Pharmacological Research

Papers
(The TQCC of Pharmacological Research is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)435
Candidate drugs against SARS-CoV-2 and COVID-19389
Traditional Chinese medicine for COVID-19 treatment388
Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor250
The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis244
Properties of FDA-approved small molecule protein kinase inhibitors: A 2021 update240
The Application of Ferroptosis in Diseases234
The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders205
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance196
Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)193
30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: A prospective cohort study188
Berberine pharmacology and the gut microbiota: A hidden therapeutic link172
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms169
Curcumin: an inflammasome silencer166
Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study162
Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status154
Efficacy and Safety of Integrated Traditional Chinese and Western Medicine for Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis151
Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy145
Efficacy of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in treatment of COVID-19: A randomized controlled trial143
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology142
Hydrogen sulfide: An endogenous regulator of the immune system136
Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder136
Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update132
ACEI/ARB use and risk of infection or severity or mortality of COVID-19: A systematic review and meta-analysis131
Ferroptosis and its emerging roles in cardiovascular diseases127
Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications118
Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials118
Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis114
New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily114
The hormetic dose-response mechanism: Nrf2 activation113
HDAC6 as privileged target in drug discovery: A perspective112
Empagliflozin protects heart from inflammation and energy depletion via AMPK activation112
Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review111
Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis110
Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis107
Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives105
Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study103
Properties of FDA-approved small molecule protein kinase inhibitors: A 2023 update102
Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases102
Cytokines in inflammatory bowel diseases – Update 2020101
“Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”99
Intercellular crosstalk of hepatic stellate cells in liver fibrosis: New insights into therapy99
Targeting obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review97
Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology97
Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway97
Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology96
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke95
Clinical impact of pre-admission antithrombotic therapy in hospitalized patients with COVID-19: A multicenter observational study93
Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence93
Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis93
Skeletal muscle atrophy: From mechanisms to treatments91
Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer91
RNA methylation and cancer treatment90
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice89
Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review89
Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy89
Prospective therapeutic potential of Tanshinone IIA: An updated overview88
Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner88
A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)88
TGF-β in radiotherapy: Mechanisms of tumor resistance and normal tissues injury87
Nose to brain drug delivery - A promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion87
Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells86
Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2/AMPK/TSC2 pathway86
Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder84
Drugs and hepatic transporters: A review84
Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer – A comprehensive review from chemotherapy to immunotherapy84
The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?83
Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro83
Resveratrol and endothelial function: A literature review83
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects82
The interactions between gut microbiota and bioactive ingredients of traditional Chinese medicines: A review81
Acute lung injury: The therapeutic role of Rho kinase inhibitors81
Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission81
Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance81
Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of T80
Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis79
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism79
Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent77
EGFR mutation mediates resistance to EGFR tyrosine kinase inhibitors in NSCLC: From molecular mechanisms to clinical research77
The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases77
Mechanisms of statin-associated skeletal muscle-associated symptoms77
Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites77
Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy76
Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases75
PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinoma75
Current Policies and Measures on the Development of Traditional Chinese Medicine in China74
Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability74
Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol74
Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals73
Targeting inflammation and cytokine storm in COVID-1972
Anti-diabetic drugs and weight loss in patients with type 2 diabetes72
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications72
Amelioration of diastolic dysfunction by dapagliflozin in a non-diabetic model involves coronary endothelium71
Genetics and epigenetics of IBD71
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization70
Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease70
Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review70
Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy70
Baicalin mediated regulation of key signaling pathways in cancer69
Nitazoxanide/azithromycin combination for COVID-19: A suggested new protocol for early management68
Obesity and NRF2-mediated cytoprotection: Where is the missing link?68
Lycopene in protection against obesity and diabetes: A mechanistic review68
Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives67
Acute kidney injury is associated with severe infection and fatality in patients with COVID-19: A systematic review and meta-analysis of 40 studies and 24,527 patients67
Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review67
Efficacy and safety of current therapeutic options for COVID-19 - lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis66
The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists66
MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis65
Tumor-associated macrophages: A promising target for a cancer immunotherapeutic strategy65
Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp2764
Reproductive toxic potential of phthalate compounds – State of art review64
Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms64
The current use and evolving landscape of nutraceuticals64
Blame the signaling: Role of cAMP for the resolution of inflammation63
COVID-19 and Kawasaki disease in children63
The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence63
Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: A retrospective multicenter cohort study63
Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells63
Endoplasmic reticulum stress and protein degradation in chronic liver disease61
Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers61
A molecular view of the function and pharmacology of acid-sensing ion channels61
COVID-19, hypertension and cardiovascular diseases: Should we change the therapy?60
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways60
Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells60
Epigenetics in NAFLD/NASH: Targets and therapy60
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy59
Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways58
Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome57
Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection57
CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent57
A unique CDK4/6 inhibitor: Current and future therapeutic strategies of abemaciclib57
Optimal use of lipid-lowering therapy after acute coronary syndromes: A Position Paper endorsed by the International Lipid Expert Panel (ILEP)56
Exploring the mechanism of TCM formulae in the treatment of different types of coronary heart disease by network pharmacology and machining learning56
Sesquiterpenes and their derivatives-natural anticancer compounds: An update56
A review of pharmacological and pharmacokinetic properties of stachydrine56
Effect of sodium-glucose co-transporter 2 inhibitors on lipid profile: A systematic review and meta-analysis of 48 randomized controlled trials56
Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway56
HBV induced hepatocellular carcinoma and related potential immunotherapy55
Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors55
The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis54
Clinical approach to the inflammatory etiology of cardiovascular diseases54
Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders54
Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic54
Map kinase signaling as therapeutic target for neurodegeneration53
Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach53
NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators?53
STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response53
Why do some asthma patients respond poorly to glucocorticoid therapy?52
Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system52
Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production51
Pirfenidone is a cardioprotective drug: Mechanisms of action and preclinical evidence51
Ivermectin, a potential anticancer drug derived from an antiparasitic drug51
Repurposing of antipsychotic trifluoperazine for treating brain metastasis, lung metastasis and bone metastasis of melanoma by disrupting autophagy flux51
Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases51
Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system51
Targeting the β-catenin signaling for cancer therapy50
Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors50
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry50
Role of 5-HT receptors in neuropathic pain: potential therapeutic implications50
Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues50
Purinergic signaling orchestrating neuron-glia communication50
The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review50
Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications49
Resveratrol: Mechanistic and therapeutic perspectives in pulmonary arterial hypertension49
MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB249
Celastrol in metabolic diseases: Progress and application prospects49
The role of the LTB4-BLT1 axis in health and disease49
Parthanatos and its associated components: Promising therapeutic targets for cancer49
A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics48
Endoplasmic reticulum stress signaling in cancer and neurodegenerative disorders: Tools and strategies to understand its complexity48
Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations48
Darunavir does not prevent SARS-CoV-2 infection in HIV patients48
Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis48
Orally effective FDA-approved protein kinase targeted covalent inhibitors (TCIs)47
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications47
Naturally-derived targeted therapy for wound healing: Beyond classical strategies47
Gold Nanoparticles in Glioma Theranostics47
BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection47
Autophagy-related microRNAs: Possible regulatory roles and therapeutic potential in and gastrointestinal cancers47
Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe47
Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities47
Structure and function of USP5: Insight into physiological and pathophysiological roles46
Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification46
Polypharmacology: The science of multi-targeting molecules46
DNA methylation of FTO promotes renal inflammation by enhancing m6A of PPAR-α in alcohol-induced kidney injury46
Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway46
A review of pharmacological and pharmacokinetic properties of Forsythiaside A46
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury46
ASTILBIN: A PROMISING UNEXPLORED COMPOUND WITH MULTIDIMENSIONAL MEDICINAL AND HEALTH BENEFITS46
Metabolomics identified new biomarkers for the precise diagnosis of pancreatic cancer and associated tissue metastasis46
Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 202045
Role of epigenetic regulation in myocardial ischemia/reperfusion injury45
Hypoxia-inducible factor-1: Regulatory mechanisms and drug development in stroke45
Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway44
Cognitive impairment and type 2 diabetes mellitus: Focus of SGLT2 inhibitors treatment44
MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH44
Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications44
Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets44
Developing effective combination therapy for pancreatic cancer: An overview44
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy44
Targeting LSD1 for acute myeloid leukemia (AML) treatment44
Oral administration of protein nanoparticles: An emerging route to disease treatment44
The revitalization of antimicrobial peptides in the resistance era44
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases43
Inflammatory Bowel Disease – Non-biological treatment43
Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes43
Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action43
Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions43
Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy43
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats43
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis43
The study on the treatment of Xuebijing injection (XBJ) in adults with severe or critical Corona Virus Disease 2019 and the inhibitory effect of XBJ against SARS-CoV-242
Dysbiosis is one of the risk factor for stroke and cognitive impairment and potential target for treatment42
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey42
Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2): Achievement and Future for Novel Cancer Therapy42
Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases42
PACS-2: A key regulator of mitochondria-associated membranes (MAMs)42
Clinical experience with CTLA-4 blockade for cancer immunotherapy: From the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules targeting the tumor microenvironment42
SIRT1-FOXOs activity regulates diabetic complications42
New frontiers against sorafenib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers42
Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer42
Lactobacillus fermentum CECT5716 ameliorates high fat diet-induced obesity in mice through modulation of gut microbiota dysbiosis42
Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases42
Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis42
ER membranes associated with mitochondria: Possible therapeutic targets in heart-associated diseases42
Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy41
Delivery routes for faecal microbiota transplants: Available, anticipated and aspired41
Aducanumab for Alzheimer’s disease: A regulatory perspective41
Angiotensin receptor blockers and COVID-1941
The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates40
Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation40
Mulberry leaf (Morus alba L.): A review of its potential influences in mechanisms of action on metabolic diseases40
USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury40
Natural and synthetic compounds as dissociated agonists of glucocorticoid receptor40
Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis40
Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds40
Efficacy and safety of HIF prolyl-hydroxylase inhibitor vs epoetin and darbepoetin for anemia in chronic kidney disease patients not undergoing dialysis: A network meta-analysis40
Thioredoxin reductase as a pharmacological target40
Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonists39
The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics39
Borneol in cardio-cerebrovascular diseases: Pharmacological actions, mechanisms, and therapeutics39
Lipoprotein(a): Knowns, unknowns and uncertainties39
Management of inflammation in cardiovascular diseases39
TRAIL in oncology: From recombinant TRAIL to nano- and self-targeted TRAIL-based therapies39
Properties of FDA-approved small molecule phosphatidylinositol 3-kinase inhibitors prescribed for the treatment of malignancies39
Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies39
miR-103a-3p regulates mitophagy in Parkinson’s disease through Parkin/Ambra1 signaling39
Targeting of endoplasmic reticulum (ER) stress in gliomas39
Neutrophil extracellular traps in inflammatory bowel diseases: Implications in pathogenesis and therapeutic targets39
DNA methyltransferase mediates the hypermethylation of the microRNA 34a promoter and enhances the resistance of patient-derived pancreatic cancer cells to molecular targeting agents38
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