OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Fabrication of bio-engineered chitosan nanoformulations to inhibition of bacterial infection and to improve therapeutic potential of intestinal microflora, intestinal morphology, and immune response i	135
The treatment efficacy of three-layered functional polymer materials as drug carrier for orthotopic colon cancer	133
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity	116
Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation	112
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	100
Extravasation of biodegradable microspheres in the rat brain	92
Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice	85
Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats	68
Formulation and characterization of eprosartan mesylate and β-cyclodextrin inclusion complex prepared by microwave technology	62
Mesoporous tantalum oxide nanomaterials induced cardiovascular endothelial cell apoptosis via mitochondrial-endoplasmic reticulum stress apoptotic pathway	57
Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery	56
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles	45
Aptamer-mediated hollow MnO ₂ for targeting the delivery of sorafenib	42
Chitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors	41
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity	41
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	38
K. Zheng et al. Gold-nanoparticle-based multistage drug delivery system for antitumor therapy	37
Green synthesis and characterization of gold nanoparticles from Pholiota adiposa and their anticancer effects on hepatic carcinoma	37
Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy	36
Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability	35
Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity	35
Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia	35
Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease	34
Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity	33
Rationalized design to explore the full potential of PLGA microspheres as drug delivery systems	33

Transferrin receptor targeting segment T7 containing peptide gene delivery vectors for efficient transfection of brain tumor cells	33
Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo	33
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy	32
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	31
D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes	31
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality	31
Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy	31
Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability	30
Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy	30
Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management	30
Single pot organic solvent-free thermocycling technology for siRNA-ionizable LNPs: a proof-of-concept approach for alternative to microfluidics	29
Utilization of a nanostructured lipid carrier encapsulating pitavastatin– Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line	29
Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy	29
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	29
Magnesium ascorbyl phosphate vesicular carriers for topical delivery; preparation, in-vitro and ex-vivo evaluation, factorial optimization and clinical assessment in melasma patients	28
Development of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study	28
Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks	28
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models	28
The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma	27
Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex	27
Optimal treatment occasion for ultrasound stimulated microbubbles in promoting gemcitabine delivery to VX2 tumors	27
Lipidization as a tool toward peptide therapeutics	27
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice	27
An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications	26
Silk nanoparticles for the protection and delivery of guava leaf ( Psidium guajava L.) extract for cosmetic industry, a new approach for an old herb	26
Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model	25
Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management	25
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	25
Advanced hydrogel material for colorectal cancer treatment	25
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	25
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	25
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	24
Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization andin vivoburn wound healing activity	24
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	24
Arenobufagin-loaded PEG-PLA nanoparticles for reducing toxicity and enhancing cancer therapy	24
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models	24
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell ana	24
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects	24
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	23
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	23
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment	23
Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution	22
Research progress of ophthalmic preparations of immunosuppressants	22
Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization	22
The efficacy ofOriganum majoranananocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats	21
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	21
Preparation of baicalin-loaded ligand-modified nanoparticles for nose-to-brain delivery for neuroprotection in cerebral ischemia	21
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment	21
Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evalua	21
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	21

Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment	21
Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape	21
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	21
Risedronate-loaded aerogel scaffolds for bone regeneration	21
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system	21
Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria	20
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	20
Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance	20
Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles	19
Statement of Retraction: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer	19
Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma	19
Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective	19
An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis	19
Immunomodulatory nano-preparations for rheumatoid arthritis	19
Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application	18
Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management	18
Correction notice	18
Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization	18
Ferric-loaded lipid nanoparticles inducing ferroptosis-like cell death for antibacterial wound healing	18
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy	18
Enzyme-triggered- and tumor-targeted delivery with tunable, methacrylated poly(ethylene glycols) and hyaluronic acid hybrid nanogels	18
Statement of Retraction	18
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives	17
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application	17
Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids	17
Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy	17
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	17
Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity	17
Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives	17
Biodegradable gemcitabine-loaded microdevice with sustained local drug delivery and improved tumor recurrence inhibition abilities for postoperative pancreatic tumor treatment	17
Thermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions	17
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy	17
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	17
Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells	16
Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer	16
Formulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment	16
Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats	16
The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics	16
Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂	16
Novel cannula design improves large volume auto-injection rates for high viscosity solutions	16
Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases	16
A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer	16
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, andin vivoreno-protective effect in cisplatin induced nephrotoxicity	16
Application of mPEG-CS-cRGD/ Bmi-1RNAi -PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells	16
Recent advances in drug delivery systems for targeting brain tumors	16
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	16
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques	16
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery	16