Immunity

Article	Citations
IgG sialylation puts lung inflammation to REST	777
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	662
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	505
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	458
Resident memory T cells call the shots in tissue immunity	422
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	393
Nerve-racking worms	392
Not so aDAMant after all: Plasticity of phagocytic microglia	372
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	368
Computationally designed proteins mimic antibody immune evasion in viral evolution	367
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	356
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry	313
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	312
Plasma cell ontogenies, functions, and lifespans	310
Universal vaccines? Only if your antibody genes agree	307
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	270
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils	263
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	258
The B7:CD28 family and friends: Unraveling coinhibitory interactions	255
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading	246
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	244
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	244
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	240
The best offense is a good beta-defensin	233
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	233

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology	226
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	219
Something old, something new: The marriage of PD-1 and IL-2	211
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	205
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	204
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	196
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	196
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition	184
Glymphatics and meningeal lymphatics unlock the brain-immune code	181
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	172
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	171
Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation	170
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	163
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	162
Non-canonical IKKs side with N4BP1 against the family	160
Genetics of autoinflammation instructs selective IL-1 targeting	158
TREMendous microglial effects on neurons	158
Cystine fuels ILC2s to survive lung inflammation	157
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	156
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	155
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	152
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	151
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	150
Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches	149
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	147
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	145
Mitochondria reactive oxygen species signaling in immune responses	142
Sex hormone signaling and regulation of immune function	141
Antibody-mediated feedback modulates interclonal competition in the germinal center	139
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	139
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	138
CD8+ T cell tolerance: It doesn’t translate	133
Defining the landscape of human epidermal mononuclear phagocytes	131
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	128
IL-33 is alarmin the uterus for labor	128
A universe of second messengers for cGLR-STING signaling	127
Gutcha: The microbiota drives tumor-induced mortality	127
An anti-aging vaccine: BCG turns back the clock on remyelination failure	126
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	124
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	123
ILC3s sense gut microbiota through STING to initiate immune tolerance	120
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	120
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	119
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	119
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	118
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	117
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	117
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	117
Human determinants of age-dependent patterns of death from infection	117
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	116

Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	116
Training, memory, and tissue adaptation of NK cells and innate lymphoid cells	115
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	115
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	115
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	113
The conceptual foundations of innate immunity: Taking stock 30 years later	113
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	111
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	111
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	111
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	109
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	108
Antigen-presenting cells as specialized drivers of intestinal T cell functions	108
GATA4 as a maestro of gut regionalization	108
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	108
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	107
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	107
Strength in diversity: Widening B cell recruitment for broader vaccine protection	107
Are we there yet? An immune field trip through human embryonic development	105
Response to identifying the epidermal dendritic cell landscape	103
Sex-biased gut dopamine signaling in multiple sclerosis	101
“Bloody” good factors for keeping the brain young	101
Trade-offs inside the black box of neoantigen prediction	99
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	99
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	98
Gut instincts: Gasdermin D feeds while it fights	98
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	97
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	97
Primitive macrophages take a road less traveled	97
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	97
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	97
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	96
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	96
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	95
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	94
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	93
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	93
Diverse priming outcomes under conditions of very rare precursor B cells	92
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	91
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	91
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	90
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	90
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	89
Molecular and cellular bases of trained immunity	89
Meningeal macrophages protect against viral neuroinfection	89
Antibodies and complement are key drivers of thrombosis	89
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	88
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	88
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	88
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4	87
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	87
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	85
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	85
Dimeric IgA specifically disables intracellular mutated oncodrivers	84
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing	84
How does lipid phosphatase 1 (LPP1) regulate antitumor CD8+ T cell activity?	84
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections	84
IL-17 receptor goes solo in autoimmune inflammation	84
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma	83
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes	83
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	83
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells	82
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1	82
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells	82
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	81
Fermenting T cell stemness for cancer immunity	81
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	81
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	81
HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice	80
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	80
Good intentions gone wrong: The B cell block to epithelial repair	80
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	79
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	78
The immunology of stroke and dementia	78
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity	78
Antibody modulation of B cell responses—Incorporating positive and negative feedback	78
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse	76
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B	75
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	75
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	74
Long-distance microbial mechanisms impacting cancer immunosurveillance	74

Glymphatics and meningeal lymphatics unlock the brain-immune code	74
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	73
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	73
Older and wiser: The benefits to neonates of aged neutrophils	72
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	72
Drugging inflammation: Easier NSAID than done	72
Of tenants and nomads: The faces of memory T cells	71
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	69
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms	68
Personalized syringes offer hope for pancreatic cancer patients	68
Fooling TLR4 to promote fungal virulence	68
Host-microbial crosstalk relies on “tuft” love	68
A gut response: Modulating chemotherapy efficacy with microbial metabolites	67
TKI resistance in brain metastasis: A CTLA4 state of mind	67
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	67
DC-T cell power couples in rheumatoid arthritis joints	67
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	67
Tame the Hydra’s head: Targeting bone marrow maladaptive myelopoiesis to reverse macrophage-mediated immunosuppression in cancer	65
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	65
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation	64
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease	64
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	64
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	64
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	64
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	64
Persistence is key: Refining immunotherapy response prediction	64
The cancer-immunity cycle: Indication, genotype, and immunotype	63
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	63
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	63
Dendritic cells as shepherds of T cell immunity in cancer	62
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair	62
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	62
An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment	61
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	61
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors	61
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages	61
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	61
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses	61
Macrophages in the gut: Masters in multitasking	61
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	60
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	60
Succinate preserves CD8+ T cell fitness to augment antitumor immunity	60
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	60
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	60
The microbiota control the neonatal WNT-ernet	59
Superficial ice and deep blaze: A defense strategy of the skin	59
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	59
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation	58
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	58
Not aIL Treg-mediated suppress10n is equal	57
Inflammasome signaling in astrocytes modulates hippocampal plasticity	57
Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension	57
Learning from the nexus of autoimmunity and cancer	57
The Spleen in Local and Systemic Regulation of Immunity	57
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	56
IRF2 integrates inflammatory signals to balance T cell exhaustion	56
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	56
Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection	56
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	56
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo	56
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	55
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	55
Boundaries and integration between microbiota, the nervous system, and immunity	55
Memory T cell aging and rejuvenation	55
Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment	55
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	54
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	54
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	54
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	54
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	54
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	54
Myeloid C-type lectin receptors in innate immune recognition	53
Skin deep: Epithelial cell metabolism and chronic skin inflammation	53
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions	53
Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection	53
Physiological functions of RIG-I-like receptors	53
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases	53
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	52
Approaches toward understanding human immunity	52
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	52
SARS-CoV-2 in immunocompromised individuals	52
Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells	51
Deconstruction and reconstruction of lymphocytes for precision medicine	51
Next generation lysosome: Brought to you by cGAS-STING	51
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	51
Cellular memory of sub-lethal stress	50
Sensory neurons shape local macrophage identity via TGF-β signaling	50
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	50
Immo-bile-izing CD8+ T cell anti-tumor immunity	50
Mitochondrial control of macrophage polarity in tumors	50
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells	50
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	50
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis	49
Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells	49
Programmed and environmental determinants driving neonatal mucosal immune development	49