Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2417
A genetic test to predict adverse drug reactions	1951
LLMs get a medical education	1632
Liquid biopsies and tumor mutational burden: the cutoff conundrum	880
In vivo gene editing for inherited vision loss	824
Recapitulating sensory feedback in artificial skin	803
Telemonitoring for complicated pregnancies	775
Rise in ambient temperature is associated with increased mortality in Latin America	714
Easing the pain of endometriosis	713
SCOTUS v. reproductive health in United States	670
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	654
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	644
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	614
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	614
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	577
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	554
A global metric of immune health	550
HIV prevention through PrEP in cisgender women	517
An AI chatbot for talking therapy referrals	510
First tumor-agnostic approval for an ADC	503
The effect of geopolitical flux on antimicrobial resistance	492
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	472
Estimating the total effect of anthropogenic climate change on human health and wellbeing	462
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	448
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	443

HIPAA is a misunderstood and inadequate tool for protecting medical data	440
In utero origin of myelofibrosis presenting in adult monozygotic twins	437
The uncertain science of preimplantation and prenatal genetic testing	436
Hippocampal network activity forecasts epileptic seizures	433
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	420
Supported decision-making can advance clinical research participation for people with disabilities	419
Gene-edited pig liver successfully transplanted into human	414
Author Correction: Digital consults in heart failure care: a randomized controlled trial	410
The capacity of brain circuits to enhance psychiatry	406
FDA approves first drug to delay type 1 diabetes	406
The role of research in China’s successful elimination of malaria	405
AI as a new paradigm for risk-based screening for breast cancer	399
Author Correction: Unexplained post-acute infection syndromes	397
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	395
Combating vaccine revisionism	393
Ending the taboo on periods and period problems	391
Concerns about the Burden of Proof studies	382
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	375
The inconvenient reality of AI-assisted embryo selection in IVF	371
Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets	367
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	361
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	359
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	356
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	350
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	348
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	347
Targeted therapy for osteoarthritis: progress and pitfalls	346
An explainable foundation model for drug repurposing	345
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	345
PD-L1 and the dawn of modern cancer immunotherapy	344
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	338
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	337
Continuous glucose monitoring and intrapersonal variability in fasting glucose	334
Solving medicine’s data bottleneck: Nightingale Open Science	334
The WHO genomics program of work for equitable implementation of human genomics for global health	334
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	332
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	331
How virtual reality therapy is shaping mental health	329
Will ChatGPT transform healthcare?	327
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	322
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	321
Integrating the environmental and genetic architectures of aging and mortality	319
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	318
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	313
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	313
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	312
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	303
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	302
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	302
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	298

Integrated image-based deep learning and language models for primary diabetes care	297
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	297
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	294
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	289
The landscape of mRNA nanomedicine	285
Health in the Amazon	281
An outdated loophole is letting faulty lab tests hit the market	280
An anti-obesity drug from the diabetes toolbox	279
WHO sets research agenda for refugee and migrant health	278
How patient advocates influence health policy	277
Mapping the cellular landscape of the brain	277
Using genetics to predict toxicity of cancer immunotherapy	276
The effect of embryonic genome imbalances on pregnancy	275
Brain pathology of COVID-19	274
Menstrual health without stigma	274
Microbes convert plastic waste into paracetamol	273
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	272
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	272
An international treaty to regulate misuse of alcohol and cannabis	272
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	266
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	265
A gene-by-sex interaction contributes to liver disease susceptibility in women	264
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	264
An African One Health network for antimicrobial resistance and neglected tropical diseases	259
Health benefits of calorie restriction	259
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	251
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	248
The visible and hidden mortality caused by flooding	247
siRNA therapy lowers triglycerides in patients with rare condition	246
Prenatal exposure to famine affects lifelong health	245
Machine learning improves prediction of clinical outcomes for invasive breast cancers	244
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	244
Use of mobile diagnostics and digital clinical trials in cardiology	242
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	241
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	241
Overcoming zero-sum thinking to advance US population health	240
The mind-bending power of placebo	239
The economics of investing in women and health	238
Geographical shifting of cholera burden in Africa and its implications for disease control	238
Meningioma risk stratification with a targeted gene-expression biomarker	236
Coproducing health research with Indigenous peoples	233
Peace in Colombia requires healing the scars of conflict on the mind and brain	233
A brief digital cognitive test improves Alzheimer’s disease detection	232
Using unlabeled data to enhance fairness of medical AI	232
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	231
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	230
Strategies for shortening tuberculosis therapy	229
Familial confounding in the associations between maternal health and autism	229
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	227
A benchmarking crisis in biomedical machine learning	227
Mpox continues to spread in Africa and threatens global health security	226
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	223
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	222
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	222
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	217
AI-generated text may have a role in evidence-based medicine	215
Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial	214
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	211
Steps to prevent and respond to an H5N1 epidemic in the USA	209
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	208
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	208
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	208
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	208
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	207
Clinical AI tools must convey predictive uncertainty for each individual patient	206
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	206
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	206
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	206
Advancing global antibiotic research, development and access	205
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	204
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	204
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	203
Genome-wide polygenic score to predict chronic kidney disease across ancestries	203
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	201
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	200
Self-improving generative foundation model for synthetic medical image generation and clinical applications	199
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	199
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	198
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	196
Air pollution interventions for health	195

Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	195
The limits of fair medical imaging AI in real-world generalization	194
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	193
Emerging diagnostics and therapeutics for Alzheimer disease	191
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	190
An integrated cell atlas of the lung in health and disease	189
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	188
Gene therapy for alcohol-use disorder	188
Could video games be good for your health?	187
A human brain circuit for addiction remission	187
ALS therapy hits molecular mark but misses clinical one	186
A smart solution for detecting ear problems	186
Pig-to-human transplants inch closer to reality	186
A framework to assess the effects of genetic risk factors on disability-adjusted life years	185
Human embryo models offer glimpse into early development	183
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	178
A neural stem-cell treatment for progressive multiple sclerosis	178
Concern for the validity of short-term dietary crossover trials	177
Permissive gun laws in the USA linked to thousands of child deaths	177
Hope for patients facing deadly infections	175
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	174
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	173
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	172
New neurons are born in the adult human brain	172
Gene-editing breakthrough for a rare hereditary disorder	170
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	169
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	169
Imatinib and the dawn of precision cancer therapy	169
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	168
Adequate information about clinical trial results must be given to participants	168
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	166
Why paying individual people for their health data is a bad idea	166
Countering the impact of the climate crisis on health will require data	166
Targeted radiation adds precision to cancer therapy	166
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	164
AI-guided precision parenteral nutrition for neonatal intensive care units	162
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	161
Hibernation science harnessed to treat obesity and modify metabolism	160
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	159
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	159
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	158
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	157
Bacterial SNPs in the human gut microbiome associate with host BMI	156
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	156
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	155
The economic value of reducing avoidable mortality	155
Determinants and inequities in healthy working life expectancy in China	155
Cities, communities and clinics can be testbeds for human exposome and aging research	154
A federated learning system for precision oncology in Europe: DigiONE	154
Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020	153
Deciphering the heritability of human height	152
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	150
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	150
Teaching machines to doubt	149
The unseen climate health risks of antimicrobial resistance in urban informal settlements	149
Africa’s continental plan to end cholera	149
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	148
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	148
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	148
Using implementation science to navigate the complexity of integrating genomics into healthcare	148
City-level impact of extreme temperatures and mortality in Latin America	147
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	147
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	146
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	145
A H3K27M-targeted vaccine in adults with diffuse midline glioma	144
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	144
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	141
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	141
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	140
Multi-ancestry polygenic mechanisms of type 2 diabetes	139
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	139
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	139
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	139
Targeting KRAS in cancer	138
Mapping the mediators of Alzheimer’s disease	138
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	137
Boosting the efficacy of emergency contraception	136
Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance	136
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	136
The role of placebo control in clinical trials for neurodegenerative diseases	136
Balancing the risks of HIV transmission at low viral load	135
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	135
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results	134
Publisher Correction: Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial	134
Biological and health effects of fire smoke exposure	134
Publisher Correction: Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses	134
Location matters for brain gene therapy in lysosomal disorders	134
Author Correction: Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial	134
Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression	134
Education does not affect memory decline or brain aging	134
Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial	133
Lifetime benefits of comprehensive medical therapy in heart failure with mildly reduced or preserved ejection fraction	132
Surge in endometriosis research after decades of underfunding could herald new era for women’s health	132
Evolution, genetic diversity, and health	131
Ebola vaccine safe for mothers and infants	130