Journal of Pharmacological and Toxicological Methods

Article	Citations
First-order compartment model solutions – Exponential sums and beyond	20
Editorial Board	17
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma	16
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	14
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats	13
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	12
Editorial Board	12
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	12
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	10
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes	10
A novel device for serial venous blood sampling in a canine model	9
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	9
Non-invasive method of obtaining milk from mice using carbetocin, a synthetic analogue of oxytocin	9
Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling	9
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species	9
Human iPS cell-derived cardiomyocytes aligning on flexible gelatin fiber network show contraction and pharmacological responses relevant to human heart	8
Improved screening of the cardiovascular safety of COVID-19 anti-viral compounds	8
Flavonoids from Chromolaena leivensis and Caesalpinia spinosa as potential protectors against doxorubicin-induced cardiomyopathy	8
An integrative computational platform for the multiparametric analysis of cardiomyocyte signals	8
Three in silico human iPSC cardiomyocyte models to recapitulate in vitro drug trials	7
Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes	7
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	7
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	6
The underlying molecular mechanisms of drug-induced seizures	6
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	6

Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes	6
Chronic bladder catheterization for precise urine collection in awake mice	6
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	6
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	6
MEA assessment to anti-epilepsy drugs in human iPSC-derived neural network	6
Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system	6
Visualizing QT prolongation in the anesthetized guinea pig	6
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	5
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	5
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	5
A fast optical kinetic plate reader for assessing action potentials in human-induced pluripotent stem cell cardiomyocytes	5
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	5
Biological variations in hemodynamics and electrocardiogram rhythms among telemetered cynomolgus monkeys	5
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead	5
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	4
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity	4
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	4
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	4
A highly efficient liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay for etomidate and etomidate acid in urine, liver and kidney	4
Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents	4
Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients	4
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	4
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum	4
Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs	4
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models	4
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	4
Comparative analysis of high-throughput RNA extraction kits in Naïve Non-Human Primate (NHP) tissues for downstream applications utilizing Xeno Internal Positive Control (IPC)	4
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	3
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium	3
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations	3
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model	3
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds	3
Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes	3
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration	3
Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis	3
Contractility assessment using aligned human iPSC-derived cardiomyocytes	3
Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators	3
Screening of anticonvulsant activity of Xylopia aethiopica dry fruit using zebrafish	3
Editorial Board	3
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance	3
The efficient method to get better raw brain signal on rat anesthetics experiment	3
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	3
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	3
Optimization of psoriasis mouse models	3
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity	3
Effects of intracellular fluoride and temperature on hERG blocker potency in vitro	2
Editorial Board	2
In vitro cardiac safety evaluation for repurposed COVID-19 drugs by using human iPS cell-derived cardiomyocyte with gelatin fiber scaffold	2
Automated cardiac tissue assay system with perfusion for monitoring contractility	2
Ultraviolet spectrophotometry as method to determine the concentration of β-myrcene released from chitosan in aqueous medium	2

Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility	2
Assessment of cardiac safety liabilities via 3D engineered heart tissue contractility using a novel high-throughput instrumentation platform	2
Late sustained sodium current in the adult human heart	2
HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations	2
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	2
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profil	2
A rapid spectrophotometric method to identify inhibitors of human erythropoiesis	2
Editorial Board	2
Human engineered cardiac tissues grown in a plate-based platform for analysis of acute and chronic contractility response	2
Editorial Board	2
Comparison of SYBR green I and lactate dehydrogenase antimalarial in vitro assay in Plasmodium falciparum field isolates	2
Assessment of intracellular accumulation of cadmium and thallium	2
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	2
Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study	2
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6	2
Drug testing using a novel in silico human cardiac Purkinje cell model and comparison with experimental data	2
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	2
Overcoming obstacles in three-dimensional cell culture model establishment: Approaches for growing A549 non-small cell lung cancer spheroids using a clinostat system	1
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	1
Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment	1
Chicken embryo as animal model to study drug distribution to the developing brain	1
MEA assay with human iPSC-derived neurons generated by a rapid differentiation method	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
Combining human-based in silico and in vitro models of inherited cardiac diseases for drug safety and efficacy evaluation	1
Identification of safety margins for polysorbate 80 exposure in canines	1
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments	1
A cross-species comparison study of undesired drug-induced hypothermia using telemetry	1
Test facility management: Responsibilities and paradigms of a new era	1
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons	1
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development	1
Method of transverse aortic constriction in mice with reduced variability of the aortic peak pressure gradient	1
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	1
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification	1
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	1
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia	1
AI analysis in MEA data of hiPSC-derived neurons is useful method for risk prediction of pesticides	1
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	1
Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering	1
Innovative approaches to cardiovascular safety pharmacology assessment	1
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model	1
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis	1
Translational understanding of PDE4 inhibition	1
Corrigendum to “The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies” [Jour	1
Dosing in the dark—effect of time of dosing on preclinical safety profiles	1
Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation	1
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	1
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	1
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	1
In vitro neurotoxicity testing using functional human iPSC-derived neurons	1
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates	1
Development of predictive inotropy in silico cardiac safety assay for drug candidate screening	1
Improved detection of compound arrhythmogenicity in 2D cardiac stem cell models via advanced maturation strategies	1
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	1
QA interval heart rate correction: Species comparison of an indirect ventricular contractility biomarker	1
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in rats plasma using GC–MS / MS	1
Preclinical safety pharmacology risk assessment for oligonucleotides put into practice	1
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	1
Neuroelectrophysiology assays performed on dorsal root ganglion from non-human primate and rodent origins	1
Editorial Board	0
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	0
Editorial Board	0
Editorial Board	0
Core battery safety pharmacology testing – An assessment of its utility in early drug development	0
Quantification of anti-drug antibodies against E6011, an anti-fractalkine monoclonal antibody, in monkey and human serum, by an electrochemiluminescence assay	0
Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities.	0
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	0
Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose–response in nonhuman primates	0
Telemetric long-term assessment of autonomic function in experimental heart failure	0
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model	0
Evaluation of 4 quantification methods for monitoring 16 antidepressant drugs and their metabolites in human plasma by LC-MS/MS	0
QT Ratio: A simple solution to individual QT correction	0
CiPA-compliant assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine	0
Isolation and electrophysiological recording of Ixodes ricinus synganglion neurons	0
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	0
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project	0
Evaluation of acute and long-term drug effects on contractility at 1 Hz electrical pacing with human induced pluripotent stem cell-derived cardiac cell sheet-tissues	0
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	0
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	0
Evaluation of a left ventricular pressure catheterized rat telemetry model to measure cardiac contractility: Prevalence of post-surgical arrhythmias	0
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	0

The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies	0
Editorial Board	0
A case report of cardiovascular safety outcomes in mice supported by a pharmacodynamic biomarker	0
Cation chloride cotransporter modulation of the seizure phenotype in rat cortical MEA	0
In silico study of drug effects on human non-failing and failing cardiomyocytes	0
Inter-rater agreement between WHO- Uppsala Monitoring Centre system and Naranjo algorithm for causality assessment of adverse drug reactions	0
Do behavioral test scores represent repeatable phenotypes of female mice?	0
Editorial Board	0
Assessing the reversibility of acetylcholinesterase (AChE) inhibitors	0
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	0
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era	0
Improvement of contractile function of human iPS cell-derived cardiac cell sheets by electric stimulation for several days	0
The electrophysiological responses to antibacterial drugs in human iPSC-derived neurons demonstrate the classification of antibacterial drug encephalopathy clinically	0
Editorial Board	0
Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs	0
Electrophysiological analysis of seroquel’s activity in sodium ion channels, CiPA ion channels and hiPSC-neuronal cells	0
A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods	0
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	0
Editorial Board	0
Method of measuring effects of study procedures in single and pair housed New Zealand White rabbits (Oryctolagus cuniculus)	0
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis	0
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	0
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects	0
Preclinical mitigation of 5-HT2B agonism-related cardiac valvulopathy revisited	0
Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods	0
Comparative assessment of Ca2+ oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks	0
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	0
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	0
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	0
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach	0
A method for assessing and monitoring consistency of nonclinical ECG analysis	0
Voltage imaging of single contracting human iPSC-CMs using ratiometric voltage-sensitive dyes	0
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	0
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma	0
Preclinical nerve conduction: Nerve battery options for primate studies	0
Investigating the effects of mitochondrial inhibitors and uncoupler on hiPSC-CM MEA assay to predict drug-induced cardiotoxicity	0
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	0
Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma	0
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies	0
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	0
Cardiotoxicity with immune checkpoint inhibitors	0
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs	0
Mouse models for actinic keratoses	0
CNS (EEG & behavior) safety assessment in freely moving/socially housed non-rodents	0
Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment	0
Evoked responses to electrical stimulation in acute brain slice using a high-density and large-scale CMOS-MEA system	0
Editorial Board	0
STRhiPS: A safety trials tool based on human-induced pluripotent stem cells to evaluate drug-induced arrhythmias	0
Rodent model in safety pharmacology to evaluate effects of learning and memory properties of a drug	0
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	0
Evaluation of chronic drug-induced effects of oncologic compounds on cardiac function and cardiac biomarkers release in human induced pluripotent stem cell-derived cardiomyocytes	0
In vitro drug evaluation model of human iPS cell-derived neural cell by using novel gelatin fiber scaffold	0
A retrospective analysis of the spontaneous incidence of neurological clinical signs across species	0
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis	0
CNS safety assessment in freely moving socially housed rodents	0
Safety pharmacology during the COVID pandemic	0
Unattended screening workflow in a 384-well automated patch clamp system	0
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability	0
Distinction of IKr blockers based on channel state preference using voltage clamp simulations and machine learning	0
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	0
Optimization of bioanalysis of dried blood samples	0
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva	0
Common chemistry, manufacturing, and control deficiencies in abbreviated new drug applications assessed by the US Food and drug administration: Hurdle to access cost-effective medicines	0
Cutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study	0
Safety Pharmacology Society Annual Meeting Abstracts	0
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	0
Assessment of antiemetic activity of dihydrocoumarin: In vivo and in silico approaches on receptor binding affinity and modulatory effects	0
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	0
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	0
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	0
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy	0
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension	0
Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues	0
Drug combination assays using Caenorhabditis elegans as a model system	0
An immunoblot assay for cysteine oxidation by reactive oxygen species allows detection of novel thioprotective efficacy of black tea extracts	0
Virtual clinical QT exposure-response studies – A translational computational approach	0
Doxorubicin-induced cardiotoxicity: Investigating the effect on miRNA expression and G-protein coupled receptors mediated vascular tone	0
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms	0
Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assays	0
Evaluation methods using tear volume in a conjunctivitis mice model	0
Potential for use of a flavone isolated from Chromolaena leivensis as anti-inflammatory drug	0
Are drugs marketed nowadays more selective and safe than those approved 20 years ago?	0
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification	0
A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity	0
Solvents effect on dansyl cysteamine depletion and reactivity classification of skin sensitizers: Tackling the challenges using binary solvent systems	0
Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the “3Rs” principles in core battery safety pharmacology studies	0
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment	0
Comparison of automated analysis methods for small animal activity assessment	0
Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies	0
The use of normative qEEG databases increases the accuracy of subject screening in phase I clinical trials of drugs with seizure liabilities	0
Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B	0
Application of rapid iPSC differentiation to neurotoxicity assays	0
Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?	0
Drug effects on human Na+/Ca2+ exchanger and implications for testing new drug candidates	0
Improved prediction of adverse drug reactions for loperamide and pramipexole with in vitro secondary pharmacology profiling panels	0