OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application	259
Metal nanoparticles as a promising technology in targeted cancer treatment	135
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis	119
Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review	112
Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy	111
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis	92
Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions	91
Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation	88
Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges	83
Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review	82
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	82
Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles	81
Progress in the development of stabilization strategies for nanocrystal preparations	74
Recent advances in the local antibiotics delivery systems for management of osteomyelitis	68
Preparation and use of nanogels as carriers of drugs	67
Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage	66
Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery	64
Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy	62
Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis	57
Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents	57
Targeted treatment for osteoarthritis: drugs and delivery system	57
Drug delivery of amoxicillin molecule as a suggested treatment for covid-19 implementing functionalized mesoporous SBA-15 with aminopropyl groups	56
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	56
Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer	56
Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy	50

Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model	50
Structural and biological investigation of chitosan/hyaluronic acid with silanized-hydroxypropyl methylcellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engi	47
Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release	47
Recent advances in cell membrane-camouflaged nanoparticles for inflammation therapy	45
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	45
Layer-by-Layer assembled nano-drug delivery systems for cancer treatment	45
Topical delivery of l -ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin	45
Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment	45
A detailed insight of the tumor targeting using nanocarrier drug delivery system	42
Stimuli-responsive drug delivery systems for head and neck cancer therapy	41
Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications	41
Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo	41
Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery	41
Gemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery	38
Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions	38
Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo	37
Nanocrystals based pulmonary inhalation delivery system: advance and challenge	37
Novel cubosome based system for ocular delivery of acetazolamide	37
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vi	36
Sonodynamical reversion of immunosuppressive microenvironment in prostate cancer via engineered exosomes	35
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	35
Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development	35
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis	35
Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation	34
Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke	34
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation	34
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice	34
Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid ca	33
Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy	33
Flexible nano-liposomes-based transdermal hydrogel for targeted delivery of dexamethasone for rheumatoid arthritis therapy	33
Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer	33
Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment	33
Recent advances in anti-multidrug resistance for nano-drug delivery system	32
Thymoquinone-entrapped chitosan-modified nanoparticles: formulation optimization to preclinical bioavailability assessments	32
Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment	31
Recent advances in drug delivery systems for targeting brain tumors	31
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology	31
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models	31
Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer	31
Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization an	31
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs	30
Construction of pH-sensitive targeted micelle system co-delivery with curcumin and dasatinib and evaluation of anti-liver cancer	30
From blood to brain: blood cell-based biomimetic drug delivery systems	30
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles	30
Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer	30
Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease	29
Pullulan based derivatives: synthesis, enhanced physicochemical properties, and applications	29
Statistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice	29
Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and ex vivo evaluation	29
Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection	29

An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice	29
Development and optimization of curcumin analog nano-bilosomes using 2¹.3¹full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma:in-vitro<	29
Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment	29
Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone	29
Targeted therapy of rheumatoid arthritis via macrophage repolarization	29
Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin	29
The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery	28
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, andin vivoreno-protective effect in cisplatin induced nephrotoxicity	28
The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials	28
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	27
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment	27
Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo	27
Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges : in-vitro and in-vivo evaluation	27
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	27
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo	27
Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury	26
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects	26
Hybrid thermosensitive-mucoadhesive in situ forming gels for enhanced corneal wound healing effect of L-carnosine	26
Cubogel as potential platform for glaucoma management	26
Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells	26
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy	25
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer	25
Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain	25
Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis	25
Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives	25
Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy	25
Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy	25
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy	25
Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment	24
Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂	24
Synthesis of dual-stimuli responsive metal organic framework-coated iridium oxide nanocomposite functionalized with tumor targeting albumin-folate for synergistic photodynamic/photothermal cancer ther	24
Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors	24
Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management	24
The most promising microneedle device: present and future of hyaluronic acid microneedle patch	24
Delivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis	24
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery	24
Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential	24
Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment	24
Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment	23
Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents	23
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms	23
Microfluidic-based fabrication and characterization of drug-loaded PLGA magnetic microspheres with tunable shell thickness	23
Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules	23
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management	23
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases	23
Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery	22
Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy	22
Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage	22
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles	22
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats	22
Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment	22
Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m	22
Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury	21
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3	21
Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability	21
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	21
Preparation of baicalin-loaded ligand-modified nanoparticles for nose-to-brain delivery for neuroprotection in cerebral ischemia	21
Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro , and	21
Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation	21
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity	21
Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer	21
Simulating drug penetration during hyperthermic intraperitoneal chemotherapy	21
Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment	21
Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations	21
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system	21
Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia	21
pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer	21
Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery	20
Carbopol emulgel loaded with ebastine for urticaria: development, characterization,in vitroandin vivoevaluation	20
In vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein recept	20
Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments	20
Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction	20
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation	20
Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer	20
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea	20
Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery	20
Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models	20
Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases	19
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy	19
Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats	19

Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis	19
Nanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis	19
Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation	19
Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evalua	19
Design and applications of liposome-in-gel as carriers for cancer therapy	18
Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration	18
Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal	18
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	18
Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges	18
Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study	18
RPE-derived exosomes rescue the photoreceptors during retina degeneration: an intraocular approach to deliver exosomes into the subretinal space	18
Docetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy	18
Anti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer	18
Nanotechnological approaches for diagnosis and treatment of ovarian cancer: a review of recent trends	18
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing	18
Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer	18