OOIR: Observatory of International Research

Papers

(The TQCC of Immunity is 120. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases	1287
Inflammation and Cancer: Triggers, Mechanisms, and Consequences	1181
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes	951
Transforming Growth Factor-β Signaling in Immunity and Cancer	934
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases	682
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy	652
Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species	631
The IL-17 Family of Cytokines in Health and Disease	544
Shared and Distinct Functions of Type I and Type III Interferons	518
Caspases in Cell Death, Inflammation, and Disease	471
The Cytokines of Asthma	451
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4	446
Regulation of the Immune Response by the Aryl Hydrocarbon Receptor	445
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages	443
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity	433
Targeting Interleukin-6 Signaling in Clinic	410
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation	400
The Broad Spectrum of Human Natural Killer Cell Diversity	374
Mechanisms and Therapeutic Relevance of Neuro-immune Communication	358
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells	318
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer	318
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease	298
Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy	282
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision	280
A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult	275
CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer	274
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche	265
T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming	262
Plasmacytoid Dendritic Cells: Development, Regulation, and Function	262
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation	260
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice	257
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells	254
Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines	252
High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice	252
Class-Switch Recombination Occurs Infrequently in Germinal Centers	251
NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8	250
Western Diet and the Immune System: An Inflammatory Connection	249
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection	245
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells	244
Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages	215
The Immunobiology of the Interleukin-12 Family: Room for Discovery	214
The Immune Landscape of Cancer	195
A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns	191
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells	188
Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells	183
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches	180
B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells	178
Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis	177
GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation	176
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection	172
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity	166
The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells	165
Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells	164
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications	163
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways	162
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming	157
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch	155
Immune Signaling in Neurodegeneration	154
Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration	154
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons	150
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology	149
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells	149
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming	148
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses	148
Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase	144
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis	143
Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation	138
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages	134
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity	131
Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction	131
Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure	130
Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons	127
Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ	121
Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers	121
Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals	120