Molecular Medicine

Article	Citations
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy	85
Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation	79
The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling	78
CircRNAs and their regulatory roles in cancers	69
Novel targeted therapies for Parkinson’s disease	66
Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3	64
Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways	63
The roles of the gut microbiota–miRNA interaction in the host pathophysiology	56
The pyroptosis-related gene signature predicts prognosis and indicates immune activity in hepatocellular carcinoma	56
CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study	54
METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho	53
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism	51
LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia	48
Escape from X chromosome inactivation and female bias of autoimmune diseases	47
LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis	46
Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway	43
MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6	41
ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to improve wound healing of diabetic foot ulcers	40
Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19	39
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation	39
FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress	38
Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis	38
Essential properties and pitfalls of colorimetric Reverse Transcription Loop-mediated Isothermal Amplification as a point-of-care test for SARS-CoV-2 diagnosis	37
Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis	37
G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1	36

LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy	36
Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism	35
Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors	35
Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes	35
Macrophages and cancer stem cells: a malevolent alliance	34
lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway	34
TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells	33
Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats	33
Clinical implications for dopaminergic and functional neuroimage research in cognitive symptoms of Parkinson’s disease	32
The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection	32
Long non-coding RNA XIST: a novel oncogene in multiple cancers	32
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1	32
New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases	30
Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer	30
Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease	29
Oxalate-induced apoptosis through ERS-ROS–NF-κB signalling pathway in renal tubular epithelial cell	29
PTEN inhibitor improves vascular remodeling and cardiac function after myocardial infarction through PI3k/Akt/VEGF signaling pathway	29
The involvement of neuroimmune cells in adipose innervation	29
Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling	29
Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90	29
Genotype-driven therapeutic developments in Parkinson’s disease	28
Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis	28
The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation	28
Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway	28
Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER–ERK–NF-κB signaling pathway	27
MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure	26
Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis	26
Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats	26
Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression	26
Exosomal microRNA-140-3p from human umbilical cord mesenchymal stem cells attenuates joint injury of rats with rheumatoid arthritis by silencing SGK1	26
CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis	26
Role of miRNA dysregulation in sepsis	25
Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype	25
microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene	25
The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF	25
Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway	25
Role of long non-coding RNA H19 in the development of osteoporosis	25
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy	25
Immunometabolism in biofilm infection: lessons from cancer	24
Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients	24
Zebrafish: an efficient vertebrate model for understanding role of gut microbiota	24
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals	24
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling	24
MCM2 in human cancer: functions, mechanisms, and clinical significance	24
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease	24
Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus	23
Long non-coding RNA profile study identifies a metabolism-related signature for colorectal cancer	23
Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis	23
Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism	23
LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma	23

MiR-27a-3p promotes the osteogenic differentiation by activating CRY2/ERK1/2 axis	23
MiR-206 regulates the Th17/Treg ratio during osteoarthritis	23
Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress	23
Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2	22
Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway	22
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine	22
Evaluation of serum tRF-23-Q99P9P9NDD as a potential biomarker for the clinical diagnosis of gastric cancer	21
Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα	21
The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion	21
Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis	21
The mechanism of nicotinamide on reducing acute lung injury by inhibiting MAPK and NF-κB signal pathway	20
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway	20
Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis	20
Fibroblast growth factor-2 alleviates the capillary leakage and inflammation in sepsis	20
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways	20
LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b	20
Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction	20
Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease	19
Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases	19
Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes	19
Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome	19
Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients	19
Role of long noncoding RNA taurine‐upregulated gene 1 in cancers	18
Vagal afferent fibers contribute to the anti-inflammatory reactions by vagus nerve stimulation in concanavalin A model of hepatitis in rats	18
Activation of dopamine receptor D1 promotes osteogenic differentiation and reduces glucocorticoid-induced bone loss by upregulating the ERK1/2 signaling pathway	18
Diagnostic performance of automated, streamlined, daily updated exome analysis in patients with neurodevelopmental delay	18
Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway	18
ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice	18
MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway	18
Role of long non-coding RNA H19 in therapy resistance of digestive system cancers	18
FADD as a key molecular player in cancer progression	17
DMAG, a novel countermeasure for the treatment of thrombocytopenia	17
Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry	17
Depression of lncRNA MINCR antagonizes LPS-evoked acute injury and inflammatory response via miR-146b-5p and the TRAF6-NFkB signaling	17
EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes	17
Interleukin-22: a potential therapeutic target in atherosclerosis	17
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy	17
High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene	17
CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction	17
Oscillatory shear stress promotes angiogenic effects in arteriovenous malformations endothelial cells	17
CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro	17
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2	17
Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis	16
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway	16
Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome	16
Heterologous vaccine interventions: boosting immunity against future pandemics	16
UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis	16
Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism	16
Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks	16
LncRNA H19 induces immune dysregulation of BMMSCs, at least partly, by inhibiting IL-2 production	16
ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axis	16
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson’s disease models in vitro and vivo	15
LncRNA KCNA2-AS regulates spinal astrocyte activation through STAT3 to affect postherpetic neuralgia	15
The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo	15
Nuclear receptors: a bridge linking the gut microbiome and the host	15
MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice	15
Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes	15
Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way	15
The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis	15
Inflammatory macrophages interrupt osteocyte maturation and mineralization via regulating the Notch signaling pathway	15
m6A-modified circRNAs: detections, mechanisms, and prospects in cancers	15
OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats	15
Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling	14
Molecular hydrogen is a potential protective agent in the management of acute lung injury	14
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation	14
Expediting rare disease diagnosis: a call to bridge the gap between clinical and functional genomics	14
Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer	14
Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe reactions to SARS-CoV-2 infection	14
Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo	14
Molecular landscape of IDH-mutant astrocytoma and oligodendroglioma grade 2 indicate tumor purity as an underlying genomic factor	14
Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways	14
Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection	14
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm	13
Immunoglobulin G N-glycan, inflammation and type 2 diabetes in East Asian and European populations: a Mendelian randomization study	13
Overexpressed XRCC2 as an independent risk factor for poor prognosis in glioma patients	13
Genomic imbalances in the placenta are associated with poor fetal growth	13
NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties	13
IL-17 deficiency aggravates the streptozotocin‐induced diabetic nephropathy through the reduction of autophagosome formation in mice	13
Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice	13
LncRNA-ATB participates in the regulation of calcium oxalate crystal-induced renal injury by sponging the miR-200 family	13

PIAS3 suppresses damage in an Alzheimer’s disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway	12
High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis	12
Upregulated lncARAT in Schwann cells promotes axonal regeneration by recruiting and activating proregenerative macrophages	12
The emerging role of pyroptosis-related inflammasome pathway in atherosclerosis	12
MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes	12
The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells	12
The role of iron metabolism in chronic diseases related to obesity	12
Peptidomimetics in cancer targeting	12
MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy	12
Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis	12
Targeting miR-21 in spinal cord injuries: a game-changer?	12
Involvement of Hdac3-mediated inhibition of microRNA cluster 17-92 in bronchopulmonary dysplasia development	12
Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma	12
Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer	12
Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding	11
CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis	11
Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis	11
CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-β1 axis	11
Betacellulin regulates peripheral nerve regeneration by affecting Schwann cell migration and axon elongation	11
Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor for the treatment of human hepatocellular carcinoma	11
The role and mechanism of long non-coding RNA H19 in stem cell osteogenic differentiation	11
Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma	11
Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease	11
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis	11
Modulating brain networks associated with cognitive deficits in Parkinson’s disease	11
Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis	11
Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth	11
IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy	11
Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children	11
The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors	11