OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives	20
Chicken embryo as animal model to study drug distribution to the developing brain	17
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	16
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	14
Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics	14
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model	13
Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS	12
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods	12
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy	12
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	12
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies	12
A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin	10
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	10
Improving corrected QT; Why individual correction is not enough	9
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes	9
Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice	9
Core battery safety pharmacology testing – An assessment of its utility in early drug development	9
Development of an easy and rapid analytical method for the extraction and preconcentration of chloroquine phosphate from human biofluids prior to GC–MS analysis	9
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes	9
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	8
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	8
Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples	8
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	8
Use of automated patch clamp in cardiac safety assessment: Past, present & future perspectives	8
Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples	7

Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients	7
Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy	7
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	7
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model	7
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	7
Aggregation and analysis of secondary pharmacology data from investigational new drug submissions at the US Food and Drug Administration	6
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	6
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands	6
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	6
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead	6
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	6
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model	6
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	6
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	5
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	5
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	5
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats	5
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	5
Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability	5
Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes	5
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs	5
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	5
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs	4
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension	4
LC-MS/MS method for rapid and accurate detection of caffeine in a suspected overdose case	4
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia	4
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	4
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification	4
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project	4
Fluorescent opioid receptor ligands as tools to study opioid receptor function	4
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	4
Optimization of psoriasis mouse models	4
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	4
In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells	4
On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment	4
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol	4
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance	4
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds	3
Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents	3
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma	3
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	3
Schiefer counter: An alternative method for clonogenic assay evaluation	3
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	3
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	3
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	3
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	3
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies	3
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS	3
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	3
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	3

Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators	3
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification	3
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	3
Optimization of bioanalysis of dried blood samples	3
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	3
Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum	3
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates	3
A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity	2
Assessment of intracellular accumulation of cadmium and thallium	2
Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy	2
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species	2
Development of binary classification models for assessment of drug-induced liver injury in humans using a large set of FDA-approved drugs	2
An optimized method for intratracheal instillation in mice	2
A new group housing approach for non-human primate metabolism studies	2
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis	2
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models	2
Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies	2
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	2
Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: Dream or reality?	2
A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates	2
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	2
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
QT Ratio: A simple solution to individual QT correction	2
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
Characterization of an i.p. D-galactose-induced cataract model in rats	2
Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs	2