Journal of Structural Biology

Article	Citations
3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM	612
A streamlined workflow for automated cryo focused ion beam milling	73
Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM	43
Protein-water hydrogen-bond networks of G protein-coupled receptors: Graph-based analyses of static structures and molecular dynamics	43
Crossfibrillar mineral tessellation in normal and Hyp mouse bone as revealed by 3D FIB-SEM microscopy	37
Comparison of carbonate precipitation induced by Curvibacter sp. HJ-1 and Arthrobacter sp. MF-2: Further insight into the biomineralization process	35
Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography	31
Orientation patterns of aragonitic crossed-lamellar, fibrous prismatic and myostracal microstructures of modern Glycymeris shells	31
Ellipsoidal mesoscale mineralization pattern in human cortical bone revealed in 3D by plasma focused ion beam serial sectioning	30
Measuring collagen fibril diameter with differential interference contrast microscopy	29
CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy	29
Multishot tomography for high-resolution in situ subtomogram averaging	27
ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation	27
Light-coupled cryo-plunger for time-resolved cryo-EM	26
It’s noisy out there! A review of denoising techniques in cryo-electron tomography	26
Phosphatidylserine controls calcium phosphate nucleation and growth on lipid monolayers: A physicochemical understanding of matrix vesicle-driven biomineralization	25
Montage electron tomography of vitrified specimens	25
Algorithmic robustness to preferred orientations in single particle analysis by CryoEM	24
A graph-based approach identifies dynamic H-bond communication networks in spike protein S of SARS-CoV-2	23
Effect of charge on protein preferred orientation at the air–water interface in cryo-electron microscopy	23
EMDA: A Python package for Electron Microscopy Data Analysis	23
Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data	22
A computer-simulated mechanism of familial Alzheimer’s disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase	21
Mineral tessellation in bone and the stenciling principle for extracellular matrix mineralization	20
Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase	20

3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy	20
A genetic model for the secretory stage of dental enamel formation	20
High-resolution cryo-EM performance comparison of two latest-generation cryo electron microscopes on the human ribosome	20
Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs	20
Cryo-EM analysis of the SctV cytosolic domain from the enteropathogenic E. coli T3SS injectisome	19
Dual-axis Volta phase plate cryo-electron tomography of Ebola virus-like particles reveals actin-VP40 interactions	19
Nanobeam X-ray fluorescence and diffraction computed tomography on human bone with a resolution better than 120 nm	19
The biological regulation of sea urchin larval skeletogenesis – From genes to biomineralized tissue	19
DeepAlign, a 3D alignment method based on regionalized deep learning for Cryo-EM	18
Controls of nature: Secondary, tertiary, and quaternary structure of the enamel protein amelogenin in solution and on hydroxyapatite	18
VHUT-cryo-FIB, a method to fabricate frozen hydrated lamellae from tissue specimens for in situ cryo-electron tomography	17
Markov state modeling of membrane transport proteins	17
Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging	17
Structural insights into the NAD+-dependent formate dehydrogenase mechanism revealed from the NADH complex and the formate NAD+ ternary complex of the Chaetomium thermophilum enzyme	17
Structural basis for inhibitory effects of Smad7 on TGF-β family signaling	16
The SIRAH force field: A suite for simulations of complex biological systems at the coarse-grained and multiscale levels	16
Protein-driven biomineralization: Comparing silica formation in grass silica cells to other biomineralization processes	16
Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex	16
Rapid tilt-series method for cryo-electron tomography: Characterizing stage behavior during FISE acquisition	15
Deep generative modeling for volume reconstruction in cryo-electron microscopy	15
Multi-scale alignment of respiratory cilia and its relation to mucociliary function	15
Imaging biological samples by integrated differential phase contrast (iDPC) STEM technique	15
Metallic support films reduce optical heating in cryogenic correlative light and electron tomography	14
Structure of the cytoplasmic domain of SctV (SsaV) from the Salmonella SPI-2 injectisome and implications for a pH sensing mechanism	14
Calcite crystal orientation patterns in the bilayers of laminated shells of benthic rotaliid foraminifera	14
Spike protein fusion loop controls SARS-CoV-2 fusogenicity and infectivity	14
New insight on spatial localization and microstructures of calcite-aragonite interfaces in adult shell of Haliotis tuberculata: Investigations of wild and farmed abalones by FTIR and Raman mapping	14
ContinuousFlex: Software package for analyzing continuous conformational variability of macromolecules in cryo electron microscopy and tomography data	14
Accurate, automatic determination of astigmatism and phase with Ctfplotter in IMOD	13
Evolution and biomineralization of pteropod shells	13
A disulfide-stabilised helical hairpin fold in acrorhagin I: An emerging structural motif in peptide toxins	13
Revisiting the Ramachandran plot based on statistical analysis of static and dynamic characteristics of protein structures	13
A set of common movements within GPCR-G-protein complexes from variability analysis of cryo-EM datasets	13
Small-angle neutron scattering solution structures of NADPH-dependent sulfite reductase	13
Heterogeneity of the osteocyte lacuno-canalicular network architecture and material characteristics across different tissue types in healing bone	13
Cryo-EM structure of the cetacean morbillivirus nucleoprotein-RNA complex	13
Structure and heterogeneity of a highly cargo-loaded encapsulin shell	12
Integration of software tools for integrative modeling of biomolecular systems	12
Structural principles of CRISPR-Cas enzymes used in nucleic acid detection	12
Amelogenesis: Transformation of a protein-mineral matrix into tooth enamel	12
Structural and dynamic insights into the HNH nuclease of divergent Cas9 species	12
TomoAlign: A novel approach to correcting sample motion and 3D CTF in CryoET	12
Conformational switch that induces GDP release from Gi	11
External bone size identifies different strength-decline trajectories for the male human femora	11
Desmosomal protein structure and function and the impact of disease-causing mutations	11
TAPASS: Tool for annotation of protein amyloidogenicity in the context of other structural states	11
PickYOLO: Fast deep learning particle detector for annotation of cryo electron tomograms	11
Multi-curve fitting and tubulin-lattice signal removal for structure determination of large microtubule-based motors	11
Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodeling by Hfq master regulator	10
Probing intracellular vesicle trafficking and membrane remodelling by cryo-EM	10

Structural basis of the partially open central gate in the human CNGA1/CNGB1 channel explained by additional density for calmodulin in cryo-EM map	10
Elastin calcification in in vitro models and its prevention by MGP’s N-terminal peptide	10
Structural modeling of two plant UDP-dependent sugar-sugar glycosyltransferases reveals a conserved glutamic acid residue that is a hallmark for sugar acceptor recognition	10
Structural organization of xanthine crystals in the median ocellus of a member of the ancestral insect group Archaeognatha	10
Insights into the dynamic interactions at chemokine-receptor interfaces and mechanistic models of chemokine binding	10
Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism	10
Recent advances in the application of atomic force microscopy to structural biology	10
Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7	9
Movement analysis of primate molar teeth under load using synchrotron X-ray microtomography	9
Insights into the oligomeric structure of the HIV-1 Vpu protein	9
Porous assembly of an antifungal protein mediated by zinc and sulfonato-calix[8]arene	9
The ultrastructure of resurrection: Post-diapause development in an Antarctic freshwater copepod	9
The calcifying interface in a stony coral primary polyp: An interplay between seawater and an extracellular calcifying space	9
Characterization of the growth plate-bone interphase region using cryo-FIB SEM 3D volume imaging	9
Embedding cells within nanoscale, rapidly mineralizing hydrogels: A new paradigm to engineer cell-laden bone-like tissue	9
Cryo-EM density maps adjustment for subtraction, consensus and sharpening	9
Lattice micropatterning for cryo-electron tomography studies of cell-cell contacts	9
Shark centra microanatomy and mineral density variation studied with laboratory microComputed Tomography	9
Epitope-Analyzer: A structure-based webtool to analyze broadly neutralizing epitopes	9
Unliganded and CMP-Neu5Ac bound structures of human α-2,6-sialyltransferase ST6Gal I at high resolution	9
Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana	9
Genetic background dependent modifiers of craniosynostosis severity	9
Structural and biochemical insights into His-tag-induced higher-order oligomerization of membrane proteins by cryo-EM and size exclusion chromatography	8
A biophysical and structural analysis of the interaction of BLNK with 14-3-3 proteins	8
A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication	8
Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme	8
Sequence dependent influence of an A…A mismatch in a DNA duplex: An insight into the recognition by hZαADAR1 protein	7
Crystal structure of the anti-CRISPR repressor Aca2	7
Globular structure of the hypermineralized tissue in human femoral neck	7
Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2	7
OpenFIBSEM: A universal API for FIBSEM control	7
Structural basis for promoter DNA recognition by the response regulator OmpR	7
Measuring cryo-TEM sample thickness using reflected light microscopy and machine learning	7
NMR sample optimization and backbone assignment of a stabilized neurotensin receptor	7
Endocytosed nanogold fiducials for improved in-situ cryo–electron tomography tilt-series alignment	7
Determination of amino acids that favour the αL region using Ramachandran propensity plots. Implications for α-sheet as the possible amyloid intermediate	7
Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases	7
Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of β-lactam antibiotics	7
A review of the approaches used to solve sub-100 kDa membrane proteins by cryo-electron microscopy	7
Investigation of the human pineal gland 3D organization by X-ray phase contrast tomography	7
SAM1 domain of SASH1 harbors distinctive structural heterogeneity	7
Matrix/mineral ratio and domain size variation with bone tissue age: A photothermal infrared study	7
Genetic basis of stony coral biomineralization: History, trends and future prospects	7
Tying the knot in the tetrahydrofolate (THF) riboswitch: A molecular basis for gene regulation	7
The β-hairpin from the Thermus thermophilus HB27 laccase works as a pH-dependent switch to regulate laccase activity	7
Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins	6
Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode	6
Focused classifications and refinements in high-resolution single particle cryo-EM analysis	6
Increased cochlear otic capsule thickness and intracortical canal porosity in the oim mouse model of osteogenesis imperfecta	6
Unit quaternion description of spatial rotations in 3D electron cryo-microscopy	6
Sub-micrometric spatial distribution of amorphous and crystalline carbonates in biogenic crystals using coherent Raman microscopy	6
Correlative transmission electron microscopy and high-resolution hard X-ray fluorescence microscopy of cell sections to measure trace element concentrations at the organelle level	6
Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice	6
Visualizing transiently associated catalytic domains in assembly-line biosynthesis using cryo-electron microscopy	6
Electron-counting MicroED data with the K2 and K3 direct electron detectors	6
Microstructural heterogeneity of the collagenous network in the loaded and unloaded periodontal ligament and its biomechanical implications	6
Identification of incorrectly oriented particles in cryo-EM single particle analysis	6
OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton	6
Automated picking of amyloid fibrils from cryo-EM images for helical reconstruction with RELION	6
Morphology and organization of the internal shell of Ariolimax californicus (Gastropoda; Stylommatophora), an asymmetric two-face biomineralized matrix	6
Correlating cryo-super resolution radial fluctuations and dual-axis cryo-scanning transmission electron tomography to bridge the light-electron resolution gap	6
Direct transfer of electron microscopy samples to wetted carbon and graphene films via a support floatation block	6
On the structural organization of the bacillary band of Trichuris muris under cryopreparation protocols and three-dimensional electron microscopy	6
A feature-guided, focused 3D signal permutation method for subtomogram averaging	6
Structural insights into ring-building motif domains involved in bacterial sporulation	6
Crystal structure of chloroplast fructose-1,6-bisphosphate aldolase from the green alga Chlamydomonas reinhardtii	5
Rapid tool for cell nanoarchitecture integrity assessment	5
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM	5
Characterization and functional insights into the Entamoeba histolytica pyridoxal kinase, an enzyme essential for its survival	5
Insight into structural biophysics from solution X-ray scattering	5
WITHDRAWN: SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time	5
Structural basis for proteolytic processing of Aspergillus sojae α-glucosidase L with strong transglucosylation activity	5
Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC	5
A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly	5
High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis	5
Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein–protein association model in pheromone/receptor interactions	5
Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders	5
Protein repeats evolve and emerge in giant viruses	5
Simple assay for adsorption of proteins to the air–water interface	5
Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP	5

Mean curvature motion facilitates the segmentation and surface visualization of electron tomograms	5
Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E	5
Structure and mineralization of the spearing mantis shrimp (Stomatopoda; Lysiosquillina maculata) body and spike cuticles	5
Structural and biochemical insights into the substrate-binding mechanism of a glycoside hydrolase family 12 β-1,3-1,4-glucanase from Chaetomium sp.	5
Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii	5
NUDIM: A non-uniform fast Fourier transform based dual-space constraint iterative reconstruction method in biological electron tomography	5
Identification and evaluation of potential inhibitor molecules against TcyA from Candidatus Liberibacter asiaticus	5
Keratin intermediate filament chains in tuatara (Sphenodon punctatus): A comparison of tuatara and human sequences	5
Role of a high centrality residue in protein dynamics and thermal stability	5
Cryo-Electron Microscopy: The field of 1,000+ methods	5
Smart data collection for CryoEM	5
Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478	5
Structure of a consensus chitin-binding domain revealed by solution NMR	5
Structural basis for cell type specific DNA binding of C/EBPβ: The case of cell cycle inhibitor p15INK4b promoter	5
Crystal structure of the potato leafroll virus coat protein and implications for viral assembly	4
Deep Learning-based structure modelling illuminates structure and function in uncharted regions of β-solenoid fold space	4
Unusual commonality in active site structural features of substrate promiscuous and specialist enzymes	4
Divalent cations influence the dimerization mode of murine S100A9 protein by modulating its disulfide bond pattern	4
Cementum thickening leads to lower whole tooth mobility and reduced root stresses: An in silico study on aging effects during mastication	4
A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate	4
Crystal structure of the indole-3-acetic acid-catabolizing enzyme DAO1 from Arabidopsis thaliana	4
From sporadic single genes to a broader transcriptomic approach: Insights into the formation of the biomineralized exoskeleton in decapod crustaceans	4
A STRP-ed definition of Structured Tandem Repeats in Proteins	4
Crystal structure of the Escherichia coli CusS kinase core	4
Structure and dynamics of the von Willebrand Factor C6 domain	4
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2	4
Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids	4
Biochemical, structural and dynamical studies reveal strong differences in the thermal-dependent allosteric behavior of two extremophilic lactate dehydrogenases	4
Isolation and reconstruction of cardiac mitochondria from SBEM images using a deep learning-based method	4
New protein families with hendecad coiled coils in the proteome of life	4
Exploring the folding landscape of leptin: Insights into threading pathways	4
3D microstructural study of selachimorph enameloid evolution	4
Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain	4
Prokaryotic membrane coat - like proteins: An update	4
Three dimensional structures of the inner and outer pig petrous bone using FIB-SEM: Implications for development and ancient DNA preservation	4
Molecular dynamics study of enhanced autophosphorylation by S904F mutation of the RET kinase domain	4
The role of propeptide-mediated autoinhibition and intermolecular chaperone in the maturation of cognate catalytic domain in leucine aminopeptidase	4
Crystal structure of breast regression protein 39 (BRP39), a signaling glycoprotein expressed during mammary gland apoptosis, at 2.6 Å resolution	4
Dynamic dentin: A quantitative microscopic assessment of age and spatial changes to matrix architecture, peritubular dentin, and collagens types I and III	4
Disorder-to-order transition of Synaptobrevin-2: Tracing the conformational diversity of a synaptic SNARE protein	4
The 3D organization of the mineralized scales of the sturgeon has structures reminiscent of dentin and bone: A FIB-SEM study	4
Isotope-edited vibrational circular dichroism study reveals a flexible N-terminal structure of islet amyloid peptide (NFGAIL) in amyloid fibril form: A site-specific local structural analysis	4
Structural insights into novel mechanisms of inhibition of the major β-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus	4
MlaC belongs to a unique class of non-canonical substrate-binding proteins and follows a novel phospholipid-binding mechanism	4
Integrating on-grid immunogold labeling and cryo-electron tomography to reveal photosystem II structure and spatial distribution in thylakoid membranes	4
Towards in situ high-resolution imaging of viruses and macromolecular complexes using cryo-electron tomography	4
Patterns of crystal organization and calcite twin formation in planktonic, rotaliid, foraminifera shells and spines	4
Predicting virus Fitness: Towards a structure-based computational model	3
Structure of maize BZR1-type β-amylase BAM8 provides new insights into its noncatalytic adaptation	3
A practical multicellular sample preparation pipeline broadens the application of in situ cryo-electron tomography	3
Perspective: Emerging strategies for determining atomic-resolution structures of macromolecular complexes within cells	3
The role of S126 in the Staphylococcus equorum MnSOD activity and stability	3
Proton irradiation induced reactive oxygen species promote morphological and functional changes in HepG2 cells	3
The structure of exopolyphosphatase (PPX) from Porphyromonas gingivalis in complex with substrate analogs and magnesium ions reveals the basis for polyphosphate processivity	3
The repetitive structure of DNA clamps: An overlooked protein tandem repeat	3
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells	3
Crystal structure and enzymatic characterization of the putative adenylyl cyclase HpAC1 from Hippeastrum reveal dominant triphosphatase activity	3
Gold nanomaterials and their potential use as cryo-electron tomography labels	3
Identification and demonstration of roGFP2 as an environmental sensor for cryogenic correlative light and electron microscopy	3
Morphological and genetic mechanisms underlying the plasticity of the coral Porites astreoides across depths in Bermuda	3
Structural insights into Pseudomonas aeruginosa Type six secretion system exported effector 8	3
Lipid nanodiscs as a template for high-resolution cryo-EM structures of peripheral membrane proteins	3
Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity	3
Structure guided mutagenesis reveals the substrate determinants of guanine deaminase	3
2.85 and 2.99 Å resolution structures of 110 kDa nitrite reductase determined by 200 kV cryogenic electron microscopy	3
Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase	3
Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM	3
An exon-biased biophysical approach and NMR spectroscopy define the secondary structure of a conserved helical element within the HOTAIR long non-coding RNA	3
The structures of the C146A variant of the amidase from Pyrococcus horikoshii bound to glutaramide and acetamide suggest the basis of amide recognition	3