Seminars in Cancer Biology

Papers
(The median citation count of Seminars in Cancer Biology is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-09-01 to 2024-09-01.)
ArticleCitations
Ferroptosis is a type of autophagy-dependent cell death611
Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy312
Natural product-based nanoformulations for cancer therapy: Opportunities and challenges235
The role of SOX family members in solid tumours and metastasis227
Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy217
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer216
SOX2 in development and cancer biology200
Radiomics in breast cancer classification and prediction196
Targeting p53 for the treatment of cancer184
Evolving concepts in HER2 evaluation in breast cancer: Heterogeneity, HER2-low carcinomas and beyond178
The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics176
Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression169
RAF-MEK-ERK pathway in cancer evolution and treatment162
Immune checkpoints in the tumor microenvironment152
Curcumin and colorectal cancer: An update and current perspective on this natural medicine152
Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives147
lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions145
Artificial intelligence for breast cancer detection in mammography and digital breast tomosynthesis: State of the art143
Pathology of triple negative breast cancer141
Machine and deep learning approaches for cancer drug repurposing137
An update on vitamin D signaling and cancer136
Regulation of autophagy by canonical and non-canonical ER stress responses135
The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies130
Dietary fat, bile acid metabolism and colorectal cancer129
Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC128
SOX4: The unappreciated oncogene128
Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects126
An updated overview on metal nanoparticles toxicity117
The complexity of p53-mediated metabolic regulation in tumor suppression115
Regulation and function of SOX9 during cartilage development and regeneration113
The impact of VEGF on cancer metastasis and systemic disease113
Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer111
Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges111
PROTACs: A novel strategy for cancer therapy106
Epigenetics in hepatocellular carcinoma105
Precision medicine in non-small cell lung cancer: Current applications and future directions105
Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics104
DNMT1: A key drug target in triple-negative breast cancer104
Artificial intelligence aids in development of nanomedicines for cancer management101
Combining epigenetic and immune therapy to overcome cancer resistance98
Applications and strategies in nanodiagnosis and nanotherapy in lung cancer98
The oral microbiota and its role in carcinogenesis98
The Skp2 Pathway: A Critical Target for Cancer Therapy98
EGFR signaling pathway as therapeutic target in human cancers97
Neutrophil extracellular traps in cancer96
Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches94
RNA methylations in human cancers94
Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics94
Tumor glycolysis, an essential sweet tooth of tumor cells92
TGF-β in developmental and fibrogenic EMTs91
Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers91
Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement90
Immune checkpoint inhibitors: Key trials and an emerging role in breast cancer90
Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds87
The balance between breast cancer and the immune system: Challenges for prognosis and clinical benefit from immunotherapies87
Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities86
Drug repurposing for breast cancer therapy: Old weapon for new battle85
Anticancer potential of garlic and its bioactive constituents: A systematic and comprehensive review84
Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics84
Epidemiology of breast cancer, a paradigm of the “common soil” hypothesis83
Tumor intrinsic and extrinsic immune functions of CD15582
Colorectal cancer occurrence and treatment based on changes in intestinal flora80
Immune checkpoint proteins: Signaling mechanisms and molecular interactions in cancer immunotherapy79
Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications79
Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology77
Recent insight into the role of FBXW7 as a tumor suppressor77
Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives76
Hedgehog signaling mechanism and role in cancer75
NEDD4 E3 ligase: Functions and mechanism in human cancer75
SOX4: Epigenetic regulation and role in tumorigenesis74
Circular RNAs in cancer: Limitations in functional studies and diagnostic potential74
Dissenting degradation: Deubiquitinases in cell cycle and cancer74
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature73
Mechanisms of cancer metastasis73
Role of iron in cancer73
Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications73
Chemotherapy resistance in epithelial ovarian cancer: Mechanisms and emerging treatments72
Predictive biomarkers for response to immune checkpoint inhibition72
Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress72
AMPK signaling and its targeting in cancer progression and treatment72
The potential of liquid biopsy in the management of cancer patients71
Emerging roles of long noncoding RNAs in chemoresistance of pancreatic cancer71
At a glance: A history of autophagy and cancer70
Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy70
Artificial intelligence-based multi-omics analysis fuels cancer precision medicine70
Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer70
PD-L1 status in breast cancer: Current view and perspectives69
Chemokines in colon cancer progression69
Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis69
Functionalized mesoporous silica nanoparticles in anticancer therapeutics69
Molecular targets of tyrosine kinase inhibitors in thyroid cancer68
Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors67
Circular RNAs as biomarkers and therapeutic targets in cancer67
Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy67
Extracellular vesicles in cancer nanomedicine66
Cellular heterogeneity and plasticity in liver cancer66
Challenges for immunotherapy for the treatment of platinum resistant ovarian cancer66
Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives65
Artificial intelligence in lung cancer diagnosis and prognosis: Current application and future perspective65
Vimentin and cytokeratin: Good alone, bad together64
miRNA dysregulation is an emerging modulator of genomic instability64
APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis64
Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targets64
The intricacies of NRF2 regulation in cancer63
The functions and regulation of Smurfs in cancers63
Anticancer activity of lactic acid bacteria63
Slow-cycling (dormant) cancer cells in therapy resistance, cancer relapse and metastasis63
‘Warburg effect’ controls tumor growth, bacterial, viral infections and immunity – Genetic deconstruction and therapeutic perspectives62
Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance61
Nanomedicine in treatment of breast cancer – A challenge to conventional therapy61
Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy61
Determinants of response and resistance to CAR T cell therapy59
RBR E3 ubiquitin ligases in tumorigenesis59
Engineered nanoparticles for imaging and drug delivery in colorectal cancer59
Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer59
Repurposing of drugs as STAT3 inhibitors for cancer therapy58
Oncogenic signaling pathways associated with immune evasion and resistance to immune checkpoint inhibitors in cancer57
Advancement of cancer immunotherapy using nanoparticles-based nanomedicine57
The development and progress of nanomedicine for esophageal cancer diagnosis and treatment55
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology55
Unraveling tumor microenvironment of small-cell lung cancer: Implications for immunotherapy54
Excess body weight: Novel insights into its roles in obesity comorbidities54
Long non-coding RNA and RNA-binding protein interactions in cancer: Experimental and machine learning approaches53
RNA-binding proteins and cancer metastasis53
Nanoparticle mediated cancer immunotherapy52
Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic52
Systems biology based drug repositioning for development of cancer therapy52
Dysregulated FOXM1 signaling in the regulation of cancer stem cells52
Nano-immunotherapy: Overcoming tumour immune evasion51
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-1951
Regulatory roles for SOX11 in development, stem cells and cancer51
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer51
Interference between copper transport systems and platinum drugs51
Glyco-nanoparticles: New drug delivery systems in cancer therapy51
Repurposing quinacrine for treatment-refractory cancer51
Integrated approaches for precision oncology in colorectal cancer: The more you know, the better51
Small cell lung cancer transformation: From pathogenesis to treatment51
Implications of nanotechnology for the treatment of cancer: Recent advances51
Senescence and the tumor-immune landscape: Implications for cancer immunotherapy50
Effects of statins on brain tumors: a review50
Transcription factors in SOX family: Potent regulators for cancer initiation and development in the human body49
Targeting NRF2 to treat cancer49
Biological functions of therapy-induced senescence in cancer48
The genomic landscape of pediatric acute lymphoblastic leukemia and precision medicine opportunities48
Vaginal microbiome and cervical cancer48
Turning liabilities into opportunities: Off-target based drug repurposing in cancer48
Probiotics in microbiome ecological balance providing a therapeutic window against cancer48
Noncoding RNAs as potential mediators of resistance to cancer immunotherapy47
Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance47
The evolutionary legacy of immune checkpoint inhibitors47
How far have we explored fungi to fight cancer?46
Uveal melanoma pathobiology: Metastasis to the liver46
Dendrimers as nanoscale vectors: Unlocking the bars of cancer therapy46
Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment46
Post-translational regulations of PD-L1 and PD-1: Mechanisms and opportunities for combined immunotherapy46
Microbiota and gastric cancer45
Targeted delivery of miRNA based therapeuticals in the clinical management of Glioblastoma Multiforme45
Cancer stem cells in TNBC45
Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling45
The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib45
Cancer epigenetics: Past, present and future45
Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for clinical translation45
Polyploidy formation in cancer cells: How a Trojan horse is born45
Emerging roles of long non-coding RNAs in breast cancer biology and management45
Epithelial-mesenchymal transition: Insights into nickel-induced lung diseases45
Gold nanoparticles and cancer: Detection, diagnosis and therapy44
Extracellular vesicles, the cornerstone of next-generation cancer diagnosis?44
Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment44
Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging44
Repurposing drugs in oncology: From candidate selection to clinical adoption44
Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy44
Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment43
Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies43
Cullin-RING Ligase 5: Functional characterization and its role in human cancers43
Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent43
MicroRNA and ER stress in cancer42
ITCH as a potential therapeutic target in human cancers42
Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review42
Exposing Hidden Targets: Combining epigenetic and immunotherapy to overcome cancer resistance42
New Advances in Molecular Breast Cancer Pathology42
Microbes-mediated synthesis strategies of metal nanoparticles and their potential role in cancer therapeutics41
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy41
The interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era40
STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges40
The two sides of Hippo pathway in cancer40
Epigenetic modifications of autophagy in cancer and cancer therapeutics40
Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data40
Genome chaos: Creating new genomic information essential for cancer macroevolution40
Emerging applications of bacteria as antitumor agents40
Autophagy in cancer: Recent advances and future directions40
Chemokines in triple-negative breast cancer heterogeneity: New challenges for clinical implications39
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications39
Multiple endocrine neoplasia type 2: A review39
Clinical utility of whole-genome sequencing in precision oncology39
Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator39
The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance39
Nanotechnological based miRNA intervention in the therapeutic management of neuroblastoma39
Understanding and targeting prostate cancer cell heterogeneity and plasticity39
News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors38
Transcriptomics and solid tumors: The next frontier in precision cancer medicine38
Dissecting miRNA facilitated physiology and function in human breast cancer for therapeutic intervention38
Artificial intelligence-based prediction of clinical outcome in immunotherapy and targeted therapy of lung cancer38
Deep computational pathology in breast cancer38
Targeting integrins for cancer management using nanotherapeutic approaches: Recent advances and challenges38
Targeting the tumour microenvironment in platinum-resistant ovarian cancer38
Progress and promises of epigenetic drugs and epigenetic diets in cancer prevention and therapy: A clinical update38
Tumor hypoxia: From basic knowledge to therapeutic implications38
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer38
Drug rechanneling: A novel paradigm for cancer treatment38
Radiation therapy-induced remodeling of the tumor immune microenvironment38
Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers38
Roles of microbiota in response to cancer immunotherapy38
Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins37
Nanoparticle-based drug delivery systems in cancer: A focus on inflammatory pathways37
SOX17 in cellular reprogramming and cancer37
Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplas37
Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs37
Multifaceted role of chemokines in solid tumors: From biology to therapy37
Carcinogenic microbiota and its role in colorectal cancer development37
Tumor antigens heterogeneity and immune response-targeting neoantigens in breast cancer37
Cyclin D degradation by E3 ligases in cancer progression and treatment37
Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer37
Tumor microenvironment conditions that favor vessel co-option in colorectal cancer liver metastases: A theoretical model37
Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity37
Microbiota and prostate cancer36
HDL and cancer - causality still needs to be confirmed? Update 202036
Significance of human microbiome in breast cancer: Tale of an invisible and an invincible36
Small cell lung cancer: Novel treatments beyond immunotherapy36
New approaches for targeting platinum-resistant ovarian cancer36
Polyploid giant cancer cells: An emerging new field of cancer biology36
Pomegranate bioactive constituents target multiple oncogenic and oncosuppressive signaling for cancer prevention and intervention35
The clinical value of detecting microcalcifications on a mammogram35
Targeting the acetylation signaling pathway in cancer therapy35
Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy35
Targeting matrix metalloproteinases by E3 ubiquitin ligases as a way to regulate the tumor microenvironment for cancer therapy35
Drug repurposing for cancer therapy, easier said than done35
Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment35
Paradoxes of cancer: Survival at the brink35
The unique immune microenvironment of liver metastases: Challenges and opportunities35
Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer35
Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics?35
Nanomedicine as a putative approach for active targeting of hepatocellular carcinoma34
Targeting tumor cell senescence and polyploidy as potential therapeutic strategies34
Overcoming immunotherapeutic resistance by targeting the cancer inflammation cycle34
Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: Current status and future perspectives34
The role of tumor microenvironment and exosomes in dormancy and relapse34
Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation34
Natural compounds modulate the crosstalk between apoptosis- and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells34
Necroptosis pathways in tumorigenesis34
Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics34
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