Nature Medicine

(The TQCC of Nature Medicine is 130. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome2251
High-performance medicine: the convergence of human and artificial intelligence2006
Chronic inflammation in the etiology of disease across the life span1363
A guide to deep learning in healthcare1290
Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network1172
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study930
Clinical-grade computational pathology using weakly supervised deep learning on whole slide images871
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease797
End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography759
Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids729
The practical implementation of artificial intelligence technologies in medicine703
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction692
Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus676
Clonal replacement of tumor-specific T cells following PD-1 blockade667
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma663
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer529
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer526
The microbiome, cancer, and cancer therapy515
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer501
A cellular census of human lungs identifies novel cell states in health and in asthma488
The pros, cons, and many unknowns of probiotics481
Identification of preexisting adaptive immunity to Cas9 proteins in humans480
Screening for cardiac contractile dysfunction using an artificial intelligence–enabled electrocardiogram457
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease440
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma430
The vaginal microbiome and preterm birth423
Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial416
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation409
Single-cell immune landscape of human atherosclerotic plaques377
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10374
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants373
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models372
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade370
Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma364
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma362
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers360
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein358
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer357
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma353
Biomimetic 3D-printed scaffolds for spinal cord injury repair351
Privacy in the age of medical big data349
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity347
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism341
Identifying facial phenotypes of genetic disorders using deep learning326
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study325
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis325
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy320
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers315
Undulating changes in human plasma proteome profiles across the lifespan306
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR292
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery287
Do no harm: a roadmap for responsible machine learning for health care285
Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence284
Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial279
Genomic correlates of response to immune checkpoint blockade277
Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial274
Clinical lessons learned from the first leg of the CAR T cell journey272
The landscape of cancer cell line metabolism264
Highly efficient therapeutic gene editing of human hematopoietic stem cells255
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency255
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers255
A longitudinal big data approach for precision health251
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy248
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States248
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy248
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity245
Programmable bacteria induce durable tumor regression and systemic antitumor immunity243
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome243
A safe and potent anti-CD19 CAR T cell therapy238
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring235
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice235
A rectal cancer organoid platform to study individual responses to chemoradiation234
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination231
High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population230
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer226
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report225
Spinal cord repair: advances in biology and technology221
Healthy infants harbor intestinal bacteria that protect against food allergy220
Deep learning-based classification of mesothelioma improves prediction of patient outcome216
Microbial network disturbances in relapsing refractory Crohn’s disease203
Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma201
Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma198
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1197
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation195
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research193
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes192
Immunogenic neoantigens derived from gene fusions stimulate T cell responses191
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids189
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer180
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy177
T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant171
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss171
Farm-like indoor microbiota in non-farm homes protects children from asthma development167
Plasma protein patterns as comprehensive indicators of health167
An immune-cell signature of bacterial sepsis166
Sex differences in cardiometabolic disorders165
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma165
Modeling shield immunity to reduce COVID-19 epidemic spread163
Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study162
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts154
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic153
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques153
Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children153
ApoE attenuates unresolvable inflammation by complex formation with activated C1q152
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients151
Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect150
Methionine is a metabolic dependency of tumor-initiating cells148
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy146
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer145
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia144
Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults143
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy142
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study141
A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate141
IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure138
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions138
Translation control of the immune checkpoint in cancer and its therapeutic targeting135
Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants133
Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level133
Rational design of anti-GITR-based combination immunotherapy132
Vaginal microbiome transplantation in women with intractable bacterial vaginosis130