OOIR: Observatory of International Research

Papers

(The TQCC of Nature Genetics is 148. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
Tumor mutational load predicts survival after immunotherapy across multiple cancer types	1920
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing	1404
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk	1193
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder	1191
Clinical use of current polygenic risk scores may exacerbate health disparities	1171
Identification of common genetic risk variants for autism spectrum disorder	1143
Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice	1072
Genome-wide association study identifies 30 loci associated with bipolar disorder	934
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use	899
A global overview of pleiotropy and genetic architecture in complex traits	536
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases	527
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa	461
Opportunities and challenges for transcriptome-wide association studies	435
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations	425
A primer on deep learning in genomics	417
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways	404
Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton	396
An atlas of genetic influences on osteoporosis in humans and mice	396
Durum wheat genome highlights past domestication signatures and future improvement targets	379
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences	367
A catalog of genetic loci associated with kidney function from analyses of a million individuals	363
Reference genome sequences of two cultivated allotetraploid cottons, Gossypium hirsutum and Gossypium barbadense	360
Origin and evolution of the octoploid strawberry genome	339
Molecular landmarks of tumor hypoxia across cancer types	331
The tomato pan-genome uncovers new genes and a rare allele regulating fruit flavor	326
The genome sequence of segmental allotetraploid peanut Arachis hypogaea	311
Comparative genetic architectures of schizophrenia in East Asian and European populations	304
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene	300
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors	292
Comparative genomics of the major parasitic worms	282
PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia	278
The genome of cultivated peanut provides insight into legume karyotypes, polyploid evolution and crop domestication	277
High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer	270
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch	264
A reference genome for pea provides insight into legume genome evolution	261
Discovery of common and rare genetic risk variants for colorectal cancer	258
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease	254
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries	248
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals	247
Quantitative evidence for early metastatic seeding in colorectal cancer	246
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis	234
Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia	234
A method for genome-wide genealogy estimation for thousands of samples	223
A compendium of promoter-centered long-range chromatin interactions in the human genome	221
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data	220
Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression	218
Assembly of a pan-genome from deep sequencing of 910 humans of African descent	215
Genebank genomics highlights the diversity of a global barley collection	211
A resource-efficient tool for mixed model association analysis of large-scale data	200
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease	196
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy	193
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations	193
The landscape of viral associations in human cancers	192
A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat	192
Probabilistic fine-mapping of transcriptome-wide association studies	187
PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels	185
Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity	182
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels	182
Functional dissection of the Sox9–Kcnj2 locus identifies nonessential and instructive roles of TAD architecture	180
Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk	179
Biological and clinical insights from genetics of insomnia symptoms	177
Multivariate genome-wide analyses of the well-being spectrum	173
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction	173
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies	173
A statistical framework for cross-tissue transcriptome-wide association analysis	172
Transposable elements drive widespread expression of oncogenes in human cancers	169
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells	168
Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions	167
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor	165
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes	163
A genome-wide algal mutant library and functional screen identifies genes required for eukaryotic photosynthesis	160
Resequencing of 429 chickpea accessions from 45 countries provides insights into genome diversity, domestication and agronomic traits	160
Exome sequencing highlights the role of wild-relative introgression in shaping the adaptive landscape of the wheat genome	158
A map of constrained coding regions in the human genome	154
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses	154
Genome assembly of a tropical maize inbred line provides insights into structural variation and crop improvement	150
Landscape of stimulation-responsive chromatin across diverse human immune cells	149
The mutational footprints of cancer therapies	148