OOIR: Observatory of International Research

Papers

(The median citation count of Free Radical Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Autoxidation of ascorbate mediates lysine N-pyrrolation	73
Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker for the prognosis of acute poisoning patients in the emergency Intensive-care unit: a prospective observational study	37
Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells	30
Selenomethionine enhances transplant organ preservation by attenuating oxidative stress-induced proteolysis in rats	27
Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease	26
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy	26
Unveiling the anti-aging activities and mechanism of melibiose: insights from metabolomics and RT-qPCR analyses	24
Reduction of oxidative damage in prostate tissue caused by radiation and/or chloroquine by apocynin	23
Untargeted metabonomic analysis of non-alcoholic fatty liver disease with iron overload in rats via UPLC/MS	22
Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway	22
Unveiling an oxidative stress-linked diagnostic signature and molecular subtypes in preeclampsia: novel insights into pathogenesis	22
The interplay between microRNAs and oxidative stress and its implications in respiratory diseases	22
Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway	18
Spatiotemporal analysis of ROS in hepatic ischemia-reperfusion and prediction of organ damage using MRI	17
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury	16
Molecular targets for anti-oxidative protection of açaí berry against diabetes myocardial ischemia/reperfusion injury	15
Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for Parkinson’s disease at early stages	15
Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells	15
Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma	14
Mitochondria and redox homeostasis - the backseat drivers in glioma	14
Mechanistic and kinetic insights into the radical scavenging capacity and Keap1-Nrf2 inhibition potency of A-type avenanthramides: DFT and molecular docking	14
Involvement of iron ions in 6-hydroxydopamine-induced disruption of intracellular copper metabolism	14
Distal substituents effect of 4-oxo-TEMPO derivatives bearing a benzyl group at the 2-position on the reduction resistance toward ascorbate	13
Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway	13
Oxidative imbalance linked to impaired mitochondrial bioenergetics mediates the toxicity of mesoionic compounds MI-D and MI-J in hepatocarcinoma cells (HepG2)	12

Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins	12
Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function	11
Betulinic acid mitigates oxidative stress-mediated apoptosis and enhances longevity in the yeast Saccharomyces cerevisiae model	10
The microbiota catabolites of quercetin glycosides concertedly enhance the resistance against acetaldehyde-induced oxidative stress	10
NADPH oxidase derived ROS promote arterial contraction in early postnatal rats by activation of L-type voltage-gated Ca ²⁺ channels	9
Copper induces cystine/glutamate antiporter SLC7A11 through the activation of Nrf2 and Atox1 pathways	9
Beneficial effects of vitamin B ₁₂ treatment in pediatric patients diagnosed with vitamin B ₁₂ deficiency regarding total-native t	9
Association of circulatory PCSK-9 with biomarkers of redox imbalance and inflammatory cascades in the prognosis of diabetes and associated complications: a pilot study in the Indian population	9
Peroxiredoxins: regulatory roles and potential clinical significances in breast cancer	8
Low density lipoprotein oxidized under lysosomal conditions decreases arterial vasodilatation	8
Dissecting the potential role of ferroptosis in liver diseases: an updated review	8
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis	8
Low-temperature plasma modulates seed germination through reactive oxygen species in dose-dependent manner	7
Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous sulfate through p38MAPK/NF-κB/GPX4/Nrf2/keap-1/HO-1 signaling axis	7
Hyper-energy metabolism of oxidative phosphorylation and enhanced glycolysis contributes to radioresistance in glioma cells	7
Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from Croton argyrophylloides	7
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress	7
Retinoic acid reduces oxidative stress and enhances migration-related signaling in vascular endothelial cells	7
Non-thermal plasma prevents IgE-mediated Ca ²⁺ influx and allergic response in RBL-2H3 cells	6
Thermodynamic and kinetic studies on antioxidant capacity of amentoflavone: a DFT (density functional theory) computational approach	6
Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications	6
Growth acceleration of Nile tilapia at 21 to 31 weeks of age with plasma-treated air-supplied water	6
In vitro analysis of catalase and superoxide dismutase mimetic properties of blue tattoo ink	6
Relationship between toxicity and oxidative stress of the nanoencapsulated colchicine in a model of Drosophila melanogaster	6
Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork	6
Epoxides: an underestimated lipid oxidation product	6
Impact of genetic variability on NADPH oxidase activity: an extensive genotype-phenotype assessment	6
Thioredoxin improves contact dermatitis through an anti-inflammatory mechanism different from glucocorticoids	6
Serum and cecal metabolic profile of the insulin resistant and dyslipidemic p47^phoxknockout mice	6
EP4 receptor agonist CAY10598 upregulates ROS-dependent Hsp90 cleavage in colorectal cancer cells	5
Heme-catalyzed degradation of linoleate 9-hydroperoxide (9-HPODE) forms two allylic epoxy-ketones via a proposed pseudo-symmetrical diepoxy radical intermediate	5
Fullerene C ₆₀ reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/caspase-3/beclin	5
Cigarette smoke induces endoplasmic reticulum stress-associated mucus hypersecretion via orosomucoid 1-like protein 3 in airway epithelia	5
Mechanism of non-thermal atmospheric plasma in anti-tumor: influencing intracellular RONS and regulating signaling pathways	5
Transferrin-mediated increase of labile iron Pool following simulated ischemia causes lipid peroxidation during the early phase of reperfusion	5
Recent advances in the antioxidant activity of metal-curcumin complexes: a combined computational and experimental review	5
Effect of repeated sprint training in hypoxia on acute and chronic redox balance modulation	5
Decreased plasma H₂O₂ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality	5
Accumulation of polyunsaturated lipids fuels ferroptosis to promote liver failure after extended hepatectomy in mice	5
Carnosine alleviates high glucose-induced renal tubular cell pyroptosis by activating the AMPK/SIRT3/SOD2 pathway	5
Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice	5
Acorus gramineus ethanol extract suppresses MITF-mediated melanogenesis under oxidative stress conditions	5
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation	5
Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: a role in liver cancer resistance to oxidative stress	4
Redox system and ROS-related disorders in peroxisomes	4
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells	4
Correction	4
Superoxide-producing associates from gastrointestinal bacteria: stimulation of its growth by exogenous superoxide-producing complex from raspberries	4
Melatonin inhibits liver ferroptosis in copper-laden rats: a potential therapy mechanism underlying Wilson’s disease	4
Fluoxetine Alleviates Vascular Cognitive Impairment by Activating the Nrf2/ARE Pathway via Sp1-Mediated OTUD1 Transcription	4

Spermidine improve high copper diet-induced intestinal oxidative stress and microbiota community composition	4
Cutting-edge insights into Helicobacter research	4
Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis	4
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen	4
Brca2 ^{(p.T1942fs/+)} dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells	4
Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling	4
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation	4
Non-thermal plasma elicits ferrous chloride-catalyzed DMPO-OH	4
Anti-oxidants as therapeutic agents for oxidative stress associated pathologies: future challenges and opportunities	4
Differential dihydroethidium fluorescence spectra in cell-free and cellular superoxide models: roles of riboflavin, FMN, FAD, and ions	4
NRF2 signaling and amino acid metabolism in cancer	3
New era of plasma dentistry	3
Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells	3
Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH	3
The complementary role of the TRX system in the enzymatic antioxidant defense against iron overload-induced oxidative stress in the mouse kidney	3
The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice	3
Redox factors in the antioxidant activity of nitroxides toward DNA guanyl and 2-deoxyribose-peroxyl radicals	3
Carboxymethylnaringenin: a promising antioxidant in the aqueous physiological environment	3
FOXO signaling pathway participates in oxidative stress-induced histone deacetylation	3
Antioxidative activity of a novel antioxidant resorcimoline	3
Effect of pumpkin polysaccharide-milk combinations on oxidative stress resistance of Caenorhabditis elegans based on Chou-Talalay model	3
Protective effects of sinensetin against oxidative stress damage induced by AAPH in the brain-gut	3
Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation	3
Catechol-derived Mannich bases: radical regulatory properties, cytotoxicity and interaction with biomolecules	3
Radiation-induced transformation of peptides into nanoparticles for nano-theranostics of pancreatic cancer with controllable drug delivery and sustained release	3
The role of oxidative stress and inflammation biomarkers in pre- and postoperative monitoring of prostate cancer patients	3
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation	3
Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications	3
Hyperoxia induces autophagy in pulmonary epithelial cells: insights from in vivo and in vitro experiments	3
Plasma activated Ringer’s lactate solution	2
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway	2
A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages	2
Development of a radioiodinated boronic acid probe for the detection of hydrogen peroxide and peroxynitrite	2
Protective effect of ebselen on bleomycin-induced lung fibrosis: analysis of the molecular mechanism of lung fibrosis mediated by oxidized diacylglycerol	2
Role of ferroptosis in 2, 4, 6-trinitrobenzenesulfonic acid induced ulcerative colitis: targeting iron metabolism for therapeutic gain	2
Gold nanoparticles-supported iron oxide particles endows bone scaffolds with anti-tumor function	2
Enhanced cytotoxicity against cancer cells by acetylation of a planar catechin analog	2
Metformin ameliorates gestational diabetes mellitus via inhibiting ferroptosis of trophoblasts through the Nrf2/HO-1 signaling pathway	2
Hydroxyl radical scavenging and chemical repair capabilities of positively charged peptides (PCPs): a pulse radiolysis study	2
Mitochondrial electron transport chain disruption and oxidative stress in lipopolysaccharide-induced cardiac dysfunction in rats and mice	2
Insights into H ₂ O ₂ -induced signaling in Jurkat cells from analysis of gene expression	2
Electrochemical and spectrophotometric assessment of antioxidant properties in Asphodelus tenuifolius Cav. extracts	2
DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species	2
Oxidation of fluorogenic probes detecting reactive oxygen species in the extracellular medium	2
Nitric oxide is an irreversible human diamine oxidase inhibitor	2
Tetrahydrocurcumin exhibits neuroprotective effects by inhibiting neuron ferroptosis via activity of iPLA2β/p38 MAPK phosphorylation in rat TBI model	2
Ferritin with methylglyoxal produces reactive oxygen species but remains functional	2
The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets	2
Mito-TEMPO protects against bisphenol-A-induced testicular toxicity: an in vivo study	2
Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity	2
Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage	2
Antioxidant properties of 34 alkaloids of natural origin: a density functional theory study	2
Statement of Retraction: ‘Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: Association with reduction of oxidative stress	2
Exploring the oxidative mechanism of methotrexate on catalase enzyme: an in vitro study	2