Journal of Pharmacological and Toxicological Methods

Article	Citations
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives	20
Chicken embryo as animal model to study drug distribution to the developing brain	17
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	16
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	14
Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics	14
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model	13
Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS	12
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods	12
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy	12
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	12
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies	12
A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin	10
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	10
Improving corrected QT; Why individual correction is not enough	9
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes	9
Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice	9
Core battery safety pharmacology testing – An assessment of its utility in early drug development	9
Development of an easy and rapid analytical method for the extraction and preconcentration of chloroquine phosphate from human biofluids prior to GC–MS analysis	9
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes	9
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	8
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	8
Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples	8
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	8
Use of automated patch clamp in cardiac safety assessment: Past, present & future perspectives	8
Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples	7

Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients	7
Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy	7
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	7
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model	7
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	7
Aggregation and analysis of secondary pharmacology data from investigational new drug submissions at the US Food and Drug Administration	6
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	6
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands	6
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	6
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead	6
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	6
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model	6
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	6
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	5
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	5
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	5
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats	5
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	5
Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability	5
Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes	5
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs	5
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	5
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs	4
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension	4
LC-MS/MS method for rapid and accurate detection of caffeine in a suspected overdose case	4
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia	4
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	4
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification	4
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project	4
Fluorescent opioid receptor ligands as tools to study opioid receptor function	4
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	4
Optimization of psoriasis mouse models	4
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	4
In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells	4
On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment	4
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol	4
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance	4
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds	3
Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents	3
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma	3
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	3
Schiefer counter: An alternative method for clonogenic assay evaluation	3
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	3
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	3
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	3
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	3
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies	3
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS	3
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	3
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	3

Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators	3
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification	3
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	3
Optimization of bioanalysis of dried blood samples	3
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	3
Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum	3
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates	3
Assessment of intracellular accumulation of cadmium and thallium	2
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species	2
A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity	2
Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy	2
Development of binary classification models for assessment of drug-induced liver injury in humans using a large set of FDA-approved drugs	2
An optimized method for intratracheal instillation in mice	2
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models	2
A new group housing approach for non-human primate metabolism studies	2
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	2
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis	2
Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies	2
Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: Dream or reality?	2
A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates	2
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	2
QT Ratio: A simple solution to individual QT correction	2
Characterization of an i.p. D-galactose-induced cataract model in rats	2
Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs	2
In vitro cardiac safety evaluation for repurposed COVID-19 drugs by using human iPS cell-derived cardiomyocyte with gelatin fiber scaffold	1
Do behavioral test scores represent repeatable phenotypes of female mice?	1
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	1
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects	1
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum	1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	1
Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs	1
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	1
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	1
Study design criteria for regulatory-based drug control action: Drug discrimination	1
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma	1
A simple accurate method for concentration-QTc analysis in preclinical animal models	1
The rat telemetry assay and venous catheter access buttons for use in cardiovascular safety pharmacology assessments – Surgical methods, refinements and colony maintenance	1
Lung physiology and controlled exposure study design	1
Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities.	1
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development	1
An immunoblot assay for cysteine oxidation by reactive oxygen species allows detection of novel thioprotective efficacy of black tea extracts	1
A rapid spectrophotometric method to identify inhibitors of human erythropoiesis	1
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment	1
Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment	1
Comparative assessment of Ca2+ oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks	1
A highly efficient liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay for etomidate and etomidate acid in urine, liver and kidney	1
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis	1
Contractility assessment using aligned human iPSC-derived cardiomyocytes	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1
Non-invasive method of obtaining milk from mice using carbetocin, a synthetic analogue of oxytocin	1
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era	1
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment	1
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions.	1
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	1
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	1
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis	1
Mouse models for actinic keratoses	1
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments	1
Virtual clinical QT exposure-response studies – A translational computational approach	1
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium	1
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	1
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity	1
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability	1
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations	1
Development, validation, and clinical application of a UPLC-MS/MS method for omadacycline determination in human serum	1
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats	1
Use of subcutaneous transponders to monitor body temperature in laboratory rats	1
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	1
Adaptation of closed-chest infarction porcine model to adult Pannon minipigs	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
Ultraviolet spectrophotometry as method to determine the concentration of β-myrcene released from chitosan in aqueous medium	1
Screening of anticonvulsant activity of Xylopia aethiopica dry fruit using zebrafish	0
Measuring the impact of known inotropes on rat papillary muscles via the force-clamped feedback work-loop	0
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	0
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies	0
Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis	0
Comparison of automated analysis methods for small animal activity assessment	0
Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA	0

Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	0
Safety Pharmacology Society Annual Meeting Abstracts	0
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	0
A fast optical kinetic plate reader for assessing action potentials in human-induced pluripotent stem cell cardiomyocytes	0
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva	0
Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation	0
Visualizing QT prolongation in the anesthetized guinea pig	0
Test facility management: Responsibilities and paradigms of a new era	0
Innovative approaches to cardiovascular safety pharmacology assessment	0
MEA assessment to anti-epilepsy drugs in human iPSC-derived neural network	0
Dosing in the dark—effect of time of dosing on preclinical safety profiles	0
Effects of intracellular fluoride and temperature on hERG blocker potency in vitro	0
AI analysis in MEA data of hiPSC-derived neurons is useful method for risk prediction of pesticides	0
Editorial Board	0
Chronic bladder catheterization for precise urine collection in awake mice	0
Development of predictive inotropy in silico cardiac safety assay for drug candidate screening	0
Editorial Board	0
Three in silico human iPSC cardiomyocyte models to recapitulate in vitro drug trials	0
Improved detection of compound arrhythmogenicity in 2D cardiac stem cell models via advanced maturation strategies	0
Drug testing using a novel in silico human cardiac Purkinje cell model and comparison with experimental data	0
Human iPS cell-derived cardiomyocytes aligning on flexible gelatin fiber network show contraction and pharmacological responses relevant to human heart	0
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	0
Post-exercise hypotension induced by six-minutes walking test in dogs with naturally occurring mitral insufficiency	0
A novel device for serial venous blood sampling in a canine model	0
QA interval heart rate correction: Species comparison of an indirect ventricular contractility biomarker	0
Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes	0
Assessment of cardiac reserve and chronotropic effects using dobutamine stress echocardiography in healthy male rats	0
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	0
Preclinical safety pharmacology risk assessment for oligonucleotides put into practice	0
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	0
A case report of cardiovascular safety outcomes in mice supported by a pharmacodynamic biomarker	0
Editorial Board	0
Comparative analysis of high-throughput RNA extraction kits in Naïve Non-Human Primate (NHP) tissues for downstream applications utilizing Xeno Internal Positive Control (IPC)	0
Evaluation of chronic drug-induced effects of oncologic compounds on cardiac function and cardiac biomarkers release in human induced pluripotent stem cell-derived cardiomyocytes	0
Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods	0
Editorial Board	0
Inhibition of hERG K channels by verapamil at physiological temperature: Implications for the CiPA initiative	0
Corrigendum to “The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies” [Jour	0
Biological variations in hemodynamics and electrocardiogram rhythms among telemetered cynomolgus monkeys	0
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	0
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profil	0
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	0
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in rats plasma using GC–MS / MS	0
Editorial Board	0
Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system	0
Neuroelectrophysiology assays performed on dorsal root ganglion from non-human primate and rodent origins	0
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration	0
In vitro neurotoxicity testing using functional human iPSC-derived neurons	0
Comparison of SYBR green I and lactate dehydrogenase antimalarial in vitro assay in Plasmodium falciparum field isolates	0
Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes	0
Combining human-based in silico and in vitro models of inherited cardiac diseases for drug safety and efficacy evaluation	0
Editorial Board	0
Improved screening of the cardiovascular safety of COVID-19 anti-viral compounds	0
Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility	0
Flavonoids from Chromolaena leivensis and Caesalpinia spinosa as potential protectors against doxorubicin-induced cardiomyopathy	0
Identification of safety margins for polysorbate 80 exposure in canines	0
Assessment of cardiac safety liabilities via 3D engineered heart tissue contractility using a novel high-throughput instrumentation platform	0
A comparison of multiple left ventricular pressure endpoints as a screening tool in rats	0
Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling	0
A cross-species comparison study of undesired drug-induced hypothermia using telemetry	0
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity	0
A novel nonhuman primate model of citric acid-induced cough	0
Editorial Board	0
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons	0
The efficient method to get better raw brain signal on rat anesthetics experiment	0
CNS (EEG & behavior) safety assessment in freely moving/socially housed non-rodents	0
Editorial Board	0
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	0
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	0
Evaluation methods using tear volume in a conjunctivitis mice model	0
First-order compartment model solutions – Exponential sums and beyond	0
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	0
Overcoming obstacles in three-dimensional cell culture model establishment: Approaches for growing A549 non-small cell lung cancer spheroids using a clinostat system	0
Establishment of drug screening in human embryonic stem cells based on a high-content screening system	0
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	0
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6	0
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	0
Editorial Board	0
Late sustained sodium current in the adult human heart	0
The underlying molecular mechanisms of drug-induced seizures	0
MEA assay with human iPSC-derived neurons generated by a rapid differentiation method	0
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	0
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model	0
Editorial Board	0
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	0
Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering	0
HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations	0
An integrative computational platform for the multiparametric analysis of cardiomyocyte signals	0
Automated cardiac tissue assay system with perfusion for monitoring contractility	0
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	0
Method of transverse aortic constriction in mice with reduced variability of the aortic peak pressure gradient	0
Human engineered cardiac tissues grown in a plate-based platform for analysis of acute and chronic contractility response	0
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model	0
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes	0
Translational understanding of PDE4 inhibition	0