OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	276
Editorial Board	256
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	235
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	223
Gut-vascular axis and postbiotics: The need for clear definitions and further research	200
An account on the history of pharmacology in Spain	195
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	188
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	180
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	174
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	159
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	154
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	151
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	150
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	145
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	143
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	137
Polypharmacology: The science of multi-targeting molecules	135
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	134
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	132
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	130
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	127
Astaxanthin: A promising therapeutic agent for organ fibrosis	126
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	126
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	119
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	118

Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	114
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	113
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	110
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	109
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	108
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	108
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	107
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	104
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	102
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	102
Time-dependent proteomics and drug response in expanding cancer cells	101
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	101
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	99
Progress in the development of modulators targeting Frizzleds	99
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	98
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	97
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	97
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	96
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	95
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	93
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	93
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	91
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	91
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	90
Targeting regulated cell death in aortic aneurysm and dissection therapy	90
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	89
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	88
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	87
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	86
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	84
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	84
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review	83
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	83
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	82
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	81
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries	81
WITHDRAWN: Red blood cell-derived extracellular vesicles deliver NUP85 siRNA to alleviate MASLD through downregulating SLC27A1/PPAR-γ in hepatocyte	80
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy	79
Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient as	79
Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease	79
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	79
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	79
Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets	79
Nasal accumulation and metabolism of Δ9-tetrahydrocannabinol following aerosol (‘vaping’) administration in an adolescent rat model	78
Targeted and cytotoxic inhibitors used in the treatment of lung cancers	78
Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions	77
Metabolic disorders affecting the liver and heart: Therapeutic efficacy of miRNA-based therapies?	77
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges	76
The complementary and alternative roles of elemene injection in cancer: An umbrella review	75
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	75

Net clinical benefit of a reduced dose of DOACs in non-valvular atrial fibrillation: A meta-analysis of randomized trials	75
Editorial Board	75