OOIR: Observatory of International Research

Papers

(The median citation count of Free Radical Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Autoxidation of ascorbate mediates lysine N-pyrrolation	60
Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease	32
Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells	30
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy	25
Unveiling the anti-aging activities and mechanism of melibiose: insights from metabolomics and RT-qPCR analyses	24
Selenomethionine enhances transplant organ preservation by attenuating oxidative stress-induced proteolysis in rats	22
Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker for the prognosis of acute poisoning patients in the emergency Intensive-care unit: a prospective observational study	22
Reduction of oxidative damage in prostate tissue caused by radiation and/or chloroquine by apocynin	21
Unveiling an oxidative stress-linked diagnostic signature and molecular subtypes in preeclampsia: novel insights into pathogenesis	21
Untargeted metabonomic analysis of non-alcoholic fatty liver disease with iron overload in rats via UPLC/MS	20
Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway	20
Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway	20
The interplay between microRNAs and oxidative stress and its implications in respiratory diseases	20
Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells	18
Molecular targets for anti-oxidative protection of açaí berry against diabetes myocardial ischemia/reperfusion injury	16
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury	16
Spatiotemporal analysis of ROS in hepatic ischemia-reperfusion and prediction of organ damage using MRI	16
Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for Parkinson’s disease at early stages	15
Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma	15
Ferulic acid protects renal tubular epithelial cells against anoxia/reoxygenation injury mediated by AMPKα1	14
Mitochondria and redox homeostasis - the backseat drivers in glioma	14
Involvement of iron ions in 6-hydroxydopamine-induced disruption of intracellular copper metabolism	14
Distal substituents effect of 4-oxo-TEMPO derivatives bearing a benzyl group at the 2-position on the reduction resistance toward ascorbate	13
Graphene oxide nanoflakes prevent reperfusion injury of Langendorff isolated rat heart providing antioxidative activity in situ	13
Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway	13

Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins	12
NADPH oxidase derived ROS promote arterial contraction in early postnatal rats by activation of L-type voltage-gated Ca ²⁺ channels	11
Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function	11
The microbiota catabolites of quercetin glycosides concertedly enhance the resistance against acetaldehyde-induced oxidative stress	11
Oxidative imbalance linked to impaired mitochondrial bioenergetics mediates the toxicity of mesoionic compounds MI-D and MI-J in hepatocarcinoma cells (HepG2)	11
Betulinic acid mitigates oxidative stress-mediated apoptosis and enhances longevity in the yeast Saccharomyces cerevisiae model	11
Beneficial effects of vitamin B ₁₂ treatment in pediatric patients diagnosed with vitamin B ₁₂ deficiency regarding total-native t	11
Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis	10
Association of circulatory PCSK-9 with biomarkers of redox imbalance and inflammatory cascades in the prognosis of diabetes and associated complications: a pilot study in the Indian population	10
Low-temperature plasma modulates seed germination through reactive oxygen species in dose-dependent manner	10
Low density lipoprotein oxidized under lysosomal conditions decreases arterial vasodilatation	10
Carbonylation induced by antibiotic and pesticide residues on casein increases its IgE binding and allergenicity	10
Copper induces cystine/glutamate antiporter SLC7A11 through the activation of Nrf2 and Atox1 pathways	10
Dissecting the potential role of ferroptosis in liver diseases: an updated review	9
Hyper-energy metabolism of oxidative phosphorylation and enhanced glycolysis contributes to radioresistance in glioma cells	9
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress	9
Thermodynamic and kinetic studies on antioxidant capacity of amentoflavone: a DFT (density functional theory) computational approach	8
Peroxiredoxins: regulatory roles and potential clinical significances in breast cancer	8
Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from Croton argyrophylloides	8
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis	8
Epoxides: an underestimated lipid oxidation product	7
Growth acceleration of Nile tilapia at 21 to 31 weeks of age with plasma-treated air-supplied water	7
The Val16Ala MnSOD gene polymorphism is associated with hypertension in self-declared black individuals	7
Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications	7
In vitro analysis of catalase and superoxide dismutase mimetic properties of blue tattoo ink	7
Thioredoxin improves contact dermatitis through an anti-inflammatory mechanism different from glucocorticoids	6
Relationship between toxicity and oxidative stress of the nanoencapsulated colchicine in a model of Drosophila melanogaster	6
Cigarette smoke induces endoplasmic reticulum stress-associated mucus hypersecretion via orosomucoid 1-like protein 3 in airway epithelia	6
Serum and cecal metabolic profile of the insulin resistant and dyslipidemic p47^phoxknockout mice	6
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation	6
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway	6
Impact of genetic variability on NADPH oxidase activity: an extensive genotype-phenotype assessment	6
Changes in tumor suppressors and inflammatory responses during hydrogen peroxide-induced senescence in rat fibroblasts	6
Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork	6
Decreased plasma H₂O₂ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality	6
Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice	5
Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: a role in liver cancer resistance to oxidative stress	5
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells	5
Accumulation of polyunsaturated lipids fuels ferroptosis to promote liver failure after extended hepatectomy in mice	5
Antioxidant activity of erlotinib and gefitinib: theoretical and experimental insights	5
Fullerene C ₆₀ reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/caspase-3/beclin	5
Mechanism of non-thermal atmospheric plasma in anti-tumor: influencing intracellular RONS and regulating signaling pathways	5
Theoretical insights into the radical scavenging activity of glipizide: DFT and molecular docking studies	5
Brca2 ^{(p.T1942fs/+)} dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells	5
EP4 receptor agonist CAY10598 upregulates ROS-dependent Hsp90 cleavage in colorectal cancer cells	5
Heme-catalyzed degradation of linoleate 9-hydroperoxide (9-HPODE) forms two allylic epoxy-ketones via a proposed pseudo-symmetrical diepoxy radical intermediate	5
Effect of repeated sprint training in hypoxia on acute and chronic redox balance modulation	5
Recent advances in the antioxidant activity of metal-curcumin complexes: a combined computational and experimental review	5
Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling	5
Cutting-edge insights into Helicobacter research	5

Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol	5
Transferrin-mediated increase of labile iron Pool following simulated ischemia causes lipid peroxidation during the early phase of reperfusion	5
Mutyh deficiency downregulates mitochondrial fusion proteins and causes cardiac dysfunction via α-ketoglutaric acid reduction with oxidative stress	5
Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis	4
Upregulation of p67^phox in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3	4
Superoxide-producing associates from gastrointestinal bacteria: stimulation of its growth by exogenous superoxide-producing complex from raspberries	4
Anti-oxidants as therapeutic agents for oxidative stress associated pathologies: future challenges and opportunities	4
Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications	4
6-Gingerol Alleviates NNK-Induced Lung Carcinogenesis by Boosting Antioxidation and Reducing Inflammation	4
Differential dihydroethidium fluorescence spectra in cell-free and cellular superoxide models: roles of riboflavin, FMN, FAD, and ions	4
Melatonin inhibits liver ferroptosis in copper-laden rats: a potential therapy mechanism underlying Wilson’s disease	4
Correction	4
Redox system and ROS-related disorders in peroxisomes	4
Non-thermal plasma elicits ferrous chloride-catalyzed DMPO-OH	4
Role of oxidative stress in induction of trans-differentiation of neutrophils in patients with rheumatoid arthritis	4
Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice	4
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen	4
New era of plasma dentistry	3
The role of oxidative stress and inflammation biomarkers in pre- and postoperative monitoring of prostate cancer patients	3
Mito-TEMPO protects against bisphenol-A-induced testicular toxicity: an in vivo study	3
Insights into H ₂ O ₂ -induced signaling in Jurkat cells from analysis of gene expression	3
Carboxymethylnaringenin: a promising antioxidant in the aqueous physiological environment	3
Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation	3
Redox factors in the antioxidant activity of nitroxides toward DNA guanyl and 2-deoxyribose-peroxyl radicals	3
Hyperoxia induces autophagy in pulmonary epithelial cells: insights from in vivo and in vitro experiments	3
FOXO signaling pathway participates in oxidative stress-induced histone deacetylation	3
Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells	3
Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH	3
Protective effects of sinensetin against oxidative stress damage induced by AAPH in the brain-gut	3
Catechol-derived Mannich bases: radical regulatory properties, cytotoxicity and interaction with biomolecules	3
Correction	3
Antioxidative activity of a novel antioxidant resorcimoline	3
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling	3
The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets	3
The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice	3
NRF2 signaling and amino acid metabolism in cancer	3
Antioxidant properties of 34 alkaloids of natural origin: a density functional theory study	2
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway	2
Radiation-induced transformation of peptides into nanoparticles for nano-theranostics of pancreatic cancer with controllable drug delivery and sustained release	2
Protective effect of ebselen on bleomycin-induced lung fibrosis: analysis of the molecular mechanism of lung fibrosis mediated by oxidized diacylglycerol	2
DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species	2
Statement of Retraction: ‘Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: Association with reduction of oxidative stress	2
Formation of radicals in irradiated maltose – the role of hydrogen bonding with water	2
Tetrahydrocurcumin exhibits neuroprotective effects by inhibiting neuron ferroptosis via activity of iPLA2β/p38 MAPK phosphorylation in rat TBI model	2
Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity	2
Ferritin with methylglyoxal produces reactive oxygen species but remains functional	2
A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages	2
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation	2
Plasma activated Ringer’s lactate solution	2
Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage	2
A new mitochondrial probe combining pyrene and a triphenylphosphonium salt for cellular oxygen and free radical detection via fluorescence lifetime measurements	2
Exploring the oxidative mechanism of methotrexate on catalase enzyme: an in vitro study	2
Gold nanoparticles-supported iron oxide particles endows bone scaffolds with anti-tumor function	2
Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1	2
Electrochemical and Spectrophotometric Assessment of Antioxidant Properties in Asphodelus tenuifolius Cav. Extracts	2
Mitochondrial electron transport chain disruption and oxidative stress in lipopolysaccharide-induced cardiac dysfunction in rats and mice	2
Hydroxyl radical scavenging and chemical repair capabilities of positively charged peptides (PCPs): a pulse radiolysis study	2
Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress	2
Nitric oxide is an irreversible human diamine oxidase inhibitor	2
Metformin ameliorates gestational diabetes mellitus via inhibiting ferroptosis of trophoblasts through the Nrf2/HO-1 signaling pathway	2
Correction	2
Enhanced cytotoxicity against cancer cells by acetylation of a planar catechin analog	2