OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
A practical guide to secondary pharmacology in drug discovery	25
Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method	21
Revisiting the hERG safety margin after 20 years of routine hERG screening	20
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives	17
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment	14
Chicken embryo as animal model to study drug distribution to the developing brain	13
Evaluation of urinary biomarkers for early detection of acute kidney injury in a rat nephropathy model	12
Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics	12
A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin	10
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods	10
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	10
Inotropic assessment in engineered 3D cardiac tissues using human induced pluripotent stem cell-derived cardiomyocytes in the BiowireTM II platform	9
Host cell proteins induce inflammation and immunogenicity as adjuvants in an integrated analysis of in vivo and in vitro assay systems	9
Development of an easy and rapid analytical method for the extraction and preconcentration of chloroquine phosphate from human biofluids prior to GC–MS analysis	9
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes	9
Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS	9
A capillary electrophoresis based approach for the identification of anti-drug antibodies against camelid VHH biologics (Nanobodies®)	9
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies	9
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model	8
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	8
Use of automated patch clamp in cardiac safety assessment: Past, present & future perspectives	8
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model	8
An improved two-step method for extraction and purification of primary cardiomyocytes from neonatal mice	8
Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative	7
Improving corrected QT; Why individual correction is not enough	7

Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes	7
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy	7
Core battery safety pharmacology testing – An assessment of its utility in early drug development	7
Insights into toxicology, safety pharmacology, and drug dependence testing: The performance and predictive values of nonclinical tests	7
Is there a role for the no observed adverse effect level in safety pharmacology?	7
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	7
Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project	6
Combined cSLO-OCT imaging as a tool in preclinical ocular toxicity testing: A comparison to standard in-vivo and pathology methods	6
Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy	6
Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples	6
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model	6
Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples	6
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	6
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	6
Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice	6
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	6
Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage	6
Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients	6
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	5
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model	5
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	5
Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment	5
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	5
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	5
Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes	5
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	5
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs	5
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	5
Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes	5
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands	5
Intrapulmonary inoculation of multicellular spheroids to construct an orthotopic lung cancer xenograft model that mimics four clinical stages of non-small cell lung cancer	4
Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys	4
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology	4
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance	4
Optimization of psoriasis mouse models	4
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs	4
Dynamic features of cardiac vector as alternative markers of drug-induced spatial dispersion	4
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats	4
A Bayesian approach to toxicological testing	4
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	4
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	4
On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment	4
LC-MS/MS method for rapid and accurate detection of caffeine in a suspected overdose case	4
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol	4
Aggregation and analysis of secondary pharmacology data from investigational new drug submissions at the US Food and Drug Administration	4
Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability	4
Comparison of sublingual, facial and retro-bulbar blood sampling in mice in relation to animal welfare and blood quality	3
Schiefer counter: An alternative method for clonogenic assay evaluation	3
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	3
Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents	3

The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies	3
In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells	3
Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum	3
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	3
RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener	3
QT Ratio: A simple solution to individual QT correction	3
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification	3
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	3
Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators	3
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	3
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	3
A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity	2
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis	2
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension	2
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS	2
Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: Dream or reality?	2
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	2
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds	2
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	2
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	2
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma	2
Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery	2
Voltage-sensing optical recording: A method of choice for high-throughput assessment of cardiotropic effects	2
Optimization of bioanalysis of dried blood samples	2
Fluorescent opioid receptor ligands as tools to study opioid receptor function	2
The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of	2
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification	2
Assessment of cardiorespiratory function using telemetric jacket in rodents	2
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	2
A new group housing approach for non-human primate metabolism studies	2
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	2
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs	2
Impact of housing conditions on cardiovascular parameters in telemetry-implanted cynomolgus monkeys	2
Development of binary classification models for assessment of drug-induced liver injury in humans using a large set of FDA-approved drugs	2
Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs	2
Assessment of intracellular accumulation of cadmium and thallium	2
L-Citrulline as translational safety biomarker for the small intestine—An update	2
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	2
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	1
Evaluation of PhysioTel™ digital M11 cardiovascular telemetry implant in socially housed cynomolgus monkeys using etilefrine and moxifloxacin	1
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	1
Human in silico drug trials with a novel human ventricular electrophysiology model	1
The database for in silico cardiac risk prediction tools	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	1
Use of subcutaneous transponders to monitor body temperature in laboratory rats	1
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	1
An optimized method for intratracheal instillation in mice	1
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia	1
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum	1
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species	1
Mouse models for actinic keratoses	1
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models	1
IC50 evaluation is critically dependent on the protocol used for measurement	1
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	1
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability	1
Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies	1
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation	1
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	1
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates	1
Cardiovascular and respiratory (impedance) by digital telemetry monitoring in cynomolgus monkeys, Beagle dogs and Göttingen minipigs	1
Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints	1
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma	1
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects	1
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead	1
An immunoblot assay for cysteine oxidation by reactive oxygen species allows detection of novel thioprotective efficacy of black tea extracts	1
Changes in the housing arrangement (single versus paired) in cynomolgus monkeys and the impact on telemetry data in drug safety evaluations	1
Comparative assessment of Ca2+ oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks	1
Do behavioral test scores represent repeatable phenotypes of female mice?	1
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project	1
Characterization of an i.p. D-galactose-induced cataract model in rats	1
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era	1
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	1
Automated patch clamp system introducing simulated Ik1 into human iPSC-cardiomycoytes using dynamic clamp	1
Evaluation of two hERG channel trafficking modulators, pentamidine and pilsicainide, on stably transfected cell line and human induced pluripotent stem cell-derived cardiomyocytes	1
Reliable identification of hERG liability in drug discovery by automated patch clamp	1
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats	1
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment	1