Drug Delivery

Article	Citations
PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application	185
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis	89
Metal nanoparticles as a promising technology in targeted cancer treatment	79
Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy	75
Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions	74
Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation	63
Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review	63
Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles	61
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis	57
Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review	57
Progress in the development of stabilization strategies for nanocrystal preparations	56
Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents	54
Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges	53
Drug delivery of amoxicillin molecule as a suggested treatment for covid-19 implementing functionalized mesoporous SBA-15 with aminopropyl groups	52
Recent advances in the local antibiotics delivery systems for management of osteomyelitis	50
Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer	50
Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery	48
Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage	46
Preparation and use of nanogels as carriers of drugs	45
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	45
Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy	44
Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy	43
Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis	42
Recent advances in cell membrane-camouflaged nanoparticles for inflammation therapy	41
Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release	40

Structural and biological investigation of chitosan/hyaluronic acid with silanized-hydroxypropyl methylcellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engi	37
Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model	37
Targeted treatment for osteoarthritis: drugs and delivery system	37
Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment	37
Stimuli-responsive drug delivery systems for head and neck cancer therapy	36
Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery	34
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	34
Layer-by-Layer assembled nano-drug delivery systems for cancer treatment	33
Topical delivery of l -ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin	32
Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment	31
Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo	31
Thymoquinone-entrapped chitosan-modified nanoparticles: formulation optimization to preclinical bioavailability assessments	30
Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications	30
Gemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery	30
Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions	29
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation	29
Recent advances in anti-multidrug resistance for nano-drug delivery system	28
Sonodynamical reversion of immunosuppressive microenvironment in prostate cancer via engineered exosomes	28
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	28
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology	28
Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid ca	27
Statistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice	27
Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo	27
Targeted therapy of rheumatoid arthritis via macrophage repolarization	27
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vi	27
Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke	27
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis	27
Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development	27
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice	26
Novel cubosome based system for ocular delivery of acetazolamide	26
Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone	26
Construction of pH-sensitive targeted micelle system co-delivery with curcumin and dasatinib and evaluation of anti-liver cancer	26
From blood to brain: blood cell-based biomimetic drug delivery systems	25
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles	25
Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and ex vivo evaluation	25
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs	25
Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease	25
Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer	24
Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization an	24
Development and optimization of curcumin analog nano-bilosomes using 21.31full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma:in-vitro<	24
The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials	24
Hybrid thermosensitive-mucoadhesive in situ forming gels for enhanced corneal wound healing effect of L-carnosine	24
Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment	23
Cubogel as potential platform for glaucoma management	23
Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain	23
An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice	23
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models	23
Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy	22
Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management	22
A detailed insight of the tumor targeting using nanocarrier drug delivery system	22

Nanocrystals based pulmonary inhalation delivery system: advance and challenge	22
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy	21
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery	21
Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation	21
Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells	21
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms	21
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	21
Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents	20
Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment	20
Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin	20
Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy	20
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, and in vivo reno-protective effect in cisplatin induced nephrotoxicity	20
Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability	19
Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m	19
Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery	19
Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer	19
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer	19
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management	19
Flexible nano-liposomes-based transdermal hydrogel for targeted delivery of dexamethasone for rheumatoid arthritis therapy	19
pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer	19
Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection	19
Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery	18
Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges : in-vitro and in-vivo evaluation	18
Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury	18
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	18
Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential	18
Pullulan based derivatives: synthesis, enhanced physicochemical properties, and applications	18
Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction	18
The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery	18
Simulating drug penetration during hyperthermic intraperitoneal chemotherapy	18
Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro , and	18
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo	18
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3	18
Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy	18
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects	18
Nanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis	17
Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study	17
Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models	17
Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives	17
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	17
Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment	17
Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment	17
Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer	17
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment	17
Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment	17
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea	17
Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer	17
Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy	17
Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury	16
Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations	16
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system	16
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases	16
The most promising microneedle device: present and future of hyaluronic acid microneedle patch	16
Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer	16
In vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein recept	16
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	16
Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment	16
Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo	16
Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery	16
RPE-derived exosomes rescue the photoreceptors during retina degeneration: an intraocular approach to deliver exosomes into the subretinal space	16
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy	16
Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments	15
Docetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy	15
Dasatinib self-assembled nanoparticles decorated with hyaluronic acid for targeted treatment of tumors to overcome multidrug resistance	15
Carbopol emulgel loaded with ebastine for urticaria: development, characterization, in vitro and in vivo evaluation	15
Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer	15
Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules	15
Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis	15
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles	15
Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC	15
Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer	15
D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes	15
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats	15
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance	15
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis	15
Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage	14
Topical anesthetic and pain relief using penetration enhancer and transcriptional transactivator peptide multi-decorated nanostructured lipid carriers	14
Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation	14
Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis	14
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells	14

Pulmonary delivery of resveratrol-β-cyclodextrin inclusion complexes for the prevention of zinc chloride smoke-induced acute lung injury	14
Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats	14
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity	14
Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia	14
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy	14
Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films	14
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing	14
Oral delivery of carrier-free dual-drug nanocrystal self-assembled microspheres improved NAD + bioavailability and attenuated cardiac ischemia/reperfusion injury in	14
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy	14