OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 95. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
IgG sialylation puts lung inflammation to REST	1516
Something old, something new: The marriage of PD-1 and IL-2	644
Resident memory T cells call the shots in tissue immunity	583
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	557
Not so aDAMant after all: Plasticity of phagocytic microglia	503
The best offense is a good beta-defensin	441
Nerve-racking worms	375
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	363
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	309
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	302
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	300
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	296
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	289
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	285
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	282
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	279
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	274
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	274
Computationally designed proteins mimic antibody immune evasion in viral evolution	269
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils	251
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	236
The B7:CD28 family and friends: Unraveling coinhibitory interactions	228
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	224
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry	211
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	206

A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	200
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	196
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	194
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	191
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	186
The domiNO effect turns macrophage activation deadly	183
TREMendous microglial effects on neurons	174
Genetics of autoinflammation instructs selective IL-1 targeting	174
Non-canonical IKKs side with N4BP1 against the family	171
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	169
Plasmacytoid dendritic cells: Welcome back to the DC fold	167
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	166
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	165
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	163
Mitochondria reactive oxygen species signaling in immune responses	157
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	155
Glymphatics and meningeal lymphatics unlock the brain-immune code	152
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	147
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	145
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	145
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	141
Sex hormone signaling and regulation of immune function	140
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	139
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	135
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	134
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	134
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	133
CD8+ T cell tolerance: It doesn’t translate	132
A universe of second messengers for cGLR-STING signaling	129
IL-33 is alarmin the uterus for labor	129
Gutcha: The microbiota drives tumor-induced mortality	129
Defining the landscape of human epidermal mononuclear phagocytes	129
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	128
An anti-aging vaccine: BCG turns back the clock on remyelination failure	125
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	124
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	122
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	121
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	121
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	119
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	118
ILC3s sense gut microbiota through STING to initiate immune tolerance	117
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	117
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	116
Human determinants of age-dependent patterns of death from infection	113
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	112
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	112
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	112
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	110
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	110
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	109

Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	107
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	107
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	106
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	105
The conceptual foundations of innate immunity: Taking stock 30 years later	105
Antigen-presenting cells as specialized drivers of intestinal T cell functions	105
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	104
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	103
Gut instincts: Gasdermin D feeds while it fights	102
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	102
GATA4 as a maestro of gut regionalization	101
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	100
Are we there yet? An immune field trip through human embryonic development	99
Response to identifying the epidermal dendritic cell landscape	99
Strength in diversity: Widening B cell recruitment for broader vaccine protection	98
Sex-biased gut dopamine signaling in multiple sclerosis	97
“Bloody” good factors for keeping the brain young	96
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	96
Trade-offs inside the black box of neoantigen prediction	96
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	95
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	95