OOIR: Observatory of International Research

Papers

(The median citation count of Clinical and Experimental Hypertension is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Comparative analysis of inflammatory and metabolic indices (HALP score, NLR, LMR, and TyG index) in healthy individuals, dipper, and non-dipper hypertensive phenotypes	151
Ghrelin improves endothelial function and reduces blood pressure in Ang II-induced hypertensive mice: Role of AMPK	145
Identification of endoplasmic reticulum stress-associated signatures of human pulmonary arterial hypertension: A bioinformatic analysis	98
New insights into clinical strategies for acute coronary syndrome based on biomarker-driven multiomics research	46
Xinshuaining preparation protects H9c2 cells from H ₂ O ₂ -induced oxidative damage through the PI3K/Akt/Nrf-2 signaling pathway	42
What is the prevalence of chronic kidney disease among hypertensive non-diabetic Egyptian patients attending primary healthcare?	42
Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study	36
Presenting non-insulin-based indices of insulin resistance relevant to pre-hypertension: A systematic review and meta-analysis	34
AMPK-dependent maturation of hiPSC-derived cardiomyocytes induced by human cardiac fibroblast exosomes	32
Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis	31
Mechanisms linking hypertension to cardiovascular and cerebrovascular diseases and their clinical implications: A comprehensive review	31
Calcitriol reverses age-related hypertension via downregulating renal AP1/AT ₁ R pathway through regulating mitochondrial function	24
FUNDC2 contributes to hypertensive vascular remodeling by regulating mitochondrial dynamics and ferroptosis in perivascular adipose tissue	23
Gestational diabetes causes hyperactivity of the sympathetic nervous system and hypertension in adult mice offspring	23
Blood pressure variability: From predictive marker to intervention target-breaking the vicious cycle of hypertensive target organ damage	23
Ketogenic diet inhibits neointimal hyperplasia by suppressing oxidative stress and inflammation	22
Establishment of a lupus-prone mouse model of pulmonary arterial hypertension with intermittent hypoxia: functional, biochemical and histological verifications	22
Thymoquinone improved redox homeostasis in the heart and aorta of hypothyroid rats	21
Soyasaponin I alleviates hypertensive intracerebral hemorrhage by inhibiting the renin–angiotensin–aldosterone system	21
High-salt diets provoke phosphorus absorption from the small intestine in mice	21
The causal relationship between aspartate aminotransferase and hypertension: A bidirectional Mendelian randomization study	21
Factors influencing blood pressure variability in postmenopausal women: evidence from the China Health and Nutrition Survey	20
Relationship between kidney length and renal risk in malignant hypertension patients with renal thrombotic microangiopathy	20
Research hotspots and trends regarding microRNAs in hypertension: a bibliometric analysis	20
The correlation between nuts and algae-less diet and children’s blood pressure: from a cross-sectional study in Chongqing	19

Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study	16
Mechanistic study of the association between microRNA-126 and hypertension in obstructive sleep apnea-hypopnea syndrome	15
Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension	15
FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction	15
The causal relationship between circulating metabolites and gestational hypertension, pre-eclampsia, eclampsia: A bidirectional two-sample Mendelian randomization study	14
Hypertensive disorders of pregnancy: A comprehensive review of pathophysiology, diagnosis, treatment, and long-term cardiovascular implications	13
Circulating circular RNAs as biomarkers for the diagnosis of essential hypertension with carotid plaque	13
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury	12
FGF21 attenuates salt-sensitive hypertension via regulating HNF4α/ACE2 axis in the hypothalamic paraventricular nucleus of mice	12
Relationship between inflammatory cells level and longer duration of hypertension in Chinese community residents	12
Disruption of the caspase-1/IL-1β axis alleviates myocardial Ischemia/Reperfusion injury via improvement of mitochondrial homeostasis and reduction of Pyroptosis	12
Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models	11
The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China	11
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China	11
Genetic causal assessment between major depression and hypertension: A two-sample bidirectional Mendelian randomization study	10
A retrospective analysis of incidence and severity of COVID-19 among hypertensive patients: the other side	10
Iron status mediates the causal effects of high-altitude adaptation signals in the HIF–PHD axis on pulmonary vascular and right-heart outcomes	10
Correlation between pulmonary vascular performance and hemodynamics in patients with pulmonary arterial hypertension	10
Relationship between ambulatory arterial stiffness index and the severity of angiographic atherosclerosis in patients with H-type hypertension and coronary artery disease	10
Effects of YM155 on the proliferation and apoptosis of pulmonary artery smooth muscle cells in a rat model of high pulmonary blood flow-induced pulmonary arterial hypertension	10
TIP60 mediates stress-induced hypertension via promoting glutamate ^dmPFC- ^to- ^vCA1 release	9
Age, creatinine, and ejection fraction (ACEF) score as predictive values for late non-valvular atrial fibrillation recurrence after radiofrequency ablation	9
Correction	9
Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis	9
Rebound sign: a case report and review of literature	9
Exploration and validation of signature genes and immune associations in septic cardiomyopathy	9
Knowledge, attitude and preparedness of healthcare students toward basic life support at King Khalid University, Abha, Kingdom of Saudi Arabia	9
Central Venous Catheter as a Novel Approach to Postoperative Thrombolysis in Patients with Acute Iliofemoral Deep Venous Thrombosis	9
Influence of blood pressure variations during hemodialysis on the prognosis of dialysis patients	9
Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study	8
Interdisciplinary collaborative care model combined with family empowerment in patients with comorbid hypertension and diabetes: A study on blood pressure/glucose control and psychosocial adaptation b	8
GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload	8
Expression of TGF-β/Smad pathway-related indices in patients with isolated iliac artery aneurysms complicated with iliac arteriovenous fistula and their relationship with prognosis	8
The effect of calcium channel blocker (CCB) treatment on retinal and choroidal vessels in a group of hypertensive patients	8
RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling	8
Association of triglycerides to high density lipoprotein cholesterol ratio with hypertension in Chinese adults: a cross-sectional study	8
The role of immune mechanisms in hypertension and advances in immunomodulatory research	8
Ginsenoside Rh2 mitigates myocardial damage in acute myocardial infarction by regulating pyroptosis of cardiomyocytes	8
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation	8
A retrospective cohort study on the effects of Down’s screening markers and maternal characteristics on pregnancy outcomes in preeclampsia	7
The proliferation/migration ability mediated by CD151/PI3K/AKT pathway determines the therapeutic effect of hUC-MSCs transplantation on rheumatoid arthritis	7
MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension	7
Red wine but not alcohol consumption improves cardiovascular function and oxidative stress of the hypertensive-SHR and diabetic-STZ rats	7
Association between hypertension and prognosis of patients with COVID-19: A systematic review and meta-analysis	7
Serum uric acid levels as a causal factor in hypertension: Insights from Mendelian randomization analysis	7
Comorbidities and anthropometric parameters in obstructive sleep apnea syndrome: a phenotype-based study	7
Association between composite dietary antioxidant index and hypertension: insights from NHANES	7
Transcatheter hybrid closure of a large muscular ventricular septal defect with severe pulmonary hypertension using a duct occluder	7
CircUsp9x/miR-599/stim1 axis regulates proliferation and migration in vascular smooth muscle cells induced by oxidized-low density lipoprotein	7
Chest pain with ST-elevation in leads AVR, III, AVF, V ₁ , V _3R , V _4R and V ₅	6

Comparing of the effects of sesame oil and rapeseed oil versus suet oil and animal butter on the reproductive system of male rats	6
Association of different diet quality scores with cardiovascular disease mortality risk in hypertension treatment group	6
The effect of comprehensive intervention on children with anxiety/depression and increased blood pressure	6
Association of blood pressure dipping status with Naples Prognostic Score and arterial stiffness in newly diagnosed hypertensive patients	6
Comprehensive viewpoints on heart rate variability at high altitude	6
Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites	6
Inflammatory mechanisms and targeted drugs in heart failure	6
Correction	5
Effects of potassium channel knockdown on peripheral blood T lymphocytes and NFAT signaling pathway in Xinjiang Kazak patients with hypertension	5
The effect of auricular acupuncture on preoperative blood pressure across age groups: a prospective randomized controlled trial	5
Effect of oral potassium supplementation on urinary potassium excretion and its diagnostic value for primary aldosteronism	5
Bilateral hypertensive retinopathy (grade 4): Case report and review of the literature on intravitreal injection anti-VEGF therapy	5
Follistatin-like 1 protects endothelial function in the spontaneously hypertensive rat by inhibition of endoplasmic reticulum stress through AMPK-dependent mechanism	5
A propensity score matched comparison of blood pressure lowering in essential hypertension patients treated with antihypertensive Chinese herbal Medicine: comparing the real-world registry data vs. ra	5
Neuroprotective peptide OL-FS13 attenuates cardiac apoptosis and myocardial infarction injury through Nrf2/HO-1 pathway	5
L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure	5
Association of carotid body size with left atrial strain and peripheral hemodynamics in patients with hypertension: An exploratory study	5
Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension	5
Predictive model combining blood pressure, glycemic and renal markers for diabetic nephropathy in elderly hypertensive patients with type 2 diabetes	5
Targeting the PHD2/HIF-1α/HO-1 pathway: A key role of trimetazidine in hypertensive nephropathy	5
A potential model of systemic sclerosis with pulmonary hypertension induced by monocrotaline plus bleomycin	5
The ApoB/ApoA-I ratio supersedes conventional lipids in predicting coronary artery disease and clinical phenotypes requiring revascularization	5
MG53 alleviates hypoxia/reoxygenation-induced cardiomyocyte injury by succinylation and ubiquitination modification	4
Diagnostic signature and immune characteristic of aging-related genes from placentas in Preeclampsia	4
Restoration of vascular dysfunction resulting from maternal high-fat diet via modulation of the NLRP3/IL-1β axis	4
Relation between endothelial nitric oxide synthase genetic polymorphisms and pulmonary arterial hypertension in newborns with congenital heart disease	4
Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation	4
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells	4
Optimizing the aldosterone-to-renin ratio cut-off for screening primary aldosteronism based on cardiovascular risk: a collaborative study	4
Accumulated exposure to high non-high-density lipoprotein cholesterol increases the risk of cardiovascular diseases in hypertensive individuals: An 11-year prospective cohort study	4
Effects of RAAS blocker use on AKI in elderly hypertensive STEMI patients with propensity score weighed method	4
Folic acid enhances the cardiovascular protective effect of amlodipine in renal hypertensive rats with elevated homocysteine	4
Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy	4
Dipping Pattern and 1-year stroke functional outcome in ischemic stroke or transient ischemic attack	4
Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway	4