Nature Medicine

Article	Citations
AI to expand the reach of oncology trials	3415
CAR T cells drive multiple myeloma out	3303
Immunity boost against pancreatic cancer	1761
Treatment boost for spinal muscular atrophy	1317
Tocilizumab for the treatment of severe COVID-19	1118
Oligonucleotides get triglycerides under control	973
Gene therapy helps children with immunodeficiency	906
An implant to treat cluster headaches	840
A solid start for gene therapy in Tay–Sachs disease	810
A genetic test to predict adverse drug reactions	736
Digital intervention improves tuberculosis treatment outcomes	687
Health nationalism in Aotearoa New Zealand during COVID-19: problems for global health equity	633
Combination treatment for immune-mediated HIV remission	595
MRI decoders translate thoughts into words	572
Telehealth enables safe medication abortion in shifting health and legal contexts	570
Precision medicine for advanced breast cancer	553
Making treatment decisions in a void of information	552
siRNA against anti-thrombin reduces bleeding in hemophilia	527
International transmission complicates HCV elimination	524
Questionable role of new techniques in IVF embryo culture	509
Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses	501
Population-based, first-tier genomic newborn screening in the maternity ward	500
Genetic basis of early onset and progression of type 2 diabetes in South Asians	494
Phenome-wide associations of sleep characteristics in the Human Phenotype Project	490
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	483

Diabetes risk after COVID-19	475
Sustainable, low-cost cancer diagnostics	473
Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis	469
Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial	464
Big tech companies invest billions in health research	461
CAR T cells reach clinical milestone in prostate cancer	455
Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution	454
Cancer immunotherapy: the quest for better biomarkers	451
Diagnostic classification of childhood cancer using multiscale transcriptomics	451
Wearables and AI better predict the progression of muscular dystrophy	424
Sexual and reproductive health and rights must be enshrined in universal healthcare	420
In vivo gene editing for inherited vision loss	405
Reporting standards for the use of large language model-linked chatbots for health advice	403
Heterogeneity and predictors of the effects of AI assistance on radiologists	398
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access	394
RET inhibitors go tumor-agnostic	393
Unmasking the elusive erythropoietin-producing ‘Norn’ cell	391
CAR-T cell therapies for large B cell lymphoma	383
Repurposing a diabetes drug to treat Parkinson’s disease	383
Psychiatry goes psychedelic	381
Cracking the code of the Y chromosome	357
Vaccine development needs a boost	357
LLMs get a medical education	355
Immunotherapy for esophageal cancer	348
Recapitulating sensory feedback in artificial skin	347
Deciphering the genetic architecture of pain intensity	343
The international Unity study for antivirals against mpox is a blueprint for future epidemics	343
“I had to be with bodyguards with guns”—attacks on scientists during the pandemic	337
FDA approves first drug to delay type 1 diabetes	336
Subcutaneous infusion of exenatide and cardiovascular outcomes in type 2 diabetes: a non-inferiority randomized controlled trial	332
Hitting the right notes for pain relief	325
Easing the pain of endometriosis	324
Can an implanted minipump deliver for diabetes patients?	323
Career equity in medicine	318
Mapping peripartum brain changes in women	317
Predicting breast cancer risk in women of African ancestry	316
A plethora of gene therapies for hemoglobinopathies	308
SCOTUS v. reproductive health in United States	306
A randomized controlled trial to test financial incentives for COVID-19 vaccination in Ghana	306
Innovative approaches from recent conflicts can aid the health crisis in Ukraine	306
Renewed action on hypertension to improve health and reduce global inequalities	301
Lingering cardiac involvement in previously well people after mild COVID-19	297
The capacity of brain circuits to enhance psychiatry	294
What will it take to make precision health a global reality	289
Navigating the health frontiers of Africa’s climate challenge	286
Precision public health in the era of genomics and big data	285
Ancestral SARS-CoV-2-specific T cells cross-recognize Omicron	283
JAK inhibitor reinvigorates cancer immunotherapy	281
A life-course multisectoral approach to precision health in LMICs	280
A little knowledge can be a dangerous thing	277

Supported decision-making can advance clinical research participation for people with disabilities	277
Improving the FITness of colorectal cancer screening	277
Tackling under-reporting of violence against women	276
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	269
Rare and common genetic determinants of metabolic individuality and their effects on human health	264
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	262
The poorest and most vulnerable communities should be the first to be vaccinated	262
Base editors in the clinic	260
A blood test for prenatal genetic diagnosis	258
Telemedicine for abortion access	254
Epigenomic dysregulation correlates with arachnoid cyst formation and neurodevelopmental symptoms	253
Telemonitoring for complicated pregnancies	251
Persistent mutations render cancer cells susceptible to immunotherapy	251
Putting the brakes on Alzheimer’s disease	249
AI as a new paradigm for risk-based screening for breast cancer	247
Progress at last against RSV	247
Reply to: Concerns about the Burden of Proof studies	246
Trialing precision medicine for type 2 diabetes	244
Liquid biopsies and tumor mutational burden: the cutoff conundrum	244
Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial	241
Microbiome research in Africa must be based on equitable partnerships	241
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	240
Integrated image-based deep learning and language models for primary diabetes care	239
Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition	238
Hippocampal network activity forecasts epileptic seizures	237
Brain aging patterns in a large and diverse cohort of 49,482 individuals	236
Health benefits of fermented foods	230
The recombinant shingles vaccine is associated with lower risk of dementia	230
Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder	230
Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk	229
A common framework for health data governance standards	228
New and emerging approaches to treat psychiatric disorders	228
Hindsight is 2020? Lessons in global health governance one year into the pandemic	223
Concerns about the Burden of Proof studies	222
HIPAA is a misunderstood and inadequate tool for protecting medical data	219
Evidence-based COVID-19 policy-making in schools	218
Aiming for equitable precision medicine in diabetes	217
Long-term health risks linked to childbirth	216
A global initiative to deliver precision health in diabetes	215
Five award-winning researchers share their tips for inclusive health research	214
Monitoring metabolic changes during the menstrual cycle	214
Rise in ambient temperature is associated with increased mortality in Latin America	212
Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation	209
Gene editing advances on all fronts	208
Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes	208
Genetic testing in the neonatal ICU	207
How publishers can fight misinformation in and about science and medicine	206
Phthalate exposure linked to adverse pregnancy outcomes	204
Prescription for a healthy diet	204
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	203
Dementia research needs a global approach	202
Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation	200
The uncertain science of preimplantation and prenatal genetic testing	200
How virtual reality therapy is shaping mental health	200
Delivering high-quality childbirth care	195
Dynamics and durability of HIV-1 neutralization are determined by viral replication	193
The role of research in China’s successful elimination of malaria	190
Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved	190
Evidence for iatrogenic transmission of Alzheimer’s disease	188
Effectiveness and safety of telehealth medication abortion in the USA	188
Screening for fibrosis to diagnose liver diseases early: the LIVERSCREEN project	186
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist	186
HIV prevention through PrEP in cisgender women	184
Clinical trials assess a precision-medicine approach to cancer screening	184
Semaglutide and risk of suicidal ideations	182
Datopotamab–deruxtecan in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial	181
A foundation model for clinician-centered drug repurposing	181
Spatial multiomic landscape of the human placenta at molecular resolution	180
Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial	179
Fratricide-resistant CD7-CAR T cells in T-ALL	179
An explainable foundation model for drug repurposing	179
Computational brain models map diversity embedded in aging and dementia	179
HIV-1 remission following stem cell transplant without CCR5Δ32 mutation	179
The battle for COVID-19 vaccines highlights the need for a new global governance mechanism	177
Citizen science as an instrument for women’s health research	177
Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases	176
Integrative microbiomics in bronchiectasis exacerbations	175
Vaccine development for emerging infectious diseases	174
One Health interprofessional stewardship to combat antimicrobial resistance	173
Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis	173

APOE4 homozygosity is a new genetic form of Alzheimer’s disease	171
Putting the MD back into MDMA	170
An AI chatbot for talking therapy referrals	169
Tissue perfusion pressure enables continuous hemodynamic evaluation and risk prediction in the intensive care unit	169
Molecular pathology markers of FTD and ALS in blood extracellular vesicles	169
Long COVID includes breathing and reproductive problems and has a range of risk factors	168
COVID-19 vaccines: acting on the evidence	166
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing	165
HIV drug resistance to integrase inhibitors in low- and middle-income countries	165
The future of personalized brain stimulation	164
Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping	163
Surgery versus no surgery in platinum-sensitive relapsed ovarian cancer: final overall survival analysis of the SOC-1 randomized phase 3 trial	163
Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial	162
COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence	162
Estimating the total effect of anthropogenic climate change on human health and wellbeing	162
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma	161
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	160
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade	160
A brain cell atlas integrating single-cell transcriptomes across human brain regions	160
Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome	159
Polygenic embryo testing: understated ethics, unclear utility	155
A call to invest in emergency, critical and operative care for universal health coverage	155
Sick as a dog: how understanding canine diseases will save human lives	155
Every baby deserves access to genetic screening	152
Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial	152
Point-of-care testing for sepsis in remote Australia and for First Nations peoples	151
Building trust and transparency in biomedical sciences through data walks	151
The German Network for Personalized Medicine to enhance patient care and translational research	150
Sex-specific genetic architecture of blood pressure	150
Retrieval of vector integration sites from cell-free DNA	149
Viral and host mediators of non-suppressible HIV-1 viremia	149
A candidate antibody drug for prevention of malaria	149
The centuries long pursuit to map the human lymphatic system	147
Towards personalizing radiotherapy for brain metastasis	146
A lightspeed approach to pandemic drug development	146
New AI regulation in the EU seeks to reduce risk without assessing public benefit	146
Challenges to identifying risk versus protective factors in Alzheimer’s disease	145
Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis	145
Influence of believed AI involvement on the perception of digital medical advice	144
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	142
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	142
The European Health Data Space can be a boost for research beyond borders	142
The inconvenient reality of AI-assisted embryo selection in IVF	141
High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity	140
Are GLP-1 drugs really for everybody?	140
Echocardiographic screening for heart failure and optimization of the care pathway for individuals with pacemakers: a randomized controlled trial	138
Mpox is a public health emergency — what happens now?	138
Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography	138
A gut microbial signature for combination immune checkpoint blockade across cancer types	137
Disparities in healthy working life expectancy in different Chinese populations	137
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain	135
Finding the right target for drug-resistant inflammatory bowel disease	134
Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial	134
The unknown efficacy of tecovirimat against monkeypox	132
The WHO genomics program of work for equitable implementation of human genomics for global health	130
A deep learning system for predicting time to progression of diabetic retinopathy	130
Pembrolizumab in brain metastases of diverse histologies: phase 2 trial results	128
Pandemic-related barriers to the success of women in research: a framework for action	128
Solving medicine’s data bottleneck: Nightingale Open Science	127
Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial	127
Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial	127
Development of a clinical polygenic risk score assay and reporting workflow	126
Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial	125
Belantamab mafodotin, pomalidomide and dexamethasone in refractory multiple myeloma: a phase 1/2 trial	124
Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial	124
Autoimmune disease is the next frontier for CAR T cell therapy	124
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial	123
Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial	122
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study	122
Evaluating generalizability of oncology trial results to real-world patients using machine learning-based trial emulations	122
Geographic sources of ozone air pollution and mortality burden in Europe	122
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor	121
A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories	121
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome	120
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer	119
Long COVID after breakthrough SARS-CoV-2 infection	117
Clinical outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) variant and BA.1/BA.1.1 or BA.2 subvariant infection in Southern California	116
The landscape of mRNA nanomedicine	115
Acute and postacute sequelae associated with SARS-CoV-2 reinfection	115
Incident type 2 diabetes attributable to suboptimal diet in 184 countries	115
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	114
Will ChatGPT transform healthcare?	113
Intratumoral heterogeneity in cancer progression and response to immunotherapy	113
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	111
Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma	111
Effects of urban living environments on mental health in adults	111
IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies	111
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment	111
Postacute sequelae of COVID-19 at 2 years	111
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps	110
Tracing the origins of antibiotic resistance	110
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial	110
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	110
Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury	108
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders	108