OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	366
Editorial Board	365
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	269
Progress in the development of modulators targeting Frizzleds	261
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	247
An account on the history of pharmacology in Spain	235
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	223
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	217
Discovery, development, and characterization of potent and selective USP11 inhibitors	204
Corrigendum to “Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders” [Phar	201
Gut-vascular axis and postbiotics: The need for clear definitions and further research	180
Rapid 64Cu radiolabeling and in vivo evaluation of DSPE–NODAGA liposomes in a murine mammary tumor model	170
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	168
Time-dependent proteomics and drug response in expanding cancer cells	165
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	164
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	156
Chronic caffeine consumption prevents obesity-induced cognitive and memory impairments by reducing neuroinflammation and enhancing neuronal activity in the hippocampus	152
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	149
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	146
Protective effect and mechanisms of puerarin in metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis of animal studies	142
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	135
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	127
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	127
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	125
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	124

Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	123
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	121
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	115
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	115
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	113
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	113
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	112
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	107
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	106
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	106
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	105
Spatial proteomic profiling reveals conserved prognostic immune microenvironment features across molecular subtypes in small cell lung cancer	104
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	103
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	100
Bridging appetite and emotional dynamics: the oxytocinergic system as a therapeutic axis in feeding and eating disorders	100
The immunomodulatory role of vitamins in tumor: Mechanisms and therapeutic implications	95
Targeting pulmonary vascular–alveolar coupling in bronchopulmonary dysplasia: Therapeutic mechanisms and translational prospects of extracellular vesicle-based drug delivery	94
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	94
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	94
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	93
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	93
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review	92
Fig-derived exosome-like nanoparticles attenuating bone metastasis of breast cancer through establishing an anti-tumor microenvironment	91
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	91
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	90
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	90
Astaxanthin: A promising therapeutic agent for organ fibrosis	90
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	89
Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus	89
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	89
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	88
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	88
Editorial Board	87
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	85
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	85
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges	84
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-/- mice corpus cavernosum microcirculation	84
Atrial fibrillation: Epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors	84
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries	84
Hormesis: wound healing and fibroblasts	83
Fei-Yan-Qing-Hua decoction inhibits influenza viral replication by enhancing NK cell maturation and activation through the upregulation of JAK/STAT/T-bet signalling axis	83
A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine	83
The complementary and alternative roles of elemene injection in cancer: An umbrella review	83
The major histocompatibility complex participates in Parkinson’s disease	83
Corrigendum to “Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy” [Pharm. Res. 100 (2015) 175–89]	82
α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation	82
WITHDRAWN: Red blood cell-derived extracellular vesicles deliver NUP85 siRNA to alleviate MASLD through downregulating SLC27A1/PPAR-γ in hepatocyte	79
Nasal accumulation and metabolism of Δ9-tetrahydrocannabinol following aerosol (‘vaping’) administration in an adolescent rat model	79
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	79
Pharmacological targeting of microglia dynamics in Alzheimer’s disease: Preclinical and clinical evidence	79

Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics	78
Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets	78
Targeted and cytotoxic inhibitors used in the treatment of lung cancers	77
TAK1 blockade as a therapy for retinal neovascularization	77
Gut microbiota and their metabolites in stroke: From mechanistic study toward therapeutic perspectives	77
Remote ischemic conditioning attenuates blood-brain barrier disruption after recombinant tissue plasminogen activator treatment via reducing PDGF-CC	77