OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Drug Targeting is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma	69
Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances	56
Cancer cell membrane camouflaging mesoporous nanoplatform interfering with cellular redox homeostasis to amplify photodynamic therapy on oral carcinoma	43
Nose-to-brain delivery of transferrin-modified carmustine-loaded iron nanoparticles for enhanced glioblastoma treatment	41
Advancement in transporter-oriented nanoplatforms for cancer therapy	41
Polymyxin B delivery systems: smart solutions for improved antibacterial activity and reduced toxicity	35
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches	32
Combined photodynamic therapy and hollow microneedle approach for effective non-invasive delivery of hypericin for the management of imiquimod-induced psoriasis	32
Significant metabolic alterations in patients with hepatitis B virus replication observed via serum untargeted metabolomics shed new light on hepatitis B virus infection	28
Chitosan–β-glycerophosphate thermogelling microneedles for transdermal contraceptive delivery of levonorgestrel	28
Correction	27
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control	26
Role of curcumin and its nanoformulations in the treatment of neurological diseases through the effects on stem cells	26
Trends in iron oxide nanoparticles: a nano-platform for theranostic application in breast cancer	26
Emerging role of ferroptosis in diabetic retinopathy: a review	25
Correction	23
Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes	23
Engineered extracellular vesicle with RAGE-antagonist peptide for delivery of anti-miRNA155 oligonucleotides to inflammatory lung cells	23
Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases	23
Absorption enhancer approach for protein delivery by various routes of administration: a rapid review	22
Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer	22
Ferroptosis-targeting drugs in breast cancer	21
Exosomes derived from cancer cells relieve inflammatory bowel disease in mice	21
Interactions and communications in lung tumour microenvironment: chemo/radiotherapy resistance mechanisms and therapeutic targets	21
Stimulus-responsive peptide hydrogels: a safe and least invasive administration approach for tumor treatment	20

Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy	20
Erythrocyte-derived liposomes for the treatment of inflammatory diseases	20
Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin	20
Emerging trends in viral infection inhibition using a chitosan-based drug delivery system	19
Comprehensive insights into herbal P-glycoprotein inhibitors and nanoformulations for improving anti-retroviral therapy efficacy	19
siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model	19
Identifying factors controlling cellular uptake of gold nanoparticles by machine learning	19
Redefining hepatocellular carcinoma treatment: nanotechnology meets tumor immune microenvironment	19
Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro , and in vivo	18
In vivo application of magnetic molecularly imprinted polymer in rheumatoid arthritis rat model	18
Isoform-specific vs. isoform-universal drug targeting: a new targeting paradigm illustrated by new anti-ICAM-1 antibodies	18
Formulation, optimisation, and evaluation of Lornoxicam-loaded Novasomes for targeted ulcerative colitis therapy: in vitro and in vivo investigations	17
Crafting two-dimensional materials for contrast agents, drug, and heat delivery applications through green technologies	17
Harnessing the synergistic potential of NK1R antagonists and selective COX-2 inhibitors for simultaneous targeting of TNBC cells and cancer stem cells	16
Targeting lipopolysaccharides in gram-negative sepsis: therapeutic advances and challenges	16
pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery	16
Non-coding RNAs enhance the apoptosis efficacy of therapeutic agents used for the treatment of glioblastoma multiform	16
Targeted delivery of epirubicin to cancerous cell using copper sulphide nanoparticle coated with polyarginine and 5TR1 aptamer	15
Emerging biologics for the treatment of pulmonary arterial hypertension	15
L-Carnosine loaded chondroitin sulphate functionalized proposomes as an effective tool for transdermal rheumatoid arthritis management	15
microRNAs: critical targets for treating rheumatoid arthritis angiogenesis	15
Advances, challenge and prospects in cell-mediated nanodrug delivery for cancer therapy: a review	15
From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins	15
The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review	14
An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer	14
Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system	14
Lipo/TK-CDN/TPP/Y6 nanoparticles inhibit cutaneous melanoma formation	14
A novel micellar carrier to reverse multidrug resistance of tumours: TPGS derivatives with end-grafted cholesterol	14
Combination therapy based on targeted nano drug co-delivery systems for liver fibrosis treatment: a review	14
Angiopep-2 modified dual drug-loaded liposomes with brain targeting functionality mitigate Alzheimer’s disease-related symptoms in APP/PS-1 mice	14
Research progress of p38 as a new therapeutic target against morphine tolerance and the current status of therapy of morphine tolerance	14
Folate receptor-mediated targeted therapy for rheumatoid arthritis by methotrexate-phospholipid complex nano-emulsions	13
Recent developments in nanoparticles for the treatment of diabetes	13
Smart delivery of epirubicin to cancer cells using aptamer-modified ferritin nanoparticles	13
Drug repurposing strategies and key challenges for COVID-19 management	13
Recent advances in curcumin-based nanoformulations in diabetes	12
Exploring the translocation behaviours in vivo of herpetrione amorphous nanoparticles via oral delivery	12
Lymphatic targeting for therapeutic application using nanoparticulate systems	12
Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model	12
Study on lipid nanomicelles targeting placenta for the treatment of preeclampsia	12
Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing	12
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model	12
The Golgi apparatus as a strategic target in cancer: mechanisms, diagnosis and therapeutic opportunities	12
Targeted therapy of tumour microenvironment by gold nanoparticles as a new therapeutic approach	12
MicroRNA-206 inhibition and activation of the AMPK/Nampt signalling pathway enhance sevoflurane post-conditioning-induced amelioration of myocardial ischaemia/reperfusion injury	12
Smart design and preclinical evaluation of folate-functionalized mesoporous nanoparticles for targeted paclitaxel delivery in cancer therapy	11
ROS1-positive non-small cell lung cancer (NSCLC): biology, diagnostics, therapeutics and resistance	11
Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds	11
In vitro studies support clinical trials showing platelet-rich fibrin-mediated local delivery of antibiotics improves outcomes in impacted mandibular third molar surgery	11
Boosting breast cancer immunotherapy through targeted siRNA delivery and sequential chemotherapy	11

Nanotransethosomal dual-drug loaded gel of methotrexate and mangiferin as a potent synergistic intervention for rheumatoid arthritis via transdermal delivery	10
Edoxaban enfolded beta-1,4-poly- d -glucosamine nanoparticles for targeting eponym Stuart–Prower factor for treatment of venous thrombosis	10
Development of mRNA nano-vaccines for COVID-19 prevention and its biochemical interactions with various disease conditions and age groups	10
Calpeptin promotes osteogenesis through the Dlx3–RUNX2 pathway: in vitro and in vivo evidence for a dual-action osteoporosis therapy	10
ceRNA networks in gynecological cancers progression and resistance	10
The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion	9
Nanoparticle-Based gene therapy strategies in retinal delivery	9
Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of isoniazid: a promising approach in the treatment of tuberculosis	9
Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies	9
Olaparib@human serum albumin nanoparticles as sustained drug-releasing tumour-targeting nanomedicine to inhibit growth and metastasis in the mouse model of triple-negative breast cancer	9
Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma	9
Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway	9
Advancement on nanoparticles-based approaches for the management of rheumatoid arthritis (RA): molecular mechanism, toxicity, and clinical perspectives	9
Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target	9
Albumin-encapsulated HSP90-PROTAC BP3 nanoparticles not only retain protein degradation ability but also enhance the antitumour activity of BP3 in vivo	8
2,2,6,6-tetramethylpiperidin-1-oxyl: a new potential targeted ligand based on lipid peroxidation for targeted drug delivery	8
Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis	8
Integrating machine learning and multitargeted drug design to combat antimicrobial resistance: a systematic review	8
Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging	8
Role of liposomes in chemoimmunotherapy of breast cancer	8
A paradigm use of monoclonal antibodies-conjugated nanoparticles in breast cancer treatment: current status and potential approaches	8
Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma	8
Aptamers: ushering in new hopes in targeted glioblastoma therapy	8
Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy	8
Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy	8
Ofirnoflast: a first-in-class NEK7-targeted inhibitor of the NLRP3 inflammasome	7
Exploring the potential of ferulic acid-loaded nanostructured lipid carriers: angiotensin inhibition via docking, formulation and pharmacokinetic and pharmacodynamics studies	7
DOX-loaded mesoporous hydroxyapatite modified by hyaluronic acid can achieve efficient targeted therapy for lung cancer	7
Formulation and optimisation of nanoemulsions for enhancing topical delivery of methotrexate in CFA induced arthritis rat model	7
Fabrication of crosslinker-free chitosan-HPMC hydrogel for implant coating: a new approach for the treatment of osteomyelitis	7
Celastrol nano-emulsions selectively regulate apoptosis of synovial macrophage for alleviating rheumatoid arthritis	7
A review of recombinant HER3 affibodies with an effective diagnostic view of cancer cells	7
Octreotide and Octreotide-derived delivery systems	7
Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells	7
Methodological advances in liposomal encapsulation efficiency determination: systematic review and analysis	7
Protein biomarker modulation and wound healing efficacy of mentha piperita-based green-synthesized silver nanoparticles in alloxan-induced diabetic rats	7
Human plasma-derived exosomal gel: a biomimetic cargo for the transdermal delivery of methotrexate	7
Dectin-1 receptor-targeted β-glucan microparticles as dry powder inhalation system – a novel strategy to improve lung pharmacokinetics of rifampicin	7
Preparation of cationic liposomes loaded with Sirtuin 6 plasmid for the treatment of arthritis in rats	7
Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies	7
Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cance	7
Niosomal formulation for antibacterial applications	7
A platelet-cloaking tetramethylprazine-loaded microemulsion for improved therapy of myocardial ischaemia/reperfusion injury	7
Efficacy of intranasal delivery of VEGFR inhibitors to cervical lymph nodes for inhibiting tongue cancer metastasis in mice	7
Molecular mechanism of Wilms tumour 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1	7
Research progress of microneedle drug delivery system in the treatment of autoimmune diseases	7