Molecular Biology of the Cell

Article	Citations
Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo	121
A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents	86
The Toxoplasma gondii homolog of ATPase inhibitory factor 1 is critical for mitochondrial cristae maintenance and stress response	65
Roles for the canonical polarity machinery in the de novo establishment of polarity in budding yeast spores	56
Optogenetic control of receptor-mediated growth cone dynamics in neurons	55
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae	53
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration	48
Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2	41
Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling	38
The mitochondrial RNA granule modulates manganese-dependent cell toxicity	38
Preprint Highlight: Distinct regions of Helicobacter pylori's bactofilin CcmA regulate protein-protein interactions to control helical cell shape	36
Preprint Highlight: Mitotic clustering of pulverized chromosomes from micronuclei	35
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1	33
Inclusion: an individual pursuit requiring organization-level investment to sustain it	32
Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects	32
Laser ablation reveals the impact of Cdc15p on the stiffness of the contractile ring	31
Depicting a cellular space occupied by condensates	29
Dynamics of intracellular neonatal Fc receptor–ligand interactions in primary macrophages using biophysical fluorescence techniques	29
Centromere proteins are asymmetrically distributed between newly divided germline stem and daughter cells and maintain a balanced niche in Drosophila males	28
2021 ASCB Annual Meeting abstracts	28
Correction	26
Inner-nuclear-membrane–associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity	25
Results from the MBoC Preprint Highlight experiment	25
ALK1 regulates the internalization of endoglin and the type III TGF-β receptor	25
A WICB 50th Favorite: Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment	25

CANVS: an easy-to-use application for the analysis and visualization of mass spectrometry–based protein–protein interaction/association data	24
2020 in 20/20 hindsight	23
Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in Caenorhabditis elegans zygotes	23
A conundrum in 3-D genome organization and expression?	23
Science: priceless, but costly	23
Newfound features of meiotic chromosome organization that promote efficient congression and segregation in Caenorhabditis elegans oocytes	23
Calcineurin promotes adaptation to chronic stress through two distinct mechanisms	22
E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6	22
A fine balance among key biophysical factors is required for recovery of bipolar mitotic spindle from monopolar and multipolar abnormalities	22
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic	22
Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes	22
p52Shc regulates the sustainability of ERK activation in a RAF-independent manner	22
Preprint Highlight: Multiplexed bioluminescence microscopy via phasor analysis	21
Preprint Highlight: Shelterin components modulate nucleic acids condensation and phase separation in the context of telomeric DNA	21
Dimerization activates the Inversin complex in C. elegans	21
Preprint Highlight: PGC1α regulates the endothelial response to fluid shear stress via telomerase reverse transcriptase control of heme oxygenase‐1	21
The tubulin structure, a quarter of a century later	21
Preprint Highlight: Hyphal compartmentalization and sporulation in Streptomyces require the conserved cell division protein SepX	21
Preprint Highlight: All-optical visualization of specific molecules in the ultrastructural context of brain tissue	21
Suppression of chromosome instability by targeting a DNA helicase in budding yeast	21
Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging the Drosophila apical microtubule network through quantitative image analysis	20
Preprint Highlight: Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration	20
F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic apoptosis	20
STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases	19
The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system	19
Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing	19
The roles of yeast formins and their regulators Bud6 and Bil2 in the pheromone response	19
BioID2 screening identifies KIAA1671 as an EPS8 proximal factor that marks sites of microvillus growth	18
Identification of a Golgi-localized peptide reveals a minimal Golgi-targeting motif	18
SET levels contribute to cohesion fatigue	18
Scaling of nuclear numbers and their spatial arrangement in skeletal muscle cell size regulation	18
An approach for quantitative mapping of synaptic periactive zone architecture and organization	17
The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes	17
Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs	17
Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins	17
Preprint Highlight: Lateral and longitudinal compaction of PRC1 overlap zones drives stabilization of interzonal microtubules	17
Preprint Highlight: A lysosomal lipid transport pathway that enables cell survival under choline limitation	16
Disruption of a ∼23–24 nucleotide small RNA pathway elevates DNA damage responses inTetrahymena thermophila	16
Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition	16
Plasma membrane protrusions mediate host cell–cell fusion induced by Burkholderia thailandensis	16
Preprint Highlight: Dodecaploid Xenopus longipes provides insight into the emergence of size scaling relationships during development	16
Load adaptation by endocytic actin networks	16
You are the most valuable reagent in the lab: mental health before and during the pandemic	16
The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly	15
Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1	15
Polymer models reveal how chromatin modification can modulate force at the kinetochore	15
A model of actin-driven endocytosis explains differences of endocytic motility in budding and fission yeast	15
Coordinated efforts of different actin filament populations are needed for optimal cell wound repair	15
Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast	15
A novel tool for the unbiased characterization of epithelial monolayer development in culture	15

p97/VCP Promotes the Recycling of Endocytic Cargo	15
The cell-end protein Tea4 spatially regulates hyphal branch initiation and appressorium remodeling in the blast fungus Magnaporthe oryzae	15
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia	15
Evidence for low-level translation in human erythrocytes	15
BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1	15
Integrin-linked kinase tunes cell–cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1	15
Spatial variation of microtubule depolymerization in large asters	14
Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience	14
Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast	14
Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization	14
Improved tools for live imaging of F-actin structures in yeast	13
Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating	13
Divergent regulation of α-arrestin ARRDC3 function by ubiquitination	13
BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2	13
The biochemical composition of the actomyosin network sets the magnitude of cellular traction forces	13
Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling	13
Identification of defined structural elements within TOR2 kinase required for TOR complex 2 assembly and function in Saccharomyces cerevisiae	13
Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch	13
Cross talk-dependent cortical patterning of Rho GTPases during cell repair	13
Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeast	13
Differential nuclear import regulates nuclear RNA inheritance following mitosis	13
After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells	13
Time-varying mobility and turnover of actomyosin ring components during cytokinesis inSchizosaccharomyces pombe	13
Landmarks in the discovery of a role for actin in cell locomotion	13
Interface extension is a continuum property suggesting a linkage between AP contractile and DV lengthening processes	13
Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence	13
Superresolution light microscopy of the Drosophila histone locus body reveals a core–shell organization associated with expression of replication–dependent histone genes	13
Trisomy 21 increases microtubules and disrupts centriolar satellite localization	13
Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function	12
Image-based discrimination of the early stages of mesenchymal stem cell differentiation	12
TFG regulates inner COPII coat recruitment to facilitate anterograde secretory protein transport	12
In pancreatic β-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi	12
The ciliary lumen accommodates passive diffusion and vesicle-assisted trafficking in cytoplasm–ciliary transport	12
An invariant C-terminal tryptophan in McdB mediates its interaction and positioning function with carboxysomes	12
Mutation of the PEBP-like domain of the mitoribosomal MrpL35/mL38 protein results in production of nascent chains with impaired capacity to assemble into OXPHOS complexes	12
Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E	12
Sec18 binds the tethering/SM complex HOPS to engage the Qc-SNARE for membrane fusion	12
K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15	12
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability	12
Nucleoli and the nucleoli–centromere association are dynamic during normal development and in cancer	12
Synaptobrevin-2 dependent regulation of single synaptic vesicle endocytosis	11
L-bodies are RNA–protein condensates driving RNA localization in Xenopus oocytes	11
Nanotopography modulates cytoskeletal organization and dynamics during T cell activation	11
The Arp2/3 complex enhances cell migration on elastic substrates	11
A defined tubby domain β-barrel surface region of TULP3 mediates ciliary trafficking of diverse cargoes	11
Fluorescence complementation-based FRET imaging reveals centromere assembly dynamics	11
Centrosomal enrichment and proteasomal degradation of SYS-1/β-catenin requires the microtubule motor dynein	11
The ASCB andMBoC: Our cell biology power couple	11
How many authors does it take to publish a high profile or classic paper?	11
Survey of cancer cell anatomy in nonadhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb–based migration	11
Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner	11
On the role of myosin-induced actin depolymerization during cell migration	11
Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei	11
Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1	11
Actin contraction controls nuclear blebbing and rupture independent of actin confinement	11
Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis	11
Cytoplasmic redox imbalance in the thioredoxin system activates Hsf1 and results in hyperaccumulation of the sequestrase Hsp42 with misfolded proteins	11
Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity	11
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells	10
Activation of CWI pathway through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae	10
Violin SuperPlots: visualizing replicate heterogeneity in large data sets	10
α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions	10
ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation	10
In vivo imaging reveals independent intraflagellar transport of the nexin–dynein regulatory complex subunits DRC2 and DRC4	10
The kinesin-5 tail and bipolar minifilament domains are the origin of its microtubule crosslinking and sliding activity	10
Evaluation of cell segmentation methods without reference segmentations	10
CDK signaling via nonconventional CDK phosphorylation sites	10
Branched microtubule nucleation and dynein transport organize RanGTP asters in Xenopus laevis egg extract	10
Docosahexanoic acid signals through the Nrf2–Nqo1 pathway to maintain redox balance and promote neurite outgrowth	10
Mannose receptor (MRC1) mediates uptake of dextran by bone marrow–derived macrophages	10
Lithium-induced ciliary lengthening sparks Arp2/3 complex–dependent endocytosis	10
Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response	10
CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis	10
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function	10
We need to address ableism in science	10
Plakophilin 3 and Par3 facilitate desmosomes’ association with the apical junctional complex	10
The p24-family and COPII subunit SEC24C facilitate the clearance of alpha1-antitrypsin Z from the endoplasmic reticulum to lysosomes	10
Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network	10
Calcium-binding Cab45 regulates the polarized apical secretion of soluble proteins in epithelial cells	9
Calcium flow at ER-TGN contact sites facilitates secretory cargo export	9

The story of science: successes, failures, luck, privilege, and bias	9
Quantitative biophysical metrics for rapid evaluation of ovarian cancer metastatic potential	9
PI(3)P and DFCP1 regulate the biogenesis of lipid droplets	9
Multiple quality control mechanisms monitor yeast chitin synthase folding in the endoplasmic reticulum	9
Katnip is needed to maintain microtubule function and lysosomal delivery to autophagosomes and phagosomes	9
Mechanobiology: forcing the second act	9
Zooming in on the cell biology of disease	9
Tepsin binds LC3B to promote ATG9A trafficking and delivery	9
DNA damage–induced EMT controlled by the PARP-dependent chromatin remodeler ALC1 promotes DNA repair efficiency through RAD51 in tumor cells	9
Valosin-containing protein p97 extracts capping protein CP110 from the mother centriole to promote ciliogenesis	9
Preprint Highlight: Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis	9
Calcium dynamics of skin-resident macrophages during homeostasis and tissue injury	9
Loss of the HOPS complex disrupts early-to-late endosome transition, impairs endosomal recycling and induces accumulation of amphisomes	9
Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants	9
LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7	9
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation	9
Bistability in the polarity circuit of yeast	9
Preprint Highlight: Self‐supervised deep learning encodes high-resolution features of protein subcellular localization	8
Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation	8
Selective destabilization of polypeptides synthesized from NMD-targeted transcripts	8
Preprint Highlight: Dynamic interplay of protrusive microtubule and contractile actomyosin forces drive tissue extension	8
VASP localization to lipid bilayers induces polymerization driven actin bundle formation	8
Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression	8
Paradigms Lost Perspectives: revisiting well-worn models and concepts	8
Nanoscale dynamics of actin filaments in the red blood cell membrane skeleton	8
KIF18B is a cell type–specific regulator of spindle orientation in the epidermis	8
Preprint Highlight: Polarized Disheveled dissolution and condensation drives embryonic axis specification in oocytes	8
A modified motor-clutch model reveals that neuronal growth cones respond faster to soft substrates	8
Large-scale mapping of positional changes of hypoxia-responsive genes upon activation	8
Preprint Highlight: A motor-based approach to induce chromosome-specific mis-segregations in human cells	8
A practical guide to expert learner skills in the research environment	8
Maximizing Access to Cell Biology for PEERS: Retracting the term minority in favor of a more inclusive lexicon	8
Preprint Highlight: Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging	8
Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages	8
Preprint Highlight: Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation	8
The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition	8
Evolutionary divergence of anaphase spindle mechanics in nematode embryos constrained by antagonistic pulling and viscous forces	8
Preprint Highlight: Vimentin intermediate filaments organize organellar ER architecture in response to stress	8
Evidence for a nuclear role for Drosophila Dlg as a regulator of the NURF complex	8
HSPA8 inhibitors augment cancer chemotherapeutic effectiveness via potentiating necroptosis	8
Preprint Highlight: Pressure and curvature control of contact inhibition in epithelia growing under spherical confinement	8
PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis	8
Preprint Highlight: Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding	8
Myosin II isoforms promote internalization of spatially distinct clathrin-independent endocytosis cargoes through modulation of cortical tension downstream of ROCK2	7
Preprint Highlight: ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue	7
Acute ethanol stress induces sumoylation of conserved chromatin structural proteins inSaccharomyces cerevisiae	7
Single-molecule imaging of IQGAP1 regulating actin filament dynamics	7
Role of intraflagellar transport in transcriptional control during flagellar regeneration in Chlamydomonas	7
GpsB interacts with FtsZ in multiple species and may serve as an accessory Z-ring anchor	7
Preprint Highlight: A synthetic signaling network imitating the action of immune cells in response to bacterial metabolism	7
Correction	7
Regulation ofBlos1by IRE1 prevents the accumulation of Huntingtin protein aggregates	7
Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila	7
Preprint Highlight: Detyrosination enrichment on microtubule subsets is established by the interplay between a stochastically acting enzyme and microtubule stability	7
Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin	7
Career advice from my father: “Go where you are loved”	7
Direct observation of the conformational states of formin mDia1 at actin filament barbed ends and along the filament	7
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A	7
Evidence that tissue recoil in the early Drosophila embryo is a passive not active process	7
Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes	7
EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events	7
Spatiotemporal analysis of axonal autophagosome–lysosome dynamics reveals limited fusion events and slow maturation	7
Chaperone requirements for de novo folding of Saccharomyces cerevisiae septins	7
Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells	7
Preprint Highlight: ATR protects centromere identity by promoting DAXX association with PML nuclear bodies	7
Preprint Highlight: Actomyosin cables position cell cohorts during Drosophila germband retraction by entraining their morphodynamic and mechanical properties	7
Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP2 homeostasis	7
The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery	7
Superresolution microscopy reveals actomyosin dynamics in medioapical arrays	7
The Kinesin Kar3 is Required for Endoplasmic Reticulum-Associated Degradation	7
A year since George Floyd	7
VAMP5 promotes Fcγ receptor-mediated phagocytosis and regulates phagosome maturation in macrophages	7
Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism	7
The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges	7
Endoplasmic Reticulum Exit Sites scale with somato-dendritic size in neurons	7
Quantitative live-cell PALM reveals nanoscopic Faa4 redistributions and dynamics on lipid droplets during metabolic transitions of yeast	7
Preprint Highlight: Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer	7
Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization	7
Inclusivity in cell biology: cultural identity and the power of authenticity	6
Baculovirus actin-rearrangement-inducing factor ARIF-1 induces the formation of dynamic invadosome clusters	6
Membrane fusion by Drosophila atlastin does not require GTP hydrolysis	6
Extracellular matrix regulates force transduction at VE-cadherin junctions	6
Dishevelled controls bulk cadherin dynamics and the stability of individual cadherin clusters during convergent extension	6
Damage–repair events increase the instability of cortical microtubules in Arabidopsis	6
Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone	6
Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins	6
New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation	6
From pipette to palette: Bridging science and art at MBoC	6
Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility	6
Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane	6
A methodology for specific disruption of microtubule polymerization into dendritic spines	6
Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis	6
Agent-based modeling predicts RAC1 is critical for ovarian cancer metastasis	6
A mathematical model of calcium signals around laser-induced epithelial wounds	6
Modeling and analysis of the macronutrient signaling network in budding yeast	6