OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	35
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	32
Quantitative comparison of ECG limb lead configurations: Evaluating synonymity of interval measurements using alternative leads under appropriately controlled study conditions	25
Off-target of a novel TYK2 inhibitor is associated with myocardial necrosis mediated by hemodynamic changes in rats	21
Reproducible safety pharmacology echocardiography studies in vehicle-treated canines and NHPs	21
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform	20
Organelle profiling of compound-induced effects in human iPSC-derived cardiomyocytes in combination with electrophysiology assays for in vitro prediction of cardiac safety	18
The impact of collaborative science on cardiovascular safety evaluation – A 10-year update of the HESI cardiac safety committee	17
Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats	16
A retrospective analysis of the concordance between cardiovascular effects in telemetry studies, toxicity studies, and early clinical trials	15
Corrigendum to ‘PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks’ [Journal of pharmacological	15
Metabolomics using high-resolution magic angle spinning nuclear magnetic resonance: Neurotoxicological applications	12
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	12
Contractility assessment using aligned human iPSC-derived cardiomyocytes	12
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	12
Ciprofloxacin does not accelerate aortic stiffness or aortic dilation in healthy, hypertensive and diseased mouse models	11
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	11
hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels	11
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	11
Investigation of in vitro I /hERG assays under physiological temperature conditions using the semi-automated patch-clamp system QPatch compact with temperature control system	10
Enhanced interpretation of secondary pharmacology data through automated visualization tools to support safety assessment	9
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	9
Effects of temperature, compound concentration verification, and internal fluoride on hERG	9
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	9
Retrospective review of the safety pharmacology assessment of emerging therapeutic modalities approved from 2010 to 2023	9

Enhanced detection sensitivity in nonclinical cardiovascular telemetry studies: Impact of a characterized facility	9
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation	9
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	9
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	8
Monitoring cardiomyocyte function with hybrid EFP-impedance technology for drug safety evaluation	8
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	8
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	8
Development of electrophysiological toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	8
Advances in microfluidic endothelium-on-chip for assessing endothelial function	8
An investigation into the relationship between acetazolamide systemic exposure, blood gas changes and ventilatory parameters in the sprague Dawley® rat	8
Effect of telemetry study design on minimum detectable difference values for QTc interval	8
Comparison of quinine-induced QRS prolongation in canine and primate telemetry studies: Applying concentration-effect modeling to assess ventricular conduction delay risk	7
Comparisons of hERG data for 30 drugs generated by automated and manual patch clamp systems by the same laboratory	7
Analyzing atrial human iPSC-cardiomyocyte responses to GPCR and ion channel modulators: Introducing a chamber-specific cell model for preclinical testing	7
Evaluation of the J-Tpeak and Tpeak-to-tend intervals of the ECG as proarrhythmia biomarkers in telemetered dogs	7
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	6
Non-invasive monitoring of cardiac output: Validation in anesthetized laboratory rats by pharmacological beta-adrenergic pathway modulation	6
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	6
Minimal requirements for stem-cells derived cardiomyocytes and MEA usage in view of field potential analysis by reverse modeling - A theoretical study on the impact of 3 variability factors	6
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	6
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	6
Gene therapy: A different challenge for toxicologists?	6
Streamlined dispersive solid phase extraction for determination of amitriptyline, cocaine, and benzoylecgonine in urine	6
Taking a deep breath: Evidence-based approaches to respiratory safety assessment	5
Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies	5
Analytical performance of poly(L-cysteine) modified pencil graphite electrode for dapsone detection	5
Editorial Board	5
Analytical method development for detection and quantification of AMB-FUBINACA in mouse brain tissue using GC–MS/MS	5
The translation of hERG block and APD90 in vitro to clinical QTc prolongation in man	5
Regulatory safety pharmacology & toxicology assessment studies: Measurement of the ECG and hemodynamic parameters in non-rodent species	5
Exploratory safety investigations in normal, freely moving Göttingen Minipigs using telemetry: Pharmacological validation	5
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	5
Are current rat studies sensitive to detect blood pressure changes per the new FDA draft clinical blood pressure guidance?	5
In silico modeling of hemodynamic and autonomic effects of a selective α2-adrenoceptor agonist in beagle dogs by telemetry	5
Editorial Board	5
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	5
QT Ratio: A simple solution to individual QT correction	5
An in silico approach during safety pharmacology studies	4
Using automated patch clamp for high throughput pharmacological characterization of cardiac action potentials	4
Evaluation of the head twitch response in male C57BL/6J mice as a measure of 5-HT receptor activation	4
Non-clinical cardiovascular safety testing: Current status, gaps and emerging trends	4
Establishment of high-throughput toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	4
Establishment of functional observational battery test in large animals (dogs and non-human primates)	4
In silico modeling of effects of pimobendan on cardiac output and systemic vascular resistance in beagle dogs by telemetry	4
Serum starvation magnifies the delayed suppression of IK by probucol	4
Recording of transcellular voltage deflections from cardiomyocytes on MEA devices using laser poration	4
Improving on-tissue detection of doxorubicin by using matrix assisted laser desorption ionization mass spectrometry imaging	4
Editorial Board	3
Variability of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices	3
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	3

Enhancing cardiac safety evaluation: Assessing drug interactions with the late Nav1.5 current	3
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	3
Development of spectroscopic methods using charge transfer complex for the quantitative estimation of proguanil hydrochloride: Insights from greenness evaluation, BSA binding, molecular docking, antim	3
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	3
High-throughput evaluation of cardiac electrophysiology and predicted actions on cardiac ion channels using hiPSC-CM and MEA technology	3
Assessing the cardiotoxicity of 31 compounds using a multiplexed kinetic image cytometry (KIC)-based assay: Harnessing the predictive power of human iPSC-cardiomyocytes for early drug development	3
Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans	3
A retrospective review of the effects of moxifloxacin in NHP at four different test sites	3
Study to compare effects of a positive inotrope administered concurrently with a beta-blocker in ventricular Tachy-Paced dogs in mild heart failure	3
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	3
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	3
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	3
Combining a systems immunology approach with in vitro data to evaluate drug-induced changes in the immune response after Influenza A Virus infection – A blueprint for the preclinical assessment of inf	2
Cardiac 3D electromechanical tissue simulations for cardiac safety analysis	2
ICH E14/S7B Q&A integrated risk assessment: Strategies for managing TQT waivers if S7B non-clinical studies don't meet best practice expectations	2
Development of a pharmaceutical database to support the nonclinical evaluation of drug-induced cardiac toxicity	2
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	2
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non–rodent species in regulatory safety assessment studies	2
A translational study between human induced pluripotent stem cell-derived cardiomyocytes (Hipsc-Cm) and an in vivo model to predict proarrhythmogenic properties	2
In silico predictions of drug-induced changes on cardiac contractility in human ventricular cardiomyocytes	2
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	2
Virtual clinical QT exposure-response studies – A translational computational approach	2
Development of a novel milli-fluidic liver tissue chip for mechanistic drug-induced liver injury (DILI) studies	2
Multi-site validation of in vivo QT ICH E14/S7B Q&A guidance in canines and non-human primates	2
Editorial Board	2
Correlation electrical repolarization and membrane hERG abundance in iPSC cardiomyocytes induced by chronic drugs actions on channel trafficking	2
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	2
Elucidating the challenges with categorizing drugs that block cardiac sodium channels − The impact of temperature on drug-cardiac sodium channel interactions	2
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	2
Discovery and development of digital biomarkers to inform home-cage neuro-behavioral assessments in the rodent	2
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	2
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	2
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	2
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	2
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	2
Dog and minipig telemetry assay sensitivity to detect QTc prolongation: Moxifloxacin effects by timepoint and concentration-QTc relationship analysis	2
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	2
QTc least significant difference in stand-alone implanted telemetry safety pharmacology and jacketed external telemetry regulatory toxicology studies in dogs	2
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	2
Spectrum of effects detected in the rat functional observational battery following administration of non-CNS targeted and CNS targeted compounds	2
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	2
State-of-the-art in secondary pharmacology and its impact on the safety of new medicines	2
Therapeutic drug monitoring of busulfan and cyclophosphamide in hematologic malignancies: An LC-MS/MS development, validation and application	2
Lipopolysaccharide-induced abdominal nociception behavioral model in adult zebrafish (Danio rerio)	2
Long-term monitoring of cardiac action potentials for the assessment of chronic cardiotoxicity	2
Rapid quantification of CSF total protein via smartphone digital colorimetry: Enabling early diagnosis of central nervous system diseases	2