Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2050
A genetic test to predict adverse drug reactions	1730
LLMs get a medical education	1564
Liquid biopsies and tumor mutational burden: the cutoff conundrum	829
In vivo gene editing for inherited vision loss	739
Recapitulating sensory feedback in artificial skin	701
Telemonitoring for complicated pregnancies	695
Rise in ambient temperature is associated with increased mortality in Latin America	682
Easing the pain of endometriosis	616
SCOTUS v. reproductive health in United States	609
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	606
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	560
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	535
Can an implanted minipump deliver for diabetes patients?	530
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	529
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	514
The inconvenient reality of AI-assisted embryo selection in IVF	509
The capacity of brain circuits to enhance psychiatry	498
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	475
Combating vaccine revisionism	473
A global metric of immune health	468
HIPAA is a misunderstood and inadequate tool for protecting medical data	464
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	454
First tumor-agnostic approval for an ADC	453
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	434

Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	428
The effect of geopolitical flux on antimicrobial resistance	424
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	414
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	410
Ending the taboo on periods and period problems	403
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	396
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	385
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	379
How virtual reality therapy is shaping mental health	378
The WHO genomics program of work for equitable implementation of human genomics for global health	376
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	373
AI as a new paradigm for risk-based screening for breast cancer	369
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	365
Estimating the total effect of anthropogenic climate change on human health and wellbeing	365
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	364
Concerns about the Burden of Proof studies	362
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	358
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	356
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	356
Solving medicine’s data bottleneck: Nightingale Open Science	356
Anemia in women — an intractable problem that requires innovative solutions	356
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	355
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	344
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	344
An explainable foundation model for drug repurposing	336
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	336
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	336
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	333
Integrated image-based deep learning and language models for primary diabetes care	332
HIV prevention through PrEP in cisgender women	330
PD-L1 and the dawn of modern cancer immunotherapy	328
In utero origin of myelofibrosis presenting in adult monozygotic twins	327
An AI chatbot for talking therapy referrals	326
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	325
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	324
Supported decision-making can advance clinical research participation for people with disabilities	319
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	316
Gene-edited pig liver successfully transplanted into human	314
The role of research in China’s successful elimination of malaria	311
Author Correction: Digital consults in heart failure care: a randomized controlled trial	306
FDA approves first drug to delay type 1 diabetes	303
The uncertain science of preimplantation and prenatal genetic testing	299
Author Correction: Unexplained post-acute infection syndromes	293
Targeted therapy for osteoarthritis: progress and pitfalls	292
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	290
Integrating the environmental and genetic architectures of aging and mortality	287
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	286
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	282
Hippocampal network activity forecasts epileptic seizures	280
Continuous glucose monitoring and intrapersonal variability in fasting glucose	279

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	279
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	278
Will ChatGPT transform healthcare?	275
The landscape of mRNA nanomedicine	275
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	272
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	272
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	270
Rethinking aspirin for heart health	269
Health in the Amazon	269
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	269
An outdated loophole is letting faulty lab tests hit the market	267
An anti-obesity drug from the diabetes toolbox	266
WHO sets research agenda for refugee and migrant health	265
The Yearbook	262
Mapping the cellular landscape of the brain	258
How patient advocates influence health policy	254
Using genetics to predict toxicity of cancer immunotherapy	253
The effect of embryonic genome imbalances on pregnancy	252
Brain pathology of COVID-19	251
Advancing global antibiotic research, development and access	250
Menstrual health without stigma	248
Air pollution interventions for health	246
Peace in Colombia requires healing the scars of conflict on the mind and brain	245
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	240
Microbes convert plastic waste into paracetamol	240
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	237
Familial confounding in the associations between maternal health and autism	234
An international treaty to regulate misuse of alcohol and cannabis	234
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	233
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	232
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	231
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	229
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	229
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	227
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	227
Strategies for shortening tuberculosis therapy	227
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	226
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	226
A gene-by-sex interaction contributes to liver disease susceptibility in women	223
Health benefits of calorie restriction	221
An African One Health network for antimicrobial resistance and neglected tropical diseases	220
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	219
Steps to prevent and respond to an H5N1 epidemic in the USA	218
The visible and hidden mortality caused by flooding	217
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	217
siRNA therapy lowers triglycerides in patients with rare condition	216
Machine learning improves prediction of clinical outcomes for invasive breast cancers	212
Prenatal exposure to famine affects lifelong health	212
Coproducing health research with Indigenous peoples	211
Overcoming zero-sum thinking to advance US population health	209
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	209
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	208
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	208
Using unlabeled data to enhance fairness of medical AI	207
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	205
A benchmarking crisis in biomedical machine learning	205
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	205
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	204
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	202
Self-improving generative foundation model for synthetic medical image generation and clinical applications	202
Mpox continues to spread in Africa and threatens global health security	201
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	200
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	199
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	199
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	198
Meningioma risk stratification with a targeted gene-expression biomarker	197
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	196
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	195
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	194
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	193
Geographical shifting of cholera burden in Africa and its implications for disease control	192
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	191
The economics of investing in women and health	191
Clinical AI tools must convey predictive uncertainty for each individual patient	191
Use of mobile diagnostics and digital clinical trials in cardiology	191
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	189
AI-generated text may have a role in evidence-based medicine	188
Genome-wide polygenic score to predict chronic kidney disease across ancestries	188
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	187
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	187

An integrated cell atlas of the lung in health and disease	187
The limits of fair medical imaging AI in real-world generalization	186
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	185
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	185
Emerging diagnostics and therapeutics for Alzheimer disease	184
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	184
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	183
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	180
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	179
Gene therapy for alcohol-use disorder	179
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	179
Could video games be good for your health?	178
A human brain circuit for addiction remission	176
A smart solution for detecting ear problems	175
Pig-to-human transplants inch closer to reality	174
The unseen climate health risks of antimicrobial resistance in urban informal settlements	174
ALS therapy hits molecular mark but misses clinical one	174
Determinants and inequities in healthy working life expectancy in China	174