Genes Chromosomes & Cancer

Article	Citations
Neonatal osteoblastic tumor with a novel PTBP1::FOSB fusion	76
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ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations	48
Uncovering variable neoplasms between ATM protein‐truncating and common missense variants using 394 694 UK Biobank exomes	39
An SS18::NEDD4 cutaneous spindled and epithelioid sarcoma: An hitherto unclassified cutaneous sarcoma, resembling epithelioid sarcoma with aggressive clinical behavior	38
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Insertion of the CXXC domain of KMT2A into YAP1: An unusual mechanism behind the formation of a chimeric oncogenic protein	24
Polymorphisms of the PD‐L1 gene 3′‐untranslated region are associated with the expression of PD‐L1 in non‐small cell lung cancer	24
MDM4 amplification in atypical lipomatous tumors/well‐differentiated liposarcoma: Private event or alternative oncogenic mechanism?	23
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Table of Content Volume 60, Number 7, July 2021	22
Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck	22
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Issue Information	19
Near complete remission of an inoperable pancreatic acinar cell carcinoma after BRAF‐/MEK‐inhibitor treatment—A case report and review of the literature	18
Issue Information	18
Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart	17
Comprehensive Analyses of Somatic Copy Number Alterations and Mutations Based on the Adenoma–Carcinoma Sequence	16
Correction to “Temporal Trends and Regional Variability in BRAF and KRAS Genetic Testing in Denmark (2010–2022): Implications for Precision Medicine”	16
Ewing sarcoma and related FET family translocation‐associated round cell tumors: A century of clinical and scientific progress	16
ERRATUM	16
Fusion‐positive non‐small cell lung carcinoma: Biological principles, clinical practice, and diagnostic implications	15
Issue Information	15
The somatic p.T81dup variant in AKT3 gene underlies a mild cerebral phenotype and expands the spectrum including capillary malformation and lateralized overgrowth	15
Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report	15

Issue Information	15
Aneurysmal bone cyst with an unusual clinical presentation and a novel VDR‐USP6 fusion	15
Malignant Bone‐Forming Neoplasm With NIPBL::BEND2 Fusion	14
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VIM::KMT2A‐rearranged sarcomas: A report of two new cases confirming an entity with distinct histologic features	14
Assigning evidence to actionability: An introduction to variant interpretation in precision cancer medicine	14
Genomic profile analysis of leiomyomas with bizarre nuclei and fumarate hydratase deficient leiomyomas: Strengths, weaknesses, and limitations of array‐CGH interpretation	14
ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma	13
Issue Information	12
Clear cell mesotheliomas with inactivating VHL mutations and near‐haploid genomic features	12
Epithelioid hemangioendothelioma (EHE) with WWTR1::TFE3 gene fusion, a novel fusion variant	12
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EWSR1::SSX1 Fusion‐Driven Synovial Sarcoma: A Case Presentation and Review of the Literature	12
Digital pathology systems enabling quality patient care	12
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3′RNA and whole‐genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1	11
Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome	11
The presence of a chromosomal abnormality in cytopenia without dysplasia identifies a category of high‐risk clonal cytopenia of unknown significance	11
Issue Information	11
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A Clinicopathologic and Molecular Reappraisal of Myxoinflammatory Fibroblastic Sarcoma—A Controversial and Pathologically Challenging Low‐Grade Sarcoma	10
Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma	10
IDH‐negative chondrosarcoma with metachronous dedifferentiation only in the metastatic site—A diagnostic pitfall	10
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Low‐Level BCR::ABL1 Transcript at Diagnosis in Childhood Leukemia: A 10‐Year Single Institution Study	10
Structural Variant Analysis of Complex Karyotype Myelodysplastic Neoplasia Through Optical Genome Mapping	10
Issue Information	10
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Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions	10
Expanding the spectrum of mesenchymal neoplasms with NR1D1‐rearrangement	10
RREB1::MRTFB fusion‐positive extra‐glossal mesenchymal neoplasms: A series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversit	9
Molecular investigation of ALK‐rearranged epithelioid fibrous histiocytomas identifies CLTC as a novel fusion partner and evidence of fusion‐independent transcripti	9
Spindle Cell Rhabdomyosarcoma of the Prostate With ZFP64::NCOA2 Fusion	9
Whole genome duplication in oral squamous cell carcinoma in patients younger than 50 years: implications for prognosis and adverse clinicopathological factors	9
Identification of a novel SH3PXD2B::FER fusion in a case of plexiform myofibroblastic tumor and review of the literature	9
A cloud‐based resource for genome coordinate‐based exploration and large‐scale analysis of chromosome aberrations and gene fusions in cancer	9
Fibromyxoid aSoft Tissue Tumor With PLAG1 Fusion—The First Case in an Adult Patient	9
The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis	8
Influence of Cytogenetics on the Outcome of Patients With High‐Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide	8
A Bibliometric Analysis on the Risk Factors of Cancer	8
Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1‐SSX2 fusion identified by RNA‐based next‐generation sequencing	8
A case of a lipoblastoma with EEF1A1::PLAG1 fusion and metaplastic ossification	7
Prevalence and Reclassification of Genetic Variants in South African Populations with Breast Cancer	7
Gene amplification in neoplasia: A cytogenetic survey of 80 131 cases	7
Refined cytogenetic IPSS‐R evaluation by the use of SNP array in a cohort of 290 MDS patients	7
Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC‐rearranged sarcoma	7
Issue Information	7
MicroRNA Expression in High‐Grade B‐Cell Lymphoma With 11q Aberration	7

Recurrent PTBP1::MAML2 fusions in composite hemangioendothelioma with neuroendocrine differentiation: A report of two cases involving neck lymph nodes	7
PMS2 or PMS2CL? Characterization of variants detected in the 3′ of the PMS2 gene	7
Rhabdomyosarcoma With EWSR1::NF2 Gene Fusion: A Case Report Potentially Expanding Its Genetic Spectrum	7
Issue Information	7
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Tyrosine kinase‐altered spindle cell neoplasms with EGFR internal tandem duplications	7
Identification of Rare EIF3E::RSPO2 Fusion in Recurrent and Aggressive Urachal Adenocarcinoma	7
Nanopore DNA Sequencing Detected Chromothripsis‐Induced PAFAH1B1::USP6 Rearrangement in Periosteal Solid Aneurysmal Bone Cyst Initially Diagnosed as Osteosarcoma	7
Gastroblastoma with a novel EWSR1‐CTBP1 fusion presenting in adolescence	7
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How to use AI in pathology	6
A unique epithelioid vascular neoplasm of bone characterized by EWSR1/FUS‐NFATC1/2 fusions	6
Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T‐ALL: Focus on miR‐363‐3p and promoter methylation	6
A novel IRF2BP2::CDX2 Gene fusion in digital intravascular myoepithelioma of soft tissue: An enigma!	6
Issue Information	6
NovelHNRNPM::LEUTXfusion resulting from chromothripsis of chromosome 19 in a pediatric undifferentiated small round cell neoplasm	6
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FIP1L1::PDGFRA Fusion in a Pediatric Patient Presenting With B‐Cell Lymphoblastic Leukemia	6
Ovarian germ cell tumor/mastocytosis with KIT mutation: A unique clinicopathological entity	6
POU2AF3‐rearranged sarcomas: A novel tumor defined by fusions of EWSR1 or FUS to a gene formerly designated COLCA2	6
Genomic and transcriptomic characterization of desmoplastic small round cell tumors	6
Cryptic TCF3 fusions in childhood leukemia: Detection by RNA sequencing	6
GLI1, CDK4, and MDM2 Co‐Amplification Gastric Plexiform Fibromyxoma: A Case Report and Literature Review	6
Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case‐based review	6
Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish	6
The novel KIT exon 11 germline mutation K558N is associated with gastrointestinal stromal tumor, mastocytosis, and seminoma development	5
TAF15::NR4A3 gene fusion identifies a morphologically distinct subset of extraskeletal myxoid chondrosarcoma mimicking myoepithelial tumors	5
Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor	5
Giemsa‐negative chromosome bands preferentially recombine in cancer‐associated translocations and gene fusions	5
Survey of germline variants in cancer‐associated genes in young adults with colorectal cancer	5
Alternative genetic alterations of MYC, BCL2, and/or BCL6 in high‐grade B‐cell lymphoma (HGBL) and diffuse large B‐cell lymphoma (DLBCL): Can we identify dif	5
Uncovering the WWTR1::NCOA2 Gene fusion in low‐grade myoepithelial‐rich neoplasm with HMGA2 expression: A case report	5
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Adolescent presentation of FGFR1::EBF2 gene fusion mesenchymal tumor	5
Issue Information	5
ALK‐rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors	5
RBM10‐TFE3 fusions: A FISH‐concealed anomaly in adult renal cell carcinomas displaying a variety of morphological and genomic features: Comprehensive study of six novel cases	5
Malignant Peripheral Nerve Sheath Tumor (MPNST) With Smooth Muscle Differentiation of the Uterus—A Case Report With Emphasis on Diagnostic Pitfalls and Value of DNA Methylation A	4
Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia	4
Corrigendum	4
Gene fusions in gastrointestinal tract cancers	4
A cutaneous epithelioid vascular tumor harboring a TPM3::ALK fusion	4
Cell Senescence and the Genetics of Melanoma Development	4
GAB1‐ABL1 fusions in tumors that have histologic overlap with NTRK‐rearranged spindle cell tumors	4
Novel EWSR1::UBP1 fusion expands the spectrum of spindle cell rhabdomyosarcomas	4
Merged testing for colorectal cancer syndromes and re‐evaluation of genetic variants improve diagnostic yield: Results from a nationwide prospective cohort	4
Metastasizing aneurysmal dermatofibroma initially diagnosed as angiosarcoma confirmed by CD63::PRKCD fusion gene detection with nanopore sequencing	4
Corrigendum	4
Issue Information	4
Neuregulin 1 (NRG1) fusion‐positive high‐grade spindle cell sarcoma: A distinct group of soft tissue tumors with metastatic potential	4
Germline variation in RASAL2 may predict survival in patients with RAS‐activated colorectal cancer	4
Sporadic Breast Angiosarcoma With MYC Amplification on Extrachromosomal Circular DNA Detected Using Nanopore Sequencing in an Adolescent Female	4
Issue Information	4
Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma—diagnostic challenge and report of two cases	4
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Calcifying Spindle Cell Soft Tissue Tumor With SOX10::PLAG1 Fusion: A Case Report of a Morphologically Distinctive and Potentially Novel Soft Tissue Tumor	4
GAB1::ABL1 fusions define a distinctive soft tissue neoplasm, with variable perineurial differentiation, and a predilection for children and young adults	3
MYH9::LTK Fusion in a Pediatric Acral Soft Tissue Spindle Cell Neoplasm	3
Clinicopathologic and survival correlates of embryonal rhabdomyosarcoma driven by RAS/RAF mutations	3
Osteoblastoma of the thumb with a novel PRSS44::ALK fusion and literature review of osteoblastoma of hands and feet bones	3
Issue Information	3
Development and validation of blood tumor mutational burden reference standards	3
DICER1‐mutated rhabdomyosarcoma of the ovary with teratoid features	3
Shallow whole‐genome sequencing of bone marrow aspirates in myelodysplastic neoplasms: A retrospective comparison with cytogenetics	3
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Corrigendum	3
Recurrent NF1 gene variants and their genotype/phenotype correlations in patients with Neurofibromatosis type I	3
Frequent breakpoints of focal deletion and uniparental disomy in 22q11.1 or 11.2 segmental duplication region reveal distinct tumorigenesis in rhabdoid tumor of the kidney	3
Low‐grade endometrial stromal sarcoma‐like tumors in male with JAZF1 gene fusions	3
Successful treatment with MEK‐inhibitor in a patient with NRAS‐related cutaneous skeletal hypophosphatemia syndrome	3
Spindle cell neoplasms with novel LTK fusion – Expanding the spectrum of kinase fusion‐positive soft tissue tumors	3
A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia	3
A Challenging Case of an Intraosseous Composite Hemangioendothelioma of the Occipital Bone With YAP1::FOXR1 Fusion	3
Assessing acute myeloid leukemia susceptibility in rearrangement‐driven patients by DNA breakage at topoisomerase II and CCCTC‐binding factor/cohesin binding sites	3
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Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin‐Positive Giant Cell Tumor	3
N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4<	3
FGFR1 gene fusions in a subset of pediatric mesenchymal tumors: Expanding the genetic spectrum of tumors sharing histologic overlap with infantile fibrosarcoma and “NTRK<	3
Expanding the spectrum of GLI1‐altered mesenchymal tumors—A high‐grade uterine sarcoma harboring a novel PAMR1::GLI1 fusion and literature review of GLI1‐altered mesenchyma	3

Soft‐tissue sarcoma with MN1‐BEND2 fusion: A case report and comparison with astroblastoma	3
The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non‐AML myeloid neoplasms	3
TFG::MET‐rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low‐grade triphasic morphology	3
A Novel JAK2 Fusion in T‐Cell Prolymphocytic Leukemia	3
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)	3
Vanished MDM2 amplification in multiple recurrences of an irradiated poorly differentiated sarcoma with amplified TRIO::TERT fusion gene	3
Wholistic approach: Transcriptomic analysis and beyond using archival material for molecular diagnosis	3
A case of spindle cell rhabdomyosarcoma with a ZFP64::NCOA3 fusion	3
MicroRNA‐192‐5p inhibits migration of triple negative breast cancer cells and directly regulates RhoGTPaseactivating protein 19	2
Malignant undifferentiated epithelioid neoplasms with MAML2 rearrangements: A clinicopathologic study of seven cases demonstrating a heterogenous entity	2
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Genomic profiling of pleomorphic rhabdomyosarcoma reveals a genomic signature distinct from that of embryonal rhabdomyosarcoma	2
Mismatch repair deficiency: The what, how and why it is important	2
Issue Information	2
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Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation	2
COL1A1::PDGFB fusion uterine sarcoma with a TERT promoter mutation	2
An Inflammatory Myofibroblastic Tumor With a Novel ALKV1180L Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors	2
Sustained remission after ruxolitinib and chimeric antigen receptor T‐cell therapy bridged to a second allogeneic hematopoietic stem cell transplantation for relapsed Philadelphia chromosome‐like B‐ce	2
Discovery of Cis‐Regulatory Mechanisms via Non‐Coding Mutations in Acute Lymphoblastic Leukemia	2
Erratum	2
Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype	2
FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor	2
Microsatellite Instability and Loss of Heterozygosity as Prognostic Markers in Oral Squamous Cell Carcinoma: Molecular Mechanisms, Detection Techniques, and Therapeutic Strategies	2
When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion	2
ANNOUNCEMENT	2
Gene Expression Profiles of AHNAK2, DCSTAMP, FN1, and TERT Correlate With Mutational Status and Recurrence in Papillary Thyroid Carcinoma	2
Issue Information	2
Schwann Cells Deficient in Neurofibromin Lack Sensitivity to Their Biomechanical Microenvironment	2
Complementary value of molecular analysis to expert review in refining classification of uncommon soft tissue tumors	2
A case of FN1‐fused calcified chondroid mesenchymal neoplasm of the hand with novel FGFR3 partner gene	2
A novel colony‐stimulating factor 1 (CSF1) translocation  involving human endogenous retroviral element in a tenosynovial giant cell tumor	2
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Typical, atypical and cryptic t(15;17)(q24;q21) (PML::RARA) observed in acute promyelocytic leukemia: A retrospective review of 831 patients with concurrent chromosome and PML::RARA dual	2
Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?	2
A novel STRN3::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland with high‐grade transformation	2
Issue Information	2
Spindle Cell Sarcoma With Novel JAZF1::NUDT5 Gene Fusion: Report of a Previously Undescribed Neoplasm	2
Methylation classifiers: Brain tumors, sarcomas, and what's next	2
A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias	2
Issue Information	2
17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas	1
The novel finding of an FGFR1::TACC1 fusion in an undifferentiated spindle cell sarcoma of soft tissue with aggressive clinical course	1
A novel HMGA2::KITLG fusion in a dedifferentiated liposarcoma with amplification of MDM2 and HMGA2	1
Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes	1
Standardizing analysis of intra‐tumoral heterogeneity with computational pathology	1
High‐Grade Uterine Sarcoma: First Report of a MEIS2::FOXO4 Fusion	1
Clinicopathologic and molecular correlates to neoadjuvant chemotherapy‐induced pathologic response in breast angiosarcoma	1
Related mechanisms, current treatments, and new perspectives in meningioma	1
Novel PDGFRB Gene Fusions in Two Cases of Infantile Myofibromatosis	1
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Translocation carcinomas of the kidney	1
Constitutional and acquired genetic variants in ARID5B in pediatric B‐cell precursor acute lymphoblastic leukemia	1
Primary mediastinal large B‐cell lymphoma is characterized by large‐scale copy‐neutral loss of heterozygosity	1
Issue Information	1
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Pediatric Fibromatosis Lacks the Internal Tandem Duplication of EGFR Seen in Congenital Mesoblastic Nephroma	1
Gastrointestinal stromal tumors withBRAFgene fusions. A report of two cases showing low or absentKITexpression resulting in diagnostic pitfalls	1
Segregation, immunohistochemical, molecular and functional analyses classify a novel missense variant in fumarate hydratase (FH) as pathogenic	1
Transcriptomic profiles‐based approach to decode the role of miR‐122 in triple negative breast cancer	1
Challenging Conventional Perceptions of Oncogenes and Tumor Suppressor Genes: A Comprehensive Analysis of Gene Expression Patterns in Cancer	1
An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion	1
Sarcomas with sclerotic epithelioid phenotype harboring novel EWSR1‐SSX1 fusions	1
Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values	1
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NR1D1::MAML1 epithelioid and spindle cell sarcoma mimicking pseudomyogenic hemangioendothelioma in core biopsy: A case report and review of the literature	1
Clonal origin and genomic diversity in Lynch syndrome‐associated endometrial cancer with multiple synchronous tumors: Identification of the pathogenicity of MLH1 p.L582H	1
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Rethinking cancer initiation: The role of large‐scale mutational events	1
Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel	1
The Transcriptomic and Gene Fusion Landscape of Pleomorphic Salivary Gland Adenomas	1
Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study	1