OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 96. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Inflammation in obesity, diabetes, and related disorders	792
Autophagy in inflammation, infection, and immunometabolism	446
Chemokines and the immune response to cancer	399
Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination	381
The immunology of sepsis	379
MDSC: Markers, development, states, and unaddressed complexity	377
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	369
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors	365
Microglia: Immune and non-immune functions	339
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer	337
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease	334
The Neutrophil	328
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging	310
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation	304
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity	299
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19	293
Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity	287
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling	284
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein	284
Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19	282
Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity	280
Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19	277
Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease	257
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses	253
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions	250

Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19	243
Biology of lung macrophages in health and disease	237
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation	233
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations	228
Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox	225
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer	217
SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors	201
Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species	200
The cancer-immunity cycle: Indication, genotype, and immunotype	195
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke	191
Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity	184
PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19	184
The Intersection of Epigenetics and Metabolism in Trained Immunity	184
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity	182
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	182
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children	180
COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses	179
Accelerated COVID-19 vaccine development: milestones, lessons, and prospects	179
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses	173
Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity	171
Innate immune mechanisms of mRNA vaccines	165
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19	165
Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response	160
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration	159
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses	158
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy	156
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens	154
Liver macrophages in health and disease	153
Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes	152
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade	152
Metabolic adaptation of lymphocytes in immunity and disease	144
The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake	138
Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer	138
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor	137
Astrocyte-immune cell interactions in physiology and pathology	136
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity	130
A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages	129
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts	129
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation	128
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid	128
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2	123
T Cell Memory: Understanding COVID-19	123
The unique biology of germinal center B cells	121
Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants	121
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control	120
The pathogenesis of rheumatoid arthritis	120
Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease	119
A subset of Kupffer cells regulates metabolism through the expression of CD36	117
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant	115
B cell memory: understanding COVID-19	114

Principles of regulatory T cell function	114
Resident cardiac macrophages mediate adaptive myocardial remodeling	114
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	114
Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge	113
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants	112
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets	110
Modification of Proteins by Metabolites in Immunity	110
Mucosal immune responses to infection and vaccination in the respiratory tract	108
Germline genetic contribution to the immune landscape of cancer	108
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity	108
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function	107
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques	105
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins	104
Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection	103
Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease	100
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis	99
Transition to endemicity: Understanding COVID-19	99
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons	98
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery	98
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity	96
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis	96