Molecular Biology of the Cell

Article	Citations
SuperPlotsOfData—a web app for the transparent display and quantitative comparison of continuous data from different conditions	113
Predicting cell health phenotypes using image-based morphology profiling	86
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function	65
SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation	56
Roles of leader and follower cells in collective cell migration	55
New twists in actin–microtubule interactions	54
The burden of service for faculty of color to achieve diversity and inclusion: the minority tax	53
Open-source deep-learning software for bioimage segmentation	51
pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells	50
Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties	48
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import	47
Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion	41
Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface	39
Three-dimensional superresolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex	38
Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation	36
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons	36
Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization	35
Cell Painting predicts impact of lung cancer variants	34
DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy	33
Nonmuscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli	32
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field	32
Violin SuperPlots: visualizing replicate heterogeneity in large data sets	31
Diversity through equity and inclusion: The responsibility belongs to all of us	30
Regulation of meiotic progression by Sertoli-cell androgen signaling	30
The LINC complex is required for endothelial cell adhesion and adaptation to shear stress and cyclic stretch	28

DynaMorph: self-supervised learning of morphodynamic states of live cells	28
Hsf1 activation by proteotoxic stress requires concurrent protein synthesis	28
R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast	27
An update on genetically encoded lipid biosensors	27
Photobleaching step analysis for robust determination of protein complex stoichiometries	26
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation	26
Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells	25
Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2	25
Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription	25
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis	25
SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data	24
Beyond Langmuir: surface-bound macromolecule condensates	23
Fibroblast to myofibroblast transition is enhanced by increased cell density	23
Mapping the electrostatic profiles of cellular membranes	23
Integrin-linked kinase tunes cell–cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1	23
Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division	23
Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry	22
Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10	22
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells	22
The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism	22
Osmosensing by WNK Kinases	22
Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion	22
Fascin-induced actin protrusions are suppressed by dendritic networks in giant unilamellar vesicles	22
Distinct proteostasis states drive pharmacologic chaperone susceptibility for cystic fibrosis transmembrane conductance regulator misfolding mutants	22
L-bodies are RNA–protein condensates driving RNA localization in Xenopus oocytes	22
Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains	21
The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins	21
Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways	21
Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone	21
Catalysts for change: the cellular neurobiology of psychedelics	21
Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT	21
Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch	21
VPS13D interacts with VCP/p97 and negatively regulates ER- mitochondrial interactions	20
PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity	20
DNA content contributes to nuclear size control inXenopus laevis	20
Microtubule-dependent pushing forces contribute to long-distance aster movement and centration inXenopus laevisegg extracts	20
Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane	20
Roles for L o microdomains and ESCRT in ER stress-induced lipid droplet microautophagy in budding yeast	19
Protein turnover dynamics suggest a diffusion-to-capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins	19
The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery	19
PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis	19
Roles for ELMOD2 and Rootletin in ciliogenesis	18
PxdA interacts with the DipA phosphatase to regulate peroxisome hitchhiking on early endosomes	18
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1	18
β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming	18
Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination	18
Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis	18
Structurally distinct endocytic pathways for B cell receptors in B lymphocytes	18
Exploiting differential effects of actomyosin contractility to control cell sorting among breast cancer cells	18
Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network	18

Elevating PI3P drives select downstream membrane trafficking pathways	17
Unconventional endocytosis and trafficking of transferrin receptor induced by iron	17
Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA	17
Flexible pivoting of dynamin pleckstrin homology domain catalyzes fission: insights into molecular degrees of freedom	17
Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis	17
Asymmetric chromosome segregation and cell division in DNA damage-induced bacterial filaments	17
APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells	16
The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions	16
Structural insights into the cause of human RSPH4A primary ciliary dyskinesia	16
RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy	16
Single-molecule imaging of IQGAP1 regulating actin filament dynamics	16
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein	16
p53 induces a survival transcriptional response after nucleolar stress	16
The two-hit theory hits 50	16
Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis	16
Epistatic, synthetic, and balancing interactions among tubulin missense mutations affecting neurite growth inCaenorhabditis elegans	16
Scientific societies fostering inclusivity through speaker diversity in annual meeting programming: a call to action	16
ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms	16
Superresolution light microscopy of the Drosophila histone locus body reveals a core–shell organization associated with expression of replication–dependent histone genes	15
Diffusion of kinesin motors on cargo can enhance binding and run lengths during intracellular transport	15
Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling	15
Selective destabilization of polypeptides synthesized from NMD-targeted transcripts	15
Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in Caenorhabditis elegans zygotes	15
Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis	15
A yeast FRET biosensor enlightens cAMP signaling	15
We need to address ableism in science	15
Cell cycle and developmental control of cortical excitability in Xenopus laevis	15
Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains	15
Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration	15
Cholesterol- and actin-centered view of the plasma membrane: updating the Singer–Nicolson fluid mosaic model to commemorate its 50th anniversary†	14
Scaling of biosynthesis and metabolism with cell size	14
Tau differentially regulates the transport of early endosomes and lysosomes	14
Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control	14
RUSC2 and WDR47 oppositely regulate kinesin–1-dependent distribution of ATG9A to the cell periphery	14
Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton	14
Dynein self-organizes while translocating the centrosome in T-cells	13
Quantification of microtubule stutters: dynamic instability behaviors that are strongly associated with catastrophe	13
Fibronectin fibril alignment is established upon initiation of extracellular matrix assembly	13
Analysis of senescence-responsive stress fiber proteome reveals reorganization of stress fibers mediated by elongation factor eEF2 in HFF-1 cells	13
Myosin II isoforms promote internalization of spatially distinct clathrin-independent endocytosis cargoes through modulation of cortical tension downstream of ROCK2	13
Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs	13
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8	13
More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites	13
ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion	13
Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport	13
Chromatin condensation regulates endothelial cell adaptation to shear stress	13
Evaluation of cell segmentation methods without reference segmentations	13
Nucleoli and the nucleoli–centromere association are dynamic during normal development and in cancer	13
RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness	13
Septins and a formin have distinct functions in anaphase chiral cortical rotation in theCaenorhabditis eleganszygote	13
MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia	13
Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration	13
Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility	13
Cross talk-dependent cortical patterning of Rho GTPases during cell repair	13
Basal bodies bend in response to ciliary forces	13
Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae	12
Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion	12
Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD	12
Spatiotemporal analysis of axonal autophagosome–lysosome dynamics reveals limited fusion events and slow maturation	12
Nanotopography modulates cytoskeletal organization and dynamics during T cell activation	12
Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole	12
Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone	12
NgCAM and VAMP2 reveal that direct delivery and dendritic degradation maintain axonal polarity	12
Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP2 homeostasis	12
Survey of cancer cell anatomy in nonadhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb–based migration	12
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality	12
Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites	12
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium	12
Docosahexanoic acid signals through the Nrf2–Nqo1 pathway to maintain redox balance and promote neurite outgrowth	12
PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes	11
Intracellular connections between basal bodies promote the coordinated behavior of motile cilia	11
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy	11
Quantitative and time-resolved monitoring of organelle and protein delivery to the lysosome with a tandem fluorescent Halo-GFP reporter	11
Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast	11
One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines	11
Developmental changes in ciliary composition during gametogenesis inChlamydomonas	11
Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis	11
Mitotic spindle: lessons from theoretical modeling	11
Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites	11
Nanoscale dynamics of actin filaments in the red blood cell membrane skeleton	11

Load adaptation by endocytic actin networks	11
The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor	11
Spatial proximity of proteins surrounding zyxin under force-bearing conditions	11
AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network	11
A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding	11
Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity	11
BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2	11
Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity	11
The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2	11
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells	11
Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments	10
Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics	10
Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells	10
Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms	10
An update to the CRM1 cargo/NES database NESdb	10
Challenges and advice for MD/PhD applicants who are underrepresented in medicine	10
ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation	10
Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS	10
Integrin cross-talk modulates stiffness-independent motility of CD4+ T lymphocytes	10
Cytoskeleton integrity influences XRCC1 and PCNA dynamics at DNA damage	10
Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state	10
New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation	10
Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1	10
Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E	10
Reflections on race, ethnicity, and NIH research awards	10
F-actin organization and target constriction during primary macrophage phagocytosis is balanced by competing activity of myosin-I and myosin-II	10
The short flagella 1 (SHF1) gene in Chlamydomonas encodes a Crescerin TOG-domain protein required for late stages of flagellar growth	10
Nucleoporins’ exclusive amino acid sequence features regulate their transient interaction with and selectivity of cargo complexes in the nuclear pore	10
Fast and parallel nanoscale three-dimensional tracking of heterogeneous mammalian chromatin dynamics	10
Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response	10
Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells	10
Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome	9
Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis	9
p115RhoGEF activates RhoA to support tight junction maintenance and remodeling	9
Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips	9
The biochemical composition of the actomyosin network sets the magnitude of cellular traction forces	9
Coordinated efforts of different actin filament populations are needed for optimal cell wound repair	9
Costameric integrin and sarcoglycan protein levels are altered in aDrosophilamodel for Limb-girdle muscular dystrophy type 2H	9
Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation	9
Maf1 regulates intracellular lipid homeostasis in response to DDR activation	9
Stress deprivation of tendon explants or Tpm3.1 inhibition in tendon cells reduces F-actin to promote a tendinosis-like phenotype	9
Acute ethanol stress induces sumoylation of conserved chromatin structural proteins inSaccharomyces cerevisiae	9
BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1	9
K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15	9
Myosin II and Arp2/3 cross-talk governs intracellular hydraulic pressure and lamellipodia formation	9
Imaging methods in mechanosensing: a historical perspective and visions for the future	9
Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods	9
AdipoQ—a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro	9
Quantitative live-cell PALM reveals nanoscopic Faa4 redistributions and dynamics on lipid droplets during metabolic transitions of yeast	9
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia	9
A year since George Floyd	8
Identification of a Golgi-localized peptide reveals a minimal Golgi-targeting motif	8
ALK1 regulates the internalization of endoglin and the type III TGF-β receptor	8
The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly	8
Cell contractility drives mechanical memory of oral squamous cell carcinoma	8
Terminally differentiated osteoclasts organize centrosomes into large clusters for microtubule nucleation and bone resorption	8
Actomyosin dynamics modulate microtubule deformation and growth during T-cell activation	8
Dynamic cell cycle–dependent phosphorylation modulates CENP-L–CENP-N centromere recruitment	8
A perinuclear α-helix with amphipathic features in Brl1 promotes NPC assembly	8
Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin	8
Evidence for low-level translation in human erythrocytes	8
Fission yeast cell cycle mutants and the logic of eukaryotic cell cycle control	8
Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish	8
The ultrastructural organization of endoplasmic reticulum-plasma membrane contacts is conserved in epithelial cells	8
MRX8, the conserved mitochondrial YihA GTPase family member, is required for de novo Cox1 synthesis at suboptimal temperatures in Saccharomyces cerevisiae	8
Alternate histories of cytokinesis: lessons from the trypanosomatids	8
A conserved STRIPAK complex is required for autophagy in muscle tissue	8
Performance of deep learning restoration methods for the extraction of particle dynamics in noisy microscopy image sequences	8
The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition	8
Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis	8
Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function	8
Complementary and divergent functions of zebrafish Tango1 and Ctage5 in tissue development and homeostasis	8
Fusion with wild-type SNARE domains is controlled by juxtamembrane domains, transmembrane anchors, and Sec17	8
Glutamylation is a negative regulator of microtubule growth	8
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila	8
Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast	8
Predicting reprogramming-related gene expression from cell morphology in human induced pluripotent stem cells	7
Rab21 in enterocytes participates in intestinal epithelium maintenance	7
Mechanisms that ensure monogamous mating inSaccharomyces cerevisiae	7
Large-scale mapping of positional changes of hypoxia-responsive genes upon activation	7
CDK signaling via nonconventional CDK phosphorylation sites	7
Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating	7
The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis	7
Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking	7
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division	7
ZC3HC1 is a structural element of the nuclear basket effecting interlinkage of TPR polypeptides	7
Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling	7
Synaptobrevin-2 dependent regulation of single synaptic vesicle endocytosis	7
Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions	7
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy	7
Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 CIP1 signaling cascade	7
Nucleotide- and Protein-Dependent Functions of Actg1	7
Laser ablation reveals the impact of Cdc15p on the stiffness of the contractile ring	7
Time-varying mobility and turnover of actomyosin ring components during cytokinesis inSchizosaccharomyces pombe	7
Signed, sealed, and delivered: RNA localization and translation at centrosomes	7