OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 74. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	345
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	343
Editorial Board	335
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	249
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	245
Progress in the development of modulators targeting Frizzleds	228
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	212
An account on the history of pharmacology in Spain	199
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	194
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	183
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	178
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	177
Discovery, development, and characterization of potent and selective USP11 inhibitors	164
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	156
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	154
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	146
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	141
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	141
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	140
Time-dependent proteomics and drug response in expanding cancer cells	135
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review	132
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	124
Astaxanthin: A promising therapeutic agent for organ fibrosis	123
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	121
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	118

Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	115
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	113
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	111
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	110
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	108
Corrigendum to “Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders” [Phar	105
Gut-vascular axis and postbiotics: The need for clear definitions and further research	103
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	102
Rapid 64Cu radiolabeling and in vivo evaluation of DSPE–NODAGA liposomes in a murine mammary tumor model	102
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	102
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	101
Chronic caffeine consumption prevents obesity-induced cognitive and memory impairments by reducing neuroinflammation and enhancing neuronal activity in the hippocampus	99
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	99
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	97
Fig-derived exosome-like nanoparticles attenuating bone metastasis of breast cancer through establishing an anti-tumor microenvironment	94
Spatial proteomic profiling reveals conserved prognostic immune microenvironment features across molecular subtypes in small cell lung cancer	94
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	93
Protective effect and mechanisms of puerarin in metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis of animal studies	93
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	91
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	91
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	88
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	88
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	86
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	84
Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus	83
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	83
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	83
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	83
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	83
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	83
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression	82
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	82
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	82
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	81
Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets	80
A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME	79
Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient as	79
TSPO-mediated mitochondrial retrograde signaling primes the microglial NLRP3 inflammasome	78
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis	78
Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice	77
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	77
Regulation of nicotinic acetylcholine receptors by post-translational modifications	77
Editorial Board	77
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	76
Remote ischemic conditioning attenuates blood-brain barrier disruption after recombinant tissue plasminogen activator treatment via reducing PDGF-CC	76
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy	75
CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential	75
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges	75
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy	74
Role of hypoxia in cellular senescence	74