OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice	224
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	219
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	202
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	174
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	171
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	157
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity	150
Immunomodulatory nano-preparations for rheumatoid arthritis	145
Advanced hydrogel material for colorectal cancer treatment	103
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility	85
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	85
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	80
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	78
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	75
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	74
Electroporation induced changes in extracellular vesicle profile	69
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	68
Correction	67
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms	66
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats	65
Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements	64
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach	64
The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions	61
The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics	57
Thermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions	57

Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant	57
Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂	57
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques	56
Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model	56
Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management	55
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases	55
Advance in placenta drug delivery: concern for placenta-originated disease therapy	55
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin	54
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis	51
Nanoparticles-based anti-aging treatment of Alzheimer’s disease	51
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments	51
Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption	49
Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs	48
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide	48
SREKA-targeted liposomes for highly metastatic breast cancer therapy	48
Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment	48
Platinum-based drugs and hydrogel: a promising anti-tumor combination	48
Tumor microenvironment-responsive conformational activation of apoA-I mimetic peptides for targeted cancer therapy	46
Application of chitosan-based drug delivery systems in the treatment of bacterial diseases: a review	46
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation	46
Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease	45
Targeting interleukin-13 receptor α2 (IL-13Rα2) for glioblastoma therapy with surface functionalized nanocarriers	45
PEGylation technology: addressing concerns, moving forward	45
Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin	44
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles	44
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective	44
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling	44
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA	44
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo	43
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring	43
Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia	42
Modification of sodium aescinate into a safer, more stable and effective water-soluble drug by liposome-encapsulation: anin vitroandin vivostudy	42
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats	42
Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy	41
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro	40
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2	40
Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration	39
Integrating micro-needle jet injection and sustained GLP-1 therapy with structured feeding: a comprehensive strategy for obesity management	39
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in viv	39
Artificial intelligence-assisted development ofin situforming nanoparticles for arthritis therapy via intra-articular delivery	39
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	39
Oxaliplatin-loaded nanoemulsion containingTeucrium poliumL. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway	39
Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	39
Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid	38
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy	37
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors	37
Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells	37
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques	37
Chitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors	36
Design and applications of liposome-in-gel as carriers for cancer therapy	36

Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum	36
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies	36
Metal nanoparticles as a promising technology in targeted cancer treatment	36
Utilization of DOX–Fe complex and RSL3 co-loaded liposomes in ferroptosis-enhanced treatment of triple-negative breast cancer	35
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	35
Modeling the synergistic enhancement of drug permeation by a dual-microbubble system under ultrasonic excitation	35
Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats	35
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models	35
Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors	35
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	35
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	34
Extravasation of biodegradable microspheres in the rat brain	34
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment	34
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	33
A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer	33
Correction notice	33
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor	33
Selective expansion and differentiation of antigen-specific CD4 ⁺ T-helper cells by engineered extracellular vesicles	33
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis	33
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application	32
Development of a drug delivering round window niche implant for cochlear pharmacotherapy	32
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy	31
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	31
Advances in vaccine adjuvant development and future perspectives	30
Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model	30
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	30
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis	29
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives	29
Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles	29
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer	29
Drug retention after intradiscal administration	29
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	29
Sustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma	28
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity	28
A non-invasive direct nose to brain drug delivery platform vs. invasive brain delivery approach: patient-centered care impact analysis	28
Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice	28
Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro	28
Nanomaterial-mediated multidimensional regulation of the bone microenvironment: a precise therapeutic strategy for bone metabolic imbalance	27
Induction of antigen-specific regulatory T cells by engineered extracellular vesicles	27
Phenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen delivery in cancer immunotherapy	27
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules	27
Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis	27
GRP78-targeted and doxorubicin-loaded nanodroplets combined with ultrasound: a potential novel theranostics for castration-resistant prostate cancer	27
Implementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo a	26
Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management	26
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis	26
Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, in vitro, and in vivo evaluation	26
Ultrasound targeted microbubbles for theranostic applications in liver diseases: from molecular imaging to targeted therapy	25
Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects	25
Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation	25
Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis	25
Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer	25
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance	25
Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells	25
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases	24
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma	24
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis	24
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3	24
Advances in cell membrane-based biomimetic nanodelivery systems for natural products	24
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion	24
Nanocrystals based pulmonary inhalation delivery system: advance and challenge	24
Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticle	24
Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats	24