162
Countering the impact of the climate crisis on health will require data	162
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	162
COVID-19 vaccination gives hope to eradicate polio	162
Imatinib and the dawn of precision cancer therapy	162
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	161
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	160
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	159
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	157
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	157
New neurons are born in the adult human brain	156
Adequate information about clinical trial results must be given to participants	155
Why paying individual people for their health data is a bad idea	155
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	153
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	153
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	151
The impact of school opening model on SARS-CoV-2 community incidence and mortality	151
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	151
The economic value of reducing avoidable mortality	150
A H3K27M-targeted vaccine in adults with diffuse midline glioma	149
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	148
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	148
AI-guided precision parenteral nutrition for neonatal intensive care units	147
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	147
Determinants and inequities in healthy working life expectancy in China	145
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	145
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	145
Caution at psychiatry’s psychedelic frontier	145
City-level impact of extreme temperatures and mortality in Latin America	144
Concern for the validity of short-term dietary crossover trials	144
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	143
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	143
Bacterial SNPs in the human gut microbiome associate with host BMI	142
A federated learning system for precision oncology in Europe: DigiONE	141
Challenges with benchmarking of MDMA-assisted psychotherapy	140
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	140
Multi-ancestry polygenic mechanisms of type 2 diabetes	140
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	139
Cities, communities and clinics can be testbeds for human exposome and aging research	138
Permissive gun laws in the USA linked to thousands of child deaths	138
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	137
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	137
Hibernation science harnessed to treat obesity and modify metabolism	137
Hope for patients facing deadly infections	137
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	136
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	136
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	133
A neural stem-cell treatment for progressive multiple sclerosis	132
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology	132
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	132
Targeting KRAS in cancer	131
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	131
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	131
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	131
Mapping the mediators of Alzheimer’s disease	130
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	130
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	130
Balancing the risks of HIV transmission at low viral load	129
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	129
Author Correction: Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial	127
Boosting the efficacy of emergency contraception	127
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	127
The role of placebo control in clinical trials for neurodegenerative diseases	127
Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial	126
Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance	125
Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial	125
Tumor infiltrating lymphocyte approval heralds new era for precision cancer immunotherapy	125
11 clinical trials that will shape medicine in 2022	125
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction	122
A joint international consensus statement for measuring quality of survival for patients with childhood cancer	121