Medicinal Chemistry Research

Article	Citations
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction	58
Osthole: an overview of its sources, biological activities, and modification development	55
In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine	52
The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations	45
Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment	44
Selective cyclooxygenase-2 inhibitors: A review of recent chemical scaffolds with promising anti-inflammatory and COX-2 inhibitory activities	39
Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions	39
Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery	38
Antimicrobial activity of quaternary ammonium salts: structure-activity relationship	36
Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents	36
Review on molnupiravir as a promising oral drug for the treatment of COVID-19	31
Genomics insights of SARS-CoV-2 (COVID-19) into target-based drug discovery	31
Pentacyclic triterpene acid conjugated with mitochondria-targeting cation F16: Synthesis and evaluation of cytotoxic activities	29
Isatin derivatives as broad-spectrum antiviral agents: the current landscape	27
Recent advances in chemical reactivity and biological activities of eugenol derivatives	24
A review of antimalarial activity of two or three nitrogen atoms containing heterocyclic compounds	23
Indazole scaffold: a generalist for marketed and clinical drugs	23
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin	23
New amino acid clubbed Schiff bases inhibit carbonic anhydrase II, α-glucosidase, and urease enzymes: in silico and in vitro	22
Synthesis and antiviral activity of some pyrrolonyl substituted heterocycles as additives to enhance inactivated Newcastle disease vaccine	22
Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity	22
A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates	22
Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties	20
Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors	20
Design, synthesis, in silico studies, and evaluation of novel chalcones and their pyrazoline derivatives for antibacterial and antitubercular activities	20

Sulfur-containing therapeutics in the treatment of Alzheimer’s disease	19
Synthesis and antimicrobial evaluation of new thiazolyl-1,2,3-triazolyl-alcohol derivatives	19
Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs	19
A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19	18
Design, synthesis, and biological evaluation of novel benzo[b]thiophene-diaryl urea derivatives as potential anticancer agents	18
Design, synthesis and biological evaluation of novel indolinedione–coumarin hybrids as xanthine oxidase inhibitors	17
Synthesis, molecular docking, and biological evaluation of nitroimidazole derivatives as potent urease inhibitors	17
α-Glucosidase and α-amylase inhibition, molecular modeling and pharmacokinetic studies of new quinazolinone-1,2,3-triazole-acetamide derivatives	17
Potent antiproliferative active agents: novel bis Schiff bases and bis spiro β-lactams bearing isatin tethered with butylene and phenylene as spacer and DNA/BSA binding behavior as well as studying mo	17
Design, synthesis, and biological evaluation of 1-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives as anticancer agents	17
Alkaloids derived from the genus Daphniphyllum	16
Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies	16
Isonicotinoyl hydrazones of pyridoxine derivatives: synthesis and antimycobacterial activity	16
Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines	16
Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors	16
Rheostat positions: A new classification of protein positions relevant to pharmacogenomics	16
Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers	16
Synthesis and cytotoxic evaluation of malachite green derived oleanolic and ursolic acid piperazineamides	16
Identification of potential anti-inflammatory and melanoma cytotoxic compounds from Aegiceras corniculatum	15
Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance	15
Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer’s disease	15
Microwave-assisted synthesis, molecular docking and anti-HIV activities of some drug-like quinolone derivatives	15
Anticancer strategies by upregulating p53 through inhibition of its ubiquitination by MDM2	15
Efficient synthesis and evaluation of antiviral and antitumor activity of novel 3-phosphonylated thiazolo[3,2-a]oxopyrimidines	14
Thiazole-based and thiazolidine-based protein tyrosine phosphatase 1B inhibitors as potential anti-diabetes agents	14
Drug–protein adducts: past, present, and future	14
Design, synthesis, docking study and urease inhibitory activity evaluation of novel 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-arylacetamide derivatives	14
Adenosine receptors as promising targets for the management of ocular diseases	14
Identification and evaluation of natural organosulfur compounds as potential dual inhibitors of α-amylase and α-glucosidase activity: an in-silico and in-vitro approach	14
Cytotoxic, anti-inflammatory, and α-glucosidase inhibitory effects of flavonoids from Lippia graveolens (Mexican oregano)	14
Evaluation of novel multifunctional organoselenium compounds as potential cholinesterase inhibitors against Alzheimer’s disease	14
DDR1 and DDR2: a review on signaling pathway and small molecule inhibitors as an anticancer agent	14
Design, synthesis, anticancer evaluation and molecular docking studies of new imidazo [2, 1-b] thiazole -based chalcones	13
Synthesis, evaluation of cytotoxicity, and antimicrobial activity of A-azepano- and A-seco-3-amino-C28-aminolupanes	13
3D-QSAR, HQSAR, molecular docking, and new compound design study of 1,3,6-trisubstituted 1,4-diazepan-7-ones as human KLK7 inhibitors	13
Ester and amide derivatives of rhodamine B exert cytotoxic effects on different human tumor cell lines	13
Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria	13
A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents	13
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study	13
Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids	12
Synthesis, in-vitro biological evaluation, and molecular docking study of novel spiro-β-lactam-isatin hybrids	12
Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2	12
Design, synthesis and biological evaluation of 8-aminoquinoline-1,2,3-triazole hybrid derivatives as potential antimicrobial agents	12
Synthesis, characterization, acetylcholinesterase inhibition, and molecular docking studies of new piperazine substituted dihydrofuran compounds	12
New phthalimide-benzamide-1,2,3-triazole hybrids; design, synthesis, α-glucosidase inhibition assay, and docking study	12
Design, synthesis and SAR of novel sulfonylurea derivatives for the treatment of Diabetes mellitus in rats	11
Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis	11
Biologically active quinazoline-based hydroxamic acids	11
Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety	11
An update on the discovery and development of reversible covalent inhibitors	11

Promising Schiff bases in antiviral drug design and discovery	11
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor	11
New synthetic 1H-1,2,3-triazole derivatives of 3-O-acetyl-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid from Boswellia sacra inhibit carbonic anhydrase II in vitro	11
Thiosemicarbazone and thiazole: in vitro evaluation of leishmanicidal and ultrastructural activity on Leishmania infantum	11
Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki–Miyaura cross-coupling reaction and their antithrombolyitc, biofilm inhibition, hemolytic potential and molecu	11
Structural diversity, natural sources, and pharmacological potential of plant-based saponins with special focus on anticancer activity: a review	11
Phenylpropanoids from Liparis nervosa and their in vitro antioxidant and α-glucosidase inhibitory activities	10
Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline–benzenesulfonamide derivatives harboring phenol/polyphenol moieties	10
Functionalized imidazolium-based ionic liquids: biological activity evaluation, toxicity screening, spectroscopic, and molecular docking studies	10
Design, synthesis, and pharmacological evaluation of aryl oxadiazole linked 1,2,4-triazine derivatives as anticonvulsant agents	10
Synthesis and biological activity of amide derivatives derived from natural product Waltherione F	10
Novel 1-methoxyindole- and 2-alkoxyindole-based chalcones: design, synthesis, characterization, antiproliferative activity and DNA, BSA binding interactions	10
Synthesis and in vitro activity of oleanolic acid derivatives against Chlamydia trachomatis and Staphylococcus aureus	10
Design, synthesis, in vitro evaluation, and docking studies on ibuprofen derived 1,3,4-oxadiazole derivatives as dual α-glucosidase and urease inhibitors	10
First in class (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs as selective CB2 modulators targeting neurodegenerative disorders	10
Molecular glues: enhanced protein-protein interactions and cell proteome editing	10
N-arylated oxathiazinane heterocycles are convenient synthons for 1,3-amino ethers and 1,3-amino thioethers	10
Recent advances on biologically active coumarin-based hybrid compounds	10
A comprehensive review of ethnopharmacological uses, phytochemistry, biological activities, and future prospects of Nigella glandulifera	9
8-cyanobenzothiazinone analogs with potent antitubercular activity	9
Mannose: a potential saccharide candidate in disease management	9
Bio-evaluation of fluoro and trifluoromethyl-substituted salicylanilides against multidrug-resistant S. aureus	9
Oxygenated xanthones as P-glycoprotein modulators at the intestinal barrier: in vitro and docking studies	9
Synthesis of arylfuran derivatives as potential antibacterial agents	9
Sulfamate-tethered aza-Wacker approach towards analogs of Bactobolin A	9
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies	9
Green synthesis of pyrano [3,2-b]pyran derivatives using nano Si–Mg–fluorapatite catalyst and the evaluation of their antibacterial and antioxidant properties	9
New acridine-9-carboxamide linked to 1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro, and in silico biological evaluations	9
Synthesis and antiproliferative activity of hybrid thiosemicarbazone derivatives bearing coumarin and d-galactose moieties with EGFR inhibitory activity and molecular docking study	9
Tankyrase inhibitors: emerging and promising therapeutics for cancer treatment	9
Synthesis, characterization, crystal structures, and anticancer activity of some new 2,3-dihydro-1,5-benzoxazepines	9
Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives	9
Fusaric acid and derivatives as novel antimicrobial agents	9
Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities	9
New Delhi metallo-β-lactamase-1 inhibitors for combating antibiotic drug resistance: recent developments	8
Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones	8
Antibacterial and antibiofilm activities of synthetic analogs of 3-alkylpyridine marine alkaloids	8
Development of new donepezil analogs: synthesis, biological screening and in silico study rational	8
Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors	8
Organotin (IV) complexes from Schiff bases ligands based on 2-amino-3-hydroxypyridine: synthesis, characterization, and cytotoxicity	8
Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents	8
Cytotoxicity, anticancer, and antioxidant properties of mono and bis-naphthalimido β-lactam conjugates	8
Antioxidant, antiproliferative, and acetylcholinesterase inhibition activity of amino alcohol derivatives from 1,4-naphthoquinone	8
Uses of dimedone to synthesis pyrazole, isoxazole and thiophene derivatives with antiproliferative, tyrosine kinase and Pim-1 kinase inhibitions	8
Synthesis of hydrazine containing piperazine or benzimidazole derivatives and their potential as α-amylase inhibitors by molecular docking, inhibition kinetics and in vitro cytotoxicity activity studi	8
Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity	8
Design and synthesis of sulphonyl acetamide analogues of quinazoline as anticancer agents	8
Albumin roles in developing anticancer compounds	8
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects	8
Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors	8
Plastoquinone analogs: a potential antimicrobial lead structure intensely suppressing Staphylococcus epidermidis and Candida albicans growth	8
Callistemon genus- a review on phytochemistry and biological activities	7
Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa	7
Triphenylphosphonium conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis and cytotoxicity evaluation	7
Facile one-pot sequential synthesis of novel diaryl urea derivatives and evaluation of their in vitro cytotoxicity on adenocarcinoma cells	7
Synthesis, characterization and antimalarial activity of isoquinoline derivatives	7
Loading harmine on nanographene changes the inhibitory effects of free harmine against MCF-7 and fibroblast cells	7
Pyridazinones containing the (4-methoxyphenyl)piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation	7
Expanding the chemical space of aryloxy-naphthoquinones as potential anti-Chagasic agents: synthesis and trypanosomicidal activity	7
Antioxidant enzyme regulating and intracellular ROS scavenging capacities of two novel bioactive peptides from white grub larvae (Polyphylla adstpersa) hydrolysate in A549 cells	7
Novel approach of multi-targeted thiazoles and thiazolidenes toward anti-inflammatory and anticancer therapy—dual inhibition of COX-2 and 5-LOX enzymes	7
The novel scaffold 1,2,4-benzothiadiazine-1,1-dioxide: a review	7
Synthesis, molecular docking, α-glucosidase inhibition, and antioxidant activity studies of novel benzimidazole derivatives	7
Synthesis, radical scavenging, and antioxidant activity of stilbazolic resveratrol analogs	7
Benzilydene and thiourea derivatives as new classes of carbonic anhydrase inhibitors: an in vitro and molecular docking study	7
Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents	7
Design and synthesis of caffeic acid derivatives and evaluation of their inhibitory activity against Pseudomonas aeruginosa	7
Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins	7
Synthesis of pyrazinamide analogues and their antitubercular bioactivity	7
An insight into prodrug strategy for the treatment of Alzheimer’s disease	7
Anti-inflammatory scalarane-type sesterterpenes, erectascalaranes A–B, from the marine sponge Hyrtios erectus attenuate pro-inflammatory cyclooxygenase-2 and 5-lipoxygenase	7
Synthesis and in vitro anticytomegalovirus activity of 5-hydroxyalkylamino-1,3-oxazoles derivatives	7
Tuberculosis: current scenario, drug targets, and future prospects	7
Inducing apoptosis through upregulation of p53: structure–activity exploration of anthraquinone analogs	7
What are the drugs having potential against COVID-19?	7
Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells	7
Design, synthesis, characterization and cytotoxic activity of new ortho-hydroxy and indole-chalcone derivatives against breast cancer cells (MCF-7)	7
Polyether macrocyclic polyketide from the muricid gastropod Chicoreus ramosus attenuates pro-inflammatory 5-lipoxygenase	6
Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents	6
Screening trimethoprim primary metabolites for covalent binding to albumin	6

Turbinafuranone A–C, new 2-furanone analogues from marine macroalga Turbinaria ornata as prospective anti-hyperglycemic agents attenuate tyrosine phosphatase-1B	6
Bioassay-guided isolation and identification of anti-Alzheimer’s active compounds from Spiranthes sinensis (Pers.) Ames	6
Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy	6
Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate-specific antigen	6
4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors	6
Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands	6
Recent updates on thienopyrimidine derivatives as anticancer agents	6
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations	6
Synthesis and anthelmintic activity of some novel (E)-2-methyl/propyl-4-(2-(substitutedbenzylidene)hydrazinyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines	6
Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors	6
Synthesis and biological evaluations of novel pyrazinoic acid derivatives as anticancer agents	6
Propargylated monocarbonyl curcumin analogues: synthesis, bioevaluation and molecular docking study	6
Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies	6
Medicinal chemistry insights into non-hydroxamate HDAC6 selective inhibitors	6
Phytochemistry, pharmacology and medicinal uses of Cola (Malvaceae) family: a review	6
RF-3192C and other polyketides from the marine endophytic Aspergillus niger ASSB4: structure assignment and bioactivity investigation	6
Benzoxazolyl linked benzylidene based rhodanine and analogs as novel antidiabetic agents: synthesis, molecular docking, and in vitro studies	6
Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus	6
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors	6
Novel antimicrobial ciprofloxacin-pyridinium quaternary ammonium salts with improved physicochemical properties and DNA gyrase inhibitory activity	6
Synthesis, in vitro and in silico enzymatic inhibition assays, and toxicity evaluations of new 4,5-diphenylimidazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors	6