OOIR: Observatory of International Research

Papers

(The median citation count of Free Radical Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Autoxidation of ascorbate mediates lysine N-pyrrolation	53
Untargeted metabonomic analysis of non-alcoholic fatty liver disease with iron overload in rats via UPLC/MS	50
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy	49
Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease	44
Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway	30
Urban aerosol particulate matter promotes cellular senescence through mitochondrial ROS-mediated Akt/Nrf2 downregulation in human retinal pigment epithelial cells	27
Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway	25
Reduction of oxidative damage in prostate tissue caused by radiation and/or chloroquine by apocynin	20
Unveiling an oxidative stress-linked diagnostic signature and molecular subtypes in preeclampsia: novel insights into pathogenesis	20
Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds	19
Selenomethionine enhances transplant organ preservation by attenuating oxidative stress-induced proteolysis in rats	19
Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker for the prognosis of acute poisoning patients in the emergency Intensive-care unit: a prospective observational study	19
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury	18
Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells	17
Molecular targets for anti-oxidative protection of açaí berry against diabetes myocardial ischemia/reperfusion injury	16
Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma	16
Ferulic acid protects renal tubular epithelial cells against anoxia/reoxygenation injury mediated by AMPKα1	16
Graphene oxide nanoflakes prevent reperfusion injury of Langendorff isolated rat heart providing antioxidative activity in situ	14
Role and management of oxidative stress in human disease	14
Involvement of iron ions in 6-hydroxydopamine-induced disruption of intracellular copper metabolism	14
Involvement of hydrogen peroxide in sonodynamical effect with sinoporphyrin sodium in hypoxic situation	14
Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for Parkinson’s disease at early stages	14
Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway	12
NADPH oxidase derived ROS promote arterial contraction in early postnatal rats by activation of L-type voltage-gated Ca ²⁺ channels	12
Distal substituents effect of 4-oxo-TEMPO derivatives bearing a benzyl group at the 2-position on the reduction resistance toward ascorbate	12

Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins	12
Oxidative imbalance linked to impaired mitochondrial bioenergetics mediates the toxicity of mesoionic compounds MI-D and MI-J in hepatocarcinoma cells (HepG2)	11
Betulinic acid mitigates oxidative stress-mediated apoptosis and enhances longevity in the yeast Saccharomyces cerevisiae model	11
Beneficial effects of vitamin B ₁₂ treatment in pediatric patients diagnosed with vitamin B ₁₂ deficiency regarding total-native t	11
Association of circulatory PCSK-9 with biomarkers of redox imbalance and inflammatory cascades in the prognosis of diabetes and associated complications: a pilot study in the Indian population	10
The microbiota catabolites of quercetin glycosides concertedly enhance the resistance against acetaldehyde-induced oxidative stress	10
Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function	10
SARS-CoV-2 induces mitochondrial dysfunction and cell death by oxidative stress/inflammation in leukocytes of COVID-19 patients	10
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress	9
Dissecting the potential role of ferroptosis in liver diseases: an updated review	9
Hyper-energy metabolism of oxidative phosphorylation and enhanced glycolysis contributes to radioresistance in glioma cells	9
Carbonylation induced by antibiotic and pesticide residues on casein increases its IgE binding and allergenicity	9
Low density lipoprotein oxidized under lysosomal conditions decreases arterial vasodilatation	9
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis	9
The Val16Ala MnSOD gene polymorphism is associated with hypertension in self-declared black individuals	9
Growth acceleration of Nile tilapia at 21 to 31 weeks of age with plasma-treated air-supplied water	8
Superoxide dismutase and glutathione peroxidase activities in a population exposed to high indoor radon concentration: a preliminary report	8
The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells via scavenging mitochondrial ROS and maintaining the stability of mitochond	7
In vitro analysis of catalase and superoxide dismutase mimetic properties of blue tattoo ink	7
Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications	7
Thermodynamic and kinetic studies on antioxidant capacity of amentoflavone: a DFT (density functional theory) computational approach	7
Circadian rhythm and time-of-day-effects of (anti)oxidant biomarkers for epidemiological studies	7
Epoxides: an underestimated lipid oxidation product	7
Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from Croton argyrophylloides	7
Serum and cecal metabolic profile of the insulin resistant and dyslipidemic p47^phoxknockout mice	7
Changes in tumor suppressors and inflammatory responses during hydrogen peroxide-induced senescence in rat fibroblasts	6
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation	6
Relationship between toxicity and oxidative stress of the nanoencapsulated colchicine in a model of Drosophila melanogaster	6
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway	6
Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork	6
Cigarette smoke induces endoplasmic reticulum stress-associated mucus hypersecretion via orosomucoid 1-like protein 3 in airway epithelia	5
Mechanism of non-thermal atmospheric plasma in anti-tumor: influencing intracellular RONS and regulating signaling pathways	5
Transferrin-mediated increase of labile iron Pool following simulated ischemia causes lipid peroxidation during the early phase of reperfusion	5
Metabolomics analysis of the effects of quercetin on hepatotoxicity induced by acrylamide exposure in rats	5
Decreased plasma H₂O₂ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality	5
Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol	5
Accumulation of polyunsaturated lipids fuels ferroptosis to promote liver failure after extended hepatectomy in mice	5
Heme-catalyzed degradation of linoleate 9-hydroperoxide (9-HPODE) forms two allylic epoxy-ketones via a proposed pseudo-symmetrical diepoxy radical intermediate	5
Impact of genetic variability on NADPH oxidase activity: An extensive genotype-phenotype assessment.	5
EP4 receptor agonist CAY10598 upregulates ROS-dependent Hsp90 cleavage in colorectal cancer cells	5
Antioxidant activity of erlotinib and gefitinib: theoretical and experimental insights	5
Fullerene C ₆₀ reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/caspase-3/beclin	5
Effect of repeated sprint training in hypoxia on acute and chronic redox balance modulation	5
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells	4
Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: a role in liver cancer resistance to oxidative stress	4
Upregulation of p67^phox in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3	4
Anti-oxidants as therapeutic agents for oxidative stress associated pathologies: future challenges and opportunities	4
Theoretical insights into the radical scavenging activity of glipizide: DFT and molecular docking studies	4
Recent advances in the antioxidant activity of metal-curcumin complexes: a combined computational and experimental review	4
Brca2 ^{(p.T1942fs/+)} dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells	4

Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling	4
Redox system and ROS-related disorders in peroxisomes	4
Mutyh deficiency downregulates mitochondrial fusion proteins and causes cardiac dysfunction via α-ketoglutaric acid reduction with oxidative stress	4
Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice	4
Cutting-edge insights into Helicobacter research	4
Role of oxidative stress in induction of trans-differentiation of neutrophils in patients with rheumatoid arthritis	4
Three-dimensional electron paramagnetic resonance imaging of mice using ascorbic acid sensitive nitroxide imaging probes	4
Correction	3
Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice	3
Non-thermal plasma elicits ferrous chloride-catalyzed DMPO-OH	3
The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice	3
NRF2 signaling and amino acid metabolism in cancer	3
New era of plasma dentistry	3
SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury	3
Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis	3
Febuxostat reduces muscle wasting in tumor-bearing mice with LM8 osteosarcoma cells via inhibition of reactive oxygen species generation	3
FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats	3
Protective effects of sinensetin against oxidative stress damage induced by AAPH in the brain-gut	3
Catechol-derived Mannich bases: radical regulatory properties, cytotoxicity and interaction with biomolecules	3
Superoxide-producing associates from gastrointestinal bacteria: stimulation of its growth by exogenous superoxide-producing complex from raspberries	3
Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications	3
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen	3
Hyperoxia induces autophagy in pulmonary epithelial cells: insights from in vivo and in vitro experiments	3
Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation	3
Carboxymethylnaringenin: a promising antioxidant in the aqueous physiological environment	3
Protective effect of ebselen on bleomycin-induced lung fibrosis: analysis of the molecular mechanism of lung fibrosis mediated by oxidized diacylglycerol	2
Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells	2
Antioxidative activity of a novel antioxidant resorcimoline	2
Correction	2
Mito-TEMPO protects against bisphenol-A-induced testicular toxicity: an in vivo study	2
Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress	2
Plasma activated Ringer’s lactate solution	2
Inhibition of glutamine metabolism increases sensitivity to plasma-activated medium-induced cytotoxicity	2
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway	2
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation	2
The role of oxidative stress and inflammation biomarkers in pre- and postoperative monitoring of prostate cancer patients	2
Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH	2
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling	2
A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages	2
Mitochondrial electron transport chain disruption and oxidative stress in lipopolysaccharide-induced cardiac dysfunction in rats and mice	2
A novel tin based hydroxamic acid complex induces apoptosis through redox imbalance and targets Stat3/JNK1/MMP axis to overcome drug resistance in cancer	2
The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets	2
FOXO signaling pathway participates in oxidative stress-induced histone deacetylation	2
Redox factors in the antioxidant activity of nitroxides toward DNA guanyl and 2-deoxyribose-peroxyl radicals	2
Insights into H₂O₂-induced signaling in Jurkat cells from analysis of gene expression	2
Ferritin with methylglyoxal produces reactive oxygen species but remains functional	2