OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Genetics is 111. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer	1605
Mapping dog behavior	1549
Epigenetic memory in 3D	1276
Temperature-induced RNA recoding in octopus	1060
Toward advances in retinoblastoma genetics in Kenya	973
DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides	754
Role of gene–gene loops in fine-tuning cross-regulation	565
Problems with dystopian representations in genetic futurism	508
Machine learning drives genetic discovery for binge eating disorder	459
Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores	452
GeneMAP enables discovery of metabolic gene function	438
Reactivation of embryonic genetic programs in tissue regeneration and disease	431
A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation	430
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption	424
An atlas of genetic determinants of forearm fracture	415
Understanding liver repair through space and time	395
Complete genomes of six ape species	394
Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness	347
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development	346
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization	334
Mitochondrial DNA mosaicism in normal human somatic cells	331
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes	307
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease	288
Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea	271
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome	267

Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence	262
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways	262
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases	262
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals	260
Rare coding variant analysis for human diseases across biobanks and ancestries	257
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells	250
Renal plasticity revealed through reversal of polycystic kidney disease in mice	249
Genome-wide RNA polymerase stalling shapes the transcriptome during aging	247
A biology-aware mutation rate model for human germline	244
Shared genetics of substance use disorders	242
Genes influence complex traits through environments that vary between geographic regions	237
Somatic mutations in the stomach	225
When RNA methylation meets DNA methylation	222
Identification of two intrinsic epithelial subtypes of colorectal cancer	214
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk	207
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases	199
APOBEC mutagenesis is a common process in normal human small intestine	191
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer	189
Interpreting cis-regulatory interactions from large-scale deep neural networks	187
Finding causal genes underlying risk for coronary artery disease	186
Epigenomic contributions to tumor cell heterogeneity and plasticity	186
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome	185
Genetic and non-genetic HLA disruption is widespread in lung and breast tumors	182
Finding cancer mutagens using signature analysis	176
Safeguard repressor locks hepatocyte identity and blocks liver cancer	175
Author Correction: Pangenome graphs and their applications in biodiversity genomics	175
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data	174
An alternative model for maternal mtDNA inheritance	174
Increasing diversity in genomics requires investment in equitable partnerships and capacity building	172
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription	170
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon	165
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity	162
Histone gene editing probes functions of H3K27 modifications in mammals	160
Bayesian estimation of gene constraint from an evolutionary model with gene features	160
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns	159
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function	159
Author Correction: The NAT1–bHLH110–CER1/CER1L module regulates heat stress tolerance in rice	158
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas	158
RNA polymerase II dynamics shape enhancer–promoter interactions	156
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction	156
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors	150
Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice	149
Establishing African genomics and bioinformatics programs through annual regional workshops	149
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders	148
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits	148
Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks	147
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice	147
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen	144
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment	143
A generalized linear mixed model association tool for biobank-scale data	142

H3K27me3 conditions chemotolerance in triple-negative breast cancer	139
Redefining teleost phylogeny	137
Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors	137
Somatic recombination of repetitive elements	136
Mutation rates across species	136
An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs	135
Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat	135
Equity, ethics and the promise of partnership in genomic medicine	134
Sarcoma predisposition	132
Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops	131
The genetic origins of multiple sclerosis	130
Genetic and biological insights into spontaneous coronary artery dissection	130
Epigenetic scars of Brca1 loss point toward breast cancer cell of origin	130
Defining genome access of transcription factors	129
Polygenic basis for seedless grapes	129
New genes helped acorn barnacles adapt to a sessile lifestyle	127
Indirect paths from genetics to education	127
Planting the milestones of human genetics in Senegal	125
Improving estimates of loss-of-function constraint for short genes	125
Mathematical modeling of neuroblastoma associates evolutionary patterns with outcomes	124
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition	123
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells	123
Consensus prediction of cell type labels in single-cell data with popV	121
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype	121
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits	119
Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance	119
Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes	119
Federated analysis of autosomal recessive coding variants in 29,745 developmental disorder patients from diverse populations	118
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases	115
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations	115
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification	114
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish	114
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements	113
Defining and pursuing diversity in human genetic studies	112
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription	111
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution	111