Journal of Structural Biology

Article	Citations
Allosteric inhibition of cytosolic NADP+-dependent isocitrate dehydrogenase by oxaloacetate	65
Deep Learning-based structure modelling illuminates structure and function in uncharted regions of β-solenoid fold space	63
Tropomyosin induces the synthesis of magnesian calcite in sea urchin spines	46
Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs	46
Characterization of NMDA receptor Allostery modulation	43
Calcium carbonate deposition in the spicules of the sponge Heteropia glomerosa (Porifera, Calcarea)	42
Dual-colour super-resolution cryoCLEM in mammalian cells using the fluorescent proteins rsTagRFP and rsEGFP2	41
ContinuousFlex: Software package for analyzing continuous conformational variability of macromolecules in cryo electron microscopy and tomography data	41
Inter-Domain interactions Slow BoNT/A’s onset of action	35
High-resolution single-particle imaging at 100–200 keV with the Gatan Alpine direct electron detector	34
Outside Front Cover	30
Structure of the type VI secretion protein VgrS from Salmonella Typhimurium	27
Multishot tomography for high-resolution in situ subtomogram averaging	26
Locating cellular contents during cryoFIB milling using cellular secondary-electron imaging	25
Focused ion beam-SEM 3D study of osteodentin in the teeth of the Atlantic wolfish Anarhichas lupus	23
Studying protein–protein interactions: Latest and most popular approaches	23
Outside Front Cover	22
Outside Front Cover	22
Changes in Arabidopsis thaliana seedling cell wall assembly induced by treatment with Yariv reagent – Molecular features & visualization with immunocytochemistry and a fluorescent Yariv reagent	21
Binding of the elastin peptide VGVAPG and lactose to the human elastin binding protein	21
3DDF-VAE: Dual-frequency variational autoencoder with pose-consistency validation for rare cryo-EM conformation discovery	21
Comprehensive structural overview of the C-terminal ligand-binding domains of the TetR family regulators	18
Transcriptome profiling of DPP stimulated DPSCs identifies the role of autophagy in odontogenic differentiation	17
Interaction of berberine with different forms of DNA in human telomeric region	17
Dual pattern of cholesterol-induced decoupling of residue-residue interactions of Kir2.2	16

3D quantification of the lacunocanalicular network on human femoral diaphysis through synchrotron radiation-based nanoCT	16
Editorial Board	16
Nanostructural evolution during carious and demineralisation process of human dentine using small angle X-ray scattering tensor tomography	16
Structure and heterogeneity of a highly cargo-loaded encapsulin shell	15
G-Quadruplex structures within the hfq gene regulate RNA–protein interactions in Acinetobacter baumannii	15
Leveraging deep learning semantic segmentation for imaging coral skeletons	15
From selenium to sulfur: predictive modeling unveils conformational and bonding changes in selenoproteins	14
JBP1 and JBP3 have conserved structures but different affinity to base-J	14
Insights into the pathogenic mechanisms associated with the SARS-CoV-2 spike protein	13
Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1	13
ArtiaX: geometric models, camera paths and image processing tools	13
New insight on spatial localization and microstructures of calcite-aragonite interfaces in adult shell of Haliotis tuberculata: Investigations of wild and farmed abalones by FTIR and Raman mapping	12
Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism	12
Crystal structure of the Escherichia coli CusS kinase core	12
Focused classifications and refinements in high-resolution single particle cryo-EM analysis	12
Metallic support films reduce optical heating in cryogenic correlative light and electron tomography	12
Outside Front Cover	12
Nickel-NTA lipid-monolayer affinity grids allow for high-resolution structure determination by cryo-EM	12
Common structural features in some of the sequentially distant neurotransmitter transporters N-termini	11
Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase	11
Daisy: An integrated repeat protein curation service	11
A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region	11
Local defocus estimation in single particle analysis in cryo-electron microscopy	11
Three dimensional structures of the inner and outer pig petrous bone using FIB-SEM: Implications for development and ancient DNA preservation	10
Deletion within ameloblastin multitargeting domain reduces its interaction with artificial cell membrane	10
A glimpse into the hidden world of the flexible C-terminal protein binding domains of human RAD52	10
Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity	10
Preferential binding as a driving mechanism of lipid domains formation	10
Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis	10
Outside Front Cover	10
Local microenvironments of capsomer variants in the PBCV-1	10
Molecular insights into the binding interactions and energetics of the omicron spike variant with hACE2 and a neutralizing antibody	10
DeepQs: Local quality assessment of cryo-EM density map by deep learning map-model fit score	10
2.0 Å cryo-EM structure of the 55 kDa nucleoplasmin domain of AtFKBP53	9
Tooth acellular extrinsic fibre cementum incremental lines in humans are formed by parallel branched Sharpey’s fibres and not by its mineral phase	9
Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy	9
Outside Front Cover	9
Distribution and size of scallop patterns at the human dentin enamel junction revealed with micro tomography	9
Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex	9
Cholesterol crystals in reservosomes of Trypanosoma cruzi	9
Corrigendum to “High-resolution single particle analysis using a scintillator camera XF416 on CRYOARM300II at 300 kV”. [J. Struct. Biol. 218(1) (2026) 108286]	9
Outside Front Cover	9
Cell recognition based on atomic force microscopy and modified residual neural network	9
Structural analysis of the water channel AQP2 by single-particle cryo-EM	9
Structural insights into the engagement of lysophosphatidic acid receptor 1 with different G proteins	9
Potential implications of the glycosylation patterns in collagen α1(I) and α2(I) chains for fibril assembly and growth	8
Editorial Board	8
Outside Front Cover	8
Morphological and genetic mechanisms underlying the plasticity of the coral Porites astreoides across depths in Bermuda	8
MEPSi: A tool for simulating tomograms of membrane-embedded proteins	8

Journal of Structural Biology – Paper of the Year 2022	8
Characterization of heterogeneity in nanodisc samples using Feret signatures	8
Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain	8
Conformational landscape of the mycobacterial inosine 5′-monophosphate dehydrogenase octamerization interface	8
Sub-micrometric spatial distribution of amorphous and crystalline carbonates in biogenic crystals using coherent Raman microscopy	8
Outside Front Cover	8
Improving CryoEM maps of symmetry-mismatched macromolecular assemblies: A case study on the flagellar motor	8
A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly	8
Computational structural biology: Evolution of the field	8
Announcement: Journal of Structural Biology: Paper of the year	7
Quantitative 3D electron microscopy characterization of mitochondrial structure, mitophagy, and organelle interactions in murine atrial fibrillation	7
The role of tandem repeats in bacterial functional amyloids	7
Direct control of shell regeneration by the mantle tissue in the pearl oyster Pinctada fucata	7
A new algorithm for particle weighted subtraction to decrease signals from unwanted components in single particle analysis	7
Editorial Board	7
Sequence/structural/functional relationships between Ganoderma fungal immunomodulatory proteins (gFIPs) and proteins involved in the modulation of immune response	7
3D distribution of biomineral and chitin matrix in the stomatopod dactyl club by high energy XRD-CT	7
Outside Front Cover	7
Mechanistic study of PDE5A inhibitors from the prepared folium of Epimedium sagittatum maxim	7
The crystal structure of the H116Q mutant of NDM-1: An enzyme devoid of zinc ions	7
Bioinformatic and experimental characterization of the RBM15 RNA binding protein	7
Membrane and vesicle structure detection in cryo-electron tomography based on deep learning	7
Cryo-Electron Microscopy: The field of 1,000+ methods	7
Determinants of site-selectivity in human ileal bile acid-binding protein by NMR dynamic analysis of a functionally-impaired mutant	7
Journal of Structural Biology – Paper of the Year 2021	7
Effects of Xylanase A double mutation on substrate specificity and structural dynamics	7
Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E	7
Crystal structures of the fatty acid biosynthesis initiation enzymes in Bacillus subtilis	7
Identification and demonstration of roGFP2 as an environmental sensor for cryogenic correlative light and electron microscopy	7
Insight into structural biophysics from solution X-ray scattering	7
The intricacies of tooth enamel: Embryonic origin, development and human genetics	7
Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete alloster	7
Structure and self-association of Arrestin-1	6
A non-parametric approach to particle picking in all frames	6
Transcriptional activity and splicing factors are preserved during physiological apoptosis	6
Editorial Board	6
Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation	6
Identification and evaluation of potential inhibitor molecules against TcyA from Candidatus Liberibacter asiaticus	6
Structural basis for the effects of Ser387 phosphorylation of MgcRacGAP on its GTPase-activating activities for CDC42 and RHOA	6
Classification of helical polymers with deep-learning language models	6
Sumoylation and the oncogenic E17K mutation affect AKT1 subcellular distribution and impact on Nanog-binding dynamics to chromatin in embryonic stem cells	6
GNN2Pfam: Integrating protein sequence and structure with graph neural networks for Pfam domain annotation	6
Towards in situ high-resolution imaging of viruses and macromolecular complexes using cryo-electron tomography	6
Cryo-EM structure of bacterial nitrilase reveals insight into oligomerization, substrate recognition, and catalysis	6
Phylogenetic analysis and homology modelling of a new Cry8A crystal protein expressed in a sporulating soil bacterium	6
NMR and semi-synthesis in synergy to study protein regulation	6
Prokaryotic membrane coat - like proteins: An update	6
Kinetic and structural studies of gamma-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis	5
Matrix/mineral ratio and domain size variation with bone tissue age: A photothermal infrared study	5
Journal of Structural Biology – Paper of the Year 2021	5
SAM1 domain of SASH1 harbors distinctive structural heterogeneity	5
Unveiling success determinants for AMB-assisted phase expansion of fusion proteins in ARP/wARP	5
Computational Engineering of siderocalin to modulate its binding affinity to the antihypertension drug candesartan	5
CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data	5
The SIRAH force field: A suite for simulations of complex biological systems at the coarse-grained and multiscale levels	5
CDP-alcohol phosphotransferases: Structures and function of highly diverse sub-classes within a protein family	5
Exploring the folding landscape of leptin: Insights into threading pathways	5
Statistical proofs of the interdependence between nearest neighbor effects on polypeptide backbone conformations	5
Three-dimensional reconstruction of Magnetofaba australis strain IT-1: Magnetosome chain position with respect to flagella	5
Single particle cryo-EM analysis of Rickettsia conorii Sca2 reveals a formin-like core	5
High-throughput segmentation, data visualization, and analysis of sea star skeletal networks	5
A generalist deep-learning volume segmentation tool for volume electron microscopy of biological samples	5
Selective signal enhancement in Fourier space as a tool for discovering ultrastructural organization of macromolecules from in situ TEM	4
TAM receptor–ligand interfaces in zebrafish and mammals: A comparative structural and electrostatic analysis	4
GCTransNet: 3D mitochondrial instance segmentation based on Global Context Vision Transformers	4
Revisiting the Ramachandran plot based on statistical analysis of static and dynamic characteristics of protein structures	4
Editorial Board	4
Molecular structure of the third immunoglobulin domain (Ig3) of human Muscle-Specific kinase (MuSK)	4
Exploring α-synuclein stability under the external electrostatic field: Effect of repeat unit	4
Recent advances in the application of atomic force microscopy to structural biology	4
Targeting Helicobacter pylori thymidylate kinase: structural insights and validation of novel inhibitors	4
Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids	4
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite	4
Conformational changes on the third PDZ domain of PSD95 upon phosphorylation of Tyr397	4
Three-dimensional cellular architecture of the sigmoid filament in Trichomonas vaginalis	4
RosettaHDX: Predicting antibody-antigen interaction from hydrogen-deuterium exchange mass spectrometry data	4
A review of the approaches used to solve sub-100 kDa membrane proteins by cryo-electron microscopy	4
Comparison of the global crystallographic texture of minerals in the shells of Bathymodiolus thermophilus Kenk et B.R. Wilson, 1985 and species of the genus Mytilus Linnaeus, 1758	4
Electron-counting MicroED data with the K2 and K3 direct electron detectors	4
Editorial Board	3

Investigating oncolytic virus M1-Associated vesicles using 3D electron microscopy	3
Binding of an N protein peptide to M protein of a bat coronavirus	3
Solution 3D structure and conformational flexibility of the endothelial monocyte activating polypeptide II (EMAP II) revealed by NMR spectroscopy and molecular dynamics simulations	3
Characterization of conformational flexibility in protein structures by applying artificial intelligence to molecular modeling	3
Precise ligand-selective mechanism at the fab domain of a tau-recognizing antibody	3
Why does the first protein repeat often become the only one?	3
Outside Front Cover	3
Outlier removal in cryo-EM via radial profiles	3
Structural and biophysical characterization of PadR family protein Rv0047c of Mycobacterium tuberculosis H37Rv	3
Cryo-EM image alignment: From pair-wise to joint with deep unsupervised difference learning	3
Insights into the dynamic interactions at chemokine-receptor interfaces and mechanistic models of chemokine binding	3
New insights into the effect of mutations on affibody-Fc interaction, a molecular dynamics simulation approach	3
Announcement: Journal of Structural Biology: Paper of the year	3
Four-dimensional microED of conformational dynamics in protein microcrystals on the femto-to-microsecond timescales	3
Lack of embryonic skeletal muscle in mice leads to abnormal mineral deposition and growth	3
Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination	3
Effects of mineral nutrition on the cuticle structure of Armadillidium vulgare	3
Comparative performance of structural aligners in functional domain annotation	3
Hurdles and advancements in experimental membrane protein structural biology	3
OpenFIBSEM: A universal API for FIBSEM control	3
Prediction of a structural change in the orientation of the cytoplasmic signaling unit of human Toll-like receptor 9 upon binding of agonistic and antagonistic DNA molecules	3
High-Resolution single particle analysis using a scintillator camera XF416 on CRYOARM300II at 300 kV	2
An inducible model for medial calcification based on matrix Gla protein deficiency	2
ProPicker: Promptable segmentation for particle picking in cryogenic electron tomography	2
Off-axis electron holography of unstained bacteriophages: Towards electrostatic potential measurement of biological samples	2
“QuickStainer”: a rapid negative staining device for improved preservation of molecular structure	2
Structural organization of the organic sheath that delineates extracellular seta silicification in diatoms	2
A strained N-capping motif in α-helices of βαβ-units	2
Biological applications of the scanning transmission electron microscope	2
Robust ab initio solution of the cryo-EM reconstruction problem at low resolution with small data sets	2
Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes	2
Structural basis for spectral red shift and UVA absorption in the microalgal water-soluble astaxanthin-binding protein AstaP-pink1	2
Deep geometric framework to predict antibody–antigen binding affinity	2
Cage versus sheet: Probing the Determinants of Protein – Cucurbit[7]uril Crystalline Architectures	2
Deep generative modeling for volume reconstruction in cryo-electron microscopy	2
Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538	2
Structural characterization of Meiothermus ruber LOV domain	2
Characterization of SARS-CoV-2 nucleocapsid protein oligomers	2
Dengue virus-host interactions: Structural and mechanistic insights for future therapeutic strategies	2
Structural and biochemical basis for the substrate specificity of Pad-1, an indole-3-pyruvic acid aminotransferase in auxin homeostasis	2
A STRP-ed definition of Structured Tandem Repeats in Proteins	2
In situ loading and patterns of trabecular deformation in the intermediale of the vertebral centrum of a great hammerhead	2
Different strategies towards strength: Unveiling the role of Zn vs Mn/Ca and chitin arrangement in scorpion stingers	2
Investigating the role of elastin and extracellular matrix damage in cardiovascular calcification	2
Phylogenetic analysis and structural studies of heteromeric acetyl-CoA carboxylase from the oleaginous Amazonian microalgae Ankistrodesmus sp.: Insights into the BC and BCCP subunits	2
Engineering of brick and staple components for ordered assembly of synthetic repeat proteins	2
Crystallographic analysis of a putative FAD-dependent oxidoreductase identifies a potentially misfolded apo structure in a soluble monomeric state	2
Disulfide bonds enhance thermal stability and thumb region drives activity of the glycoside hydrolase 11 xylanase rMxylcd	2
Crystal structure, thermostability and temperature-dependent enzymatic activity of an exo-β-d-glucosaminidase from Pyrococcus chitonophagus	2
Outside Front Cover	2
A feature-guided, focused 3D signal permutation method for subtomogram averaging	2
Effects of Gα C-terminal deletion on the intrinsic GDP release/GTPase activity and conformational dynamics	2
Chemically cross-linked hydrogels from repetitive protein arrays	2
A computational approach to predict the effects of missense mutations on protein amyloidogenicity: A case study in hereditary transthyretin cardiomyopathy	2
The repetitive structure of DNA clamps: An overlooked protein tandem repeat	2
Optimal 3D angular sampling with applications to cryo-EM problems	2
A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate	2
Montage electron tomography of vitrified specimens	2
Smart data collection for CryoEM	2