OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 96. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	1065
Not so aDAMant after all: Plasticity of phagocytic microglia	534
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	493
Nerve-racking worms	463
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	455
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential	442
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	436
IgG sialylation puts lung inflammation to REST	430
Something old, something new: The marriage of PD-1 and IL-2	423
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	412
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	401
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	376
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	355
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	354
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	321
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	288
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	282
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	277
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	276
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	269
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance	246
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children	238
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	233
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	216
The B7:CD28 family and friends: Unraveling coinhibitory interactions	216

The best offense is a good beta-defensin	215
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	212
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	212
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	210
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	208
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	202
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	196
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	192
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	189
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	187
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	187
Genetics of autoinflammation instructs selective IL-1 targeting	183
The domiNO effect turns macrophage activation deadly	180
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	178
Non-canonical IKKs side with N4BP1 against the family	173
Plasmacytoid dendritic cells: Welcome back to the DC fold	169
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	168
TREMendous microglial effects on neurons	164
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	163
Sex hormone signaling and regulation of immune function	160
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	159
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge	156
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	154
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation	148
Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses	146
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	144
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	140
A subset of Kupffer cells regulates metabolism through the expression of CD36	134
Human determinants of age-dependent patterns of death from infection	133
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection	133
An anti-aging vaccine: BCG turns back the clock on remyelination failure	132
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	128
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	128
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	128
The conceptual foundations of innate immunity: Taking stock 30 years later	126
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	126
Antigen-presenting cells as specialized drivers of intestinal T cell functions	125
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	124
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	122
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	122
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	121
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	121
CD8+ T cell tolerance: It doesn’t translate	120
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	119
Defining the landscape of human epidermal mononuclear phagocytes	118
Gutcha: The microbiota drives tumor-induced mortality	117
A universe of second messengers for cGLR-STING signaling	116
IL-33 is alarmin the uterus for labor	114
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	113
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	111

Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	111
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	110
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	108
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	104
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	104
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	104
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	102
Strength in diversity: Widening B cell recruitment for broader vaccine protection	102
Response to identifying the epidermal dendritic cell landscape	102
Are we there yet? An immune field trip through human embryonic development	101
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	101
Sex-biased gut dopamine signaling in multiple sclerosis	100
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	100
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	98
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	97
Trade-offs inside the black box of neoantigen prediction	97
“Bloody” good factors for keeping the brain young	97
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	96
Fungus fuels mucosal wounds in Crohn’s disease	96
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	96
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	96