OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 73. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	337
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	334
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	318
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	249
Editorial Board	238
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	218
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	195
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	189
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review	187
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	179
Spatial proteomic profiling reveals conserved prognostic immune microenvironment features across molecular subtypes in small cell lung cancer	174
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	171
Progress in the development of modulators targeting Frizzleds	161
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	153
An account on the history of pharmacology in Spain	150
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	143
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	137
Time-dependent proteomics and drug response in expanding cancer cells	137
Protective effect and mechanisms of puerarin in metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis of animal studies	134
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	132
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	129
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	126
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	122
Discovery, development, and characterization of potent and selective USP11 inhibitors	122
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	118

Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	116
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	113
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	105
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	105
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	105
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	104
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	102
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	101
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	100
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	99
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	98
Astaxanthin: A promising therapeutic agent for organ fibrosis	97
Rapid 64Cu radiolabeling and in vivo evaluation of DSPE–NODAGA liposomes in a murine mammary tumor model	96
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	92
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	92
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	91
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	91
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	91
Chronic caffeine consumption prevents obesity-induced cognitive and memory impairments by reducing neuroinflammation and enhancing neuronal activity in the hippocampus	90
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	88
Corrigendum to “Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders” [Phar	88
Fig-derived exosome-like nanoparticles attenuating bone metastasis of breast cancer through establishing an anti-tumor microenvironment	86
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	86
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	84
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	83
Gut-vascular axis and postbiotics: The need for clear definitions and further research	83
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	83
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	82
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	82
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries	81
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	81
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges	79
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	79
Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus	78
Metabolic disorders affecting the liver and heart: Therapeutic efficacy of miRNA-based therapies?	78
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma	77
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	76
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	76
The major histocompatibility complex participates in Parkinson’s disease	75
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression	75
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	75
Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models	75
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	75
Editorial Board	74
Regulation of nicotinic acetylcholine receptors by post-translational modifications	74
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	73
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	73
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review	73