Nature Medicine

Article	Citations
SCOTUS v. reproductive health in United States	3423
Rise in ambient temperature is associated with increased mortality in Latin America	1438
Telemonitoring for complicated pregnancies	1436
How virtual reality therapy is shaping mental health	1396
LLMs get a medical education	944
Questionable role of new techniques in IVF embryo culture	780
A genetic test to predict adverse drug reactions	775
Easing the pain of endometriosis	738
Liquid biopsies and tumor mutational burden: the cutoff conundrum	697
A global metric of immune health	650
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	626
Solving medicine’s data bottleneck: Nightingale Open Science	600
In vivo gene editing for inherited vision loss	597
Recapitulating sensory feedback in artificial skin	597
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	574
Concerns about the Burden of Proof studies	557
First tumor-agnostic approval for an ADC	553
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	547
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	542
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	516
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	512
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	508
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	487
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	483
An AI chatbot for talking therapy referrals	473

Can an implanted minipump deliver for diabetes patients?	450
The capacity of brain circuits to enhance psychiatry	429
Author Correction: Digital consults in heart failure care: a randomized controlled trial	417
AI as a new paradigm for risk-based screening for breast cancer	416
HIV prevention through PrEP in cisgender women	416
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	411
The role of research in China’s successful elimination of malaria	411
Estimating the total effect of anthropogenic climate change on human health and wellbeing	409
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	408
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	404
Combating vaccine revisionism	402
Gene-edited pig liver successfully transplanted into human	396
HIPAA is a misunderstood and inadequate tool for protecting medical data	389
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	380
FDA approves first drug to delay type 1 diabetes	375
The WHO genomics program of work for equitable implementation of human genomics for global health	373
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	370
Hippocampal network activity forecasts epileptic seizures	370
An explainable foundation model for drug repurposing	368
The uncertain science of preimplantation and prenatal genetic testing	364
Targeted therapy for osteoarthritis: progress and pitfalls	359
Continuous glucose monitoring and intrapersonal variability in fasting glucose	356
The inconvenient reality of AI-assisted embryo selection in IVF	356
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	356
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	353
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	350
In utero origin of myelofibrosis presenting in adult monozygotic twins	346
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	345
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	336
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	335
Supported decision-making can advance clinical research participation for people with disabilities	333
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	331
Author Correction: Unexplained post-acute infection syndromes	330
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	325
Integrated image-based deep learning and language models for primary diabetes care	320
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	318
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	316
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	316
Anemia in women — an intractable problem that requires innovative solutions	312
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	310
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	305
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing	304
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	303
The landscape of mRNA nanomedicine	299
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	298
Will ChatGPT transform healthcare?	296
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	292
Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial	291
Integrating the environmental and genetic architectures of aging and mortality	288
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	284

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	282
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	282
WHO sets research agenda for refugee and migrant health	281
The Yearbook	280
Machine learning improves prediction of clinical outcomes for invasive breast cancers	280
An anti-obesity drug from the diabetes toolbox	276
An outdated loophole is letting faulty lab tests hit the market	275
Handwriting with a brain implant	270
High COVID-19 death toll in Africa	269
Rethinking aspirin for heart health	269
Health in the Amazon	268
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	267
The visible and hidden mortality caused by flooding	264
Using unlabeled data to enhance fairness of medical AI	263
Mapping the cellular landscape of the brain	261
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	260
Author Correction: Identification of a new orthonairovirus associated with human febrile illness in China	259
Familial confounding in the associations between maternal health and autism	257
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	256
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	255
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	253
Steps to prevent and respond to an H5N1 epidemic in the USA	252
A benchmarking crisis in biomedical machine learning	251
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	249
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	246
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	245
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	244
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	242
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	240
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection	240
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	239
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	239
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	237
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	237
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	237
Use of mobile diagnostics and digital clinical trials in cardiology	236
Coproducing health research with Indigenous peoples	234
An African One Health network for antimicrobial resistance and neglected tropical diseases	234
The expanding universe of checkpoint inhibitors for nasopharyngeal cancer	233
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	230
A gene-by-sex interaction contributes to liver disease susceptibility in women	229
Health benefits of calorie restriction	227
Prenatal exposure to famine affects lifelong health	225
How patient advocates influence health policy	224
Meningioma risk stratification with a targeted gene-expression biomarker	223
siRNA therapy lowers triglycerides in patients with rare condition	223
The effect of embryonic genome imbalances on pregnancy	220
Brain pathology of COVID-19	220
Using genetics to predict toxicity of cancer immunotherapy	216
Menstrual health without stigma	215
Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination	214
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	214
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	212
Partial recovery of visual function in a blind patient after optogenetic therapy	211
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	209
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	207
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	205
Mpox continues to spread in Africa and threatens global health security	203
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	201
Artificial intelligence–enabled electrocardiograms for identification of patients with low ejection fraction: a pragmatic, randomized clinical trial	201
Genome-wide polygenic score to predict chronic kidney disease across ancestries	200
Advancing global antibiotic research, development and access	200
The limits of fair medical imaging AI in real-world generalization	199
Emerging diagnostics and therapeutics for Alzheimer disease	198
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	196
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	194
Clinical AI tools must convey predictive uncertainty for each individual patient	194
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	192
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	190
AI-generated text may have a role in evidence-based medicine	189
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	188
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	186
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	186
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	186
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	186
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	186
Self-improving generative foundation model for synthetic medical image generation and clinical applications	185
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	185
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	185
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	184

Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	183
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	183
An integrated cell atlas of the lung in health and disease	183
Pig-to-human transplants inch closer to reality	181
Gene therapy for alcohol-use disorder	181
ALS therapy hits molecular mark but misses clinical one	181
Could video games be good for your health?	181
A pinch of salt for heart disease	179
A smart solution for detecting ear problems	179
A human brain circuit for addiction remission	179
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	179
AI-guided precision parenteral nutrition for neonatal intensive care units	178
Challenges with benchmarking of MDMA-assisted psychotherapy	177
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	175
Reduction in life expectancy in Brazil after COVID-19	175
Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial	174
Cities, communities and clinics can be testbeds for human exposome and aging research	174
The economic value of reducing avoidable mortality	173
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology	173
Why paying individual people for their health data is a bad idea	172
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	170
A federated learning system for precision oncology in Europe: DigiONE	169
Multi-ancestry polygenic mechanisms of type 2 diabetes	168
Wearable sensors enable personalized predictions of clinical laboratory measurements	168
The impact of school opening model on SARS-CoV-2 community incidence and mortality	167
City-level impact of extreme temperatures and mortality in Latin America	165
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	165
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	163
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	162
A H3K27M-targeted vaccine in adults with diffuse midline glioma	162
The unseen climate health risks of antimicrobial resistance in urban informal settlements	161
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	161
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	159
Targeted radiation adds precision to cancer therapy	159
Deciphering the heritability of human height	159
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	157
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	156
A framework to assess the effects of genetic risk factors on disability-adjusted life years	155
Human embryo models offer glimpse into early development	155
Gene-editing breakthrough for a rare hereditary disorder	154
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	154
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	154
Determinants and inequities in healthy working life expectancy in China	154
Using implementation science to navigate the complexity of integrating genomics into healthcare	153
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	151
Imatinib and the dawn of precision cancer therapy	151
New neurons are born in the adult human brain	150
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	150
Countering the impact of the climate crisis on health will require data	149
Adequate information about clinical trial results must be given to participants	149
COVID-19 vaccination gives hope to eradicate polio	148
Author Correction: Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis	147
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	147
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	146
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	146
A neural stem-cell treatment for progressive multiple sclerosis	145
Hibernation science harnessed to treat obesity and modify metabolism	144
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	143
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	140
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	139
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	139
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination	139
Caution at psychiatry’s psychedelic frontier	138
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	138
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	138
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	137
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	137
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	136
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	136
Bacterial SNPs in the human gut microbiome associate with host BMI	136
Targeting KRAS in cancer	133
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	132
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	132
Mapping the mediators of Alzheimer’s disease	131
Balancing the risks of HIV transmission at low viral load	130
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	130
‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease	129
Boosting the efficacy of emergency contraception	129
Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering	129
Tumor infiltrating lymphocyte approval heralds new era for precision cancer immunotherapy	128
The role of placebo control in clinical trials for neurodegenerative diseases	127
Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial	126
It’s time to send children back to school	126
11 clinical trials that will shape medicine in 2022	125
Large floods drive changes in cause-specific mortality in the United States	124
Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis	124
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	124
Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality	123
Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases	122
Facilitating limb movement after stroke	122
Pakistan is failing in maternal and neonatal tetanus elimination	122
Building resilience in heatwaves	122
Evolution, genetic diversity, and health	121
Gene therapies should be for all	121
Monitoring key epidemiological parameters of SARS-CoV-2 transmission	121