OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 95. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Nerve-racking worms	1120
IgG sialylation puts lung inflammation to REST	557
Something old, something new: The marriage of PD-1 and IL-2	477
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	466
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	460
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	444
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	435
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	423
Not so aDAMant after all: Plasticity of phagocytic microglia	416
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	394
Computationally designed proteins mimic antibody immune evasion in viral evolution	392
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	375
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	340
The best offense is a good beta-defensin	292
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	292
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	283
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	281
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	251
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	245
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential	240
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	229
The B7:CD28 family and friends: Unraveling coinhibitory interactions	228
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	223
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	219
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	217

More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	217
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge	216
Genetics of autoinflammation instructs selective IL-1 targeting	210
The domiNO effect turns macrophage activation deadly	200
Plasmacytoid dendritic cells: Welcome back to the DC fold	197
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	196
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	193
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	191
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	183
Non-canonical IKKs side with N4BP1 against the family	181
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	180
TREMendous microglial effects on neurons	175
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	174
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	170
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection	169
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	167
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	162
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	153
A subset of Kupffer cells regulates metabolism through the expression of CD36	150
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	149
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	145
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	143
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	141
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation	138
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	136
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	134
Sex hormone signaling and regulation of immune function	131
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	130
An anti-aging vaccine: BCG turns back the clock on remyelination failure	130
CD8+ T cell tolerance: It doesn’t translate	129
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	128
Gutcha: The microbiota drives tumor-induced mortality	126
A universe of second messengers for cGLR-STING signaling	126
IL-33 is alarmin the uterus for labor	125
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	124
Defining the landscape of human epidermal mononuclear phagocytes	124
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	123
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	123
Human determinants of age-dependent patterns of death from infection	122
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	120
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	119
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	118
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	117
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	116
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	112
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	109
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	109
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	108
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	106
The conceptual foundations of innate immunity: Taking stock 30 years later	105

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	105
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	105
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	104
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	104
Antigen-presenting cells as specialized drivers of intestinal T cell functions	104
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	104
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	104
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	102
Response to identifying the epidermal dendritic cell landscape	101
Sex-biased gut dopamine signaling in multiple sclerosis	99
“Bloody” good factors for keeping the brain young	99
Are we there yet? An immune field trip through human embryonic development	99
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	99
Trade-offs inside the black box of neoantigen prediction	98
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	98
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	97
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	96
Diverse priming outcomes under conditions of very rare precursor B cells	96
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	95
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity	95