OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	117
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	101
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	99
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	92
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	90
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	82
Advanced hydrogel material for colorectal cancer treatment	80
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	80
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility	70
Electroporation induced changes in extracellular vesicle profile	59
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	58
Immunomodulatory nano-preparations for rheumatoid arthritis	57
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	57
Correction	55
Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant	55
The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions	51
Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model	50
Correction	49
Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity of Artocarpus altilis extrac	49
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats	48
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach	47
Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements	46
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques	46
Advance in placenta drug delivery: concern for placenta-originated disease therapy	45
Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂	45

Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice	45
Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management	44
Lysosome-directed targeted protein degradation technologies for overcoming cancer drug resistance: mechanisms, design principles, and therapeutic opportunities	42
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin	41
SREKA-targeted liposomes for highly metastatic breast cancer therapy	40
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments	40
Platinum-based drugs and hydrogel: a promising anti-tumor combination	39
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases	38
The development of DNA delivery system based on ionic liquid and carboxylic acid modified polyethyleneimine	38
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide	37
Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs	37
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective	37
Application of chitosan-based drug delivery systems in the treatment of bacterial diseases: a review	37
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation	37
Tumor microenvironment-responsive conformational activation of apoA-I mimetic peptides for targeted cancer therapy	37
Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin	36
PEGylation technology: addressing concerns, moving forward	36
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA	36
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro	35
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling	35
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2	35
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	35
Low-intensity pulsed ultrasound combined with microbubbles enhances amphotericin B delivery across the blood–brain barrier for improved therapy of cryptococcal meningitis	35
Next-generation composite vesicular systems: an in-depth review of proniosomes in advanced drug delivery	34
Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells	33
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring	33
Harnessing fluorescent probes for molecular diagnosis and theranostics of atherosclerosis	33
Design and characterization of a resveratrol spray-dried inhalable formulation for pulmonary delivery with in vivo pharmacokinetic and toxicological eval	33
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice	32
FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery	32
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies	32
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats	32
Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	32
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques	31
Wedelactone-loaded exosomes for sepsis-induced liver injury: a novel therapeutic strategy	31
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors	31
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum	30
Design and applications of liposome-in-gel as carriers for cancer therapy	30
Integrating micro-needle jet injection and sustained GLP-1 therapy with structured feeding: a comprehensive strategy for obesity management	30
Self-assembled non-steroidal anti-inflammatory drug-peptide hydrogel to effectively mitigate ocular inflammation	29
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	29
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	29
Modeling the synergistic enhancement of drug permeation by a dual-microbubble system under ultrasonic excitation	29
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis	29
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	29
Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors	29
The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity	29
Utilization of DOX–Fe complex and RSL3 co-loaded liposomes in ferroptosis-enhanced treatment of triple-negative breast cancer	28
Development of a drug delivering round window niche implant for cochlear pharmacotherapy	28
Selective expansion and differentiation of antigen-specific CD4 ⁺ T-helper cells by engineered extracellular vesicles	28

Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	28
Extravasation of biodegradable microspheres in the rat brain	28
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives	27
Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model	27
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor	27
Correction notice	27
Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice	26
Nanomaterial-mediated multidimensional regulation of the bone microenvironment: a precise therapeutic strategy for bone metabolic imbalance	26
Advancements and challenges in ophthalmic microneedles to treat eye diseases	26
Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles	26
Advances in vaccine adjuvant development and future perspectives	26
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	26
Induction of antigen-specific regulatory T cells by engineered extracellular vesicles	25
Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management	25
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules	25
Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis	25
Drug retention after intradiscal administration	25
Triptolide and l -ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation	24
Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis	24
Advances in cell membrane-based biomimetic nanodelivery systems for natural products	24
Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects	24
Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells	24
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases	24
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma	24
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion	24