OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	220
Electroporation induced changes in extracellular vesicle profile	214
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	198
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	169
Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice	167
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	151
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility	144
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	133
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	102
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	99
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	83
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	82
Advanced hydrogel material for colorectal cancer treatment	77
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	77
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity	71
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	70
Immunomodulatory nano-preparations for rheumatoid arthritis	67
Correction	65
Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant	62
Thermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions	62
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats	62
The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions	62
The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics	61
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques	57
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach	57

Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements	56
Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂	56
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms	56
Platinum-based drugs and hydrogel: a promising anti-tumor combination	55
Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption	55
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin	54
SREKA-targeted liposomes for highly metastatic breast cancer therapy	54
Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management	53
Nanoparticles-based anti-aging treatment of Alzheimer’s disease	52
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis	50
Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer	50
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments	48
Advance in placenta drug delivery: concern for placenta-originated disease therapy	48
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation	47
Targeting interleukin-13 receptor α2 (IL-13Rα2) for glioblastoma therapy with surface functionalized nanocarriers	47
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases	47
Application of chitosan-based drug delivery systems in the treatment of bacterial diseases: a review	46
PEGylation technology: addressing concerns, moving forward	46
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles	46
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective	45
Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment	45
Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs	45
Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease	45
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA	44
Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin	43
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide	43
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling	43
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro	43
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	43
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring	42
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in viv	42
Modification of sodium aescinate into a safer, more stable and effective water-soluble drug by liposome-encapsulation: anin vitroandin vivostudy	42
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2	42
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats	41
Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy	40
Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration	39
Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia	39
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo	39
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum	38
Design and applications of liposome-in-gel as carriers for cancer therapy	38
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy	38
Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid	38
Integrating micro-needle jet injection and sustained GLP-1 therapy with structured feeding: a comprehensive strategy for obesity management	38
Oxaliplatin-loaded nanoemulsion containingTeucrium poliumL. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway	38
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies	38
Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	37
Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells	37
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques	36
Artificial intelligence-assisted development ofin situforming nanoparticles for arthritis therapy via intra-articular delivery	36
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors	36

Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats	35
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models	35
Extravasation of biodegradable microspheres in the rat brain	35
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system	35
Chitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors	35
Selective expansion and differentiation of antigen-specific CD4 ⁺ T-helper cells by engineered extracellular vesicles	35
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	35
Metal nanoparticles as a promising technology in targeted cancer treatment	35
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment	34
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis	34
Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors	34
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	33
Correction notice	33
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	33
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	33
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer	32
Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model	32
Novel cannula design improves large volume auto-injection rates for high viscosity solutions	32
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	32
Development of a drug delivering round window niche implant for cochlear pharmacotherapy	32
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor	32
Advances in vaccine adjuvant development and future perspectives	32
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives	31
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	31
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	29
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy	29
Drug retention after intradiscal administration	29
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application	29
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis	29
A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer	29
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity	28
A non-invasive direct nose to brain drug delivery platform vs. invasive brain delivery approach: patient-centered care impact analysis	28
Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice	28
Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro	28
Sustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma	28
Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles	28
Phenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen delivery in cancer immunotherapy	27
Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis	27
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules	27
Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management	27
Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, in vitro, and in vivo evaluation	27
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis	27
Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis	26
Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells	26
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance	26
Ultrasound targeted microbubbles for theranostic applications in liver diseases: from molecular imaging to targeted therapy	26
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma	26
Implementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo a	26
Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer	26
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3	26
GRP78-targeted and doxorubicin-loaded nanodroplets combined with ultrasound: a potential novel theranostics for castration-resistant prostate cancer	26
Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects	25
Carbopol emulgel loaded with ebastine for urticaria: development, characterization,in vitroandin vivoevaluation	25
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases	25
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion	25
Nanocrystals based pulmonary inhalation delivery system: advance and challenge	25