OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 103. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Plasma cell ontogenies, functions, and lifespans	875
Resident memory T cells call the shots in tissue immunity	758
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	567
Nerve-racking worms	527
Universal vaccines? Only if your antibody genes agree	480
Not so aDAMant after all: Plasticity of phagocytic microglia	480
The best offense is a good beta-defensin	471
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry	435
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	434
Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity	418
Something old, something new: The marriage of PD-1 and IL-2	386
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	345
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils	337
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition	337
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	323
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	310
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	307
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	285
IgG sialylation puts lung inflammation to REST	283
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling	281
CD4+ T cells persist with their Eomes	278
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	274
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	272
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	252
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	251

Computationally designed proteins mimic antibody immune evasion in viral evolution	241
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	233
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	217
The B7:CD28 family and friends: Unraveling coinhibitory interactions	211
Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology	208
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	208
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading	197
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	194
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	191
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	189
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	183
Non-canonical IKKs side with N4BP1 against the family	180
TREMendous microglial effects on neurons	178
Genetics of autoinflammation instructs selective IL-1 targeting	176
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	166
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	164
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	162
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	162
Cystine fuels ILC2s to survive lung inflammation	162
Glymphatics and meningeal lymphatics unlock the brain-immune code	161
Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches	154
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	153
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	153
Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses	148
Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors	146
Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing	145
Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation	143
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	143
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	142
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	140
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	138
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	136
Antibody-mediated feedback modulates interclonal competition in the germinal center	135
Sex hormone signaling and regulation of immune function	131
Mitochondria reactive oxygen species signaling in immune responses	131
IL-33 is alarmin the uterus for labor	130
Defining the landscape of human epidermal mononuclear phagocytes	130
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	130
Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection	130
CD8+ T cell tolerance: It doesn’t translate	129
Gutcha: The microbiota drives tumor-induced mortality	129
A universe of second messengers for cGLR-STING signaling	129
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	129
An anti-aging vaccine: BCG turns back the clock on remyelination failure	128
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	128
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	127
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	126
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	126
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	124
ILC3s sense gut microbiota through STING to initiate immune tolerance	124

Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	123
Training, memory, and tissue adaptation of NK cells and innate lymphoid cells	122
Antigen-presenting cells as specialized drivers of intestinal T cell functions	121
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	121
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	120
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	120
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	120
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	118
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	118
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	116
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	115
Human determinants of age-dependent patterns of death from infection	114
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	112
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	112
GATA4 as a maestro of gut regionalization	110
The conceptual foundations of innate immunity: Taking stock 30 years later	110
“Bloody” good factors for keeping the brain young	109
Sex-biased gut dopamine signaling in multiple sclerosis	109
Strength in diversity: Widening B cell recruitment for broader vaccine protection	109
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	107
Trade-offs inside the black box of neoantigen prediction	107
Gut instincts: Gasdermin D feeds while it fights	107
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	107
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	107
Primitive macrophages take a road less traveled	106
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	106
Diverse priming outcomes under conditions of very rare precursor B cells	106
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling	105
Response to identifying the epidermal dendritic cell landscape	103
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	103