Journal of Pharmacological and Toxicological Methods

Papers
(The median citation count of Journal of Pharmacological and Toxicological Methods is 0. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk27
Visualizing QT prolongation in the anesthetized guinea pig25
Editorial Board23
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis22
Chronic bladder catheterization for precise urine collection in awake mice18
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods17
The underlying molecular mechanisms of drug-induced seizures16
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress14
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry14
Drug-target interaction prediction using reliable negative samples and effective feature selection methods13
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies13
A stable cell line inducibly expressing hERG1a/1b heteromeric channels13
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice11
Contractility assessment using aligned human iPSC-derived cardiomyocytes11
Automated cardiac tissue assay system with perfusion for monitoring contractility10
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals10
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys9
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry9
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells9
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model8
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS8
Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering8
Lung physiology and controlled exposure study design8
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease7
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration7
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits7
In vitro neurotoxicity testing using functional human iPSC-derived neurons7
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era6
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™6
Assessment of cardiac reserve and chronotropic effects using dobutamine stress echocardiography in healthy male rats6
Editorial Board6
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies6
Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs6
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models6
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology6
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain5
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys5
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis5
Editorial Board5
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone5
Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?5
QT Ratio: A simple solution to individual QT correction5
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition5
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples5
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys5
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment5
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As4
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients4
Mouse models for actinic keratoses4
Evoked responses to electrical stimulation in acute brain slice using a high-density and large-scale CMOS-MEA system4
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity4
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog4
A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods4
Cardiotoxicity with immune checkpoint inhibitors4
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives4
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma4
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document4
Voltage imaging of single contracting human iPSC-CMs using ratiometric voltage-sensitive dyes4
Editorial Board4
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)3
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay3
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients3
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study3
Editorial Board3
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization3
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization3
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods3
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms3
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation3
Virtual clinical QT exposure-response studies – A translational computational approach3
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak3
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis3
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry3
Editorial Board3
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability3
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee3
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes3
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine3
Identification of pharmacological targets involved in drug-induced thermoregulation impairment3
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties3
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies3
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system2
Editorial Board2
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons2
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss2
Chicken embryo as animal model to study drug distribution to the developing brain2
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies2
Establishing an in vitro assay for predicting neurotoxicity risks using functional human iPSC-derived neurons2
Drug combination assays using Caenorhabditis elegans as a model system2
Electrophysiological analysis of seroquel’s activity in sodium ion channels, CiPA ion channels and hiPSC-neuronal cells2
A comparison of multiple left ventricular pressure endpoints as a screening tool in rats2
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction2
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes2
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys2
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system2
Editorial Board2
Editorial Board2
Core battery safety pharmacology testing – An assessment of its utility in early drug development2
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds2
CNS safety assessment in freely moving socially housed rodents2
Test facility management: Responsibilities and paradigms of a new era2
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel2
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol2
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats2
Preclinical nerve conduction: Nerve battery options for primate studies2
Improvement of contractile function of human iPS cell-derived cardiac cell sheets by electric stimulation for several days1
AI analysis in MEA data of hiPSC-derived neurons is useful method for risk prediction of pesticides1
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods1
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands1
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward1
The NaV1.5 late current in WT and Nav1.5-ΔKPQ mutant channels: An automated patch clamp LQT3 electrophysiological assay comparison1
The electrophysiological responses to antibacterial drugs in human iPSC-derived neurons demonstrate the classification of antibacterial drug encephalopathy clinically1
Dosing in the dark—effect of time of dosing on preclinical safety profiles1
Editorial Board1
Evaluation methods using tear volume in a conjunctivitis mice model1
Investigating the effects of mitochondrial inhibitors and uncoupler on hiPSC-CM MEA assay to predict drug-induced cardiotoxicity1
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability1
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification1
The efficient method to get better raw brain signal on rat anesthetics experiment1
Telemetric long-term assessment of autonomic function in experimental heart failure1
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance1
Drug testing using a novel in silico human cardiac Purkinje cell model and comparison with experimental data1
Editorial Board1
Three in silico human iPSC cardiomyocyte models to recapitulate in vitro drug trials1
A novel nonhuman primate model of citric acid-induced cough1
Inter-rater agreement between WHO- Uppsala Monitoring Centre system and Naranjo algorithm for causality assessment of adverse drug reactions1
Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction1
Editorial Board1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay1
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes1
Safety pharmacology during the COVID pandemic1
Doxorubicin-induced cardiotoxicity: Investigating the effect on miRNA expression and G-protein coupled receptors mediated vascular tone1
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis1
Ultraviolet spectrophotometry as method to determine the concentration of β-myrcene released from chitosan in aqueous medium1
Solvents effect on dansyl cysteamine depletion and reactivity classification of skin sensitizers: Tackling the challenges using binary solvent systems1
Human engineered cardiac tissues grown in a plate-based platform for analysis of acute and chronic contractility response1
Editorial Board1
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium1
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations1
Editorial Board1
Human iPS cell-derived cardiomyocytes aligning on flexible gelatin fiber network show contraction and pharmacological responses relevant to human heart1
Safety Pharmacology Society Annual Meeting Abstracts1
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects1
A method for assessing and monitoring consistency of nonclinical ECG analysis1
MEA assessment to anti-epilepsy drugs in human iPSC-derived neural network1
Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities1
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma1
Evaluation of 4 quantification methods for monitoring 16 antidepressant drugs and their metabolites in human plasma by LC-MS/MS1
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis1
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum1
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins1
Editorial Board1
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies0
The rat telemetry assay and venous catheter access buttons for use in cardiovascular safety pharmacology assessments – Surgical methods, refinements and colony maintenance0
Editorial Board0
Evaluation of chronic drug-induced effects of oncologic compounds on cardiac function and cardiac biomarkers release in human induced pluripotent stem cell-derived cardiomyocytes0
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model0
Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy0
CiPA-compliant assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine0
Method of measuring effects of study procedures in single and pair housed New Zealand White rabbits (Oryctolagus cuniculus)0
Translational understanding of PDE4 inhibition0
Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study0
Improved detection of compound arrhythmogenicity in 2D cardiac stem cell models via advanced maturation strategies0
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes0
Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities.0
In vitro drug evaluation model of human iPS cell-derived neural cell by using novel gelatin fiber scaffold0
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species0
A rapid spectrophotometric method to identify inhibitors of human erythropoiesis0
Editorial Board0
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats0
Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes0
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins0
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments0
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol0
An optimized method for intratracheal instillation in mice0
Unattended screening workflow in a 384-well automated patch clamp system0
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy0
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profil0
Are drugs marketed nowadays more selective and safe than those approved 20 years ago?0
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS0
Preclinical mitigation of 5-HT2B agonism-related cardiac valvulopathy revisited0
Neuroelectrophysiology assays performed on dorsal root ganglion from non-human primate and rodent origins0
Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B0
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension0
Aggregation and analysis of secondary pharmacology data from investigational new drug submissions at the US Food and Drug Administration0
Improving corrected QT; Why individual correction is not enough0
Adaptation of closed-chest infarction porcine model to adult Pannon minipigs0
Cell monitoring using multi-frequency impedance recordings for label-free and time-resolved cell response analysis0
Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective0
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms0
CNS (EEG & behavior) safety assessment in freely moving/socially housed non-rodents0
Study design criteria for regulatory-based drug control action: Drug discrimination0
Editorial Board0
Fluorescent opioid receptor ligands as tools to study opioid receptor function0
Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation0
Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility0
Inhibition of hERG K channels by verapamil at physiological temperature: Implications for the CiPA initiative0
Comparative analysis of high-throughput RNA extraction kits in Naïve Non-Human Primate (NHP) tissues for downstream applications utilizing Xeno Internal Positive Control (IPC)0
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia0
Potential for use of a flavone isolated from Chromolaena leivensis as anti-inflammatory drug0
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells0
Assessment of intracellular accumulation of cadmium and thallium0
The 2023 safety pharmacology society (SPS) salary survey0
A cross-species comparison study of undesired drug-induced hypothermia using telemetry0
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes0
The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat0
A fast optical kinetic plate reader for assessing action potentials in human-induced pluripotent stem cell cardiomyocytes0
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development0
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model0
Use of human induced pluripotent stem cell-derived cardiomyocytes and multi-electrode array technology to explore the delayed onset of premature ventricular contractions in monkey0
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach0
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds0
Drug effects on human Na+/Ca2+ exchanger and implications for testing new drug candidates0
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions.0
Development of predictive inotropy in silico cardiac safety assay for drug candidate screening0
Isolation and electrophysiological recording of Ixodes ricinus synganglion neurons0
Development, validation, and clinical application of a UPLC-MS/MS method for omadacycline determination in human serum0
Development of binary classification models for assessment of drug-induced liver injury in humans using a large set of FDA-approved drugs0
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project0
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva0
Conduction liability of cardiac sodium channel binding sites0
Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies0
Measuring the impact of known inotropes on rat papillary muscles via the force-clamped feedback work-loop0
Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: Dream or reality?0
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies0
Editorial Board0
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates0
Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis0
Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods0
Optimization of bioanalysis of dried blood samples0
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models0
Overcoming obstacles in three-dimensional cell culture model establishment: Approaches for growing A549 non-small cell lung cancer spheroids using a clinostat system0
Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment0
Rodent model in safety pharmacology to evaluate effects of learning and memory properties of a drug0
Method of transverse aortic constriction in mice with reduced variability of the aortic peak pressure gradient0
MEA assay with human iPSC-derived neurons generated by a rapid differentiation method0
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS0
Combining human-based in silico and in vitro models of inherited cardiac diseases for drug safety and efficacy evaluation0
Use of human Caco-2 cells and HPAE-PAD for α-glucosidase assay0
A case report of cardiovascular safety outcomes in mice supported by a pharmacodynamic biomarker0
Analysis of secondary pharmacology assays received by the US Food and Drug Administration0
Comparison of SYBR green I and lactate dehydrogenase antimalarial in vitro assay in Plasmodium falciparum field isolates0
Do behavioral test scores represent repeatable phenotypes of female mice?0
A simple accurate method for concentration-QTc analysis in preclinical animal models0
Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes0
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification0
Editorial Board0
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment0
Improved screening of the cardiovascular safety of COVID-19 anti-viral compounds0
Cell-based actin polymerization assay to analyze chemokine inhibitors0
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