OOIR: Observatory of International Research

Papers

(The median citation count of Clinical and Experimental Hypertension is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination	65
Comparing of the effects of sesame oil and rapeseed oil versus suet oil and animal butter on the reproductive system of male rats	46
Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant da	31
Relationship between ambulatory arterial stiffness index and the severity of angiographic atherosclerosis in patients with H-type hypertension and coronary artery disease	25
Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models	22
Effect of prior beta-blocker use on in-hospital atrial fibrillation development in patients with ST-elevation myocardial infarction	19
A retrospective analysis of incidence and severity of COVID-19 among hypertensive patients: the other side	16
Xinshuaining preparation protects H9c2 cells from H ₂ O ₂ -induced oxidative damage through the PI3K/Akt/Nrf-2 signaling pathway	15
Antihypertensive treatment and risk factors for syncope in asymptomatic aortic stenosis patients with hypertension	14
Correlation between pulmonary vascular performance and hemodynamics in patients with pulmonary arterial hypertension	14
The relationship between mean platelet volume and reverse dipping blood pressure pattern in patients with essential hypertension	13
What is the prevalence of chronic kidney disease among hypertensive non-diabetic Egyptian patients attending primary healthcare?	11
Chest pain with ST-elevation in leads AVR, III, AVF, V ₁ , V _3R , V _4R and V ₅	11
Screening and early detection of chronic kidney disease at primary healthcare	11
Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke	11
Neutrophil and monocyte ratios to high-density lipoprotein cholesterol as biomarkers in non-dipping hypertension	11
The usefulness of morphology‐voltage‐P wave duration ECG score for predicting early left atrial dysfunction in hypertensive patients	10
Cardiovascular protective effects of PPARγ agonists in hypothyroid rats: protection against oxidative stress	10
Effects of physical exercise combined with captopril or losartan on left ventricular hypertrophy of hypertensive rats	10
TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension	10
Effects of YM155 on the proliferation and apoptosis of pulmonary artery smooth muscle cells in a rat model of high pulmonary blood flow-induced pulmonary arterial hypertension	9
Role of alginate in the mechanism by which brown seaweed Saccharina japonica intake alleviates an increase in blood pressure in 2-kidney, 1-clip renovascular hypertensive rats	9
Irisin mitigates salt-sensitive hypertension via regulating renal AMPK-Rac1 pathway	9
Ghrelin improves endothelial function and reduces blood pressure in Ang II-induced hypertensive mice: Role of AMPK	9
Study on the relationship between SLCO1B1 and ApoE gene polymorphisms and the risk of coronary heart disease in the Mongolian population	9

MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model	9
Role of chymase in blood pressure control, plasma and tissue angiotensin II, renal Haemodynamics, and excretion in spontaneously hypertensive rats	8
Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis	8
The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult	8
Mendelian randomization study on causal association of IL-6 signaling with pulmonary arterial hypertension	7
Controversial culprit of leptin in obesity hypertension: clues from a case-control study with Chinese newly diagnosed adult early-onset obesity hypertensives	7
Determinants of self-rated health among elderly patients with hypertension: a cross-sectional analysis based on the Chinese longitudinal healthy longevity survey	7
Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway	7
Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes	7
Neutrophil count is a useful marker to predict the severity of preeclampsia	7
Metabolic syndrome and its components predict the development of arterial stiffening in a sample of adult men	7
Syndecan 1 may slow the progression of subclinical atherosclerosis in patients with ankylosing spondylitis	7
Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites	7
Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study	7
Serum irisin and adropin levels may be predictors for coronary artery ectasia	7
Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study	6
Estimated 24-hour urinary sodium excretion and sodium-to-potassium ratio among Japanese elementary school teachers and school lunch cooks	6
Effect of blood pressure variability on hypertensive retinopathy	6
Evaluation of Oxidative Stress and Inflammatory Biomarkers Pre and Post-Treatment in New Diagnosed Atherosclerotic Patients	6
Evaluation of correlation between digital vs. mercury sphygmomanometer in a middle-income country: The role of socio-economic situation	6
Association between endothelial nitric oxide synthase and the renin-angiotensin-aldosterone system polymorphisms, blood pressure and training status in normotensive/pre-hypertension and hypertensive o	6
The relationship between mean platelet volume and resistant hypertension	6
Proprotein convertase subtilisin/kexin type 9 is associated with atherosclerosis in patients with Behcet’s disease	6
Rebound sign: a case report and review of literature	6
Central Venous Catheter as a Novel Approach to Postoperative Thrombolysis in Patients with Acute Iliofemoral Deep Venous Thrombosis	5
Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats	5
Calcitriol reverses age-related hypertension via downregulating renal AP1/AT ₁ R pathway through regulating mitochondrial function	5
Autophagy contributes to angiotensin II induced dysfunction of HUVECs	5
Cardiopulmonary exercise test-based assessment of the effects of sacubitril/valsartan on the blood pressure response to exercise in patients with acute myocardial infarction during hospitalization	5
Perk heterozygosity ameliorates chronic hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in male rats	5
Associations between central pulse pressure, microvascular endothelial function, and fluid overload in peritoneal dialysis patients	5
Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis	5
Knowledge, attitude and preparedness of healthcare students toward basic life support at King Khalid University, Abha, Kingdom of Saudi Arabia	5
Age, creatinine, and ejection fraction (ACEF) score as predictive values for late non-valvular atrial fibrillation recurrence after radiofrequency ablation	5
Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension	5
Resistance training to reduce resting blood pressure and increase muscle strength in users and non-users of anti-hypertensive medication: A meta-analysis	5
The effect of dexmedetomidine on liver injury secondary to lower extremity ischemia-reperfusion in a diabetic rat model	5
Triglyceride glucose index reflects the unfavorable changes of left ventricular diastolic functions and structure in uncomplicated newly diagnosed hypertensive patients	5
Gender difference in the relationship between lipid accumulation product index and pulse pressure in nondiabetic Korean adults: The Korean National Health and Nutrition Examination Survey 2013–2014	5
Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?	5
Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway	5
Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients	5
Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake	5
The protective effects of topiramate on intestinal injury induced with infrarenal aortic occlusion via oxidative stress and apoptosis	5
Gestational diabetes causes hyperactivity of the sympathetic nervous system and hypertension in adult mice offspring	4
Sestrin2 levels in patients with anxiety and depression myocardial infarction was up-regulated and suppressed inflammation and ferroptosis by LKB1-mediated AMPK activation	4
TIP60 mediates stress-induced hypertension via promoting glutamate ^dmPFC- ^to- ^vCA1 release	4
Computed tomography myocardial perfusion imaging of patients with left ventricular hypertrophy in hypertension: A retrospective study	4
Effect of GRK4 on renal gastrin receptor regulation in hypertension	4
Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway	4

SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis of human placental trophoblasts in hypertensive disorder complicating pregnancy	4
Correction	4
The effect of hypertension and antihypertensive therapies on the course of COVID-19 infection: Turkish national health system data	4
Gym and home-based combined training in men with primary hypertension: are they equally effective on functional fitness profile, body composition components, and biochemical parameters of hypertension	4
Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis	4
DNA damage and repair on hematopoietic stem cells: impact of oxidative stress in renovascular hypertension	4
Exploration and validation of signature genes and immune associations in septic cardiomyopathy	4
Inhibition of Th17 cell differentiation by aerobic exercise improves vasodilatation in diabetic mice	4
The association of aortic elasticity properties with novel inflammatory marker CRP /albumin ratio	4
Ketogenic diet inhibits neointimal hyperplasia by suppressing oxidative stress and inflammation	4
Triglyceride-glucose index is a predictive index of hyperuricemia events in elderly patients with hypertension: a cross-sectional study	4
Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertens	4
The paradox of the role of resistin in early-onset obesity hypertension: A comparative study among four Chinese adult subgroups	4
Insight into the cardiovascular mechanisms of blood pressure lowering effect of gitogenin: a steroidal saponin	4
Cardiovascular protective effect of nano selenium in hypothyroid rats: protection against oxidative stress and cardiac fibrosis	4
Thymoquinone improved redox homeostasis in the heart and aorta of hypothyroid rats	3
Soyasaponin I alleviates hypertensive intracerebral hemorrhage by inhibiting the renin–angiotensin–aldosterone system	3
Can Systemic Immune-Inflammation Index Detect the Presence of Exxaggerated Morning Blood Pressure Surge in Newly Diagnosed Treatment-Naive Hypertensive Patients?	3
Clinical presentation and diagnostic evaluation of pheochromocytoma: case series and literature review	3
Seasonal variation in diurnal blood pressure pattern	3
Omentin-1 ameliorates pulmonary arterial hypertension by inhibiting endoplasmic reticulum stress through AMPKα signaling	3
Renal denervation inhibits the renin–angiotensin–aldosterone system in spontaneously hypertensive rats	3
Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats	3
Relationship between the prognostic nutritional index and resistant hypertension in patients with essential hypertension	3
Association of Chlamydophila pneumoniae infection and hypertension during pregnancy – A case control study	3
Analysis of Cardiovascular Hemodynamic and Autonomic Variables in Individuals with Systemic Arterial Hypertension, Type 2 Diabetes Mellitus, and Parkinson’s Disease: A Comparative Study	3
Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension	3
Association study of polymorphisms of endoplasmic reticulum aminopeptidase 1 gene with preeclampsia in Chinese populations	3
Paeonol improves renal and vascular angiotensin II type 1 receptor function via inhibiting oxidative stress in spontaneously hypertensive rats	3
The effect of auricular acupuncture on preoperative blood pressure across age groups: a prospective randomized controlled trial	3
Assessment of vascular function in complete glycaemic spectrum	3
Influence of FOXP3 gene polymorphisms on the risk of preeclampsia: a meta‐analysis and a bioinformatic approach	3
A propensity score matched comparison of blood pressure lowering in essential hypertension patients treated with antihypertensive Chinese herbal Medicine: comparing the real-world registry data vs. ra	3
Mat Pilates training reduces blood pressure in both well-controlled hypertensive and normotensive postmenopausal women: a controlled clinical trial study	3
Correlation of left ventricular longitudinal strain and E/e’ ratio in primary hypertension patients	3
The correlation between T-wave abnormalities and adverse cardiovascular events and echocardiographic changes in hypertensive patients	3
Which is responsible for target organ damage in masked hypertension? Is it an increase in blood pressure or a disruption of the circadian rhythm?	3
Effects of potassium channel knockdown on peripheral blood T lymphocytes and NFAT signaling pathway in Xinjiang Kazak patients with hypertension	3
Combined effects of angiotensin receptor blocker use and physical training in hypertensive men	3
The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients	3
Follistatin-like 1 protects endothelial function in the spontaneously hypertensive rat by inhibition of endoplasmic reticulum stress through AMPK-dependent mechanism	3
Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study	3
Fatty liver is a sensitive early warning for hypertension and its complication in the Chinese population	3
Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats	3
The effect of calcium channel blocker (CCB) treatment on retinal and choroidal vessels in a group of hypertensive patients	3
The possible role of pedunculopontine tegmental nucleus (PPT) opioid receptors in the cardiovascular responses in normotensive and hemorrhagic hypotensive rats	3
Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats	2
Gut microbiota and hypertension: association, mechanisms and treatment	2
Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque	2
GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload	2
Overexpression of NaV1.6 in the rostral ventrolateral medulla in rats mediates stress-induced hypertension via glutamate regulation	2
Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na ⁺ excretion and insulin resistance	2
Association between hypertension and prognosis of patients with COVID-19: A systematic review and meta-analysis	2
Determinants of reverse dipping blood pressure in normotensive, non-diabetic population with an office measurement below 130/85mmHg	2
Body roundness index improves the predictive value of cardiovascular disease risk in hypertensive patients with obstructive sleep apnea: a cohort study	2
Current prescription status of antihypertensive drugs in Chinese patients with hypertension: analysis by type of comorbidities	2
Short-term effects of modest salt reduction combined with DASH diet on changing salt eating habits in hypertensive patients with type II diabetes	2
High-salt diets provoke phosphorus absorption from the small intestine in mice	2
A potential model of systemic sclerosis with pulmonary hypertension induced by monocrotaline plus bleomycin	2
The proliferation/migration ability mediated by CD151/PI3K/AKT pathway determines the therapeutic effect of hUC-MSCs transplantation on rheumatoid arthritis	2
Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis	2
Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults	2
The effect of transglutaminase-2 inhibitor on pulmonary vascular remodeling in rats with pulmonary arterial hypertension	2
Establishment of a canine model of pulmonary arterial hypertension induced by dehydromonocrotaline and ultrasonographic study of right ventricular remodeling	2
Clinical study on effect of wrist-ankle acupuncture on incidence of hypertension after intubation during induction of general anesthesia	2
Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy	2
Association Between the Effectiveness and Immunogenicity of Inactivated SARS-CoV2 Vaccine (CoronaVac) with the Presence of Hypertension among Health Care Workers	2
Folic acid enhances the cardiovascular protective effect of amlodipine in renal hypertensive rats with elevated homocysteine	2
FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction	2
Association of triglycerides to high density lipoprotein cholesterol ratio with hypertension in Chinese adults: a cross-sectional study	2
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells	2
Association between the triglyceride-glucose index and albuminuria in hypertensive individuals	2
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation	2
RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling	2
The correlation between nuts and algae-less diet and children’s blood pressure: from a cross-sectional study in Chongqing	2
Relationship between morning blood pressure surge and the frontal plane QRS-T angle in newly diagnosed hypertensive patients	2
Anthropometric indices of obesity as predictors of high blood pressure among school children	2
Diagnostic signature and immune characteristic of aging-related genes from placentas in Preeclampsia	2
Influence of blood pressure variations during hemodialysis on the prognosis of dialysis patients	2