OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Medicine is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy	85
Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation	79
The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling	78
CircRNAs and their regulatory roles in cancers	69
Novel targeted therapies for Parkinson’s disease	66
Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3	64
Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways	63
The roles of the gut microbiota–miRNA interaction in the host pathophysiology	56
The pyroptosis-related gene signature predicts prognosis and indicates immune activity in hepatocellular carcinoma	56
CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study	54
METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho	53
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism	51
LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia	48
Escape from X chromosome inactivation and female bias of autoimmune diseases	47
LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis	46
Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway	43
MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6	41
ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to improve wound healing of diabetic foot ulcers	40
Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19	39
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation	39
FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress	38
Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis	38
Essential properties and pitfalls of colorimetric Reverse Transcription Loop-mediated Isothermal Amplification as a point-of-care test for SARS-CoV-2 diagnosis	37
Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis	37
G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1	36

LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy	36
Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism	35
Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors	35
Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes	35
Macrophages and cancer stem cells: a malevolent alliance	34
lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway	34
TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells	33
Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats	33
Clinical implications for dopaminergic and functional neuroimage research in cognitive symptoms of Parkinson’s disease	32
The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection	32
Long non-coding RNA XIST: a novel oncogene in multiple cancers	32
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1	32
New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases	30
Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer	30
Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease	29
Oxalate-induced apoptosis through ERS-ROS–NF-κB signalling pathway in renal tubular epithelial cell	29
PTEN inhibitor improves vascular remodeling and cardiac function after myocardial infarction through PI3k/Akt/VEGF signaling pathway	29
The involvement of neuroimmune cells in adipose innervation	29
Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling	29
Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90	29
Genotype-driven therapeutic developments in Parkinson’s disease	28
Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis	28
The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation	28
Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway	28
Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER–ERK–NF-κB signaling pathway	27
MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure	26
Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis	26
Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats	26
Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression	26
Exosomal microRNA-140-3p from human umbilical cord mesenchymal stem cells attenuates joint injury of rats with rheumatoid arthritis by silencing SGK1	26
CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis	26
Role of miRNA dysregulation in sepsis	25
Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype	25
microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene	25
The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF	25
Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway	25
Role of long non-coding RNA H19 in the development of osteoporosis	25
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy	25
Immunometabolism in biofilm infection: lessons from cancer	24
Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients	24
Zebrafish: an efficient vertebrate model for understanding role of gut microbiota	24
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals	24
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling	24
MCM2 in human cancer: functions, mechanisms, and clinical significance	24
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease	24
Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus	23
Long non-coding RNA profile study identifies a metabolism-related signature for colorectal cancer	23
Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis	23
Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism	23
LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma	23

MiR-27a-3p promotes the osteogenic differentiation by activating CRY2/ERK1/2 axis	23
MiR-206 regulates the Th17/Treg ratio during osteoarthritis	23
Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress	23
Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2	22
Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway	22
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine	22
Evaluation of serum tRF-23-Q99P9P9NDD as a potential biomarker for the clinical diagnosis of gastric cancer	21
Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα	21
The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion	21
Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis	21
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway	20
Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis	20
Fibroblast growth factor-2 alleviates the capillary leakage and inflammation in sepsis	20
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways	20
LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b	20
Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction	20
The mechanism of nicotinamide on reducing acute lung injury by inhibiting MAPK and NF-κB signal pathway	20