Medicinal Chemistry Research

Article	Citations
Ultra-performance liquid chromatography coupled with quadrupole high-resolution time-of-flight mass spectrometry for metabolite profiling and biological activity of Stellaria pallida (Dumort) Piré	75
Novel pyran derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity, and molecular modeling	74
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300	65
Development of novel 2-acetylphenol-O-alkylhydroxyethylamine derivatives as multifunctional agents for Alzheimer’s disease treatment	49
Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell	41
Design, synthesis, and biological evaluation of catalpalactone and its analogs	36
Social environment during fear extinction alters the binding of [3H] MK-801 to N-methyl-D-aspartic acid receptors in Wistar-Kyoto and Wistar rats	35
Synthesis and antitumor activity evaluation in vitro of 4-aminoquinazoline derivatives containing 1,3,4-thiadiazole	33
Novel potent and highly selective DDR1 inhibitors from integrated lead finding	31
Structural optimization and biological evaluation of quinoline/naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates	28
Synthesis and evaluation of 2-methylbenzothiazole derivatives as monoamine oxidase inhibitors	26
A review of trilaciclib, a first-in-class cyclin-dependent kinase 4/6 inhibitor, for the management of metastatic small-cell lung cancer	26
The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents	25
Synthesis and antiproliferative activity of hybrid thiosemicarbazone derivatives bearing coumarin and d-galactose moieties with EGFR inhibitory activity and molecular docking study	25
Engelheptanoxides behave as liver X receptor α agonists	25
The emerging role of proteolysis targeting chimeras (PROTACs) in the treatment of Alzheimer’s disease	24
Synthesis, and docking studies of arylhydrazone compounds and evaluation of their platelet aggregation inhibitory effect and cytotoxicity	23
Discovery of novel donepezil-M30D hybrids with neuroprotective properties for Alzheimer’s disease treatment	23
Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study	23
Antimicrobial activity of some celastroloids and their derivatives	21
Quinoxaline 1,4-di-N-oxides: a review of the importance of their structure in the development of drugs against infectious diseases and cancer	21
Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents	20
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal m	18
Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1	18
Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma	18

Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors	18
Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents	18
Molecular glues: enhanced protein-protein interactions and cell proteome editing	17
Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)	17
DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n)	16
Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA	16
Increased rigidity and bioisosteric replacement in the design, synthesis and preliminary evaluation of novel, functionalized 3,3-dialkyl-γ-butyrolactones as sigma-2 ligands	16
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold	16
Self-assembled amphiphilic bipyridine and bisquinoline cisplatin analogues: synthesis and anticancer properties	16
Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues	15
Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach	15
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity	15
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus	15
Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors	14
2,3-Diketopiperazine as potential scaffold to develop new anti-Chagasic agents	13
Plastoquinone analogs: a potential antimicrobial lead structure intensely suppressing Staphylococcus epidermidis and Candida albicans growth	13
Synthesis of alkoxy-isoflavones as potential α-glucosidase inhibitors	13
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives a	13
Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents	12
Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates	12
Acetylcholinesterase inhibition, molecular docking and ADME prediction studies of new dihydrofuran-piperazine hybrid compounds	12
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3β,12β,25-triol derivatives as α-glucosidase and PTP1B inhibitors	12
Garcidepsidone B from Garcinia parvifolia: antimicrobial activities of the medicinal plants from East and North Kalimantan against dental caries and periodontal disease pathogen	12
Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity	12
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment	11
Ronald T. Borchardt: a pioneer in drug discovery and development	11
A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy	11
Role of the Caco-2 cell culture model developed in Dr. Ronald T. Borchardt’s lab in modern drug research and development: a perspective from a practitioner	11
Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus	11
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development	11
Design, synthesis and antitumor activity evaluation of 4,6,7-trisubstituted quinazoline derivatives containing benzothiazole moiety	10
Design, synthesis and antitumor activity evaluation of novel benzamide HDAC inhibitors	10
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin	10
Development of novel chalcone derivatives as multifunctional agents for the treatment of Alzheimer’s disease	10
Discovery of cytotoxic truncated vitamin D derivatives against both bortezomib‐sensitive and bortezomib‐resistant multiple myeloma phenotypes	10
Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies	10
Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent	10
Design, synthesis and biological evaluation of novel 2,4,6-trisubstituted quinazoline derivatives as potential antitumor agents	10
Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities	9
Design, synthesis, and antitumor activity evaluation of carbazole derivatives with potent HDAC inhibitory activity	9
Synthesis, anticancer evaluation and docking studies of novel adamantanyl-1,3,4-oxadiazol hybrid compounds as Aurora-A kinase inhibitors	9
Synthesis, in vitro and in silico enzymatic inhibition assays, and toxicity evaluations of new 4,5-diphenylimidazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors	9
Synthesis of 6-dialkylaminopyrimidine carboxamide analogues and their anti-tubercular properties	9
Design and synthesis of indole-based elipticine analogues as topoisomerase IIβ inhibitors	9
Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters	9
N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (Aβ42) aggregation and mitigate Aβ42-induced neurotoxicity	9
Synthesis, biological evaluation, and bioinformatics analysis of indole analogs on AChE and GST activities	9
Dual inhibition strategy addressing hyperuricemia and oxidative stress: design, biological evaluation and stability studies of febuxostat-probenecid mutual prodrug	9
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxya	9
Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes	9

Asciminib: first FDA approved allosteric inhibitor of BCR-ABL1 for the treatment of chronic myeloid leukemia	9
Pyridazinones containing the (4-methoxyphenyl)piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation	8
Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline–benzenesulfonamide derivatives harboring phenol/polyphenol moieties	8
Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids	8
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans	8
FTase inhibitors and cancer: prospects for use in targeted therapies	8
Design, synthesis, antibacterial evaluation and molecular docking studies of novel pyrazole/1,2,4-oxadiazole conjugate ester derivatives	8
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic antic	8
Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications	8
Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents	8
Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors	8
Targeting disease with benzoxazoles: a comprehensive review of recent developments	8
Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones	8
Synthesis and in vitro activity of oleanolic acid derivatives against Chlamydia trachomatis and Staphylococcus aureus	8
Structure activity relationship (SAR) driven design and discovery of WCK 5107 (Zidebactam): novel β-lactam enhancer, potent against multidrug-resistant gram-negative pathogens	8
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review	8
Drug repositioning of benzimidazole anthelmintics in the treatment of cryptococcosis: a review	8
Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities	7
Monoamine oxidase inhibition by thiazole derivatives substituted with the benzenesulfonamide moiety	7
Development of novel triconjugates fusing melatonin/isatin/N-acylhydrazone targeting colorectal cancer: design, synthesis, biological, and in silico ADME/Tox profiling	7
Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.	7
Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors	7
Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs	7
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study	7
Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria	7
Triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis, cytotoxicity and antimicrobial activity	7
Synthesis of hydrazine containing piperazine or benzimidazole derivatives and their potential as α-amylase inhibitors by molecular docking, inhibition kinetics and in vitro cytotoxicity activity studi	7
Identification and evaluation of natural organosulfur compounds as potential dual inhibitors of α-amylase and α-glucosidase activity: an in-silico and in-vitro approach	7
Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies	7
Synthesis and anti-inflammatory activity of chromone-sulfonamide derivatives as COXs/iNOS dual-target inhibitors	7
Recent insights into antibacterial potential of benzothiazole derivatives	7
2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities	7
Correction to: Design, synthesis and SAR of novel sulfonylurea derivatives for the treatment of diabetes mellitus in rats	6
The versatile NDI-based compounds: emerging anticancer and antimicrobial agents	6
Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine	6
Dedication to Dr. Thomas Baillie in recognition of his scientific career	6
Synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives	6
Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule	6
Ethical aspects of innovative medical and medicinal sciences	6
Design, synthesis, in vitro evaluation, and molecular dynamics simulation studies of novel coumarin-acetohydrazide Schiff base derivatives as urease enzyme inhibitors	6
Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development	6
Correction: Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine	6
Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship	6
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties	6
Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin I converting enzyme and dipeptidyl peptidase-IV	6
Novel antimicrobial ciprofloxacin-pyridinium quaternary ammonium salts with improved physicochemical properties and DNA gyrase inhibitory activity	5
Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis	5
Dauricine: a review of natural observation, pharmacology, and pharmacokinetics	5
Synthesis and antiviral property of polysulfate-grafted maleimide-based enediynes	5
Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers	5
Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing dihydroquinoxalinone as novel EGFRL858R/T790M kinase inhibitors against non-small-cell lung cancer	5
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants	5
Natural products and their derivatives as anti-flavivirus drug candidates	5
Structural classification of EZH2 inhibitors and prospects for the treatment of tumor: a review	5
Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties	5
Evaluation of benzoylacetonitriles as novel anti-neuroinflammatory agents	5
Synthesis and biological evaluation of pyrrolidine-functionalized nucleoside analogs	5
Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis	5
Identification of novel benzoyl hydrazine derivatives as activators of neddylation pathway to inhibit the tumor progression in vitro	5
Synthesis of 2-amino-4H-chromenes catalyst-free via sequential Knoevenagel-Michael reaction and evaluation of biological activity in tumor cells	5
Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation	5
Structure-based discovery of new polo-like kinase 1 (PLK1) inhibitors as potential anticancer agents via docking-based comparative intermolecular contacts analysis (dbCICA)	5
A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants	5
α-Glucosidase and cholinesterase inhibiting potential of a series of semisynthetic nitrogen triterpenic derivatives	4
A versatile strategy for the synthesis of various lumazine peptides	4
Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents	4
Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones	4
Design, Synthesis, and biological evaluation of pyrazolo-benzothiazole derivatives as a potential therapeutic agent for the treatment of Alzheimer’s disease	4
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile	4
Research progress on antidiabetic activity of apigenin derivatives	4
Screening of small molecule compounds targeting hnRNPA2 protein	4
Development of ketoprofen-p-aminobenzoic acid co-crystal: formulation, characterization, optimization, and evaluation	4
Design, synthesis and biological evaluation of indoline derivatives as multifunctional agents for the treatment of ischemic stroke	4
Development of LC-MS/MS methods affording identification and measurement of active metabolites in rat and dog plasma after oral dosing of a penta-ethyl ester prodrug of diethylenetriamine pentaacetic	4
Tetrahydroquinoline/4,5-dihydroisoxazole hybrids with a remarkable effect over mitochondrial bioenergetic metabolism on melanoma cell line B16F10	4
Phthalamide derivatives as ACE/AChE/BuChE inhibitors against cardiac hypertrophy: an in silico, in vitro, and in vivo modeling approach	4
Design, synthesis and antitumor activity evaluation of pyrimidine derivatives containing 4-hydroxypiperidine group	4
From the ethnomedicinal plants in northern Indochina to the development of novel anti-cancer therapeutic agents	4
Discovery of novel neuroprotective cinnamoyl-M30D hybrids targeting Alzheimer’s disease	4
Design, synthesis, and antimicrobial evaluation of novel 10-Undecenoic acid-based lipidic triazoles	4

Synthesis of tetrahydro-β-carboline analogs with N11 modifications and study of their antimalarial activities	4
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48	4
New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening	4
Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups	4
Inhibition of jack bean urease by amphiphilic peptides	4
Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties	4
Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors	4
Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands	4
Rational design and development of novel NAE inhibitors for the treatment of pancreatic cancer	4
2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study	4
Mannose: a potential saccharide candidate in disease management	4
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus	4
Harnessing the necessary nitrogen atom in chemical biology and drug discovery	4
Glycosylated triptolide affords a potent in vivo therapeutic activity to hepatocellular carcinoma in mouse model	4
Naturally occurring organosulfur for treating metabolic disorders and infectious diseases	4
Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives	4
Inhibition of protein kinases by proton pump inhibitors: computational screening and in vitro evaluation	4
Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy	4
Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors	4
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor	4
Synthesis and antitumor activity of novel pyridoxine-based structural analogs of saccharumoside-B	4
Novel Curcumin Monocarbonyl Analogue-Dithiocarbamate hybrid molecules target human DNA ligase I and show improved activity against colon cancer	4
Integrating omics data for personalized medicine in treating psoriasis	3
Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives	3
Chemical composition and vasodilator activity of different Alpinia zerumbet leaf extracts, a potential source of bioactive flavonoids	3
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review	3
Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies	3
Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities	3
Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies	3
Cyclohepta[b]pyran: an important scaffold in biologically active natural products	3
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements	3
What’s been Hapten-ing over the last 88 years?	3
Benzothiazole derivatives as effective α-glucosidase inhibitors: an insight study of structure-activity relationships and molecular targets	3
Bioassay-guided isolation and identification of anti-Alzheimer’s active compounds from Spiranthes sinensis (Pers.) Ames	3
Design, synthesis, and biological evaluation of novel 2-acetylphenol-rivastigmine hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease	3
Enantioselectivity of pinene against Leishmania amazonensis	3
Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments	3
Synthesis, bacterial and fungal inhibition assay, molecular docking study of substituted isatin (N-substituted 1,2,3,4-tetra-O-acetyl-β-glucopyranosyl)thiosemicarbazones	3
Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity	3
Synthesis and characterization of new tetrakisphosphonic acid derivatives as FPPS inhibitors and evaluation of their anti-osteoclastogenic potential for prevention of osteoporosis	3
Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives	3
Review: Chemical and biological features of genus Paralemnalia soft corals	3
Synthesis and biological evaluations of novel pyrazinoic acid derivatives as anticancer agents	3
Design, synthesis and investigating the in vitro and in silico HDAC8 inhibitory activities of derivatives of [6]-shogaol and [6]-gingerol isolated from ginger (Zingiber officinale)	3
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities	3
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments	3
Bio-evaluation of fluoro and trifluoromethyl-substituted salicylanilides against multidrug-resistant S. aureus	3
Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent	3
Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors	3
Contrasting effect of different crowding agents on pseudoknot RNA stability	3
New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer	3
Synthesis and biological activity of amide derivatives derived from natural product Waltherione F	3
The trimethoxyphenyl (TMP) functional group: a versatile pharmacophore	3
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin	3
Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors	3
Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2	3
Design, synthesis and assay of 2-(4-phenylpiperazin-1-yl)pyrimidine-5- carboxamide derivatives as acetylcholinesterase inhibitors	3
Potential effect of novel thiadiazole derivatives against radiation induced inflammation with low cardiovascular risk in rats	3
Synthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues	3
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors	3
Synthesis and in vitro antiproliferative evaluation of novel drimane oxepinyl triazoles from labdane diterpene sclareol	3
Synthesis, antibacterial evaluation and in silico study of DOTA-fluoroquinolone derivatives	3
Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers	3
Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents	3
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications	3
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy	3
Synthesis, pharmacological and molecular docking investigations of 1,3,4-oxadiazole-5-thionyl derivatives of extracted cis-clerodane diterpenoid from Cistus monspeliensis	3
Phenylpropanoids from Liparis nervosa and their in vitro antioxidant and α-glucosidase inhibitory activities	3
Loading harmine on nanographene changes the inhibitory effects of free harmine against MCF-7 and fibroblast cells	3
Clerodendrum viscosum: a critical review on phytochemistry, pharmacology, quality assurance, and safety data	3
The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism	3
Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic simulations	3
Synthesis and biological evaluation of chromone derivatives against triple-negative breast cancer cells	3
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine	3
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors	3
Effect of a hexacyclic triterpenic acid from Euscaphis japonica on the oleic acid induced HepG2 cellular model of non-alcoholic fatty liver disease	3
Novel monastrol/melatonin hybrids as a new approach for colorectal cancer intervention: design, synthesis, biological activity, and drug-likeness modeling studies	2
A vitamin D C/D ring-derived compound with cytotoxicity	2
Design and synthesis of novel pyrazolopyrimidine-based derivatives as reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma	2
Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine	2
Synthesis and analgesic potential of 4-[4–chloro-3- (trifluoromethyl)-phenyl]-4-piperidinol analogues against pain model in mice	2
Clathrolides A–B: previously undescribed macrocylic lactones from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as potential antihypertensive leads attenuating angiotensin converting	2
Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions	2
Novel 2-[(8-hydroxyquinolin-7-yl)(phenyl)methylamino]benzoic acid analogs targeting the active site of botulinum neurotoxins: designing, synthesis, and biological evaluation	2
Design, synthesis, antiproliferative and antimicrobial evaluation of a new class of disulfides containing 1,3,4-thiadiazole units	2
Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode	2
Characterization of the CO release properties of a common CO donor, CORM-401, in the context of its application in studying CO biology	2
Exploring the potential of chromone scaffold compounds in cancer therapy: targeting key kinase pathways	2
Identification of potential natural product derivatives as CK2 inhibitors based on GA-MLR QSAR modeling, synthesis and biological evaluation	2
Design, synthesis, biological evaluation and in silico studies of EGFR inhibitors based on 4-oxo-chromane scaffold targeting resistance in non-small cell lung cancer (NSCLC)	2
Dual HDAC–BRD4 inhibitors endowed with antitumor and antihyperalgesic activity	2
A new cadinane sesquiterpenoid from Eupatorium adenophorum and α-glycosidase and AChE inhibitory activities of a gossypetin acylglucoside	2
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir	2
Phosphoryl prodrugs: characteristics to improve drug development	2
Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides	2