OOIR: Observatory of International Research

Papers

(The H4-Index of Human Gene Therapy is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Intra-Articular Delivery of an AAV-Anti-TNF-α Vector Alleviates the Progress of Arthritis in a RA Mouse Model	74
PASTE, Don't Cut: Genome Editing Tool Looks Beyond CRISPR and Prime	74
Pancreatic Cancer Cell and Gene Biotherapies: Past, Present, and Future	73
First Positive Clinical Data for In Vivo Genome Editing in Humans Opens “New Era of Medicine”	72
Isolating Natural Adeno-Associated Viruses from Primate Tissues with a High-Fidelity Polymerase	50
Positron Emission Tomography Quantitative Assessment of Off-Target Whole-Body Biodistribution of I-124-Labeled Adeno-Associated Virus Capsids Administered to Cerebral Spinal Fluid	49
Gene Therapy and the Use of Animal Models: Why Mice Alone Are Not Sufficient	47
Bluebird Bio Chief Financial Officer Resigns as Company Raises “Going Concern” Doubts	44
Induction of Robust Type I Interferon Levels by Oncolytic Reovirus Requires Both Viral Replication and Interferon-α/β Receptor Signaling	42
Strategies to Attenuate Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Pigment Epithelium-Derived Factor	41
Fusion of Rabies Virus Glycoprotein or gh625 to Iduronate-2-Sulfatase for the Treatment of Mucopolysaccharidosis Type II	37
Long-Term Follow-Up of Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy	36
Graphite Bio Pauses Lead Gene Editing Program in Sickle Cell Disease	36
Advances in CRISPR/Cas9 Genome Editing for the Treatment of Muscular Dystrophies	36
Efficacious Androgen Hormone Administration in Combination with Adeno-Associated Virus Vector-Mediated Gene Therapy in Female Mice with Pompe Disease	35
Ex Vivo Gene Therapy in Organ Transplantation: Considerations and Clinical Translation	33
Ocular Inflammation with Anti-Vascular Endothelial Growth Factor Treatments	32
Development of AAV-Mediated Gene Therapy Approaches to Treat Skeletal Diseases	31
Gene Therapy in Global Health: Meeting the Needs of Chinese Patients with Beta-Thalassemia	30
A Cautiously Optimistic Outlook of a Designer Therapy for 1% of Duchenne Muscular Dystrophy Patients	30
Efficacy and Safety of FX201, a Novel Intra-Articular IL-1Ra Gene Therapy for Osteoarthritis Treatment, in a Rat Model	29
Adeno-Associated Virus-Mediated Interleukin-12 Gene Expression Alleviates Lung Inflammation and Type 2 T-Helper-Responses in Ovalbumin-Sensitized Asthmatic Mice	28
pNaSS-Grafted PCL Film-Guided rAAV TGF-β Gene Therapy Activates the Chondrogenic Activities in Human Bone Marrow Aspirates	28
Advancing Precision Medicine with Gene and Cell Therapy in Malaysia: Ethical, Legal, and Social Implications	27
Immune Regulatory Effect of Osteopontin Gene Therapy in a Murine Model of Multidrug Resistant Pulmonary Tuberculosis	27

Neuroimaging Applications for the Delivery and Monitoring of Gene Therapy for Central Nervous System Diseases	26
Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector	26