OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 71. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Development status and prospects of international standardization of medical devices of Traditional Chinese Medicine	463
Editorial Board	429
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	216
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	205
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	201
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	185
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	173
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	166
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	162
Time-dependent proteomics and drug response in expanding cancer cells	161
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	161
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	161
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	153
An account on the history of pharmacology in Spain	152
Gut-vascular axis and postbiotics: The need for clear definitions and further research	149
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect	143
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	140
The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials	134
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	134
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	132
Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications	131
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	129
In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3	121
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	121
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	119

Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma	119
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	116
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	113
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	113
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	110
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	108
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	107
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	104
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	103
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	101
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	100
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	100
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	98
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	97
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	96
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	96
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	94
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	90
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	89
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	88
The Role of Exosomes Derived from Various Sources in Facilitating the Healing of Chronic Refractory Wounds	87
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	86
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	86
Progress in the development of modulators targeting Frizzleds	85
Polypharmacology: The science of multi-targeting molecules	84
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	84
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism	82
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	82
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	81
Astaxanthin: A promising therapeutic agent for organ fibrosis	81
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	80
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	79
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	79
Targeting regulated cell death in aortic aneurysm and dissection therapy	78
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	77
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	77
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	76
Editorial Board	75
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	74
The potential modulatory role of curcumin on renal epithelial-to-mesenchymal transition in renal diseases	74
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma	74
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition	73
Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions	73
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review	71
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy	71
Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): recommendations from Italian scientific societies, patient as	71