OOIR: Observatory of International Research

Papers

(The median citation count of Free Radical Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Role of oxidative stress in nanoparticles toxicity	84
Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation	62
Protein carbonylation: molecular mechanisms, biological implications, and analytical approaches	47
Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms	46
Theoretical insights into the antioxidant activity of moracin T	40
On the relevance of hydroxyl radical to purine DNA damage	37
MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4	35
Hydroxyl radical scavenging activity of melatonin and its related indolamines	34
MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4	32
MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin	27
GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative activity in human neuroblastoma cells	27
Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs)	26
G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19)	24
Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line	23
Antioxidant action of vitamin Ein vivoas assessed from its reaction products with multiple biological oxidants	21
Protective effect of bone marrow mesenchymal stem cell-derived exosomes on cardiomyoblast hypoxia-reperfusion injury through the miR-149/let-7c/Faslg axis	21
Erythrocytes as a preferential target of oxidative stress in blood	20
MicroRNA-326 prevents sepsis-induced acute lung injury via targeting TLR4	19
Recent advances in the antioxidant activity and mechanisms of chalcone derivatives: a computational review	19
4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities	19
Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model	19
Reactive oxygen species: the root cause of nanoparticle-induced toxicity in Drosophila melanogaster	19
Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1	18
Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases	17
The effect of solvent polarity on the antioxidant potential of echinatin, a retrochalcone, towards various ROS: a DFT thermodynamic study	17

Feedback of hypoxia-inducible factor-1alpha (HIF-1alpha) transcriptional activity via redox factor-1 (Ref-1) induction by reactive oxygen species (ROS)	16
Oxidative stress and endoplasmic stress in calcium oxalate stone disease: the chicken or the egg?	15
The effect of a color tattoo on the local skin redox regulatory network: an N-of-1 study	14
Edaravone attenuates myocyte apoptosis through the JAK2/STAT3 pathway in acute myocardial infarction	14
Knockdown of LINC00473 promotes radiosensitivity of non-small cell lung cancer cells via sponging miR-513a-3p	14
Recent advances in iron homeostasis and regulation - a focus on epigenetic regulation and stroke	13
Peroxiredoxin 4 attenuates glutamate-induced neuronal cell death through inhibition of endoplasmic reticulum stress	13
Gasotransmitter signaling in energy homeostasis and metabolic disorders	13
SARS-CoV-2 induces mitochondrial dysfunction and cell death by oxidative stress/inflammation in leukocytes of COVID-19 patients	13
Redox reactions of organoselenium compounds: Implication in their biological activity	12
Early reductive stress and late onset overexpression of antioxidant enzymes in experimental myocardial infarction	12
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation	12
Histidine-rich glycoprotein possesses antioxidant activity through self-oxidation and inhibition of hydroxyl radical production via chelating divalent metal ions in Fenton’s reaction	12
Activation of DNA damage response signaling in mammalian cells by ionizing radiation	12
Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance inOgg1^–/–mice	11
Coumestrol ameliorates doxorubicin-induced cardiotoxicity via activating AMPKα	11
Chemical and biological basis for development of novel radioprotective drugs for cancer therapy	11
The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells via scavenging mitochondrial ROS and maintaining the stability of mitochond	11
An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signalling	10
Mechanistic computational modeling of the kinetics and regulation of NADPH oxidase 2 assembly and activation facilitating superoxide production	10
In vitro analysis of catalase and superoxide dismutase mimetic properties of blue tattoo ink	10
Iron metabolism: an emerging therapeutic target underlying the anti-cancer effect of quercetin	10
Lipid composition dictates the rate of lipid peroxidation in artificial lipid droplets	10
MicroRNA-328-3p facilitates the progression of gastric cancer via KEAP1/NRF2 axis	10
Autoxidation and photooxidation of tetrahydrobiopterin: a theoretical study	10
Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress	10
Redox regulation of regulatory T-cell differentiation and functions	10
Quercetin-3-rutinoside protects against gamma radiation inflicted hematopoietic dysfunction by regulating oxidative, inflammatory, and apoptotic mediators in mouse spleen and bone marrow	9
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling	9
Labile iron affects pharmacological ascorbate-induced toxicity in osteosarcoma cell lines	9
MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury	9
Reaction targets of antioxidants in azo-initiator or lipid hydroperoxide induced lipid peroxidation	9
Up-regulation of LncRNA NEAT1 induces apoptosis of human placental trophoblasts	9
Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice	9
Proportional coexistence of okanin chalcone glycoside and okanin flavanone glycoside in Bidens pilosa leaves and theoretical investigation on the antioxidant properties of their aglycones	9
Oxidative stress and gender disparity in cancer	9
Protective effects of tiopronin on oxidatively challenged human lung carcinoma cells (A549)	9
Glutathione peroxidase 2 (Gpx2) preserves mitochondrial function and decreases ROS levels in chronologically aged yeast	9
MicroRNA-217 modulates inflammation, oxidative stress, and lung injury in septic mice via SIRT1	9
Heavy-ion beam-induced reactive oxygen species and redox reactions	8
The role of miR-199b-3p in regulating Nrf2 pathway by dihydromyricetin to alleviate septic acute kidney injury	8
Autism spectrum disorder (ASD)-associated mitochondrial deficits are revealed in children’s platelets but unimproved by hyperbaric oxygen therapy	8
Serum superoxide dismutase activity: a sensitive, convenient, and economical indicator associated with the prevalence of chronic type 2 diabetic complications, especially in men	8
Effect of iron and folate supplementation on Pb levels in pregnant anemic women: a prospective study	8
Silencing of long non-coding RNA LINC00520 promotes radiosensitivity of head and neck squamous cell carcinoma cells	8
Persimmon oligomeric proanthocyanidins alleviate ultraviolet B-induced skin damage by regulating oxidative stress and inflammatory responses	8
Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells	8
Negative association between antioxidant vitamin intake and non-alcoholic fatty liver disease in Chinese non-diabetic adults: mediation models involving superoxide dismutase	7
HIF-1α protects osteoblasts from ROS-induced apoptosis	7
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway	7

Effect of Rosolic acid on endothelial dysfunction under ER stress in pancreatic microenvironment	7
Enhancement of antioxidative activity of astaxanthin by combination with an antioxidant capable of forming intermolecular interactions	7
Radiation-induced H3K9 tri-methylation in E-cadherin promoter during lung EMT: in vitro and in vivo approaches using vanillin	7
Melatonin improves the antioxidant capacity in cardiac tissue of Wistar rats after exhaustive exercise	7
Valproic acid promotes SOD2 acetylation: a potential mechanism of valproic acid-induced oxidative stress in developing systems	7
Constitutive activity of NADPH oxidase 1 (Nox1) that promotes its own activity suppresses the colon epithelial cell migration	7
Hypoxia induces proliferation via NOX4-Mediated oxidative stress and TGF-β3 signaling in uterine leiomyoma cells	7
Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions	6
Detection and structural analysis of lipid-derived radicals in vitro and in vivo	6
Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice	6
Nucleoside transporters are critical to the uptake and antioxidant activity of 7,8-dihydroneopterin in monocytic cells	6
Exercise associated with γ-oryzanol supplementation suppresses oxidative stress and prevents changes in locomotion in Drosophila melanogaster	6
Inhibition of MEK/ERK upregulates GSH production and increases RANKL-induced osteoclast differentiation in RAW 264.7 cells	6
Regulation of NRF2 by Na⁺/K⁺-ATPase: implication of tyrosine phosphorylation of Src	6
MicroRNA-214 protects L6 skeletal myoblasts against hydrogen peroxide-induced apoptosis	6
Hydroperoxyl radical (HOO^•) as a reducing agent: unexpected synergy with antioxidants. A review	6
The amplex red/horseradish peroxidase assay requires superoxide dismutase to measure hydrogen peroxide in the presence of NAD(P)H	6
Growth differentiation factor 11 mitigates cardiac radiotoxicity via activating AMPKα	6
Inhomogeneous generation of hydroxyl radicals in hydrogen peroxide solution induced by ultraviolet irradiation and in a Fenton reaction system	6
Protective effects of zinc L-carnosine against hydrogen peroxide-induced DNA damage and micronucleus formation in CCD-18co human colon fibroblast cells	6
Theoretical insights into the radical scavenging activity of glipizide: DFT and molecular docking studies	5
High-energy ionizing radiation-induced degradation of amodiaquine in dilute aqueous solution: radical reactions and kinetics	5
A new mitochondrial probe combining pyrene and a triphenylphosphonium salt for cellular oxygen and free radical detection via fluorescence lifetime measurements	5
The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells	5
Role of oxidative stress in induction of trans-differentiation of neutrophils in patients with rheumatoid arthritis	5
Oxidative damage in the liver and brain of the rats exposed to frequency-dependent radiofrequency electromagnetic exposure: biochemical and histopathological evidence	5
Electrophilic oxysterols: generation, measurement and protein modification	5
Antioxidant activity of erlotinib and gefitinib: theoretical and experimental insights	5
Mitochondrial bioenergetics and enzymatic antioxidant defense differ in Paraná pine cell lines with contrasting embryogenic potential	5
The supplementations with 2-hydroxyoleic acid and n-3 polyunsaturated fatty acids revert oxidative stress in various organs of diet-induced obese mice	5
Adsorption of free radical TEMPO onto Al₂O₃ nanoparticles and evaluation of radical scavenging activity	5
The radical scavenger capacity and mechanism of prenylated coumestan-type compounds: a DFT analysis	5
Generation of localized highly concentrated hydrogen peroxide clusters in water by X-rays	5
Free radical scavenging activity of gallic acid toward various reactive oxygen, nitrogen, and sulfur species: a DFT approach	5
Phenotypic characterization of circulating endothelial cells induced by inflammation and oxidative stress in ankylosing spondylitis	5
Influence of pubertal development on urinary oxidative stress biomarkers in adolescent girls in the New York LEGACY cohort	5
CO ameliorates cellular senescence and aging by modulating the miR-34a/Sirt1 pathway	5
Comparison of three methods for in vivo quantification of glutathione in tissues of hypertensive rats	5
Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice	5
The effects of nitric oxide or oxygen on the stable products formed from the tyrosine phenoxyl radical	4
BSC2 enhances cell resistance to AmB by inhibiting oxidative damage in Saccharomyces cerevisiae	4
Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric ca	4
Flavoenzyme-catalyzed single-electron reduction of nitroaromatic antiandrogens: implications for their cytotoxicity	4
A combined prophylactic modality of podophyllotoxin and rutin alleviates radiation induced injuries to the lymphohematopoietic system of mice by modulating cytokines, cell cycle progression, and apopt	4
Molecular and biochemical investigations of inborn errors of metabolism-altered redox homeostasis in branched-chain amino acid disorders, organic acidurias, and homocystinuria	4
Distribution and quantitative analysis of homoanserine and its 2-oxo derivative in mouse tissues	4
Febuxostat reduces muscle wasting in tumor-bearing mice with LM8 osteosarcoma cells via inhibition of reactive oxygen species generation	4
Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds	4
Generation and measurement of low-temperature plasma for cancer therapy: a historical review	4
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway	4
Betulinic acid mitigates oxidative stress-mediated apoptosis and enhances longevity in the yeast Saccharomyces cerevisiae model	4
Metabolomics analysis of the effects of quercetin on hepatotoxicity induced by acrylamide exposure in rats	4
Graphene oxide nanoflakes prevent reperfusion injury of Langendorff isolated rat heart providing antioxidative activity in situ	4
Relationship between hemodynamic alteration and sympathetic nerve activation following a single oral dose of cinnamtannin A2	4
FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats	4
Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS	4
Effects of LET on oxygen-dependent and-independent generation of hydrogen peroxide in water irradiated by carbon-ion beams	4
In vivo analysis of redox status in organs – from bench to bedside	4
Impact of eugenol onin vivomodel of 6-hydroxydopamine-induced oxidative stress	4
Relationship between the radical-scavenging activity of selected flavonols and thermodynamic parameters calculated by density functional theory	4
Cold atmospheric plasma-induced oxidative stress and ensuing immunological response – a Neo-Vista in immunotherapy	4
Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma	4
Lactobacillus brevis MTCC 1750 enhances oxidative stress resistance and lifespan extension with improved physiological and functional capacity in Caenorhabditis elegans via the DAF-16 pa	3
Five variants of the superoxide dismutase genes in Turkish women with polycystic ovary syndrome	3
Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH	3
Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol	3
Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications	3
Superoxide dismutase and glutathione peroxidase activities in a population exposed to high indoor radon concentration: a preliminary report	3
Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress	3
CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin through modulation of PPAR-γ activity	3
Effect of vitamin E on low density lipoprotein oxidation at lysosomal pH	3
Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9	3
A potential screening method for epigenetic drugs: uncovering stress-induced gene silencing in Chlamydomonas	3
The downregulation of NADPH oxidase Nox4 during hypoxia in hemangioendothelioma cells: a possible role of p22^phox on Nox4 protein stability	3
Antioxidant and prooxidant modulation of lipid peroxidation by integral membrane proteins	3
Targeting endogenous gaseous signaling molecules as novel host-directed therapies against tuberculosis infection	3
The microbiota catabolites of quercetin glycosides concertedly enhance the resistance against acetaldehyde-induced oxidative stress	3
Effects of GST null genotypes on individual susceptibility to atherosclerotic cardiovascular diseases: a meta-analysis	3
Redox interactions of immune cells and muscle in the regulation of exercise-induced pain and analgesia: implications on the modulation of muscle nociceptor sensory neurons	3
Potential role of free-radical processes in biomolecules damage during COVID-19 and ways of their regulation	3