OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Peptide Science is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
New generation of cell‐penetrating peptides: Functionality and potential clinical application	46
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability	32
Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors	27
Peptide‐based hydrogels as delivery systems for doxorubicin	25
New trends in the development of multifunctional peptides to functionalize biomaterials	24
Peptide‐based covalent inhibitors of protein–protein interactions	23
Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies	23
Multiple action mechanism and in vivo antimicrobial efficacy of antimicrobial peptide Jelleine‐I	21
N‐terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation	18
Heterochiral tetrapeptide self‐assembly into hydrogel biomaterials for hydrolase mimicry	15
Design of acid‐activated cell‐penetrating peptides with nuclear localization capacity for anticancer drug delivery	15
Antioxidant activities of major tryptophyllin L peptides: A joint investigation of Gaussian‐based 3D‐QSAR and radical scavenging experiments	15
Effects of N‐terminal modifications on the stability of antimicrobial peptide SAMP‐A4 analogues against protease degradation	14
DIC/Oxyma‐based accelerated synthesis and oxidative folding studies of centipede toxin RhTx	12
Sequence sensitivity and pH dependence of maleimide conjugated N‐terminal cysteine peptides to thiazine rearrangement	12
Self‐assembling systems comprising intrinsically disordered protein polymers like elastin‐like recombinamers	11
Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides	11
Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease	10
Discovery, synthesis, and optimization of teixobactin, a novel antibiotic without detectable bacterial resistance	10
Cyclic dipeptide‐based small molecules modulate zinc‐mediated liquid–liquid phase separation of tau	10
Interactions of two enantiomers of a designer antimicrobial peptide with structural components of the bacterial cell envelope	10
Capacity for increased surface area in the hydrophobic core of β‐sheet peptide bilayer nanoribbons	10
Structure–activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine	9
Opening the amino acid toolbox for peptide‐based NTS2‐selective ligands as promising lead compounds for pain management	8
Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion	8

Net charge tuning modulates the antiplasmodial and anticancer properties of peptides derived from scorpion venom	8
Amphiphilic conjugates of ferrocene with amino acids and peptides: Design, synthesis, and studies on their aggregation behavior	7
Multivalent dextran hybrids for efficient cytosolic delivery of biomolecular cargoes	7
Stapled peptides as potential inhibitors of SARS‐CoV‐2 binding to the hACE2 receptor	7
Mutual structural effects of unmodified and pyroglutamylated amyloid β peptides during aggregation	6
Self‐assembling tripeptide forming water‐bound channels and hydrogels	6
Current synthetic chemistry towards cyclic antimicrobial peptides	6
Antimicrobial, cytotoxic, and insulin‐releasing activities of the amphibian host‐defense peptide ocellatin‐3N and its L‐lysine‐substituted analogs	6
Synergistic effects of short peptides and antibiotics against bacterial and fungal strains	6
Design, synthesis, and evaluation of the self‐assembled antimicrobial peptides based on the ovalbumin‐derived peptide TK913	6
S‐Benzyl cysteine based cyclic dipeptide super hydrogelator: Enhancing efficacy of an anticancer drug via sustainable release	6
Transcytosis mechanisms of cell‐penetrating peptides: Cation‐independent CC12 and cationic penetratin	5
Expression and purification of the native C‐amidated antimicrobial peptide maculatin 1.1	5
Modulation of hydrogel networks by metal ions	5
Revisiting bone morphogenetic protein‐2 knuckle epitope and redesigning the epitope‐derived peptides	5
Development of membrane‐active peptide therapeutics in oncology	5
Structural and functional swapping of amyloidogenic and antimicrobial peptides: Redefining the role of amyloidogenic propensity in disease and host defense	5
Biophysical study of the structure and dynamics of the antimicrobial peptide maximin 1	5
Design, synthesis, and evaluation of peptide‐imidazo[1,2‐a]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525	5
The ring size of monocyclic ET‐1 controls selectivity and signaling efficiency at both endothelin receptor subtypes	5
d‐Amino acid substitutions and dimerization increase the biological activity and stability of an IL‐15 antagonist peptide	5
Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin	5
Solid‐phase synthesis and bioactivity evaluation of cherimolacyclopeptide E	5
Different directions for retro‐inverso peptides	4
Total synthesis of the natural, medium‐length, peptaibol pentadecaibin and study of the chemical features responsible for its membrane activity	4
Chemical approaches for the preparation of ubiquitinated proteins via natural linkages	4
Metal ion‐induced assembly of dipeptide‐attached perylenediimide for fluorometric “turn on” detection of biologically important small molecule	4
Activities of a broad‐spectrum antimicrobial peptide analogue SAMP‐A4‐C8 and its combat against pneumonia in Staphylococcus aureus‐infected mice	4
Cyclic peptides bearing thed‐Phe‐2‐Abz turn motif: Structural characterization and antimicrobial potential	4
Labeling and receptor affinity of an ultra‐short somatostatin analogue Thz‐Phe‐D‐Trp‐Lys‐Thr‐DOTA	4
N^α‐Methylation of arginine: Implications for cell‐penetrating peptides	4
Optimization of peptide synthesis time and sustainability using novel eco‐friendly binary solvent systems with induction heating on an automated peptide synthesizer	4
Non‐canonical amino acid bioincorporation into antimicrobial peptides and its challenges	4
Cyclotides: The next generation in biopesticide development for eco‐friendly agriculture	4
Efficient synthesis of Aib⁸‐Arg³⁴‐GLP‐1 (7–37) by liquid‐phase fragment condensation	4
Laminaria japonica cyclic peptides exert anti‐colorectal carcinoma effects through apoptosis induction in vitro and in vivo	4
SARS‐CoV‐2 main protease inhibitors: What is moving in the field of peptides and peptidomimetics?	4
Determination of crucial epitopes in the sperm protein calsperin employing synthetic peptides and monoclonal antibodies	4
Synthesis and characterization of two potential impurities (des‐ethyl‐Ganirelix) generated in the Ganirelix manufacturing process	3
Anti‐colon cancer activity tracking isolation of peptide from ginseng leaves and potential mechanisms evaluation in vitro and in vivo	3
Effect of the powerful plasticity of the tert‐butyl side chain on the conformational equilibrium of ascidiacyclamides	3
Composition‐dependent multivalency of peptide–peptide interactions revealed by tryptophan‐scanning mutagenesis	3
Glucopeptides derived from myelin‐relevant proteins and hyperglucosylated nontypeable Haemophilus influenzae bacterial adhesin cross‐react with multiple sclerosis specific antibodies	3
Identification, synthesis, and characterization of an unprecedented N‐(2‐carboxyethyl) adduct impurity in an injectable ganirelix formulation	3
Longer charged amino acids favor β‐strand formation in hairpin peptides	3
Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic	3
Ameliorative effect of dandelion (Taraxacum officinale) peptides on benzo(a)pyrene‐induced oxidative stress and inflammation in human umbilical vein endothelial cells	3
Hydrocarbon stapling modification of peptide alyteserin‐2a: Discovery of novel stapled peptide antitumor agents	3
Solution structure of the anticancer p28 peptide in biomimetic medium	3
Self‐assembly of a peptide sequence, EKKE, composed of exclusively charged amino acids: Role of charge in morphology and lead binding	3

Biotinylated peptides substituted with D‐amino acids with high stability as anti‐anaphylactic agents targeting platelet‐activating factor	3
Designing the antimicrobial peptide with centrosymmetric and amphipathic characterizations for improving antimicrobial activity	3
Why to target G‐quadruplexes using peptides: Next‐generation G4‐interacting ligands	3
Designed novel nuclear localizing anticancer peptide targets p53 negative regulator MDM2 protein	3
Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment	2
Exploring biocompatible chemistry to create stapled and photoswitchable variants of the antimicrobial peptide aurein 1.2	2
Evaluation of unexpected protecting group removal in solid‐phase peptide synthesis: Quantified using continuous flow methods	2
Investigation of intestinal transportation of peptide‐displaying bacteriophage particles using phage display method	2
Safety‐catch linkers for Fmoc solid‐phase synthesis of peptide thioesters and hydrazides by amide‐to‐imide activation	2
Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases	2
Solid‐phase peptide synthesis in 384‐well plates	2
Discovery of a novel antifungal agent: All‐hydrocarbon stapling modification of peptide Aurein1.2	2
Ergothioneine in a peptide: Substitution of histidine with 2‐thiohistidine in bioactive peptides	2
Advances in MRI: Peptide and peptidomimetic‐based contrast agents	2
Methionine‐associated peptide α‐amidation is directed both to the N‐ and the C‐terminal amino acids	2
Tryptophan‐cardanol fluorescent nanoparticles inhibit α‐synuclein aggregation and disrupt amyloid fibrils	2
Assessment of ¹⁷⁷Lu‐labeled carboxyl‐terminated polyamidoamine (PAMAM) dendrimer‐RGD peptide conjugate	2
Automated solid‐phase synthesis of metabolically stabilized triazolo‐peptidomimetics	2
Improving the stability of thiol–maleimide bioconjugates via the formation of a thiazine structure	2
Reversible crosslinked assembly of a trimeric coiled‐coil peptide into a three‐dimensional matrix for cell encapsulation and release	2
Intracellular targets: A multiple cargo transporting molecule	2
Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation	2
Suitability of high‐molecular‐weight tissue‐derived elastin polypeptides and their particles as cosmetic biomaterials	2
Effects of long‐acting analogues of lamprey GLP‐1 and paddlefish glucagon on alpha‐ to beta‐cell transdifferentiation in an insulin‐deficient transgenic mouse model	2
The first non‐helical Aib‐containing hexapeptide: The crystal structure of Z‐Gly‐Aib‐Gly‐Aib‐Gly‐Aib‐OtBu	2
Virtual screening and rational design of antioxidant peptides based on tryptophyllin L structures isolated from the Litoria rubella frog	2
New method for peptide purification based on selective removal of truncation peptide impurities after SPPS with orthogonal capping	2
Characterization of a heptapeptide‐modified microsphere for oriented antibody immobilization	2
Targeting Rab‐RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease	2
Landscape and progress of global peptide drugs in obstetrics and gynaecology	2
Nuclear magnetic resonance studies on conformation and stability of mastoparan in methanol	2
FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond	2
The structure and matrix dynamics of bacterial biofilms as revealed by antimicrobial peptides' diffusion	2
Relative configuration of Cys‐Pro ester peptides in thioester formation	2
Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1	2
A robust preparation method for the amyloidogenic and intrinsically disordered amyloid‐α peptide	2
FITC characterization of a cathepsin B‐responsive nanoprobe for report of differentiation of HL60 cells into macrophages	2
Insect kinin mimics act as potential control agents for aphids: Structural modifications of Trp⁴	2
Recent progress in the reprogramming of nonribosomal peptide synthetases	2
The development and optimisation of an HPLC‐based in vitro serum stability assay for a calcitonin gene‐related peptide receptor antagonist peptide	2