Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	3078
A genetic test to predict adverse drug reactions	1107
LLMs get a medical education	1028
In vivo gene editing for inherited vision loss	940
Recapitulating sensory feedback in artificial skin	932
Telemonitoring for complicated pregnancies	931
Rise in ambient temperature is associated with increased mortality in Latin America	827
Easing the pain of endometriosis	773
SCOTUS v. reproductive health in United States	736
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	706
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	704
First tumor-agnostic approval for an ADC	698
Estimating the total effect of anthropogenic climate change on human health and wellbeing	693
HIV prevention through PrEP in cisgender women	691
Gene-edited pig liver successfully transplanted into human	607
The capacity of brain circuits to enhance psychiatry	596
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	571
Supported decision-making can advance clinical research participation for people with disabilities	559
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	554
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	547
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	534
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	528
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	522
Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets	520
Author Correction: Digital consults in heart failure care: a randomized controlled trial	493

Mapping the effects of gender-affirming sex hormone therapy	479
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	466
An explainable foundation model for drug repurposing	465
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study	454
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	440
Combating vaccine revisionism	434
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	429
Liquid biopsies and tumor mutational burden: the cutoff conundrum	427
Concerns about the Burden of Proof studies	425
Author Correction: Unexplained post-acute infection syndromes	413
US vaccine policy must put America first	403
HIPAA is a misunderstood and inadequate tool for protecting medical data	388
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	388
A global metric of immune health	384
The inconvenient reality of AI-assisted embryo selection in IVF	367
Ending the taboo on periods and period problems	366
What Galen’s dissections reveal about tacit learning in modern medical education	365
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	362
Hippocampal network activity forecasts epileptic seizures	356
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	354
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	352
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	351
Will ChatGPT transform healthcare?	350
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	349
FDA approves first drug to delay type 1 diabetes	348
A large language model for complex cardiology care	345
The effect of geopolitical flux on antimicrobial resistance	340
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	336
How virtual reality therapy is shaping mental health	336
Targeted therapy for osteoarthritis: progress and pitfalls	332
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	332
The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome	331
Who owns my health data?	325
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	324
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	324
Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma	324
An AI chatbot for talking therapy referrals	324
Integrated image-based deep learning and language models for primary diabetes care	322
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	317
The landscape of mRNA nanomedicine	315
Repotrectinib in NTRK fusion–positive advanced solid tumors: a phase 1/2 trial	314
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	299
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	289
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	288
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	287
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	285
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	284
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	284
Continuous glucose monitoring and intrapersonal variability in fasting glucose	283
The WHO genomics program of work for equitable implementation of human genomics for global health	283

Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	283
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	281
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	276
PD-L1 and the dawn of modern cancer immunotherapy	275
Integrating the environmental and genetic architectures of aging and mortality	272
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	272
An anti-obesity drug from the diabetes toolbox	271
WHO sets research agenda for refugee and migrant health	270
Mapping the cellular landscape of the brain	268
How patient advocates influence health policy	267
Microbes convert plastic waste into paracetamol	265
The effect of embryonic genome imbalances on pregnancy	265
An international treaty to regulate misuse of alcohol and cannabis	262
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	260
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	259
A gene-by-sex interaction contributes to liver disease susceptibility in women	259
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	259
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	257
siRNA therapy lowers triglycerides in patients with rare condition	255
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	255
Using unlabeled data to enhance fairness of medical AI	252
Use of mobile diagnostics and digital clinical trials in cardiology	249
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	248
Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial	245
Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial	244
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	241
Mpox continues to spread in Africa and threatens global health security	239
The Italian parliament first to recognize obesity as a chronic and relapsing disease	237
Prenatal exposure to famine affects lifelong health	233
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	233
Silenced genomes	230
Machine learning improves prediction of clinical outcomes for invasive breast cancers	230
The path to safe, equitable and sustainable dialysis provision for people with chronic kidney disease	229
An African One Health network for antimicrobial resistance and neglected tropical diseases	227
Using genetics to predict toxicity of cancer immunotherapy	226
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	225
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	223
Advancing global antibiotic research, development and access	222
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	218
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	216
Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study	215
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	214
Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial	213
Steps to prevent and respond to an H5N1 epidemic in the USA	213
Is AI actually improving healthcare?	212
Menstrual health without stigma	210
Nature Medicine Commission on dialysis policy in low- and middle-income countries	209
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	209
Overcoming zero-sum thinking to advance US population health	208
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	208
The mind-bending power of placebo	206
A brief digital cognitive test improves Alzheimer’s disease detection	205
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	198
Meningioma risk stratification with a targeted gene-expression biomarker	196
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	196
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	194
Multi-omic definition of metabolic obesity through adipose tissue–microbiome interactions	194
CRISPR−Cas9 CD33-deleted allogeneic hematopoietic cell transplantation with gemtuzumab ozogamicin maintenance in AML: a phase 1/2 trial	193
Geographical shifting of cholera burden in Africa and its implications for disease control	193
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	192
Exposure to negative physical and social factors accelerates brain aging	192
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	191
Strategies for shortening tuberculosis therapy	190
A benchmarking crisis in biomedical machine learning	190
Self-improving generative foundation model for synthetic medical image generation and clinical applications	188
The patient is now in the room	186
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	186
Clinical AI tools must convey predictive uncertainty for each individual patient	186
Harnessing the power of biomarkers for diffuse intrinsic pontine gliomas	184
The visible and hidden mortality caused by flooding	184
Genome-wide polygenic score to predict chronic kidney disease across ancestries	183
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	183
Coproducing health research with Indigenous peoples	183
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	183
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	183
A pocket-sized drug for p53-mutant cancers	183
Peace in Colombia requires healing the scars of conflict on the mind and brain	182
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	182
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	181
A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism	181

Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	180
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	179
Familial confounding in the associations between maternal health and autism	178
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	178
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	177
An international mega-analysis of psychedelic drug effects on brain circuit function	177
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	177
The economics of investing in women and health	176
Fecal microbiota transplantation plus pembrolizumab and axitinib in metastatic renal cell carcinoma: the randomized phase 2 TACITO trial	174
The expanding landscape of GLP-1 medicines	173
Physical activity for public health in the 21st century	172
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	171
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes	170
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	169
Air pollution interventions for health	168
The limits of fair medical imaging AI in real-world generalization	168
An integrated cell atlas of the lung in health and disease	167
Emerging diagnostics and therapeutics for Alzheimer disease	167
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	167
AI-generated text may have a role in evidence-based medicine	166
Gene therapy for alcohol-use disorder	166
A human brain circuit for addiction remission	165
ALS therapy hits molecular mark but misses clinical one	165
Could video games be good for your health?	165
A smart solution for detecting ear problems	165
Pig-to-human transplants inch closer to reality	162
A framework to assess the effects of genetic risk factors on disability-adjusted life years	162
Human embryo models offer glimpse into early development	160
Hope for patients facing deadly infections	160
Permissive gun laws in the USA linked to thousands of child deaths	160
A neural stem-cell treatment for progressive multiple sclerosis	158
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	158
Imatinib and the dawn of precision cancer therapy	157
Gene-editing breakthrough for a rare hereditary disorder	157
Enhancing prenatal spinal surgery with stem cells	157
Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020	156
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	156
Countering the impact of the climate crisis on health will require data	156
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	156
Adequate information about clinical trial results must be given to participants	156
Hibernation science harnessed to treat obesity and modify metabolism	156
Deciphering the heritability of human height	155
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	154
New neurons are born in the adult human brain	154
Student-led efforts promoting inclusivity and belonging in US medical schools	154
Blood tests for Alzheimer’s disease could reshape research and care	151
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial	151
Determinants and inequities in healthy working life expectancy in China	151
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	150
New gene-editing approaches for β-hemoglobinopathies	150
A H3K27M-targeted vaccine in adults with diffuse midline glioma	149
Disentangling climate hazards from demographic change in climate–health projections	149
Bacterial SNPs in the human gut microbiome associate with host BMI	148
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	148
Mapping the human chemical exposome for public health	148
A federated learning system for precision oncology in Europe: DigiONE	148
Using implementation science to navigate the complexity of integrating genomics into healthcare	148
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	147
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	147
Targeting KRAS in cancer	146
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	146
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	146
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	146
Climate change and infectious diseases	145
A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses	145
Hope for control of a centuries-old epidemic	145
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	144
AI stethoscope trial highlights the perils of implementation gaps	144
Concern for the validity of short-term dietary crossover trials	143
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	143
Editorial Expression of Concern: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization	143
Targeted radiation adds precision to cancer therapy	142
Teaching machines to doubt	142
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	142
Physicians as context engineers in the era of generative AI	141
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease	141
Africa’s continental plan to end cholera	140
The gut microbiome as a fingerprint of antibiotic use history	140
Why paying individual people for their health data is a bad idea	139
The unseen climate health risks of antimicrobial resistance in urban informal settlements	138
Cities, communities and clinics can be testbeds for human exposome and aging research	138
Autonomous pathology research using agentic AI shows potential in oncology	137
BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial	136
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	136
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	136
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	135
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	135
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	133
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	133
AI-guided precision parenteral nutrition for neonatal intensive care units	133
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	133
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	132
The economic value of reducing avoidable mortality	132
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	132
City-level impact of extreme temperatures and mortality in Latin America	131