Nature Medicine

Article	Citations
SCOTUS v. reproductive health in United States	1928
Rise in ambient temperature is associated with increased mortality in Latin America	1644
Telemonitoring for complicated pregnancies	1535
LLMs get a medical education	980
Questionable role of new techniques in IVF embryo culture	814
A genetic test to predict adverse drug reactions	711
Easing the pain of endometriosis	671
Liquid biopsies and tumor mutational burden: the cutoff conundrum	668
A global metric of immune health	663
Recapitulating sensory feedback in artificial skin	607
In vivo gene editing for inherited vision loss	603
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	598
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	532
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	530
The inconvenient reality of AI-assisted embryo selection in IVF	510
The capacity of brain circuits to enhance psychiatry	509
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	491
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	483
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	478
Can an implanted minipump deliver for diabetes patients?	461
HIV prevention through PrEP in cisgender women	458
The uncertain science of preimplantation and prenatal genetic testing	455
An AI chatbot for talking therapy referrals	446
Estimating the total effect of anthropogenic climate change on human health and wellbeing	443
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	441

Gene-edited pig liver successfully transplanted into human	437
Supported decision-making can advance clinical research participation for people with disabilities	430
FDA approves first drug to delay type 1 diabetes	430
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	428
The role of research in China’s successful elimination of malaria	418
Author Correction: Digital consults in heart failure care: a randomized controlled trial	418
Author Correction: Unexplained post-acute infection syndromes	402
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	394
AI as a new paradigm for risk-based screening for breast cancer	394
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	393
First tumor-agnostic approval for an ADC	382
Anemia in women — an intractable problem that requires innovative solutions	369
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	367
Combating vaccine revisionism	364
Concerns about the Burden of Proof studies	364
How virtual reality therapy is shaping mental health	360
An explainable foundation model for drug repurposing	356
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	355
The effect of geopolitical flux on antimicrobial resistance	354
Solving medicine’s data bottleneck: Nightingale Open Science	354
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	351
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	345
Ending the taboo on periods and period problems	344
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	342
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	341
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	339
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	339
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	336
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	332
Targeted therapy for osteoarthritis: progress and pitfalls	331
PD-L1 and the dawn of modern cancer immunotherapy	327
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	324
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	324
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	324
HIPAA is a misunderstood and inadequate tool for protecting medical data	320
Hippocampal network activity forecasts epileptic seizures	316
Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial	312
Integrating the environmental and genetic architectures of aging and mortality	308
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	307
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	306
Integrated image-based deep learning and language models for primary diabetes care	305
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	300
Will ChatGPT transform healthcare?	295
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	292
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	290
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	290
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	287
Continuous glucose monitoring and intrapersonal variability in fasting glucose	280
In utero origin of myelofibrosis presenting in adult monozygotic twins	277
The WHO genomics program of work for equitable implementation of human genomics for global health	276

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	274
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	271
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	271
The landscape of mRNA nanomedicine	271
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	270
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	269
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	269
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	268
The Yearbook	265
WHO sets research agenda for refugee and migrant health	265
An anti-obesity drug from the diabetes toolbox	264
An outdated loophole is letting faulty lab tests hit the market	264
Rethinking aspirin for heart health	263
Health in the Amazon	261
The visible and hidden mortality caused by flooding	261
Mapping the cellular landscape of the brain	258
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	257
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	256
The expanding universe of checkpoint inhibitors for nasopharyngeal cancer	251
Steps to prevent and respond to an H5N1 epidemic in the USA	251
Clinical AI tools must convey predictive uncertainty for each individual patient	251
An international treaty to regulate misuse of alcohol and cannabis	246
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	245
The economics of investing in women and health	240
AI-generated text may have a role in evidence-based medicine	239
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	239
Strategies for shortening tuberculosis therapy	238
Air pollution interventions for health	237
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	233
Mpox continues to spread in Africa and threatens global health security	232
Overcoming zero-sum thinking to advance US population health	231
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	230
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	228
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	226
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	225
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	224
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	223
Advancing global antibiotic research, development and access	222
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	221
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	220
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	217
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	216
A gene-by-sex interaction contributes to liver disease susceptibility in women	215
Health benefits of calorie restriction	215
Prenatal exposure to famine affects lifelong health	214
How patient advocates influence health policy	212
siRNA therapy lowers triglycerides in patients with rare condition	211
Meningioma risk stratification with a targeted gene-expression biomarker	210
The effect of embryonic genome imbalances on pregnancy	209
Brain pathology of COVID-19	207
Using genetics to predict toxicity of cancer immunotherapy	205
Menstrual health without stigma	204
Use of mobile diagnostics and digital clinical trials in cardiology	203
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	203
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	203
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	202
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	202
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	202
Using unlabeled data to enhance fairness of medical AI	201
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	200
Peace in Colombia requires healing the scars of conflict on the mind and brain	200
Familial confounding in the associations between maternal health and autism	199
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	197
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	196
Geographical shifting of cholera burden in Africa and its implications for disease control	196
Microbes convert plastic waste into paracetamol	196
Machine learning improves prediction of clinical outcomes for invasive breast cancers	196
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	195
A benchmarking crisis in biomedical machine learning	194
Coproducing health research with Indigenous peoples	192
The limits of fair medical imaging AI in real-world generalization	192
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	191
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	190
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	188
Genome-wide polygenic score to predict chronic kidney disease across ancestries	187
An African One Health network for antimicrobial resistance and neglected tropical diseases	186
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	186
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	186
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	186
An integrated cell atlas of the lung in health and disease	185

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	184
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	184
Self-improving generative foundation model for synthetic medical image generation and clinical applications	184
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	183
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	183
Emerging diagnostics and therapeutics for Alzheimer disease	183
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	182
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	182
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	182
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	182
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	181
Gene therapy for alcohol-use disorder	174
Could video games be good for your health?	174
ALS therapy hits molecular mark but misses clinical one	173
Pig-to-human transplants inch closer to reality	171
A human brain circuit for addiction remission	171