OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
IgG sialylation puts lung inflammation to REST	1403
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	661
Something old, something new: The marriage of PD-1 and IL-2	583
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	564
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	547
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	508
Resident memory T cells call the shots in tissue immunity	464
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	405
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	356
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	328
The best offense is a good beta-defensin	326
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	277
Nerve-racking worms	276
Not so aDAMant after all: Plasticity of phagocytic microglia	274
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	266
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	266
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	265
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	260
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	258
The B7:CD28 family and friends: Unraveling coinhibitory interactions	251
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	243
Computationally designed proteins mimic antibody immune evasion in viral evolution	221
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	219
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	218
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	215

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	214
Non-canonical IKKs side with N4BP1 against the family	210
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	198
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	188
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	184
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	179
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	178
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	171
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	168
Plasmacytoid dendritic cells: Welcome back to the DC fold	161
The domiNO effect turns macrophage activation deadly	161
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	158
TREMendous microglial effects on neurons	158
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	158
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	158
Genetics of autoinflammation instructs selective IL-1 targeting	149
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	148
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	147
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	142
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	142
Sex hormone signaling and regulation of immune function	141
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	137
Mitochondria reactive oxygen species signaling in immune responses	136
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	136
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	135
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	134
CD8+ T cell tolerance: It doesn’t translate	133
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	132
An anti-aging vaccine: BCG turns back the clock on remyelination failure	129
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	128
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	126
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	125
ILC3s sense gut microbiota through STING to initiate immune tolerance	125
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	123
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	122
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	122
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	118
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	118
A universe of second messengers for cGLR-STING signaling	117
IL-33 is alarmin the uterus for labor	117
Gutcha: The microbiota drives tumor-induced mortality	114
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	114
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	113
Defining the landscape of human epidermal mononuclear phagocytes	113
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	112
Antigen-presenting cells as specialized drivers of intestinal T cell functions	112
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	111
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	111
Human determinants of age-dependent patterns of death from infection	111
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	111

Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	108
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	105
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	104
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	102
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	102
Gut instincts: Gasdermin D feeds while it fights	100
The conceptual foundations of innate immunity: Taking stock 30 years later	100
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	100
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	99
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	99
GATA4 as a maestro of gut regionalization	99
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	98
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	97
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	97
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	97
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	96
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	96
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	95
Diverse priming outcomes under conditions of very rare precursor B cells	94
Are we there yet? An immune field trip through human embryonic development	94
Strength in diversity: Widening B cell recruitment for broader vaccine protection	94