Immunity

Article	Citations
Plasma cell ontogenies, functions, and lifespans	875
Resident memory T cells call the shots in tissue immunity	758
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	567
Nerve-racking worms	527
Universal vaccines? Only if your antibody genes agree	480
Not so aDAMant after all: Plasticity of phagocytic microglia	480
The best offense is a good beta-defensin	471
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry	435
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	434
Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity	418
Something old, something new: The marriage of PD-1 and IL-2	386
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	345
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils	337
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition	337
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	323
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	310
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	307
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	285
IgG sialylation puts lung inflammation to REST	283
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling	281
CD4+ T cells persist with their Eomes	278
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	274
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	272
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	252
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	251

Computationally designed proteins mimic antibody immune evasion in viral evolution	241
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	233
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	217
The B7:CD28 family and friends: Unraveling coinhibitory interactions	211
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	208
Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology	208
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading	197
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	194
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	191
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	189
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	183
Non-canonical IKKs side with N4BP1 against the family	180
TREMendous microglial effects on neurons	178
Genetics of autoinflammation instructs selective IL-1 targeting	176
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	166
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	164
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	162
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	162
Cystine fuels ILC2s to survive lung inflammation	162
Glymphatics and meningeal lymphatics unlock the brain-immune code	161
Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches	154
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	153
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	153
Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses	148
Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors	146
Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing	145
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	143
Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation	143
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	142
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	140
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	138
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	136
Antibody-mediated feedback modulates interclonal competition in the germinal center	135
Mitochondria reactive oxygen species signaling in immune responses	131
Sex hormone signaling and regulation of immune function	131
Defining the landscape of human epidermal mononuclear phagocytes	130
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	130
Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection	130
IL-33 is alarmin the uterus for labor	130
A universe of second messengers for cGLR-STING signaling	129
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	129
CD8+ T cell tolerance: It doesn’t translate	129
Gutcha: The microbiota drives tumor-induced mortality	129
An anti-aging vaccine: BCG turns back the clock on remyelination failure	128
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	128
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	127
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	126
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	126
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	124
ILC3s sense gut microbiota through STING to initiate immune tolerance	124

Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	123
Training, memory, and tissue adaptation of NK cells and innate lymphoid cells	122
Antigen-presenting cells as specialized drivers of intestinal T cell functions	121
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	121
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	120
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	120
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	120
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	118
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	118
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	116
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	115
Human determinants of age-dependent patterns of death from infection	114
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	112
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	112
GATA4 as a maestro of gut regionalization	110
The conceptual foundations of innate immunity: Taking stock 30 years later	110
Strength in diversity: Widening B cell recruitment for broader vaccine protection	109
“Bloody” good factors for keeping the brain young	109
Sex-biased gut dopamine signaling in multiple sclerosis	109
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	107
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	107
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	107
Trade-offs inside the black box of neoantigen prediction	107
Gut instincts: Gasdermin D feeds while it fights	107
Diverse priming outcomes under conditions of very rare precursor B cells	106
Primitive macrophages take a road less traveled	106
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	106
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling	105
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	103
Response to identifying the epidermal dendritic cell landscape	103
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	102
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	101
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	101
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4	101
Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation	100
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	100
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	99
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	99
Molecular and cellular bases of trained immunity	98
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	98
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	96
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	96
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	96
Aged circulating CD8+ T cells and their secreted factors drive cognitive decline	96
Antibodies and complement are key drivers of thrombosis	95
Meningeal macrophages protect against viral neuroinfection	94
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	94
Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging	93
Neutrophil regulation of immunotherapy for cancer is controlled by type II interferon	93
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	92
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	92
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	91
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	91
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	91
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	89
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	89
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	88
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	88
HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice	86
Dimeric IgA specifically disables intracellular mutated oncodrivers	86
IL-17 receptor goes solo in autoimmune inflammation	86
Good intentions gone wrong: The B cell block to epithelial repair	85
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells	84
How does lipid phosphatase 1 (LPP1) regulate antitumor CD8+ T cell activity?	84
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections	84
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1	83
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse	81
Communicating science	81
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes	80
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing	80
Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production	80
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells	79
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity	79
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	78
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma	77
Fermenting T cell stemness for cancer immunity	77
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	77
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	76
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	76
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	76

Antibody modulation of B cell responses—Incorporating positive and negative feedback	76
Long-distance microbial mechanisms impacting cancer immunosurveillance	76
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	75
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	75
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	75
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	75
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B	74
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	73
Glymphatics and meningeal lymphatics unlock the brain-immune code	73
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	72
The immunology of stroke and dementia	72
Older and wiser: The benefits to neonates of aged neutrophils	71
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	71
Of tenants and nomads: The faces of memory T cells	71
Tame the Hydra’s head: Targeting bone marrow maladaptive myelopoiesis to reverse macrophage-mediated immunosuppression in cancer	70
Persistence is key: Refining immunotherapy response prediction	70
Fooling TLR4 to promote fungal virulence	70
TKI resistance in brain metastasis: A CTLA4 state of mind	69
Host-microbial crosstalk relies on “tuft” love	69
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	69
DC-T cell power couples in rheumatoid arthritis joints	69
Personalized syringes offer hope for pancreatic cancer patients	68
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	68
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	67
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	67
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	67
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	66
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	66
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	66
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages	66
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair	66
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors	65
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease	64
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	64
Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit	64
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	63
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms	63
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	63
A gut response: Modulating chemotherapy efficacy with microbial metabolites	63
The immunology of exercise: Mechanisms, mediators, and therapeutic opportunities	63
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	63
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	62
Succinate preserves CD8+ T cell fitness to augment antitumor immunity	62
Dendritic cells as shepherds of T cell immunity in cancer	62
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation	61
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	61
The microbiota control the neonatal WNT-ernet	61
An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment	61
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	61
Superficial ice and deep blaze: A defense strategy of the skin	61
Macrophages in the gut: Masters in multitasking	61
The cancer-immunity cycle: Indication, genotype, and immunotype	61
Learning from the nexus of autoimmunity and cancer	60
Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment	60
Not aIL Treg-mediated suppress10n is equal	60
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	59
Fibroblasts hold the key to TLS formation	59
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions	59
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress	59
Physiological functions of RIG-I-like receptors	59
Myeloid C-type lectin receptors in innate immune recognition	58
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	58
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo	58
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	58
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	58
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation	58
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	57
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	57
Memory T cell aging and rejuvenation	56
IRF2 integrates inflammatory signals to balance T cell exhaustion	56
Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension	55
Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection	55
Inflammasome signaling in astrocytes modulates hippocampal plasticity	54
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	54
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	53
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	53
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	53
Danger fuels immune escape	53
The Spleen in Local and Systemic Regulation of Immunity	52
Boundaries and integration between microbiota, the nervous system, and immunity	52
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	51
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	51
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	51
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	51
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	51
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis	50
Next generation lysosome: Brought to you by cGAS-STING	50
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	50
Approaches toward understanding human immunity	50
Deconstruction and reconstruction of lymphocytes for precision medicine	50
Skin deep: Epithelial cell metabolism and chronic skin inflammation	50
Sensory neurons shape local macrophage identity via TGF-β signaling	49
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network	49
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	49
Immo-bile-izing CD8+ T cell anti-tumor immunity	49