Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2179
A genetic test to predict adverse drug reactions	1798
LLMs get a medical education	1588
Liquid biopsies and tumor mutational burden: the cutoff conundrum	845
In vivo gene editing for inherited vision loss	761
Recapitulating sensory feedback in artificial skin	748
Telemonitoring for complicated pregnancies	718
Rise in ambient temperature is associated with increased mortality in Latin America	692
SCOTUS v. reproductive health in United States	623
Easing the pain of endometriosis	623
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	610
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	605
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	587
Can an implanted minipump deliver for diabetes patients?	549
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	547
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	540
The inconvenient reality of AI-assisted embryo selection in IVF	534
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	504
Combating vaccine revisionism	499
A global metric of immune health	487
HIV prevention through PrEP in cisgender women	486
An AI chatbot for talking therapy referrals	478
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	475
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	444
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	432

Integrating the environmental and genetic architectures of aging and mortality	429
The WHO genomics program of work for equitable implementation of human genomics for global health	423
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	417
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	400
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	398
An explainable foundation model for drug repurposing	395
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	390
Continuous glucose monitoring and intrapersonal variability in fasting glucose	389
First tumor-agnostic approval for an ADC	389
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	381
The effect of geopolitical flux on antimicrobial resistance	379
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	375
Ending the taboo on periods and period problems	374
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	373
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	371
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	370
How virtual reality therapy is shaping mental health	368
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	367
Estimating the total effect of anthropogenic climate change on human health and wellbeing	365
Concerns about the Burden of Proof studies	363
PD-L1 and the dawn of modern cancer immunotherapy	358
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	356
Supported decision-making can advance clinical research participation for people with disabilities	349
Gene-edited pig liver successfully transplanted into human	346
Author Correction: Digital consults in heart failure care: a randomized controlled trial	345
FDA approves first drug to delay type 1 diabetes	341
Author Correction: Unexplained post-acute infection syndromes	340
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	337
In utero origin of myelofibrosis presenting in adult monozygotic twins	335
AI as a new paradigm for risk-based screening for breast cancer	333
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	332
The capacity of brain circuits to enhance psychiatry	327
The role of research in China’s successful elimination of malaria	326
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	324
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	321
HIPAA is a misunderstood and inadequate tool for protecting medical data	319
Targeted therapy for osteoarthritis: progress and pitfalls	314
Solving medicine’s data bottleneck: Nightingale Open Science	310
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	310
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	310
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	304
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	302
The uncertain science of preimplantation and prenatal genetic testing	298
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	296
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	293
Will ChatGPT transform healthcare?	293
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	289
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	286
Integrated image-based deep learning and language models for primary diabetes care	283
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	283

IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	280
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	277
The landscape of mRNA nanomedicine	277
Hippocampal network activity forecasts epileptic seizures	276
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	276
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	274
Health in the Amazon	273
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	273
Rethinking aspirin for heart health	271
An outdated loophole is letting faulty lab tests hit the market	270
An anti-obesity drug from the diabetes toolbox	269
WHO sets research agenda for refugee and migrant health	265
The Yearbook	261
Mapping the cellular landscape of the brain	259
How patient advocates influence health policy	258
Menstrual health without stigma	257
Using genetics to predict toxicity of cancer immunotherapy	257
Brain pathology of COVID-19	257
The effect of embryonic genome imbalances on pregnancy	257
Air pollution interventions for health	253
Microbes convert plastic waste into paracetamol	253
An international treaty to regulate misuse of alcohol and cannabis	253
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	250
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	247
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	247
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	242
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	240
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	239
Health benefits of calorie restriction	237
A gene-by-sex interaction contributes to liver disease susceptibility in women	237
An African One Health network for antimicrobial resistance and neglected tropical diseases	236
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	235
Steps to prevent and respond to an H5N1 epidemic in the USA	234
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	233
The visible and hidden mortality caused by flooding	233
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	230
siRNA therapy lowers triglycerides in patients with rare condition	230
Prenatal exposure to famine affects lifelong health	227
Machine learning improves prediction of clinical outcomes for invasive breast cancers	225
Coproducing health research with Indigenous peoples	223
Meningioma risk stratification with a targeted gene-expression biomarker	223
Using unlabeled data to enhance fairness of medical AI	222
Mpox continues to spread in Africa and threatens global health security	222
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	222
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	221
Overcoming zero-sum thinking to advance US population health	221
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	220
Geographical shifting of cholera burden in Africa and its implications for disease control	219
A brief digital cognitive test improves Alzheimer’s disease detection	217
Peace in Colombia requires healing the scars of conflict on the mind and brain	216
The economics of investing in women and health	214
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	214
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	211
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	209
Advancing global antibiotic research, development and access	208
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	208
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	207
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	207
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	207
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	206
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	205
Clinical AI tools must convey predictive uncertainty for each individual patient	204
Use of mobile diagnostics and digital clinical trials in cardiology	204
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	203
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	202
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	199
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	198
Strategies for shortening tuberculosis therapy	198
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	196
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	196
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	195
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	195
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	194
Familial confounding in the associations between maternal health and autism	194
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	193
A benchmarking crisis in biomedical machine learning	193
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	192
Emerging diagnostics and therapeutics for Alzheimer disease	192
The limits of fair medical imaging AI in real-world generalization	192
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	192

A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	192
AI-generated text may have a role in evidence-based medicine	191
Self-improving generative foundation model for synthetic medical image generation and clinical applications	191
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	191
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	187
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	185
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	184
Genome-wide polygenic score to predict chronic kidney disease across ancestries	183
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	182
An integrated cell atlas of the lung in health and disease	182
Gene therapy for alcohol-use disorder	180
Could video games be good for your health?	179
A human brain circuit for addiction remission	177
A smart solution for detecting ear problems	176
ALS therapy hits molecular mark but misses clinical one	175
Pig-to-human transplants inch closer to reality	174
A framework to assess the effects of genetic risk factors on disability-adjusted life years	173
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	173
Human embryo models offer glimpse into early development	173
Deciphering the heritability of human height	172
A neural stem-cell treatment for progressive multiple sclerosis	171
Permissive gun laws in the USA linked to thousands of child deaths	167
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	167
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	166
Hibernation science harnessed to treat obesity and modify metabolism	166
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	165
New neurons are born in the adult human brain	164
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	164
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	164
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	163
Cities, communities and clinics can be testbeds for human exposome and aging research	160
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	159
Hope for patients facing deadly infections	159
Concern for the validity of short-term dietary crossover trials	159
The economic value of reducing avoidable mortality	159
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	158
Targeted radiation adds precision to cancer therapy	158
Why paying individual people for their health data is a bad idea	157
Using implementation science to navigate the complexity of integrating genomics into healthcare	157
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	156
Gene-editing breakthrough for a rare hereditary disorder	155
Imatinib and the dawn of precision cancer therapy	154
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	153
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	153
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	152
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	152
Adequate information about clinical trial results must be given to participants	152
Teaching machines to doubt	151
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	150
Countering the impact of the climate crisis on health will require data	147
Bacterial SNPs in the human gut microbiome associate with host BMI	146
Determinants and inequities in healthy working life expectancy in China	146
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	146
The unseen climate health risks of antimicrobial resistance in urban informal settlements	146
A federated learning system for precision oncology in Europe: DigiONE	145
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	145
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	144
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	144
Targeting KRAS in cancer	142
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	142
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	141
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	141
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	139
Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020	139
Africa’s continental plan to end cholera	137
A H3K27M-targeted vaccine in adults with diffuse midline glioma	137
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	137
AI-guided precision parenteral nutrition for neonatal intensive care units	136
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	136
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	134
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	134
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	134
Multi-ancestry polygenic mechanisms of type 2 diabetes	133
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	133
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	133
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	132
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	132
City-level impact of extreme temperatures and mortality in Latin America	132
Mapping the mediators of Alzheimer’s disease	131
Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance	130
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	130
The role of placebo control in clinical trials for neurodegenerative diseases	128
Boosting the efficacy of emergency contraception	128
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	128
Balancing the risks of HIV transmission at low viral load	127
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	126
Biological and health effects of fire smoke exposure	126
‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease	126
Location matters for brain gene therapy in lysosomal disorders	126
Education does not affect memory decline or brain aging	126
Publisher Correction: Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial	126
A joint international consensus statement for measuring quality of survival for patients with childhood cancer	125
Author Correction: Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial	125
The fragile intelligence of GPT-5 in medicine	125
Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial	125