Immunity

Article	Citations
The best offense is a good beta-defensin	1335
IgG sialylation puts lung inflammation to REST	638
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	561
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	540
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	529
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	527
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	491
Computationally designed proteins mimic antibody immune evasion in viral evolution	446
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	399
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	344
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	308
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	298
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	270
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	262
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	257
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	257
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	254
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	251
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	251
Something old, something new: The marriage of PD-1 and IL-2	250
Nerve-racking worms	240
Not so aDAMant after all: Plasticity of phagocytic microglia	218
The B7:CD28 family and friends: Unraveling coinhibitory interactions	213
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	213
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	212

Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	211
TREMendous microglial effects on neurons	207
Non-canonical IKKs side with N4BP1 against the family	201
Plasmacytoid dendritic cells: Welcome back to the DC fold	195
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	186
The domiNO effect turns macrophage activation deadly	178
Genetics of autoinflammation instructs selective IL-1 targeting	178
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	173
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	167
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	167
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	158
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	154
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	153
Sex hormone signaling and regulation of immune function	152
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	149
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	149
Mitochondria reactive oxygen species signaling in immune responses	148
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	143
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	142
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	142
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	142
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	134
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	133
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	133
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	131
CD8+ T cell tolerance: It doesn’t translate	130
Defining the landscape of human epidermal mononuclear phagocytes	127
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	126
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	124
An anti-aging vaccine: BCG turns back the clock on remyelination failure	124
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	124
A universe of second messengers for cGLR-STING signaling	123
Gutcha: The microbiota drives tumor-induced mortality	122
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	121
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	120
IL-33 is alarmin the uterus for labor	118
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	117
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	115
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	115
ILC3s sense gut microbiota through STING to initiate immune tolerance	114
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	114
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	113
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	112
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	112
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	111
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	110
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	110
Antigen-presenting cells as specialized drivers of intestinal T cell functions	109
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	108
Human determinants of age-dependent patterns of death from infection	108

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	108
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	106
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	103
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	102
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	102
The conceptual foundations of innate immunity: Taking stock 30 years later	102
Are we there yet? An immune field trip through human embryonic development	99
“Bloody” good factors for keeping the brain young	97
Sex-biased gut dopamine signaling in multiple sclerosis	97
Trade-offs inside the black box of neoantigen prediction	97
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	95
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	95
Gut instincts: Gasdermin D feeds while it fights	95
GATA4 as a maestro of gut regionalization	95
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	95
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	94
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	93
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	93
Diverse priming outcomes under conditions of very rare precursor B cells	93
Strength in diversity: Widening B cell recruitment for broader vaccine protection	93
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4	92
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	91
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	91
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	90
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	90
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	89
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	89
Antibodies and complement are key drivers of thrombosis	89
Response to identifying the epidermal dendritic cell landscape	88
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	88
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	88
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	87
Meningeal macrophages protect against viral neuroinfection	87
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	87
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	87
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	86
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	85
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	85
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	83
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	83
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	82
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	82
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	82
Good intentions gone wrong: The B cell block to epithelial repair	80
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	80
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	79
The immunology of stroke and dementia	79
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	79
Long-distance microbial mechanisms impacting cancer immunosurveillance	78
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	78
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	77
Fungus packs a punch in the gut	75
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	75
Antibody modulation of B cell responses—Incorporating positive and negative feedback	75
Dimeric IgA specifically disables intracellular mutated oncodrivers	74
IL-17 receptor goes solo in autoimmune inflammation	74
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing	73
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse	73
Glymphatics and meningeal lymphatics unlock the brain-immune code	72
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B	72
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections	71
How does lipid phosphatase 1 (LPP1) regulate antitumor CD8+ T cell activity?	71
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	71
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	71
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	71
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	71
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1	71
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	71
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	71
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	68
TKI resistance in brain metastasis: A CTLA4 state of mind	68
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity	68
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	68
Persistence is key: Refining immunotherapy response prediction	67
Older and wiser: The benefits to neonates of aged neutrophils	66
“Are you gonna go my way?”—Decisions at the Tfh-B cell interface	66
A gut response: Modulating chemotherapy efficacy with microbial metabolites	66
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses	66
Fooling TLR4 to promote fungal virulence	66
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair	66

DC-T cell power couples in rheumatoid arthritis joints	65
Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters	65
Succinate preserves CD8+ T cell fitness to augment antitumor immunity	65
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	65
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	65
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	64
Drugging inflammation: Easier NSAID than done	64
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	64
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	64
Personalized syringes offer hope for pancreatic cancer patients	64
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	63
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	63
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	62
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	61
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	60
Macrophages in the gut: Masters in multitasking	59
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease	59
Of tenants and nomads: The faces of memory T cells	59
Host-microbial crosstalk relies on “tuft” love	59
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation	58
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells	58
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	58
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	58
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	58
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	58
An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity	58
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms	57
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	57
The cancer-immunity cycle: Indication, genotype, and immunotype	57
Dendritic cells as shepherds of T cell immunity in cancer	57
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer	57
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	57
Superficial ice and deep blaze: A defense strategy of the skin	56
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	56
How does Epstein-Barr virus trigger MS?	56
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation	55
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	55
The microbiota control the neonatal WNT-ernet	55
IRF2 integrates inflammatory signals to balance T cell exhaustion	55
Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension	54
Learning from the nexus of autoimmunity and cancer	54
Myeloid C-type lectin receptors in innate immune recognition	54
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	53
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	53
Inflammasome signaling in astrocytes modulates hippocampal plasticity	53
The Spleen in Local and Systemic Regulation of Immunity	53
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	53
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	53
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	53
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	52
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo	52
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity	51
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	51
Physiological functions of RIG-I-like receptors	51
Boundaries and integration between microbiota, the nervous system, and immunity	51
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	51
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	51
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	50
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	50
Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells	50
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	50
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	50
A high-resolution view of intra-tumoral B cell immunity	49
Skin deep: Epithelial cell metabolism and chronic skin inflammation	49
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	49
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network	49
Approaches toward understanding human immunity	49
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	49
Next generation lysosome: Brought to you by cGAS-STING	49
Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells	48
Sensory neurons shape local macrophage identity via TGF-β signaling	48
Mitochondrial control of macrophage polarity in tumors	48
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	48
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes	48
Tfh cells set the stage for tumor control	48
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells	48
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	47
Genetic variation in antigen presentation and cancer immunotherapy	47
Immo-bile-izing CD8+ T cell anti-tumor immunity	47
Programmed and environmental determinants driving neonatal mucosal immune development	47
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis	47
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance	47
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases	47
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	47
Deconstruction and reconstruction of lymphocytes for precision medicine	47
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches	46
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	46
Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis	46
Decoding nociceptor-DC dialogues	46
SARS-CoV-2 in immunocompromised individuals	46
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells	46
DCs unchained: Whetting dendritic-cell appetite boosts wound healing	46
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract	46
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling	46
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients	46