Critical Reviews in Oncology Hematology

Article	Citations
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives	240
Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence	149
ctDNA as a cancer biomarker: A broad overview	128
Lung cancer in never smokers: The role of different risk factors other than tobacco smoking	112
TMB or not TMB as a biomarker: That is the question	112
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma	86
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	85
Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles	81
Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)	75
Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives	73
Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance	70
International liquid biopsy standardization alliance white paper	66
Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies	60
Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis	60
Breast cancer, screening and diagnostic tools: All you need to know	56
Unmet supportive care needs of people with advanced cancer and their caregivers: A systematic scoping review	55
Liquid biopsy in bladder cancer: State of the art and future perspectives	51
CD47: the next checkpoint target for cancer immunotherapy	51
Immunotherapy addition to neoadjuvant chemotherapy for early triple negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	51
Emerging role of exosomes as biomarkers in cancer treatment and diagnosis	49
New advances in exosome-based targeted drug delivery systems	48
Volatile organic compounds in human matrices as lung cancer biomarkers: a systematic review	48
The main sources of circulating cell-free DNA: Apoptosis, necrosis and active secretion	47
Comprehensive review of chromophobe renal cell carcinoma	46
Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis	46

Immunotherapy for head and neck cancer: Present and future	46
Autophagy-related MicroRNAs in chronic lung diseases and lung cancer	44
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	44
The role of epithelial-mesenchymal transition in regulating radioresistance	44
Novel drugs targeting EGFR and HER2 exon 20 mutations in metastatic NSCLC	42
Immunotherapy improves efficacy and safety of patients with HPV positive and negative head and neck cancer: A systematic review and meta-analysis	42
Major and minor salivary gland tumours	42
Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment	41
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societies	40
Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways	40
A BRAF new world	40
Fathoming the link between anthropogenic chemical contamination and thyroid cancer	39
COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature	39
Melanoma of unknown primary: New perspectives for an old story	38
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	38
Triple negative breast cancer in the era of miRNA	37
Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review	36
Extranodal NK/T cell lymphoma, nasal type: An updated overview	36
Radiomics in cervical cancer: Current applications and future potential	36
Molecular landscape of recurrent cervical cancer	35
Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications	35
The clinical utility of microsatellite instability in colorectal cancer	35
PD-L1 expression and Tumor mutation burden as Pathological response biomarkers of Neoadjuvant immunotherapy for Early-stage Non-small cell lung cancer: A systematic review and meta-analysis	35
Exercise for individuals with bone metastases: A systematic review	35
Prevention and treatment of FGFR inhibitor-associated toxicities	34
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	34
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials	34
Systemic Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma- A Systematic Review and Meta-Analysis	34
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	33
Efficacy and safety of ibrutinib in diffuse large B-cell lymphoma: A single-arm meta-analysis	32
Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis	32
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review	32
First-line systemic therapy for metastatic castration-sensitive prostate cancer: An updated systematic review with novel findings	31
Psychosocial, behavioral, and supportive interventions for pediatric, adolescent, and young adult cancer survivors: A systematic review and meta-analysis	31
Characteristics of gastric cancer around the world	31
miR-26 family and its target genes in tumorigenesis and development	31
Health-related quality of life in curatively-treated patients with esophageal or gastric cancer: A systematic review and meta-analysis	31
Which type of cancer patients are more susceptible to the SARS-COX-2: Evidence from a meta-analysis and bioinformatics analysis	31
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review. Part 2 – Radiological features and metric markers	31
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer	30
The significance of stromal collagen organization in cancer tissue: An in-depth discussion of literature	29
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	29
Obesity and prostate cancer: A narrative review	29
Introducing immunotherapy for advanced hepatocellular carcinoma patients: Too early or too fast?	29
Rational use of 18F-FDG PET/CT in patients with advanced cutaneous melanoma: A systematic review	29
Coronavirus infection and immune system: An insight of COVID-19 in cancer patients	28
ECCO Essential Requirements for Quality Cancer Care: Prostate cancer	28
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer	28
Non-coding RNAs and macrophage interaction in tumor progression	28
Latest evidence on immune checkpoint inhibitors in metastatic colorectal cancer: A 2022 update	28

Exposure to endocrine disruptors and risk of breast cancer: A systematic review	28
Tumor hypoxia: The major culprit behind cisplatin resistance in cancer patients	27
The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systemati	27
Predictors of efficacy of androgen-receptor-axis-targeted therapies in patients with metastatic castration-sensitive prostate cancer: A systematic review and meta-analysis	27
Radiomics and “radi-…omics” in cancer immunotherapy: a guide for clinicians	26
Impact of immune cells on the hallmarks of cancer: A literature review	26
Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer	26
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	26
Preimplantation genetic testing for carriers of BRCA1/2 pathogenic variants	26
The use of radiation therapy for oligoprogressive/oligopersistent oncogene-driven non small cell lung cancer: State of the art	26
The prevalence of cancer associated systemic inflammation: Implications of prognostic studies using the Glasgow Prognostic Score	26
Ischemic stroke: A paradoxical manifestation of cancer	26
A user’s guide to lorlatinib	25
Muscle hypertrophy in cancer patients and survivors via strength training. A meta-analysis and meta-regression	25
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies	25
Low-risk triple-negative breast cancers: Clinico-pathological and molecular features	25
A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy	25
The application of nano-medicine to overcome the challenges related to immune checkpoint blockades in cancer immunotherapy: Recent advances and opportunities	25
Osteosarcoma, chondrosarcoma and Ewing sarcoma: Clinical aspects, biomarker discovery and liquid biopsy	24
The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice: A critical review	24
Next generation sequencing for liquid biopsy based testing in non-small cell lung cancer in 2021	24
Why brain radiation therapy should take account of the individual structural and functional connectivity: Toward an irradiation “à la carte”	24
The role of chemotherapy in treatment of advanced breast cancer: an overview for clinical practice	24
Toxicity profile of epidermal growth factor receptor tyrosine kinase inhibitors for patients with lung cancer: A systematic review and network meta-analysis	24
Risk of thrombosis with thrombopoietin receptor agonists for ITP patients: A systematic review and meta-analysis	23
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications	23
Effects of mindfulness-based interventions on fatigue in cancer survivors: A systematic review and meta-analysis of randomized controlled trials	23
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis	23
Rechallenge of immune checkpoint inhibitors: A systematic review and meta-analysis	23
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	23
Cardiotoxicity in breast cancer patients treated with radiation therapy: From evidences to controversies	23
Oral potentially malignant disorders: A scoping review of prognostic biomarkers	22
NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy	22
Diagnosis and treatment of early and locally advanced non-small-cell lung cancer: The 2019 AIOM (Italian Association of Medical Oncology) clinical practice guidelines	22
Development of asciminib, a novel allosteric inhibitor of BCR-ABL1	21
Immune checkpoint inhibitors in endometrial cancer	21
Gene expression signatures: A tool for analysis of breast cancer prognosis and therapy	21
Neoadjuvant chemotherapy in hormone receptor-positive/HER2-negative early breast cancer: When, why and what?	21
TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis	20
Extracellular vesicles as biomarkers in malignant pleural mesothelioma: A review	20
The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses	20
The impact of anthropometric parameters on colorectal cancer prognosis: A systematic review and meta-analysis	20
Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients wi	20
Cell signaling pathways as molecular targets to eliminate AML stem cells	20
The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review	20
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy	20
The association between antibiotics use and outcome of cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis	20
The evolving landscape of anatomic pathology	19
Chimeric antigen receptor T cell therapy in oncology – Pipeline at a glance: Analysis of the ClinicalTrials.gov database	19
Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells	19
Role of neutrophil-lymphocyte ratio as a predictive factor of glioma tumor grade: A systematic review	19
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	19
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	19
Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations	19
Management of pain in colorectal cancer patients	19
Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy	19
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance	18
Systematic review: Soluble immunological biomarkers in advanced non-small-cell lung cancer (NSCLC)	18
Nanomedicine tactics in cancer treatment: Challenge and hope	18
A systematic review and meta-analysis of the association between circulating tumor DNA (ctDNA) and prognosis in pancreatic cancer	18
Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance	18
The relationship between hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: Systematic review and meta-analysis	18
Mantle cell lymphoma	18
Exploring the role of respiratory microbiome in lung cancer: A systematic review	18
Global frequency and distribution of head and neck cancer in pediatrics, a systematic review	18
Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy	18
Exercise and lung cancer surgery: A systematic review of randomized-controlled trials	18
Update on drug transporter proteins in acute myeloid leukemia: Pathological implication and clinical setting	18
PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance	18
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	18
Natural Killer cells and monoclonal antibodies: Two partners for successful antibody dependent cytotoxicity against tumor cells	18
Tumor infiltrating lymphocytes (TILs) as a predictive biomarker of response to checkpoint blockers in solid tumors: A systematic review	18
Prognostic value of platelet-related measures for overall survival in esophageal squamous cell carcinoma: A systematic review and meta-analysis	18
Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy: A systematic review	17
Cancer management during the COVID-19 pandemic: Choosing between the devil and the deep blue sea	17
Carotid blowout syndrome after reirradiation for head and neck malignancies: a comprehensive systematic review for a pragmatic multidisciplinary approach	17
Novel aspects on gonadotoxicity and fertility preservation in lymphoproliferative neoplasms	17
Management guidelines for stage III non-small cell lung cancer	17
Recent insights into the role of the microbiome in malignant and benign hematologic diseases	17
Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis	17

The Impact of Pelvic Nodal Radiotherapy on Hematologic Toxicity: A Systematic Review with Focus on Leukopenia, Lymphopenia and Future Perspectives in Prostate Cancer Treatment	17
PD-1/PD-L1 inhibitor monotherapy or in combination with chemotherapy as upfront treatment for advanced NSCLC with PD-L1 expression ≥ 50%: Selecting the best strategy	17
Stereotactic reirradiation for local failure of brain metastases following previous radiosurgery: Systematic review and meta-analysis	17
Lymphoma in the setting of autoimmune diseases: A review of association and mechanisms	17
Diagnosis and treatment of therapy-related acute myeloid leukemia	17
Does nutrition for cancer patients feed the tumour? A clinical perspective	17
Evolving pancreatic cancer treatment: From diagnosis to healthcare management	17
Unravelling the molecular mechanisms of prostate cancer evolution from genotype to phenotype	17
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	17
The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice	17
Telemedicine and the current opportunities for the management of oncological patients in Peru in the context of COVID-19 pandemic	17
Therapeutic potential of p53 reactivation in cervical cancer	16
State of the art of radiomic analysis in the clinical management of prostate cancer: A systematic review	16
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	16
In vivo sentinel lymph node identification using fluorescent tracer imaging in colon cancer: A systematic review and meta-analysis	16
The role of cardio-protective agents in cardio-preservation in breast cancer patients receiving Anthracyclines ± Trastuzumab: a Meta-analysis of clinical studies	16
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target	16
Electrolyte disorders in advanced non-small cell lung cancer patients treated with immune check-point inhibitors: A systematic review and meta-analysis	16
How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults	16
New perspectives in genetics and targeted therapy for blastic plasmacytoid dendritic cell neoplasm	16
Current advances in PD-1/PD-L1 axis-related tumour-infiltrating immune cells and therapeutic regimens in glioblastoma	16
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review	16
Metabolic rewiring in melanoma drug-resistant cells	16
Surgical treatment of gastric cancer liver metastases: Systematic review and meta-analysis of long-term outcomes and prognostic factors	16
Self-expandable metal stent (SEMS) placement or emergency surgery as palliative treatment for obstructive colorectal cancer: A systematic review and meta-analysis	16
BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients	16
Type I interferons in pancreatic cancer and development of new therapeutic approaches	16
Managing side effects of immune checkpoint inhibitors in breast cancer	16
MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions	16
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	16
Outcome of patients with advanced upper tract urothelial carcinoma treated with immune checkpoint inhibitors: A systematic review and meta-analysis	16
Considerations for interactions of drugs used for the treatment of COVID-19 with anti-cancer treatments	16
Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials	16
Association of periodontitis and tooth loss with liver cancer: A systematic review	15
Invadopodia: A potential target for pancreatic cancer therapy	15
The role of immune checkpoint inhibitors in the treatment sequence of advanced gastric or gastro-esophageal junction cancer: A systematic review and meta-analysis of randomized trials	15
Uterine carcinosarcoma: An overview	15
The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations	15
The cyclin-dependent kinases pathway as a target for prostate cancer treatment: rationale and future perspectives	15
Toxicity of extended adjuvant endocrine with aromatase inhibitors in patients with postmenopausal breast cancer: A Systemtic review and Meta-analysis	15
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	15
Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach	15
Osteosarcoma of the jaws: An overview of the pathophysiological mechanisms	15
Radiation recall reactions: An oncologic enigma	15
Breast cancer: An insight into its inflammatory, molecular, pathological and targeted facets with update on investigational drugs	15
Serum tumour markers in germ cell tumours: From diagnosis to cure	15
Hype or hope – Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?	15
Implications of COVID-19 pandemic on lung cancer management: A multidisciplinary perspective	15
Imaging response evaluation after neoadjuvant treatment in soft tissue sarcomas: Where do we stand?	14
Role of innate and adaptive immunity in the efficacy of anti-HER2 monoclonal antibodies for HER2-positive breast cancer	14
Milestones in the treatment of hepatocellular carcinoma: A systematic review.	14
Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis	14
Targeting acute myeloid leukemia stem cells: Current therapies in development and potential strategies with new dimensions	14
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	14
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications	14
Daratumumab-based induction therapy for multiple myeloma: A systematic review and meta-analysis	14
Diet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis	14
Current concepts and future directions for hemato-oncologic diagnostics	14
miRNA as promising theragnostic biomarkers for predicting radioresistance in cancer: A systematic review and meta‐analysis	14
Risk of bleeding complications and atrial fibrillation associated with ibrutinib treatment: A systematic review and meta-analysis	14
Circulating tumor cell detection methods in renal cell carcinoma: A systematic review	14
Effectiveness of low level laser therapy versus cryotherapy in cancer patients with oral mucositis: Systematic review and network meta-analysis	14
Radiotherapy based management during Covid-19 pandemic – A systematic review of presented consensus and guidelines	14
Current treatment options for HER2-positive breast cancer patients with brain metastases	14
Exploring the knowledge gap of immune checkpoint inhibitors in chronic renal failure: A systematic review of the literature	14
Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites	13
Fertility preservation in women with cervical cancer	13
Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae	13
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	13
Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: the THOCOoP cooperative group	13
Bipolar androgen therapy in prostate cancer: Current evidences and future perspectives	13
Association between telomere length and mitochondrial copy number and cancer risk in humans: A meta-analysis on more than 300,000 individuals	13
Role of stereotactic radiosurgery for the treatment of brain metastasis in the era of immunotherapy: A systematic review on current evidences and predicting factors	13
Molecular landscape of Hereditary Melanoma	13
Advanced and recurrent endometrial cancer: State of the art and future perspectives	13
Late radiation effects in survivors of head and neck cancer: State of the science	13
Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials	13
Metabolic disorders and gastroenteropancreatic-neuroendocrine tumors (GEP-NETs): How do they influence each other? An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Dia	13
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	13
Neoadjuvant immunotherapy in head and neck cancer: Rationale, current evidence and future perspective	13
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma	12
A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma	12
The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis	12
Double immune checkpoint blockade in advanced NSCLC	12
Induction chemotherapy plus concomitant chemoradiotherapy in nasopharyngeal carcinoma: An updated network meta-analysis	12
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	12
Brain metastasis formation and irradiation by stereotactic radiation therapy combined with immunotherapy: A systematic review	12
Unraveling molecular mechanisms of head and neck cancer	12
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act	12
Targeting TRK: A fast-tracked application of precision oncology and future directions	12
Anaplastic Astrocytoma: State of the art and future directions	12
TRK fusion positive cancers: From first clinical data of a TRK inhibitor to future directions	12
Recent therapeutic advances in urothelial carcinoma: A paradigm shift in disease management	12
Circulating Tumor DNA in KRAS positive colorectal cancer patients as a prognostic factor – a systematic review and meta-analysis	12
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis	12