Journal of Pharmacological and Toxicological Methods

Article	Citations
Antibodies against polyethylene glycol in human blood: A literature review	61
Marble-burying behavior test as a murine model of compulsive-like behavior	40
A practical guide to secondary pharmacology in drug discovery	25
Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method	21
Revisiting the hERG safety margin after 20 years of routine hERG screening	20
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives	17
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment	13
Chicken embryo as animal model to study drug distribution to the developing brain	12
Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics	12
Evaluation of urinary biomarkers for early detection of acute kidney injury in a rat nephropathy model	12
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods	10
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	10
A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin	10
Development of an easy and rapid analytical method for the extraction and preconcentration of chloroquine phosphate from human biofluids prior to GC–MS analysis	9
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies	9
Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS	9
A capillary electrophoresis based approach for the identification of anti-drug antibodies against camelid VHH biologics (Nanobodies®)	9
Radiolabelling and immunohistochemistry reveal platelet recruitment into lungs and platelet migration into airspaces following LPS inhalation in mice	9
Inotropic assessment in engineered 3D cardiac tissues using human induced pluripotent stem cell-derived cardiomyocytes in the BiowireTM II platform	9
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes	9
Host cell proteins induce inflammation and immunogenicity as adjuvants in an integrated analysis of in vivo and in vitro assay systems	8
An improved two-step method for extraction and purification of primary cardiomyocytes from neonatal mice	8
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model	8
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model	8
Use of automated patch clamp in cardiac safety assessment: Past, present & future perspectives	8

Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy	7
Core battery safety pharmacology testing – An assessment of its utility in early drug development	7
Insights into toxicology, safety pharmacology, and drug dependence testing: The performance and predictive values of nonclinical tests	7
Is there a role for the no observed adverse effect level in safety pharmacology?	7
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	7
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	7
Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative	7
Improving corrected QT; Why individual correction is not enough	7
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes	7
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model	6
Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project	6
Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples	6
Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients	6
Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice	6
Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy	6
Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage	6
Combined cSLO-OCT imaging as a tool in preclinical ocular toxicity testing: A comparison to standard in-vivo and pathology methods	6
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	6
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	6
Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes	5
Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes	5
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands	5
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	5
Regulatory safety pharmacology evaluation of BIA 10-2474	5
A pharmacological characterization of electrocardiogram PR and QRS intervals in conscious telemetered rats	5
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	5
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	5
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs	5
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	5
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	5
Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples	5
Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment	5
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	5
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model	5
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	5
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	4
A porcine model of ureteral contractile activity: Influences of age, tissue orientation, region, urothelium, COX and NO	4
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs	4
LC-MS/MS method for rapid and accurate detection of caffeine in a suspected overdose case	4
A Bayesian approach to toxicological testing	4
Optimization of psoriasis mouse models	4
Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability	4
Intrapulmonary inoculation of multicellular spheroids to construct an orthotopic lung cancer xenograft model that mimics four clinical stages of non-small cell lung cancer	4
Aggregation and analysis of secondary pharmacology data from investigational new drug submissions at the US Food and Drug Administration	4
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats	4
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	4
Generation of a robust model for inducing autoimmune arthritis in Sprague Dawley rats	4
Dynamic features of cardiac vector as alternative markers of drug-induced spatial dispersion	4
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology	4
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification	3

On the perspective of an aging population and its potential impact on drug attrition and pre-clinical cardiovascular safety assessment	3
Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys	3
RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener	3
Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays	3
Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators	3
Comparison of sublingual, facial and retro-bulbar blood sampling in mice in relation to animal welfare and blood quality	3
Schiefer counter: An alternative method for clonogenic assay evaluation	3
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol	3
A natural complex product Yaocha reduces uric acid level in a live zebrafish model	3
QT Ratio: A simple solution to individual QT correction	3
Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents	3
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	3
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	3
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance	3
Utilization of a mouse/human chimeric model for long term metabolic testing of human skin	3
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	3
In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells	3
Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: Dream or reality?	2
Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs	2
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification	2
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	2
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity	2
Optimization of bioanalysis of dried blood samples	2
Voltage-sensing optical recording: A method of choice for high-throughput assessment of cardiotropic effects	2
Fluorescent opioid receptor ligands as tools to study opioid receptor function	2
Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum	2
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	2
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	2
L-Citrulline as translational safety biomarker for the small intestine—An update	2
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	2
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	2
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma	2
Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery	2
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis	2
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension	2
Development of binary classification models for assessment of drug-induced liver injury in humans using a large set of FDA-approved drugs	2
The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of	2
Assessment of intracellular accumulation of cadmium and thallium	2
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds	2
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	2
Assessment of cardiorespiratory function using telemetric jacket in rodents	2
A new group housing approach for non-human primate metabolism studies	2
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	2
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies	2
Impact of housing conditions on cardiovascular parameters in telemetry-implanted cynomolgus monkeys	2
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	1
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	1
Cardiovascular and respiratory (impedance) by digital telemetry monitoring in cynomolgus monkeys, Beagle dogs and Göttingen minipigs	1
Automated patch clamp system introducing simulated Ik1 into human iPSC-cardiomycoytes using dynamic clamp	1
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment	1
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	1
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead	1
An immunoblot assay for cysteine oxidation by reactive oxygen species allows detection of novel thioprotective efficacy of black tea extracts	1
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models	1
Do behavioral test scores represent repeatable phenotypes of female mice?	1
The database for in silico cardiac risk prediction tools	1
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	1
Peanut butter as an alternative dose delivery method to prevent strain-dependent orogastric gavage-induced stress in mouse teratogenicity studies	1
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation	1
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	1
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates	1
Evaluation of two hERG channel trafficking modulators, pentamidine and pilsicainide, on stably transfected cell line and human induced pluripotent stem cell-derived cardiomyocytes	1
Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints	1
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects	1
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats	1
Changes in the housing arrangement (single versus paired) in cynomolgus monkeys and the impact on telemetry data in drug safety evaluations	1
Evaluation of PhysioTel™ digital M11 cardiovascular telemetry implant in socially housed cynomolgus monkeys using etilefrine and moxifloxacin	1
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	1
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	1
Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability	1
Characterization of an i.p. D-galactose-induced cataract model in rats	1
Use of subcutaneous transponders to monitor body temperature in laboratory rats	1
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS	1
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia	1
An optimized method for intratracheal instillation in mice	1
Reliable identification of hERG liability in drug discovery by automated patch clamp	1
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species	1
Comparative assessment of Ca2+ oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks	1

Human in silico drug trials with a novel human ventricular electrophysiology model	1
IC50 evaluation is critically dependent on the protocol used for measurement	1
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	1
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs	1
A highly efficient liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay for etomidate and etomidate acid in urine, liver and kidney	0
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	0
A novel device for serial venous blood sampling in a canine model	0
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum	0
Editorial Board	0
Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes	0
Effects of intracellular fluoride and temperature on hERG blocker potency in vitro	0
In vivo evaluation of acute intravenous toxicity of a [68Ga]Ga-PSMA-11- microemulsion	0
Evaluation of human induced pluripotent stem cell (hiPSC)—derived peripheral neurons as an in vitro model to screen for compounds that modulate neurite growth and stability	0
The safety profile of mitragynine, the primary constituent in kratom (Mitragyna speciosa), in comparison to morphine in rats	0
Chronic bladder catheterization for precise urine collection in awake mice	0
An evidence-based evaluation of possible sex-related differences in results from abuse and physical dependence potential testing in rats	0
Controlled large-scale manufacturing of hiPSC-derived cardiomyocytes in stirred-tank bioreactors for high-throughput safety assessment in drug discovery and development	0
Drug-induced cardiotoxicity assessment by cell motion imaging	0
SEND 3.1: A path to readiness for safety pharmacology study data	0
Establishment of drug screening in human embryonic stem cells based on a high-content screening system	0
Assessment of cardiac safety liabilities via 3D engineered heart tissue contractility using a novel high-throughput instrumentation platform	0
Translational understanding of convulsion risk due to inhibition of the GABAA chloride channel	0
Profiling cardio-active compound response between high-throughput 2D monolayers, anisotropic and 3-dimensional human induced pluripotent stem cell-derived cardiomyocytes	0
Integrated analysis of human induced pluripotent stem cell-derived cardiomyocytes in diversity and disease modeling	0
Combining field potential data and in silico simulated data to improve machine learning approaches and better assess drug cardiotoxicity	0
Is enough, enough? SEND data processing considerations when changing the logging rate	0
Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility	0
Non-invasive method of obtaining milk from mice using carbetocin, a synthetic analogue of oxytocin	0
Hemodynamic simulator: A Shiny web application for predicting drug effect on hemodynamics	0
Comparison of ECG parameters in beagle dog from stand-alone safety pharmacology and repeat dose toxicology studies	0
New potential of human induced pluripotent stem cell-derived neurons in the nonclinical study – The 2nd report from iNCENS project in collaboration with CSAHi and HESI NeuTox	0
Are animal studies sufficient to assess the abuse potential of a new molecular entity?	0
Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation	0
The use of emerging safety biomarkers in nonclinical and clinical safety assessment—the current and future state: An IQ DruSafe industry survey	0
The underlying molecular mechanisms of drug-induced seizures	0
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	0
Maximizing the information potential of EEG data sets: Preclinical pharmaco-sleep	0
The use of cytokines and oxidative stress markers as indicators for drug safety	0
Use of the comprehensive in vitro proarrhythmia assay and in silico modeling to investigate the safety profile of bisphenol analogues	0
Repolarization instability and arrhythmia susceptibility upon IKr block in isolated and 2D-monolayers of hiPSC-CMs	0
Differential temporal response patterns in rat cocaine self-administration studies: The cumulative record dose-response function	0
Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling	0
Utilization of mechanistic modelling and simulation to analyze fenspiride proarrhythmic potency–role of physiological and other non-drug related parameters	0
Machine learning and multiresolution wavelet decomposition to improve automated cardiac arrhythmia detection and classification	0
Automated cardiac tissue assay system with perfusion for monitoring contractility	0
Biological variations in hemodynamics and electrocardiogram rhythms among telemetered cynomolgus monkeys	0
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	0
A fast optical kinetic plate reader for assessing action potentials in human-induced pluripotent stem cell cardiomyocytes	0
Personalized cell lines by reproducible and functional immortalization	0
Editorial Board	0
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	0
Three in silico human iPSC cardiomyocyte models to recapitulate in vitro drug trials	0
Artificial intelligence enables structural toxicity testing for endpoint and multiple-timepoint assays	0
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma	0
Human engineered cardiac tissues grown in a plate-based platform for analysis of acute and chronic contractility response	0
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	0
Maturation of hiPSC-CM function for improved predictivity of in vitro action potential and contractility assays	0
Multiwell Microelectrode Array (MEA) Technology for the quantification of neuronal, synaptic, and network function for in vitro primary and stem cell-derived neuronal models	0
Comparison of impact of administration route (oral gavage and continuous infusion) on whole body plethysmography results using a respiratory stimulant in conscious rats	0
Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs	0
A cardiovascular assessment following a single oral (gavage) dose of digoxin and verapamil in conscious, dual pressure radiotelemetry-instrumented male Sprague-Dawley rats	0
Large intestine motility in the rodent—How does it measure up?	0
Editorial Board	0
Drug-induced QT prolongation: Concordance of preclinical canine model in relation to clinical outcome	0
MEA assessment to anti-epilepsy drugs in human iPSC-derived neural network	0
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes	0
Editorial Board	0
“INSPIRE”: A European training network in safety pharmacology creating opportunities for 15 PhD students	0
Development of an impedance based screening assay for cardiac safety and cardiotoxicity detection	0
Differential temporal response patterns for cocaine or hydrocodone in rat self-administration studies	0
Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models	0
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	0
Simultaneous measurement of Ca-transient and contractility in isolated canine ventricular myocytes using IonOptix: Assay development and validation	0
Evaluation of prucalopride, a highly selective serotonin-4 (5-hydroxytryptamine)-4 receptor agonist, demonstrates a low potential for abuse liability	0
A monkey torsadogen that in vitro cardiac ion channel assays would not predict	0
Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system	0
Flavonoids from Chromolaena leivensis and Caesalpinia spinosa as potential protectors against doxorubicin-induced cardiomyopathy	0
Improved screening of the cardiovascular safety of COVID-19 anti-viral compounds	0
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity	0
Hemodynamic systems model to characterize cardiovascular drug effects	0
NSAID-induced gastrointestinal injury: Reduction of gastric and exacerbation of enteric lesions by omeprazole and ranitidine in rats	0
Human iPS cell-derived cardiomyocytes aligning on flexible gelatin fiber network show contraction and pharmacological responses relevant to human heart	0
Late sustained sodium current in the adult human heart	0
An integrative computational platform for the multiparametric analysis of cardiomyocyte signals	0
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	0
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	0
Use of vascular access buttons (VABs) in rodent telemetry safety studies	0
Predicting proarrhythmic risk exclusively using automated patch clamp data	0
Screening of anticonvulsant activity of Xylopia aethiopica dry fruit using zebrafish	0
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	0
HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations	0
Visualizing QT prolongation in the anesthetized guinea pig	0
Development of an “augmented” hERG assay to improve assessment of cardiac liability using high-throughput electrophysiology	0