OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	27
Visualizing QT prolongation in the anesthetized guinea pig	25
Editorial Board	23
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	22
Chronic bladder catheterization for precise urine collection in awake mice	18
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	17
The underlying molecular mechanisms of drug-induced seizures	16
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	14
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	14
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	13
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	13
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	13
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	11
Contractility assessment using aligned human iPSC-derived cardiomyocytes	11
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	10
Automated cardiac tissue assay system with perfusion for monitoring contractility	10
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	9
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	9
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	9
Lung physiology and controlled exposure study design	8
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model	8
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	8
Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering	8
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	7
In vitro neurotoxicity testing using functional human iPSC-derived neurons	7

Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	7
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	7
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies	6
Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs	6
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	6
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	6
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era	6
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	6
Assessment of cardiac reserve and chronotropic effects using dobutamine stress echocardiography in healthy male rats	6
Editorial Board	6
QT Ratio: A simple solution to individual QT correction	5
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	5
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	5
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	5
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	5
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	5
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	5
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	5
Editorial Board	5
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	5
Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?	5
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives	4
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	4
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	4
Voltage imaging of single contracting human iPSC-CMs using ratiometric voltage-sensitive dyes	4
Editorial Board	4
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	4
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	4
Mouse models for actinic keratoses	4
Evoked responses to electrical stimulation in acute brain slice using a high-density and large-scale CMOS-MEA system	4
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	4
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	4
A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods	4
Cardiotoxicity with immune checkpoint inhibitors	4
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	3
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	3
Editorial Board	3
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	3
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	3
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	3
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	3
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	3
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	3
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	3
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	3
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	3
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	3
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	3
Editorial Board	3
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	3

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	3
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	3
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	3
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	3
Virtual clinical QT exposure-response studies – A translational computational approach	3
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	3
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	2
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	2
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys	2
Editorial Board	2
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	2
Editorial Board	2
Core battery safety pharmacology testing – An assessment of its utility in early drug development	2
CNS safety assessment in freely moving socially housed rodents	2
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	2
Test facility management: Responsibilities and paradigms of a new era	2
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	2
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol	2
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system	2
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	2
Preclinical nerve conduction: Nerve battery options for primate studies	2
Editorial Board	2
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons	2
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	2
Chicken embryo as animal model to study drug distribution to the developing brain	2
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies	2
Establishing an in vitro assay for predicting neurotoxicity risks using functional human iPSC-derived neurons	2
Electrophysiological analysis of seroquel’s activity in sodium ion channels, CiPA ion channels and hiPSC-neuronal cells	2
A comparison of multiple left ventricular pressure endpoints as a screening tool in rats	2
Drug combination assays using Caenorhabditis elegans as a model system	2