Pharmacological Research

Article	Citations
IUPHAR-review: Targeting the cytoskeleton as a therapeutic approach to substance use disorders	361
Promising LOX proteins for cartilage-targeting osteoarthritis therapy	356
A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol	309
Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions	270
Do cytokines play a role in the transition from acute to chronic musculoskeletal pain?	196
Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization	177
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	165
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	162
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	157
Synthesized nanoparticles, biomimetic nanoparticles and extracellular vesicles for treatment of autoimmune disease: Comparison and prospect	156
New therapeutic approaches in children’s medicine towards solving critical issues in pediatrics	154
Nucleic acid therapy in pediatric cancer	139
Substance use disorders and cooperative research on addictions: Spanish approach as a model	135
CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer	134
Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway	131
NLRP3 inflammasome links vascular senescence to diabetic vascular lesions	131
The current use and evolving landscape of nutraceuticals	129
Emerging role for branched-chain amino acids metabolism in fibrosis	127
Effect of Bifidobacterium animalis subsp. lactis SF on enhancing the tumor suppression of irinotecan by regulating the intestinal flora	126
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	120
Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail diabetic elders with chronic kidney disease	119
Selenium supplementation effect on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials	118
Photosensitizer IR700DX-6T- and IR700DX-mbc94-mediated photodynamic therapy markedly elicits anticancer immune responses during treatment of pancreatic cancer	114
Immunity and inflammation in pulmonary arterial hypertension: From pathophysiology mechanisms to treatment perspective	111
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	111

SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies	110
Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting	109
Editorial Board	107
Editorial Board	107
Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?	106
Editorial Board	100
Editorial Board	95
Comment: Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children	95
Anti-metastatic effects of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose in colorectal cancer: Regulation of cathepsin B-mediated extracellular matrix dynamics and epithelial-to-mesenchymal transition	94
Response to the comment on "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies"	94
The novel role of glucocorticoid-induced leucine zipper as a marker of mucosal healing in inflammatory bowel diseases	94
Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-	94
Phenolipid JE improves metabolic profile and inhibits gluconeogenesis via modulating AKT-mediated insulin signaling in STZ-induced diabetic mice	92
Editorial Board	90
Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond	89
BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice	85
Vitamin D supplementation: an adjunct therapy for improving inflammatory and oxidative stress?	84
Treating COVID-19 with NRICM101 and NRICM102 – Author’s reply 2	83
Ultrasound and microbubble assisted drug delivery – A clinical pharmacological perspective	82
Pearson syndrome-like anemia induced by accumulation of mutant mtDNA and anemia with imbalanced white blood cell lineages induced by Drp1 deletion in a murine model	81
Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study	79
Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving β2-agonists rescue therapy	77
Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors	76
Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder	76
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	75
eATP and autoimmune diabetes	74
Comparative efficacy and rankings of therapeutics for ALK-positive non-small cell lung cancer with brain metastasis: Updated results from a Bayesian network analysis based on randomized controlled tri	74
Response to the comment “Is SGLT2i superior to DPP4i for primary and secondary prevention of cardiovascular diseases and death in patients with type 2 diabetes?”	72
Development status and prospects of international standardization of medical devices of Traditional Chinese Medicine	72
Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes	72
Editorial Board	72
DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-κB pathway	71
Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates	71
Key factors influencing the TCM nomenclature in international standards	70
Features and development trends in international standardization of Chinese materia medica in ISO/TC 249	69
Editorial Board	67
Editorial Board	66
Mesenchymal stem cells plus bone repair materials as a therapeutic strategy for abnormal bone metabolism: Evidence of clinical efficacy and mechanisms of action implied	65
Prescribing statin therapy in physically (in)active individuals vs prescribing physical activity in statin-treated patients: A four-scenario practical approach	65
Posttranslational modifications as therapeutic targets for intestinal disorders	64
Astaxanthin: A promising therapeutic agent for organ fibrosis	64
Outcomes following KRASG12C inhibitor treatment in patients with KRASG12C-mutated solid tumors: A systematic review and meta-analysis	64
The role of pyroptosis in incomplete immune reconstitution among people living with HIV：Potential therapeutic targets	64
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	64
Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review	63
Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis	63
Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial mesenchymal transition and β-catenin signaling	63
Cannabis induced psychosis: A systematic review on the role of genetic polymorphisms	62
PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis	62
Peptidic vaccines: The new cure for heart diseases?	62

Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex	61
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	60
Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy	60
Potentiation and allosteric agonist activation of α7 nicotinic acetylcholine receptors: binding sites and hypotheses	60
Developing patient-derived organoids to predict PARP inhibitor response and explore resistance overcoming strategies in ovarian cancer	59
Anti-rheumatic drug-induced hepatitis B virus reactivation and preventive strategies for hepatocellular carcinoma	59
Commentary on “Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects”	59
Counteracting health risks by Modulating Homeostatic Signaling	57
Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan	57
Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine	57
Bedaquiline and Linezolid improve anti-TB treatment outcome in drug-resistant TB patients with HIV: A systematic review and meta-analysis	57
Role of neuroglia in neuropathic pain and depression	56
Biomimetic micelles to accurately regulate the inflammatory microenvironment for glomerulonephritis treatment	56
Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data	56
Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial	55
TRIM47 accelerates aerobic glycolysis and tumor progression through regulating ubiquitination of FBP1 in pancreatic cancer	55
The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications	55
Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine	55
IL-3 signalling in the tumour microenvironment shapes the immune response via tumour endothelial cell-derived extracellular vesicles	54
Circulating extracellular vesicles derived from tumor endothelial cells hijack the local and systemic anti-tumor immune response: Role of mTOR/G-CSF pathway	54
PCSK9 inhibition and broad health outcomes: A Mendelian randomization phenome‑wide association study	53
SIRT3 as a potential therapeutic target for heart failure	53
Checkpoints and immunity in cancers: Role of GNG12	53
When will the immune-stimulating antibody conjugates (ISACs) be transferred from bench to bedside?	53
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	53
G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation	53
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	52
STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop	52
Saliva sampling for chasing SARS-CoV-2: A Game-changing strategy	52
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	52
Pharmacometabolomics may be the next stamp in the pharmacogenetic passport	52
Editorial Board	52
Reply to the Comment on “1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis”	52
Selectively targeting individual bromodomain: Drug discovery and molecular mechanisms	52
Time-dependent proteomics and drug response in expanding cancer cells	52
New insights into the role and therapeutic potential of HSP70 in diabetes	52
Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization	52
A review on the relationship of mast cells and macrophages in breast cancer — Can herbs or natural products facilitate their anti-tumor effects?	51
GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer	51
Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia	51
Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma	50
AHR canonical pathway: in vivo findings to support novel antihypertensive strategies	50
Targeting Type I IFN/STAT1 signaling inhibited and reversed corneal squamous metaplasia in Aire-deficient mouse	50
Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients	50
Pharmacological combination of nivolumab with dendritic cell vaccines in cancer immunotherapy: An overview	50
Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy	50
Second-generation antipsychotics induce cardiotoxicity by disrupting spliceosome signaling: Implications from proteomic and transcriptomic analyses	49
Epoxymicheliolide directly targets histone H2B to inhibit neuroinflammation via recruiting E3 ligase RNF20	49
Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection	49
Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation	49
Pathophysiology of nAChRs: Limbic circuits and related disorders	49
Role of dynamin-related protein 1-dependent mitochondrial fission in drug-induced toxicity	48
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	48
Integrins play a role in stress relaxation of perivascular adipose tissue	48
Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors—A review	48
Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease	48
Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway	48
Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain	47
In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3	47
Luteolin attenuates cancer cell stemness in PTX-resistant oesophageal cancer cells through mediating SOX2 protein stability	47
Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice	46
Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine	46
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	46
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway	46
Methodological considerations in assessing GLP-1 receptor agonists and gastrointestinal cancer risk	45
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment	45
Targeting gut microbiota as a therapeutic target in T2DM: A review of multi-target interactions of probiotics, prebiotics, postbiotics, and synbiotics with the intestinal barrier	45
Corrigendum to “Overcoming limitations and advancing the therapeutic potential of antibody-oligonucleotide conjugates (AOCs): Current status and future perspectives” [Pharmacol. Res. 209 (2024) 107469	45
Erratum to “Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation” [Pharmacol Res 206 (2024) 107258]	45
GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation	44
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation	44
Management of inflammation in cardiovascular diseases	44
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	44
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	44
Targeting hypoxia inducible factor-1 alpha in rheumatoid arthritis: Rationale, opportunities and challenges	44
Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis	43
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	43
FordNet: Recommending traditional Chinese medicine formula via deep neural network integrating phenotype and molecule	43
Triptolide delivery: Nanotechnology-based carrier systems to enhance efficacy and limit toxicity	42
A Pharmacological perspective on the temporal properties of sweeteners	42

New frontiers against sorafenib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	42
Antidiabetic drugs and oxidized low-density lipoprotein: A review of anti-atherosclerotic mechanisms	42
Predicting mortality after hospitalisation for COPD using electronic health records	42
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism	42
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	42
Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions	41
A multi-omics investigation of tacrolimus off-target effects on a proximal tubule cell-line	41
Extracellular vesicles DJ-1 derived from hypoxia-conditioned hMSCs alleviate cardiac hypertrophy by suppressing mitochondria dysfunction and preventing ATRAP degradation	41
Potential therapeutic compounds from traditional Chinese medicine targeting endoplasmic reticulum stress to alleviate rheumatoid arthritis	41
Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: Neuroprotective and anti-inflammatory activities	41
The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease	41
Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib	41
SGLT2-inhibitors are effective and safe in the elderly: The SOLD study	40
Ectoines as novel anti-inflammatory and tissue protective lead compounds with special focus on inflammatory bowel disease and lung inflammation	40
Amplifying hepatic L-aspartate levels suppresses CCl4-induced liver fibrosis by reversing glucocorticoid receptor β-mediated mitochondrial malfunction	40
Relationship between clonal evolution and drug resistance in bladder cancer: A genomic research review	40
Chinese herbal formula ruangan granule enhances the efficacy of entecavir to reverse advanced liver fibrosis/early cirrhosis in patients with chronic HBV infection: A multicenter, randomized clinical	40
Pathophysiology and therapeutic relevance of PI3K(p110α) protein in atrial fibrillation	40
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	40
Efficacy of tripterygium glycosides (TG) in rheumatoid arthritis as a disease-modifying anti-rheumatic drug (DMARD) in combination with conventional DMARDs: A systematic review and meta-analysis of ra	40
Gut-vascular axis and postbiotics: The need for clear definitions and further research	39
The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function	39
Exploring the therapeutic potential of apabetalone in diabetic kidney disease: Bridging preclinical findings with clinical translation	39
A Saccharomyces boulardii-derived antioxidant protein, thioredoxin, ameliorates intestinal inflammation through transactivating epidermal growth factor receptor	39
Investigating the interplay between mitophagy and diabetic neuropathy: Uncovering the hidden secrets of the disease pathology	39
IUPHAR themed review: Opioid efficacy, bias, and selectivity	39
Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants	39
Oncogenic viruses and chemoresistance: What do we know?	38
Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications	38
Efficacy and safety of liraglutide in type 2 diabetes mellitus patients complicated with coronary artery disease: A systematic review and meta-analysis of randomized controlled trials	38
Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and network meta-analysis of 111 randomized clinical trials	38
Evidence of a dual mechanism of action underlying the anti-proliferative and cytotoxic effects of ammonium-alkyloxy-stilbene-based α7- and α9-nicotinic ligands on glioblastoma cells	38
Bioactive coatings with anti-osteoclast therapeutic agents for bone implants: Enhanced compliance and prolonged implant life	37
Unfolded protein response in the activation-induced biological processes of CD8+ T cells	37
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	37
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	37
Glucocorticoids and COVID-19	37
Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies	37
Animal models to study pathogenesis and treatments of cardiac disorders in rheumatoid arthritis: Advances and challenges for clinical translation	37
Indacaterol, glycopyrronium, and mometasone: Pharmacological interaction and anti-inflammatory profile in hyperresponsive airways	37
Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism	37
The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies	36
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	36
Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden	36
Deep learning applications for the accurate identification of low-transcriptional activity drugs and their mechanism of actions	36
Insight of neonicotinoid insecticides: Exploring exposure, mechanisms in non-target organisms, and removal technologies	36
Excessive alcohol intake produces persistent mechanical allodynia and dysregulates the endocannabinoid system in the lumbar dorsal root ganglia of genetically-selected Marchigian Sardinian alcohol-pre	36
The ZDHHC13/ZDHHC17 subfamily: From biological functions to therapeutic targets of diseases	36
The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials	36
Targeting the autoreactive CD8+ T-cell receptor in type 1 diabetes: Insights from scRNA-seq for immunotherapy	36
Orosomucoid 2 is an endogenous regulator of neuronal mitochondrial biogenesis and promotes functional recovery post-stroke	36
Developing patient-derived organoids to demonstrate JX24120 inhibits SAMe synthesis in endometrial cancer by targeting MAT2B	35
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	35
Cromolyn Sodium differentially regulates human mast cell and mouse leukocyte responses to control allergic inflammation	35
Identification of the TRPA1 cannabinoid-binding site	35
Progress in the development of modulators targeting Frizzleds	35
Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential	35
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	35
Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy	35
Thioredoxin reductase as a pharmacological target	34
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	34
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	34
α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression	34
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	34
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization	34
Dual biological therapy and small molecules in pediatric inflammatory bowel disease	34
Microsomal prostaglandin E2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance	34
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	33
Bufalin for an innovative therapeutic approach against cancer	33
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	33
Berberine ameliorates ovariectomy-induced anxiety-like behaviors by enrichment in equol generating gut microbiota	33
Alpinetin ameliorates bone loss in LPS-induced inflammation osteolysis via ROS mediated P38/PI3K signaling pathway	33
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	33
Endogenous stimuli-responsive nanoparticles for cancer therapy: From bench to bedside	33
Metabolic enzymes function as epigenetic modulators: A Trojan Horse for chromatin regulation and gene expression	33
Echinacoside: A promising active natural products and pharmacological agents	33
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	33
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	32
Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15	32
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect	32
Editorial Board	32
Targeting regulated cell death in aortic aneurysm and dissection therapy	32
An overview of the pharmacological activities of scopoletin against different chronic diseases	32
The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review	32
Selection strategy of second-line biologic therapies in adult patients with ulcerative colitis following prior biologic treatment failure: Systematic review and meta-analysis	32
The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis	32
Natural-derived alkaloids exhibit great potential in the treatment of ulcerative colitis	31
Crosstalk between non-coding RNAs expression profile, drug resistance and immune response in breast cancer	31
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	31
The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets	31
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy	31
Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases	31
Deficiency of GFRα1 promotes hepatocellular carcinoma progression but enhances oxaliplatin-mediated anti-tumor efficacy	31
Future of PD-1/PD-L1 axis modulation for the treatment of triple-negative breast cancer	31
Autophagy in vascular dementia and natural products with autophagy regulating activity	31