Immunity

Article	Citations
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	1065
Not so aDAMant after all: Plasticity of phagocytic microglia	534
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	493
Nerve-racking worms	463
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	455
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential	442
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	436
IgG sialylation puts lung inflammation to REST	430
Something old, something new: The marriage of PD-1 and IL-2	423
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	412
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	401
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	376
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	355
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	354
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	321
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	288
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	282
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	277
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	276
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	269
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance	246
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children	238
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	233
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	216
The B7:CD28 family and friends: Unraveling coinhibitory interactions	216

The best offense is a good beta-defensin	215
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	212
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	212
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	210
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	208
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	202
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	196
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	192
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	189
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	187
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	187
Genetics of autoinflammation instructs selective IL-1 targeting	183
The domiNO effect turns macrophage activation deadly	180
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	178
Non-canonical IKKs side with N4BP1 against the family	173
Plasmacytoid dendritic cells: Welcome back to the DC fold	169
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	168
TREMendous microglial effects on neurons	164
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	163
Sex hormone signaling and regulation of immune function	160
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	159
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge	156
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	154
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation	148
Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses	146
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	144
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	140
A subset of Kupffer cells regulates metabolism through the expression of CD36	134
Human determinants of age-dependent patterns of death from infection	133
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection	133
An anti-aging vaccine: BCG turns back the clock on remyelination failure	132
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	128
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	128
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	128
The conceptual foundations of innate immunity: Taking stock 30 years later	126
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	126
Antigen-presenting cells as specialized drivers of intestinal T cell functions	125
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	124
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	122
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	122
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	121
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	121
CD8+ T cell tolerance: It doesn’t translate	120
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	119
Defining the landscape of human epidermal mononuclear phagocytes	118
Gutcha: The microbiota drives tumor-induced mortality	117
A universe of second messengers for cGLR-STING signaling	116
IL-33 is alarmin the uterus for labor	114
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	113
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	111

Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	111
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	110
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	108
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	104
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	104
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	104
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	102
Strength in diversity: Widening B cell recruitment for broader vaccine protection	102
Response to identifying the epidermal dendritic cell landscape	102
Are we there yet? An immune field trip through human embryonic development	101
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	101
Sex-biased gut dopamine signaling in multiple sclerosis	100
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	100
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	98
Trade-offs inside the black box of neoantigen prediction	97
“Bloody” good factors for keeping the brain young	97
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	97
Fungus fuels mucosal wounds in Crohn’s disease	96
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	96
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	96
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	96
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	95
Diverse priming outcomes under conditions of very rare precursor B cells	95
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	94
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity	93
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	93
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	92
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	92
GATA4 as a maestro of gut regionalization	92
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	92
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	91
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	91
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	90
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	90
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	89
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response	88
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	88
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	88
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	87
Antibodies and complement are key drivers of thrombosis	87
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	87
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	87
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	84
Meningeal macrophages protect against viral neuroinfection	83
Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination	83
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	83
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	82
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	82
Fungus packs a punch in the gut	82
Good intentions gone wrong: The B cell block to epithelial repair	82
Dimeric IgA specifically disables intracellular mutated oncodrivers	82
IL-17 receptor goes solo in autoimmune inflammation	82
The immunology of stroke and dementia	82
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	81
Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants	81
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	80
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	80
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	80
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	79
Long-distance microbial mechanisms impacting cancer immunosurveillance	79
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	77
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	77
Antibody modulation of B cell responses—Incorporating positive and negative feedback	77
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	77
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	76
The unique biology of germinal center B cells	75
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity	75
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	75
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts	74
Of tenants and nomads: The faces of memory T cells	73
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	73
Persistence is key: Refining immunotherapy response prediction	73
TKI resistance in brain metastasis: A CTLA4 state of mind	73
Host-microbial crosstalk relies on “tuft” love	73
Fooling TLR4 to promote fungal virulence	71
ADAR1 edits the SenZ and SenZ-ability of RNA	71
“Are you gonna go my way?”—Decisions at the Tfh-B cell interface	71
Older and wiser: The benefits to neonates of aged neutrophils	71
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	70
Guard proteins keep watch at epithelial walls	70

A gut response: Modulating chemotherapy efficacy with microbial metabolites	70
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	69
Drugging inflammation: Easier NSAID than done	69
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	69
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	69
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses	68
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	68
Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters	68
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	68
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	67
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	67
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	67
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	67
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer	67
DC-T cell power couples in rheumatoid arthritis joints	67
An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity	66
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	66
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells	66
Dendritic cells as shepherds of T cell immunity in cancer	65
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	65
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	65
The cancer-immunity cycle: Indication, genotype, and immunotype	65
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	65
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	64
Macrophages in the gut: Masters in multitasking	64
Superficial ice and deep blaze: A defense strategy of the skin	63
How does Epstein-Barr virus trigger MS?	62
IRF2 integrates inflammatory signals to balance T cell exhaustion	61
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation	61
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	61
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	61
Boundaries and integration between microbiota, the nervous system, and immunity	61
The microbiota control the neonatal WNT-ernet	61
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	61
A. faecalis induces intestinal T helper 17 cells by promoting E3 ubiquitin ligase Trim21-mediated E3 ubiquitin ligase Fbxw7 degradation	61
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	60
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	60
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	59
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	58
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	58
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	58
Myeloid C-type lectin receptors in innate immune recognition	58
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	58
The Spleen in Local and Systemic Regulation of Immunity	57
Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection	57
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity	57
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair	57
Learning from the nexus of autoimmunity and cancer	57
Physiological functions of RIG-I-like receptors	57
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	57
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	57
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	57
Immo-bile-izing CD8+ T cell anti-tumor immunity	56
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	56
Tfh cells set the stage for tumor control	56
Genetic variation in antigen presentation and cancer immunotherapy	56
Next generation lysosome: Brought to you by cGAS-STING	55
Skin deep: Epithelial cell metabolism and chronic skin inflammation	55
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract	54
A high-resolution view of intra-tumoral B cell immunity	54
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	54
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	53
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1	52
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells	52
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	51
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	51
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development	51
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	50
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis	50
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes	50
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases	49
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING	49
Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells	49
SARS-CoV-2 in immunocompromised individuals	48
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network	48
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses	48
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells	47
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches	47
Programmed and environmental determinants driving neonatal mucosal immune development	47
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress	47
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	47
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	46
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies	45
Going viral: HBV-specific CD8+ tissue-resident memory T cells propagate anti-tumor immunity	45
Decoding nociceptor-DC dialogues	45
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling	45
Neighbor’s feedback helps macrophages learn tolerance in the gut	44
Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling	44
Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma	44
DCs unchained: Whetting dendritic-cell appetite boosts wound healing	44
Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease	44
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients	44
Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis	44
Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair	44
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1	44