OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Genetics is 109. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer	1428
Mapping dog behavior	1375
Epigenetic memory in 3D	1114
Temperature-induced RNA recoding in octopus	1030
Toward advances in retinoblastoma genetics in Kenya	951
Reactivation of embryonic genetic programs in tissue regeneration and disease	906
Mitochondrial DNA mosaicism in normal human somatic cells	839
DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides	702
Role of gene–gene loops in fine-tuning cross-regulation	514
Problems with dystopian representations in genetic futurism	472
Machine learning drives genetic discovery for binge eating disorder	469
Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores	449
Understanding liver repair through space and time	405
GeneMAP enables discovery of metabolic gene function	405
Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness	396
An atlas of genetic determinants of forearm fracture	386
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization	380
Genome-wide RNA polymerase stalling shapes the transcriptome during aging	377
A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation	362
Renal plasticity revealed through reversal of polycystic kidney disease in mice	357
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease	351
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development	328
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways	322
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases	302
Rare coding variant analysis for human diseases across biobanks and ancestries	293

Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea	289
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome	283
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence	279
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells	256
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals	249
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes	248
A biology-aware mutation rate model for human germline	241
An alternative model for maternal mtDNA inheritance	239
Identification of two intrinsic epithelial subtypes of colorectal cancer	231
Shared genetics of substance use disorders	231
Genes influence complex traits through environments that vary between geographic regions	230
Histone gene editing probes functions of H3K27 modifications in mammals	228
APOBEC mutagenesis is a common process in normal human small intestine	225
Establishing African genomics and bioinformatics programs through annual regional workshops	220
Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice	220
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas	220
Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors	217
Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks	214
Somatic mutations in the stomach	212
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns	209
Recent ultra-rare inherited variants implicate new autism candidate risk genes	204
Epigenomic contributions to tumor cell heterogeneity and plasticity	198
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk	196
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon	192
When RNA methylation meets DNA methylation	183
Finding causal genes underlying risk for coronary artery disease	179
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome	171
Interpreting cis-regulatory interactions from large-scale deep neural networks	171
Author Correction: The NAT1–bHLH110–CER1/CER1L module regulates heat stress tolerance in rice	170
Finding cancer mutagens using signature analysis	170
Genetic and non-genetic HLA disruption is widespread in lung and breast tumors	170
Author Correction: Pangenome graphs and their applications in biodiversity genomics	165
Bayesian estimation of gene constraint from an evolutionary model with gene features	162
Safeguard repressor locks hepatocyte identity and blocks liver cancer	162
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases	158
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data	156
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function	155
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction	155
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors	151
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity	151
H3K27me3 conditions chemotolerance in triple-negative breast cancer	151
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription	150
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits	149
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders	149
Increasing diversity in genomics requires investment in equitable partnerships and capacity building	148
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment	145
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer	143
RNA polymerase II dynamics shape enhancer–promoter interactions	142
A generalized linear mixed model association tool for biobank-scale data	141
Redefining teleost phylogeny	139

Mutation rates across species	137
An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs	136
Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance	136
Somatic recombination of repetitive elements	136
Equity, ethics and the promise of partnership in genomic medicine	133
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries	131
Federated analysis of autosomal recessive coding variants in 29,745 developmental disorder patients from diverse populations	131
Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes	131
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells	129
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish	128
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription	127
Precise modulation of transcription factor levels identifies features underlying dosage sensitivity	126
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture	126
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases	126
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits	125
Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank	124
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer	124
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations	124
Sarcoma predisposition	123
Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops	121
Genetic and biological insights into spontaneous coronary artery dissection	121
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements	121
The genetic origins of multiple sclerosis	120
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification	120
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype	120
Epigenetic scars of Brca1 loss point toward breast cancer cell of origin	119
Defining and pursuing diversity in human genetic studies	119
Polygenic basis for seedless grapes	118
Defining genome access of transcription factors	117
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition	116
Indirect paths from genetics to education	114
New genes helped acorn barnacles adapt to a sessile lifestyle	114
Planting the milestones of human genetics in Senegal	111
Improving estimates of loss-of-function constraint for short genes	110
A complete telomere-to-telomere assembly of the maize genome	109
Consensus prediction of cell type labels in single-cell data with popV	109
Mathematical modeling of neuroblastoma associates evolutionary patterns with outcomes	109