Nature Medicine

(The H4-Index of Nature Medicine is 176. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
The proximal origin of SARS-CoV-23337
Temporal dynamics in viral shedding and transmissibility of COVID-192959
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection2700
Post-acute COVID-19 syndrome2436
Antibody responses to SARS-CoV-2 in patients with COVID-192211
Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections2095
Extrapulmonary manifestations of COVID-191954
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes1936
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-191815
Chronic inflammation in the etiology of disease across the life span1724
A global survey of potential acceptance of a COVID-19 vaccine1629
An inflammatory cytokine signature predicts COVID-19 severity and survival1573
Respiratory virus shedding in exhaled breath and efficacy of face masks1492
A serological assay to detect SARS-CoV-2 seroconversion in humans1436
Attributes and predictors of long COVID1291
Age-dependent effects in the transmission and control of COVID-19 epidemics1188
Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy1115
A single-cell atlas of the peripheral immune response in patients with severe COVID-191098
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding1096
Real-time tracking of self-reported symptoms to predict potential COVID-191045
Digital technology and COVID-19866
Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China858
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19805
SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma784
Long-term cardiovascular outcomes of COVID-19761
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection730
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies690
A dynamic COVID-19 immune signature includes associations with poor prognosis661
Artificial intelligence–enabled rapid diagnosis of patients with COVID-19608
Digital technologies in the public-health response to COVID-19600
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers574
COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries563
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies546
Seasonal coronavirus protective immunity is short-lasting544
Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia538
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease538
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera473
An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies459
Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2454
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation444
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma441
Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong437
SARS-CoV-2 infection of the oral cavity and saliva432
Determinants of COVID-19 disease severity in patients with cancer431
Single-cell immune landscape of human atherosclerotic plaques430
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants422
Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration416
Immune determinants of COVID-19 disease presentation and severity414
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial405
Looking beyond COVID-19 vaccine phase 3 trials402
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma388
Infection of bat and human intestinal organoids by SARS-CoV-2387
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein383
Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries373
Joint international consensus statement for ending stigma of obesity373
Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine369
Undulating changes in human plasma proteome profiles across the lifespan367
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda362
Understanding COVID-19 vaccine hesitancy361
Long COVID in a prospective cohort of home-isolated patients360
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals356
If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future351
Single-cell multi-omics analysis of the immune response in COVID-19349
AI in health and medicine342
Human postprandial responses to food and potential for precision nutrition342
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR338
Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial338
Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK336
Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks332
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination332
Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study331
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19326
On the responsible use of digital data to tackle the COVID-19 pandemic323
Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus318
Long COVID after breakthrough SARS-CoV-2 infection313
Clinical lessons learned from the first leg of the CAR T cell journey313
Targeting metastatic cancer312
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy311
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study309
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination308
Disease and healthcare burden of COVID-19 in the United States308
Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China304
CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer303
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity302
Sixteen novel lineages of SARS-CoV-2 in South Africa301
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors297
Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa296
Using human genetics to understand the disease impacts of testosterone in men and women296
Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis293
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease291
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes291
Human–computer collaboration for skin cancer recognition291
Modeling COVID-19 scenarios for the United States290
BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar290
Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants289
mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar289
Biomarkers for neurodegenerative diseases287
Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension286
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection285
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers283
Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection280
Intratumoral heterogeneity in cancer progression and response to immunotherapy279
Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer275
Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant274
Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial271
SARS-CoV-2 variants of concern are emerging in India271
A deep learning system for differential diagnosis of skin diseases270
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report269
Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination267
A rectal cancer organoid platform to study individual responses to chemoradiation265
Brown adipose tissue is associated with cardiometabolic health264
Four distinct trajectories of tau deposition identified in Alzheimer’s disease264
Wearable sensor data and self-reported symptoms for COVID-19 detection263
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids262
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination262
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant261
Deep learning-based classification of mesothelioma improves prediction of patient outcome259
Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial258
Partial recovery of visual function in a blind patient after optogenetic therapy257
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States256
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters256
Magnitude, demographics and dynamics of the effect of the first wave of the COVID-19 pandemic on all-cause mortality in 21 industrialized countries256
Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination254
Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling249
Deep learning in histopathology: the path to the clinic248
Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells247
Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors245
Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas243
Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals242
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis239
Combating COVID-19: health equity matters238
Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle235
The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial234
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer234
Regenerative lineages and immune-mediated pruning in lung cancer metastasis233
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial233
BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial233
Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands232
Symptoms and risk factors for long COVID in non-hospitalized adults229
Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units229
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers228
Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England228
COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence227
The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin226
Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial225
Caring for patients with cancer in the COVID-19 era220
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research219
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses218
Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom216
Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial216
Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection216
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease215
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics215
Plasma protein patterns as comprehensive indicators of health214
A stochastic agent-based model of the SARS-CoV-2 epidemic in France211
A single-cell landscape of high-grade serous ovarian cancer211
Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension209
Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration209
An immune-cell signature of bacterial sepsis206
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial202
Toward personalized treatment approaches for non-small-cell lung cancer202
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma201
Targeting the HIF2–VEGF axis in renal cell carcinoma200
High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade196
Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection196
Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma194
Sex differences in cardiometabolic disorders194
Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies193
Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist192
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial190
Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy188
Federated learning for predicting clinical outcomes in patients with COVID-19186
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma183
First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland180
Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern180
Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies177
Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19176