American Journal of Respiratory Cell and Molecular Biology

Article	Citations
Novel Hemodynamic, Vascular Lesion, and Cytokine/Chemokine Differences Regarding Sex in a Pulmonary Arterial Hypertension Model	76
Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease	73
Temporal Release of IL-1 Family Members from Virally Infected Airway Epithelial Cells Suggests IL-36γ is the Early Responder	73
Targeting S1PR2 in Sepsis, One Fragmented Mitochondrion at a Time	62
Molecular Maestro in the Lung: The Sphingolipid Rheostat	55
LPS Increases Artery but Not Airway Contraction in Precision-Cut Lung Slices from a Mouse Model of Acute Respiratory Distress Syndrome	55
Gene-ius at Work: Decoding Cell States through Expression	41
Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis	39
Impact of Canadian Wildfire Smoke Exposure on Nasal Inflammation Markers in New York City Residents	37
Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation–Contraction Coupling	35
Cardiac and Pulmonary Vascular Dysfunction in Vitamin D–Deficient Bmpr2 -Mutant Rats	31
Sputum Metabolomic Signature and Dynamic Change of Cough Variant Asthma	31
Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension	30
CXCL14 Protects Against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages	30
Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury	30
New Insights Relating Gasdermin B to the Onset of Childhood Asthma	30
MLKL Protects Pulmonary Endothelial Cells in Acute Lung Injury	29
Plasma Proteome Profiles Associated with Early Development of Lung Injury in Extremely Preterm Infants	29
MOTS-c Promotes Glycolysis via AMPK–HIF-1α–PFKFB3 Pathway to Ameliorate Cardiopulmonary Bypass–induced Lung Injury	28
Intestinal Microbiota-Derived Propionic Acid Protects Against Zinc Oxide Nanoparticle–Induced Lung Injury	28
IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors’ Function	28
July Highlights/Papers by Junior Investigators/NIH News	27
When a DEAD-Box Protein is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction	27
Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses	27
Exposure to Urban Air Pollution Particulate Matter Modifies Th1/Th2 Mtb Immunity in the Human Lung	26

Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2	26
Long Story Short: Understanding Isoform-Specific Expression of FAM13A	26
December Highlights/Papers by Junior Investigators/NIH News	26
Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA+ Myofibroblast	25
October Highlights/Papers by Junior Investigators/NIH News	25
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures	24
MicroRNA Control Lipid-laden Alveolar Macrophages in Smokers: A Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease?	24
CSP7 Protects Alveolar Epithelial Cells by Targeting p53 -Fibrinolytic Pathways During Lung Injuries	24
Yield and Diversity of Human Distal Lung Epithelial Cells Isolated by Different Sorting Strategies	24
Circulating Myeloid Cell–derived Extracellular Vesicles as Mediators of Indirect Acute Lung Injury	24
Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium during Influenza Infection	24
Tartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma	23
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice	23
Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth	23
Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis	23
Adenovirus-mediated Overexpression of FcγRIIB Attenuates Pulmonary Inflammation and Fibrosis	22
Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor	22
ATP12A: Connecting Mucus and Fibrosis in Idiopathic Pulmonary Fibrosis	22
von Willebrand Factor: An Unhealthy Bond between Lung Endothelium and Pulmonary Fibrosis	22
Whole-Genome Methylation Sequencing Reveals that COVID-19–induced Epigenetic Dysregulation Remains 1 Year after Hospital Discharge	22
PINK1/PARKIN-mediated Mitophagy: Friend or Foe in Hypoxia-induced Pulmonary Vascular Remodeling?	21
Lung Interstitial Macrophages Can Present Soluble Antigens and Induce Foxp3+ Regulatory T Cells	21
October Highlights/Papers by Junior Investigators/NIH News	20
When It Comes to COVID-19, Inflammation Is All the RAGE	20
Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking	20
Cough-Variant Asthma: The Asthma Phenotype No One Coughs About	20
Achieving Excellence and Engaging Members	20
The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration	20
LKB1 Regulates Pulmonary Hypertension Endothelial Cell Mitochondria: Another Layer of the Pulmonary Vascular Onion?	20
KAT’s in the Cradle: p300/CBP and Regulation of HIF-1 and Blood Pressure during Intermittent Hypoxia	20
AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex	19
Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle	19
Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection	19
Akt-Driven TGF-β and DKK1 Secretion Impairs F508del Cystic Fibrosis Airway Epithelium Polarity	19
A Murine Model of Mycobacterium abscessus Infection Mimics Pathology of Chronic Human Lung Disease	19
Acidic Enough for a Healthy Breath	19
TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury	19
Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-Driven Pulmonary Hypertension by Suppressing HIF-2α	19
Enhanced Gαq Signaling in TSC2 -Deficient Cells Is Required for Their Neoplastic Behavior	19
2022-2023 Journal Award Winners	19
From Protein Folding to Precision Therapy: Surfactant Protein A in the Spotlight	18
Chronic Alcohol Intake Compromises Lung Immunity by Altering Immunometabolism in Humans and Mouse Models	18
A Single-Cell RNA Sequencing Atlas of the Chronic Obstructive Pulmonary Disease Distal Lung to Predict Cell–Cell Communication	18
A Unique CD27-IgD- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity	18
Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection	18
Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor–dependent Airway Smooth Muscle Contraction	17
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice	17
Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction	17
Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium	17
Soluble E-Cadherin Contributes to Airway Inflammation in Severe Asthma	17

Peripheral Blood Omics and Other Multiplex-based Systems in Pulmonary and Critical Care Medicine	17
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment	17
Mitochondria-derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension	16
Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia	16
Searching for an Animal Model with Clinical Features of Scleroderma	16
Pirfenidone Mitigates Transforming Growth Factor-β–induced Inflammation after Viral Infection	16
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways	16
Demystifying Bitter Taste Receptor Relaxation of Airway Smooth Muscle	16
Unveiling Organ Failure in the Critically Ill: Insights through the Metabolite Lens	16
April Highlights/Papers by Junior Investigators/NIH News	16
Loss of Iron Regulatory Protein 2 Protects Mice from Lung Inflammation during Bronchoconstriction	16
Biomarkers of Fibrosis in Patients with COVID-19 One Year After Hospital Discharge: A Prospective Cohort Study	15
TMPRSS11E-dward Scissorhands? Proteolysis Potentiates Lung Inflammation during Pathogen Insult	15
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells	15
Comparison of Droplet- and Microwell-based Methods to Analyze Cryopreserved Human BAL Cells by Single-Cell RNA Sequencing	15
An Antiviral Effect of Linoleic Acid Against Rhinovirus Infection	15
Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension through Orai-Ca2+ Channels	15
Airway Immune Signatures in Severe and Fatal Infection with COVID-19	15
Sodium Houttuyfonate Alleviates Monocrotaline-induced Pulmonary Hypertension by Regulating Orai1 and Orai2	15
Prenatal LPS Exposure Promotes Allergic Airway Inflammation via Long Coding RNA NONMMUT033452.2, and Protein Binding Partner, Eef1D	15
Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development	15
Alveolar and Bone Marrow–derived Macrophages Differ in Metabolism and Glutamine Utilization	15
A Novel Role for γδ T Cells in Protection Against Severe Melioidosis	14
Recessive Mutations in CFAP74 Cause Primary Ciliary Dyskinesia with Normal Ciliary Ultrastructure	14
January Highlights/Papers by Junior Investigators/NIH News	14
Leveraging Microbial Symbiosis to Modulate Bronchopulmonary Dysplasia	14
Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis	14
Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity	14
DNA–Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension	14
Pulmonary and Nonpulmonary Sepsis Differentially Modulate Lung Immunity toward Secondary Bacterial Pneumonia: A Critical Role for Alveolar Macrophages	14
Tipping the Balance of Ubiquitination toward a Therapy for COVID-19	14
A NEAT Discovery Hints at Altered Golgi Signaling in Lung Fibrosis	13
A New Methodology for the Oxygen Measurement in Lung Tissue of an Aged Ferret Model Proves Hypoxia during COVID-19	13
Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity	13
Breath Markers of Oxidative Stress in Children with Severe Viral Lower Respiratory Tract Infection	13
SOX17 Prevents Endothelial–Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling	13
Chronic Obstructive Pulmonary Disease Airway Epithelial Cell–derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a	13
Cell Surface RNA Expression Modulates Alveolar Epithelial Function	13
February Highlights/Papers by Junior Investigators/NIH News	13
HPS6 Deficiency Leads to Reduced Vacuolar-Type H+-ATPase and Impaired Biogenesis of Lamellar Bodies in Alveolar Type II Cells	13
Pulmonary Microvascular Endothelial Cells Support Alveolar Epithelial Growth via Bone Morphogenetic Protein 6 Secretion	13
When Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury	13
July Highlights/Papers by Junior Investigators/NIH News	12
The Gut–Lung Axis: What’s below the Diaphragm Is Also Important	12
Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer	12
A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung	12
Epigenomic Dysregulation in Youth Vapers: Implications for Disease Risk Assessment	12
Alveolar Epithelial Cell Dysfunction in Idiopathic Pulmonary Fibrosis Linked to Lipid Alterations: Therapeutic Implications	12
Dual Pigment Epithelium-derived Factor and Hepatocyte Growth Factor Overexpression: A New Therapy for Pulmonary Hypertension	12
The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia	12
Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung	12
September Highlights/Papers by Junior Investigators/NIH News	12
Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension	12
Kasugamycin Is a Novel Chitinase 1 Inhibitor with Strong Antifibrotic Effects on Pulmonary Fibrosis	12
Amphipathic Helical Peptide L37pA Protects against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor	12
June Highlights/Papers by Junior Investigators/NIH News	11
Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?	11
Activated Clec4nhi Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner	11
Peripheral Transcriptome of Severe Sarcoidosis Involves Dysregulation of Multiple Immunologic Systems	11
Investigation of CFTR Function in Human Nasal Epithelial Cells Informs Personalized Medicine	11
Cell Population–resolved Multiomics Atlas of the Developing Lung	11
Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p	11
Microenvironment Regulators of Metastasis Favor Lymphangioleiomyomatosis Cell Growth and Disease Progression	11
Monocytes: See One Queuing Local Adaptive Immune Responses to Respiratory Viruses	11
Unveiling an Important New Cell Type in the Lung: Microfold Cells	11
Chronic Kidney Disease–associated Lung Injury Is Mediated by Phosphate-induced MAPK/AKT Signaling	11
Mycobacterium tuberculosis Induces Warburg Metabolism in Human Alveolar Macrophages: A Transcriptomic Analysis	11
Bubble Trouble: Epithelial Extracellular Vesicles and Their microRNA Mischief in Chronic Obstructive Pulmonary Disease	11
Switching On Gene Therapy for Allergic Rhinitis: The AAVITS Approach	11
Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation	11
Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia	10
Lipids to the Rescue in Pulmonary Fibrosis: Biosynthesis, Bioenergetics, or Epigenetics?	10
Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Emphysema	10
On the Ultrastructure of Aberrant Basaloid Cells in Idiopathic Pulmonary Fibrosis	10
Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs	10
You Can’t Spell Shear without “She”: Mechanobiology and Sex Differences in Hypoxic Lung Disease	10
Respiratory Epithelial Cell Surface Decoration Provides Defense against Bacterial Damage during Infection	10
Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet–Neutrophil Interactions	10
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia	10
Characteristics and Regulation of Human Eosinophil ETosis In Vitro	10

One More Negative Regulator of AC6: S-Nitrosylation	10
Reply to Fujino et al. : Human Lung Cell Separation Strategies for Translational Research	10
December Highlights/Papers by Junior Investigators/NIH News	10
Engineering HMGB1-derived Peptides to Unravel Sex-Specific Mechanisms in Pulmonary Arterial Hypertension	10
Suppression of Allergic Asthma by Loss of Function of Miz1-mediated Th1 Skewing	10
LAM–CAM: In Vivo Model for Rapid Analysis of Lymphangioleiomyomatosis Tumor Formation and Inhibition	10
Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury	9
“It’s a Trap”: Eosinophils Caught between Pro- and Anti-inflammatory Responses	9
Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells	9
Mitochondrial Transfer Regulates Bioenergetics in Healthy and Chronic Obstructive Pulmonary Disease Airway Smooth Muscle	9
Reanalysis of Single-Cell RNA-Sequencing Data in Patients with COVID-19: Insights and Limitations	9
May Highlights/Papers by Junior Investigators/NIH News	9
Can ENaC “TIP” the Scales to Reduce Endothelial Reactive Oxygen Species and Vascular Leak during Pneumococcal Lung Injury?	9
Selective Inhibition of Extracellular Signal-regulated Kinases 1 and 2: When Less Is More	9
Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis	9
Cystic Fibrosis: “Ionocyte Modulators”?	9
Identification of Lymphangioleiomyomatosis-associated Serum MicroRNAs	9
The Potential of Extracellular Microvesicle MicroRNAs in Precapillary Pulmonary Hypertension	9
Interferon with Dogma in Cytokine Release Syndrome and Acute Lung Injury	9
Efficient Adeno-associated Virus–mediated Transgenesis in Alveolar Stem Cells and Associated Niches	9
Ventilator-Induced Lung Injury Promotes Inflammation Within the Pleural Cavity	9
Analysis of Aberrant Splicing Events and Gene Expression Outliers in Primary Ciliary Dyskinesia	9
A Functional Variant rs2122031 in ATG7 Is Associated with the Risk of Radiation Pneumonitis	9
Sex Matters: A Deep Dive into Sex Differences in Chronic Obstructive Pulmonary Disease	9
March Highlights/Papers by Junior Investigators/NIH News	9