OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
IgG sialylation puts lung inflammation to REST	1236
Something old, something new: The marriage of PD-1 and IL-2	596
Not so aDAMant after all: Plasticity of phagocytic microglia	516
Computationally designed proteins mimic antibody immune evasion in viral evolution	499
Nerve-racking worms	486
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	460
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	450
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	437
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	427
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	408
The best offense is a good beta-defensin	372
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	319
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	273
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	260
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	253
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	243
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	242
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	242
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	230
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	229
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	226
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	225
The B7:CD28 family and friends: Unraveling coinhibitory interactions	220
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	215
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	212

More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	207
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	200
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge	200
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	192
Genetics of autoinflammation instructs selective IL-1 targeting	188
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	188
The domiNO effect turns macrophage activation deadly	181
Non-canonical IKKs side with N4BP1 against the family	175
TREMendous microglial effects on neurons	168
Sex hormone signaling and regulation of immune function	163
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	163
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	162
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	162
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	160
Plasmacytoid dendritic cells: Welcome back to the DC fold	156
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	150
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	149
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	149
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	142
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	142
A subset of Kupffer cells regulates metabolism through the expression of CD36	139
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	139
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	135
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	134
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	134
An anti-aging vaccine: BCG turns back the clock on remyelination failure	132
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	132
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	131
CD8+ T cell tolerance: It doesn’t translate	131
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	131
IL-33 is alarmin the uterus for labor	128
Gutcha: The microbiota drives tumor-induced mortality	128
Human determinants of age-dependent patterns of death from infection	126
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	125
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	124
ILC3s sense gut microbiota through STING to initiate immune tolerance	124
A universe of second messengers for cGLR-STING signaling	122
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	118
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	114
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	114
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	114
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	113
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	110
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	109
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	109
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	109
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	108
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	106
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	106
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	106

Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	105
The conceptual foundations of innate immunity: Taking stock 30 years later	105
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	104
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	104
Antigen-presenting cells as specialized drivers of intestinal T cell functions	102
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	102
Defining the landscape of human epidermal mononuclear phagocytes	101
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	101
“Bloody” good factors for keeping the brain young	100
Sex-biased gut dopamine signaling in multiple sclerosis	100
Are we there yet? An immune field trip through human embryonic development	100
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	99
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	99
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	99
Trade-offs inside the black box of neoantigen prediction	99
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	98
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	97
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	97
Strength in diversity: Widening B cell recruitment for broader vaccine protection	96
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	94
GATA4 as a maestro of gut regionalization	94