Medicinal Chemistry Research

Article	Citations
Osthole: an overview of its sources, biological activities, and modification development	74
In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine	66
The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations	63
Antimicrobial activity of quaternary ammonium salts: structure-activity relationship	54
Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery	50
Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions	49
Review on molnupiravir as a promising oral drug for the treatment of COVID-19	38
Isatin derivatives as broad-spectrum antiviral agents: the current landscape	36
Recent advances in chemical reactivity and biological activities of eugenol derivatives	33
Pentacyclic triterpene acid conjugated with mitochondria-targeting cation F16: Synthesis and evaluation of cytotoxic activities	31
Promising Schiff bases in antiviral drug design and discovery	29
Indazole scaffold: a generalist for marketed and clinical drugs	26
Recent advances on biologically active coumarin-based hybrid compounds	26
Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers	25
Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors	25
A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19	25
Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies	24
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study	24
Mannose: a potential saccharide candidate in disease management	24
An update on the discovery and development of reversible covalent inhibitors	23
New amino acid clubbed Schiff bases inhibit carbonic anhydrase II, α-glucosidase, and urease enzymes: in silico and in vitro	23
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin	23
Efficient synthesis and evaluation of antiviral and antitumor activity of novel 3-phosphonylated thiazolo[3,2-a]oxopyrimidines	23
α-Glucosidase and α-amylase inhibition, molecular modeling and pharmacokinetic studies of new quinazolinone-1,2,3-triazole-acetamide derivatives	22
Synthesis, in-vitro biological evaluation, and molecular docking study of novel spiro-β-lactam-isatin hybrids	22

Sulfur-containing therapeutics in the treatment of Alzheimer’s disease	22
Potent antiproliferative active agents: novel bis Schiff bases and bis spiro β-lactams bearing isatin tethered with butylene and phenylene as spacer and DNA/BSA binding behavior as well as studying mo	21
Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties	21
Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors	21
DDR1 and DDR2: a review on signaling pathway and small molecule inhibitors as an anticancer agent	21
Isonicotinoyl hydrazones of pyridoxine derivatives: synthesis and antimycobacterial activity	20
Thiazole-based and thiazolidine-based protein tyrosine phosphatase 1B inhibitors as potential anti-diabetes agents	19
Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities	18
Synthesis, molecular docking, and biological evaluation of nitroimidazole derivatives as potent urease inhibitors	18
Design, synthesis, anticancer evaluation and molecular docking studies of new imidazo [2, 1-b] thiazole -based chalcones	18
Adenosine receptors as promising targets for the management of ocular diseases	17
Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance	17
Evaluation of novel multifunctional organoselenium compounds as potential cholinesterase inhibitors against Alzheimer’s disease	16
Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria	16
The pyridazine heterocycle in molecular recognition and drug discovery	16
New synthetic 1H-1,2,3-triazole derivatives of 3-O-acetyl-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid from Boswellia sacra inhibit carbonic anhydrase II in vitro	16
Phenylpropanoids from Liparis nervosa and their in vitro antioxidant and α-glucosidase inhibitory activities	16
Design, synthesis and SAR of novel sulfonylurea derivatives for the treatment of Diabetes mellitus in rats	15
Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis	15
Design, synthesis and biological evaluation of 8-aminoquinoline-1,2,3-triazole hybrid derivatives as potential antimicrobial agents	15
Identification and evaluation of natural organosulfur compounds as potential dual inhibitors of α-amylase and α-glucosidase activity: an in-silico and in-vitro approach	15
Design, synthesis, and pharmacological evaluation of aryl oxadiazole linked 1,2,4-triazine derivatives as anticonvulsant agents	15
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations	15
Design, synthesis, docking study and urease inhibitory activity evaluation of novel 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-arylacetamide derivatives	14
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor	14
Recent updates on thienopyrimidine derivatives as anticancer agents	14
Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety	13
Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies	13
Design, synthesis, in vitro evaluation, and docking studies on ibuprofen derived 1,3,4-oxadiazole derivatives as dual α-glucosidase and urease inhibitors	13
Synthesis and in vitro activity of oleanolic acid derivatives against Chlamydia trachomatis and Staphylococcus aureus	13
Synthesis and biological activity of amide derivatives derived from natural product Waltherione F	13
Development of new donepezil analogs: synthesis, biological screening and in silico study rational	12
Synthesis of arylfuran derivatives as potential antibacterial agents	12
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies	12
Tankyrase inhibitors: emerging and promising therapeutics for cancer treatment	12
Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2	12
8-cyanobenzothiazinone analogs with potent antitubercular activity	11
Molecular glues: enhanced protein-protein interactions and cell proteome editing	11
Future challenges and opportunities with fluorine in drugs?	11
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors	11
Sulfamate-tethered aza-Wacker approach towards analogs of Bactobolin A	11
Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors	11
Synthesis, characterization, crystal structures, and anticancer activity of some new 2,3-dihydro-1,5-benzoxazepines	10
Harnessing the necessary nitrogen atom in chemical biology and drug discovery	10
Pyridazinones containing the (4-methoxyphenyl)piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation	10
Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells	10
Carboxylated chalcones and related flavonoids as inhibitors of xanthine oxidase	10
Bio-evaluation of fluoro and trifluoromethyl-substituted salicylanilides against multidrug-resistant S. aureus	10
Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline–benzenesulfonamide derivatives harboring phenol/polyphenol moieties	10
Albumin roles in developing anticancer compounds	10

Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects	10
Novel 1-methoxyindole- and 2-alkoxyindole-based chalcones: design, synthesis, characterization, antiproliferative activity and DNA, BSA binding interactions	10
Synthesis and antiproliferative activity of hybrid thiosemicarbazone derivatives bearing coumarin and d-galactose moieties with EGFR inhibitory activity and molecular docking study	10
Callistemon genus- a review on phytochemistry and biological activities	9
C-C bond cleavage reactions catalyzed by cytochrome P450 enzymes	9
Synthesis of hydrazine containing piperazine or benzimidazole derivatives and their potential as α-amylase inhibitors by molecular docking, inhibition kinetics and in vitro cytotoxicity activity studi	9
Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity	9
Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa	9
A Click Synthesis, Molecular Docking and Biological Evaluation of 1,2,3-triazoles-benzoxazepine hybrid as potential anticancer agents	9
Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones	9
Medicinal chemistry insights into non-hydroxamate HDAC6 selective inhibitors	9
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects	9
Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives	9
Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents	9
Recent advances in structural types and medicinal chemistry of PARP-1 inhibitors	9
Synthesis of 1,2,3-benzotriazin-4(3H)-one derivatives as α-glucosidase inhibitor and their in-silico study	8
RF-3192C and other polyketides from the marine endophytic Aspergillus niger ASSB4: structure assignment and bioactivity investigation	8
Anti-liver and anti-breast cancer activities of 2-thioxo-4-imidazolidinone derivatives	8
1,2,3-triazole derivatives as antiviral agents	8
Synthesis and biological evaluations of novel pyrazinoic acid derivatives as anticancer agents	8
2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities	8
Plastoquinone analogs: a potential antimicrobial lead structure intensely suppressing Staphylococcus epidermidis and Candida albicans growth	8
In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas	8
Assessment of the α-glucosidase and α-amylase inhibitory potential of Paliurus spina-christi Mill. and its terpenic compounds	8
Benzoxazolyl linked benzylidene based rhodanine and analogs as novel antidiabetic agents: synthesis, molecular docking, and in vitro studies	8
1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents	8
Novel antimicrobial ciprofloxacin-pyridinium quaternary ammonium salts with improved physicochemical properties and DNA gyrase inhibitory activity	8
Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications	8
Expanding the chemical space of aryloxy-naphthoquinones as potential anti-Chagasic agents: synthesis and trypanosomicidal activity	8
An insight into prodrug strategy for the treatment of Alzheimer’s disease	8
Facile one-pot sequential synthesis of novel diaryl urea derivatives and evaluation of their in vitro cytotoxicity on adenocarcinoma cells	8
Tuberculosis: current scenario, drug targets, and future prospects	8
Benzilydene and thiourea derivatives as new classes of carbonic anhydrase inhibitors: an in vitro and molecular docking study	8
Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents	8
Synthesis, in vitro and in silico enzymatic inhibition assays, and toxicity evaluations of new 4,5-diphenylimidazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors	8
Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic simulations	7
Loading harmine on nanographene changes the inhibitory effects of free harmine against MCF-7 and fibroblast cells	7
Synthesis and antiplasmodial assessment of nitazoxanide and analogs as new antimalarial candidates	7
Anti-inflammatory scalarane-type sesterterpenes, erectascalaranes A–B, from the marine sponge Hyrtios erectus attenuate pro-inflammatory cyclooxygenase-2 and 5-lipoxygenase	7
Turbinafuranone A–C, new 2-furanone analogues from marine macroalga Turbinaria ornata as prospective anti-hyperglycemic agents attenuate tyrosine phosphatase-1B	7
Bioassay-guided isolation and identification of anti-Alzheimer’s active compounds from Spiranthes sinensis (Pers.) Ames	7
Synthesis, biological evaluation, and bioinformatics analysis of indole analogs on AChE and GST activities	7
Isonicotinoyl-butanoic acid hydrazone derivatives as anti-tubercular agents: In-silico studies, synthesis, spectral characterization and biological evaluation	7
Novel approach of multi-targeted thiazoles and thiazolidenes toward anti-inflammatory and anticancer therapy—dual inhibition of COX-2 and 5-LOX enzymes	7
Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation	7
Design, synthesis, antiproliferative and antimicrobial evaluation of a new class of disulfides containing 1,3,4-thiadiazole units	7
Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy	7
Design and synthesis of caffeic acid derivatives and evaluation of their inhibitory activity against Pseudomonas aeruginosa	7
Design, synthesis, characterization and cytotoxic activity of new ortho-hydroxy and indole-chalcone derivatives against breast cancer cells (MCF-7)	7
Design, synthesis, biological evaluation and in silico studies of EGFR inhibitors based on 4-oxo-chromane scaffold targeting resistance in non-small cell lung cancer (NSCLC)	7
Design, synthesis and α-glucosidase inhibition study of novel pyridazin-based derivatives	6
Recent progress of oridonin and its derivatives for cancer therapy and drug resistance	6
Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus	6
New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer	6
Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship	6
Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study	6
Current progress toward synthetic routes and medicinal significance of quinoline	6
Antioxidant and acetylcholinesterase inhibition activity of aliphatic and aromatic edaravone derivatives	6
Development of phosphoinositide 3-kinase delta (PI3Kδ) inhibitors as potential anticancer agents through the generation of ligand-based pharmacophores and biological screening	6
Design, synthesis and assay of 2-(4-phenylpiperazin-1-yl)pyrimidine-5- carboxamide derivatives as acetylcholinesterase inhibitors	6
Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes	6
Synthesis and evaluation of new sesamol-based phenolic acid derivatives with hypolipidemic, antioxidant, and hepatoprotective effects	6
Synthesis, antiproliferative, and antimicrobial properties of novel phthalimide derivatives	6
Phosphoryl prodrugs: characteristics to improve drug development	6
Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors	6
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities	6
4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors	6
Benzopyrylium salts as new anticancer, antibacterial, and antioxidant agents	5
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives a	5
Design, synthesis, and evaluation of novel, selective γ-butyrolactones sigma-2 ligands	5
Synthesis of new calix[4]arene derivatives and evaluation of their cytotoxic activity	5
Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase	5
Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A1 receptors for the potential treatment of epilepsy	5
Synthesis, antibacterial evaluation and in silico study of DOTA-fluoroquinolone derivatives	5
Recent insights into antibacterial potential of benzothiazole derivatives	5
Biological targets of 92 alkaloids isolated from Papaver genus: a perspective based on in silico predictions	5
Synthesis and in vitro SAR evaluation of natural vanillin-based chalcones tethered quinolines as antiplasmodial agents	5
Targeting γ-secretase for familial Alzheimer’s disease	5
A study from structural insight to the antiamyloidogenic and antioxidant activities of flavonoids: scaffold for future therapeutics of Alzheimer’s disease	5
Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine as selective COX-2 inhibitors	5

Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent	5
Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids	5
A guide for the synthesis of key nucleoside scaffolds in drug discovery	5
Design, synthesis, and LFA-1/ICAM-1 antagonist activity evaluation of Lifitegrast analogues	5
Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents	5
Design and synthesis of new pyrazolylbenzimidazoles as sphingosine kinase-1 inhibitors	5
Clerodendrum viscosum: a critical review on phytochemistry, pharmacology, quality assurance, and safety data	5
Design and synthesis of potential fungicidal compounds derived from natural products, (-)-menthol and (-)-borneol	4
A vitamin D C/D ring-derived compound with cytotoxicity	4
The SAR-based development of small molecular HBV capsid assembly modulators	4
Synthesis and antitumor activity of novel pyridoxine-based structural analogs of saccharumoside-B	4
Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease	4
Design, Synthesis, and biological evaluation of pyrazolo-benzothiazole derivatives as a potential therapeutic agent for the treatment of Alzheimer’s disease	4
Conjugates of Tetramethylpyrazine’ metabolites and amino acid as potential antiplatelet agents	4
Design, synthesis, antibacterial evaluation and molecular docking studies of novel pyrazole/1,2,4-oxadiazole conjugate ester derivatives	4
Sesquiterpene lactones isolated from Carpesium abrotanoides L. by LC–MS combined with HSCCC inhibit liver cancer through suppression of the JAK2/STAT3 signaling pathway	4
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal m	4
Baicalein—A review on its molecular mechanism against breast cancer and delivery strategies	4
Synthesis, biological evaluation, and molecular modeling studies of a new series of imidazothiazole or imidazooxazole derivatives as inhibitors of ectonucleoside triphosphate diphosphohydrolases (NTPD	4
Insights on synthetic strategies and structure-activity relationship of donepezil and its derivatives	4
Synthesis, antimicrobial, and antioxidant activities of disubstituted 1,2,3-triazoles with amide-hydroxyl functionality	4
Phenoxyacetohydrazones against Trypanosoma cruzi	4
Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides	4
Synthesis, bacterial and fungal inhibition assay, molecular docking study of substituted isatin (N-substituted 1,2,3,4-tetra-O-acetyl-β-glucopyranosyl)thiosemicarbazones	4
Synthesis and evaluation of novel, selective, functionalized γ-butyrolactones as sigma-2 ligands	4
Inhibition of protein kinases by proton pump inhibitors: computational screening and in vitro evaluation	4
Synthesis and antitumor activity screening of spiro tryptanthrin-based heterocyclic compounds	4
Phthalamide derivatives as ACE/AChE/BuChE inhibitors against cardiac hypertrophy: an in silico, in vitro, and in vivo modeling approach	4
Anti-TB evaluation of novel 2,3-dihydroquinazolin-4(1H)-ones and in silico studies of the active compounds	4
Structure activity relationship (SAR) driven design and discovery of WCK 5107 (Zidebactam): novel β-lactam enhancer, potent against multidrug-resistant gram-negative pathogens	4
The potential of 4-aryl-6-morpholino-3(2H)-pyridazinone-2-arylpiperazinylacetamide as a new scaffold for SIRT2 inhibition: in silico approach guided by pharmacophore mapping and molecular docking	4
Quinoxaline 1,4-di-N-oxides: a review of the importance of their structure in the development of drugs against infectious diseases and cancer	4
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation	4
Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies	4
Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities	4
Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives	4
Synthesis, docking, and biological evaluation of thiazolidinone derivatives against hepatitis C virus genotype 4a	4
Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation	4
Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity	4
Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives	4
Isatin derivatives as a new class of aldose reductase inhibitors with antioxidant activity	4
Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.	4
Sphingosine 1-phosphate receptor modulators for the treatment of inflammatory bowel disease and other immune-mediated diseases	4
Acetylcholinesterase inhibition, molecular docking and ADME prediction studies of new dihydrofuran-piperazine hybrid compounds	4
Perillyl alcohol and its synthetic derivatives: the rising of a novel class of selective and potent antitumoral compounds	4
Polyalthia longifolia: phytochemistry, ethnomedicinal importance, nutritive value, and pharmacological activities review	4
Isatin-linked 4,4-dimethyl-5-methylene-4,5-dihydrothiazole-2-thiols for inhibition of acetylcholinesterase	4
Synthesis, α-glucosidase inhibitory activity, and molecular docking of cinnamamides	4
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants	4
New tolfenamic acid derivatives with hydrazine-1-carbothioamide and 1,3,4-oxadiazole moieties targeting VEGFR: synthesis, in silico studies, and in vitro anticancer assessment	3
Cyclohepta[b]pyran: an important scaffold in biologically active natural products	3
Synthesis and effects of ginkgolides and ginkgolide B derivatives on platelet activating factor induced platelet aggregation in rabbits	3
Synthesis and biological evaluation of pyrrolidine-functionalized nucleoside analogs	3
Synthesis of alkoxy-isoflavones as potential α-glucosidase inhibitors	3
Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus	3
Synthesis and biological activities of new phthalimide and thiazolidine derivatives	3
Design, synthesis, biological evaluation, and molecular docking of 1,7-dibenzyl-substituted theophylline derivatives as novel BRD4-BD1-selective inhibitors	3
Design and synthesis of nature-inspired chromenopyrroles as potential modulators of mitochondrial metabolism	3
Dual HDAC/BRD4 inhibitors against cancer	3
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir	3
Synthesis of 2-amino-4H-chromenes catalyst-free via sequential Knoevenagel-Michael reaction and evaluation of biological activity in tumor cells	3
2-(3-Hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives as potential multifunctional anti-Alzheimer’s agents	3
The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism	3
Anti-tyrosinase properties of different species of turmeric and isolation of active compounds from Curcuma amada	3
Simple methods of modification of daunorubicin on the daunosamine nitrogen atom	3
Insights into the α-amylase and α-glucosidase inhibition mechanism of 4-(4-hydroxyphenyl)-but-3-en-2-one from Scutellaria barbata D. Don: enzymatic kinetics, fluorescence spectroscopy and computationa	3
Structure-based discovery of new polo-like kinase 1 (PLK1) inhibitors as potential anticancer agents via docking-based comparative intermolecular contacts analysis (dbCICA)	3
Drug repositioning of benzimidazole anthelmintics in the treatment of cryptococcosis: a review	3
Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors	3
Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma	3
Motor and non-motor symptoms, drugs, and their mode of action in Parkinson’s disease (PD): a review	3
Isoindolone derivatives as novel potential anti-Alzheimer’s candidates: synthesis, in silico, and AChE inhibitory activity evaluation	3
Platanic acid derived amides are more cytotoxic than their corresponding oximes	3
Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents	3
Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment	3
Clathrolides A–B: previously undescribed macrocylic lactones from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as potential antihypertensive leads attenuating angiotensin converting	3
Structural classification of EZH2 inhibitors and prospects for the treatment of tumor: a review	3
Synthesis and pharmacological activities of Schiff bases with some transition metal complexes: a review	3
Research progress on antidiabetic activity of apigenin derivatives	3
Development of structure-based pharmacophore to target the β-catenin-TCF protein–protein interaction	3
Development of ketoprofen-p-aminobenzoic acid co-crystal: formulation, characterization, optimization, and evaluation	3
Synthesis, antifungal activity, and molecular dynamics study of novel geranyl aromatic sulfonamide compounds as potential complex III inhibitors	3
New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening	3
Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs	3
Progress on biphenyl derivatives as PD-1/PD-L1 inhibitors	3
Discovery of novel donepezil-M30D hybrids with neuroprotective properties for Alzheimer’s disease treatment	3
Pyrrolopyrazine derivatives: synthetic approaches and biological activities	3
A review on reported phytochemicals as druggable leads with antimalarial potential	3
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells	3
Chemical and biological aspects of posaconazole as a classic antifungal agent with non-classical properties: highlighting a tetrahydrofuran-based drug toward generation of new drugs	3
Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives	3
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review	3
Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives	3
A MIST conception: what has been learned from twenty years of human metabolite safety assessment?	3
What’s been Hapten-ing over the last 88 years?	3