Critical Reviews in Oncology Hematology

Article	Citations
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives	285
ctDNA as a cancer biomarker: A broad overview	155
TMB or not TMB as a biomarker: That is the question	139
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	111
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma	97
Unmet supportive care needs of people with advanced cancer and their caregivers: A systematic scoping review	88
Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles	86
Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance	81
Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives	81
Characteristics of gastric cancer around the world	76
International liquid biopsy standardization alliance white paper	72
Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies	68
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	67
Breast cancer, screening and diagnostic tools: All you need to know	67
Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis	67
New advances in exosome-based targeted drug delivery systems	62
Emerging role of exosomes as biomarkers in cancer treatment and diagnosis	62
Liquid biopsy in bladder cancer: State of the art and future perspectives	59
Immunotherapy addition to neoadjuvant chemotherapy for early triple negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	59
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	58
The main sources of circulating cell-free DNA: Apoptosis, necrosis and active secretion	58
Immunotherapy for head and neck cancer: Present and future	56
Comprehensive review of chromophobe renal cell carcinoma	55
Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment	50
Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis	50

Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways	49
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	47
PD-L1 expression and Tumor mutation burden as Pathological response biomarkers of Neoadjuvant immunotherapy for Early-stage Non-small cell lung cancer: A systematic review and meta-analysis	46
Extranodal NK/T cell lymphoma, nasal type: An updated overview	46
Melanoma of unknown primary: New perspectives for an old story	45
Exercise for individuals with bone metastases: A systematic review	45
Obesity and prostate cancer: A narrative review	43
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societies	43
Molecular landscape of recurrent cervical cancer	42
Latest evidence on immune checkpoint inhibitors in metastatic colorectal cancer: A 2022 update	42
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	42
miR-26 family and its target genes in tumorigenesis and development	42
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	41
Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications	41
Triple negative breast cancer in the era of miRNA	41
The clinical utility of microsatellite instability in colorectal cancer	40
Prevention and treatment of FGFR inhibitor-associated toxicities	40
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	38
Psychosocial, behavioral, and supportive interventions for pediatric, adolescent, and young adult cancer survivors: A systematic review and meta-analysis	38
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review. Part 2 – Radiological features and metric markers	36
First-line systemic therapy for metastatic castration-sensitive prostate cancer: An updated systematic review with novel findings	35
Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance	35
Tumor hypoxia: The major culprit behind cisplatin resistance in cancer patients	34
Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis	34
Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer	34
Non-coding RNAs and macrophage interaction in tumor progression	34
Exposure to endocrine disruptors and risk of breast cancer: A systematic review	34
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer	34
Toxicity profile of epidermal growth factor receptor tyrosine kinase inhibitors for patients with lung cancer: A systematic review and network meta-analysis	34
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials	34
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy	33
Osteosarcoma, chondrosarcoma and Ewing sarcoma: Clinical aspects, biomarker discovery and liquid biopsy	33
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications	32
Diagnosis and treatment of therapy-related acute myeloid leukemia	32
Ischemic stroke: A paradoxical manifestation of cancer	31
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies	31
Rechallenge of immune checkpoint inhibitors: A systematic review and meta-analysis	31
Preimplantation genetic testing for carriers of BRCA1/2 pathogenic variants	30
A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy	30
Introducing immunotherapy for advanced hepatocellular carcinoma patients: Too early or too fast?	30
Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations	30
Muscle hypertrophy in cancer patients and survivors via strength training. A meta-analysis and meta-regression	29
Neoadjuvant chemotherapy in hormone receptor-positive/HER2-negative early breast cancer: When, why and what?	29
Effects of mindfulness-based interventions on fatigue in cancer survivors: A systematic review and meta-analysis of randomized controlled trials	29
Impact of immune cells on the hallmarks of cancer: A literature review	29
Tumor infiltrating lymphocytes (TILs) as a predictive biomarker of response to checkpoint blockers in solid tumors: A systematic review	28
The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses	28
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	28
The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice: A critical review	28
Risk of thrombosis with thrombopoietin receptor agonists for ITP patients: A systematic review and meta-analysis	28

Cell signaling pathways as molecular targets to eliminate AML stem cells	28
Cardiotoxicity in breast cancer patients treated with radiation therapy: From evidences to controversies	27
The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review	27
Low-risk triple-negative breast cancers: Clinico-pathological and molecular features	27
Development of asciminib, a novel allosteric inhibitor of BCR-ABL1	26
Management of pain in colorectal cancer patients	26
The application of nano-medicine to overcome the challenges related to immune checkpoint blockades in cancer immunotherapy: Recent advances and opportunities	26
Next generation sequencing for liquid biopsy based testing in non-small cell lung cancer in 2021	26
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance	26
The evolving landscape of anatomic pathology	25
Exercise and lung cancer surgery: A systematic review of randomized-controlled trials	25
Nanomedicine tactics in cancer treatment: Challenge and hope	25
The impact of anthropometric parameters on colorectal cancer prognosis: A systematic review and meta-analysis	25
Role of neutrophil-lymphocyte ratio as a predictive factor of glioma tumor grade: A systematic review	24
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	24
The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice	24
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	24
State of the art of radiomic analysis in the clinical management of prostate cancer: A systematic review	24
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis	24
Immune checkpoint inhibitors in endometrial cancer	24
Advanced and recurrent endometrial cancer: State of the art and future perspectives	24
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	23
MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions	23
Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy	23
TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis	22
Association of periodontitis and tooth loss with liver cancer: A systematic review	22
Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy	22
Chimeric antigen receptor T cell therapy in oncology – Pipeline at a glance: Analysis of the ClinicalTrials.gov database	22
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	22
Self-expandable metal stent (SEMS) placement or emergency surgery as palliative treatment for obstructive colorectal cancer: A systematic review and meta-analysis	21
Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis	21
A systematic review and meta-analysis of the association between circulating tumor DNA (ctDNA) and prognosis in pancreatic cancer	21
Prognostic value of platelet-related measures for overall survival in esophageal squamous cell carcinoma: A systematic review and meta-analysis	21
Exploring the role of respiratory microbiome in lung cancer: A systematic review	21
The Impact of Pelvic Nodal Radiotherapy on Hematologic Toxicity: A Systematic Review with Focus on Leukopenia, Lymphopenia and Future Perspectives in Prostate Cancer Treatment	21
Uterine carcinosarcoma: An overview	21
How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults	21
Size distribution of cell-free DNA in oncology	21
Natural Killer cells and monoclonal antibodies: Two partners for successful antibody dependent cytotoxicity against tumor cells	21
The relationship between hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: Systematic review and meta-analysis	21
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review	20
Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells	20
Managing side effects of immune checkpoint inhibitors in breast cancer	20
BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients	20
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	20
PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance	20
Type I interferons in pancreatic cancer and development of new therapeutic approaches	20
The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations	20
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	19
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	19
Recent insights into the role of the microbiome in malignant and benign hematologic diseases	19
Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy: A systematic review	19
Anemia in myelofibrosis: Current and emerging treatment options	19
Management guidelines for stage III non-small cell lung cancer	19
Late radiation effects in survivors of head and neck cancer: State of the science	19
Osteosarcoma of the jaws: An overview of the pathophysiological mechanisms	19
Carotid blowout syndrome after reirradiation for head and neck malignancies: a comprehensive systematic review for a pragmatic multidisciplinary approach	18
Molecular landscape of Hereditary Melanoma	18
Exercise oncology during and beyond the COVID-19 pandemic: Are virtually supervised exercise interventions a sustainable alternative?	18
PD-1/PD-L1 inhibitor monotherapy or in combination with chemotherapy as upfront treatment for advanced NSCLC with PD-L1 expression ≥ 50%: Selecting the best strategy	18
Update on drug transporter proteins in acute myeloid leukemia: Pathological implication and clinical setting	18
Unravelling the molecular mechanisms of prostate cancer evolution from genotype to phenotype	18
Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials	18
Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach	18
SELNET clinical practice guidelines for bone sarcoma	18
Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence	17
Cancer management during the COVID-19 pandemic: Choosing between the devil and the deep blue sea	17
Invadopodia: A potential target for pancreatic cancer therapy	17
In vivo sentinel lymph node identification using fluorescent tracer imaging in colon cancer: A systematic review and meta-analysis	17
Telemedicine and the current opportunities for the management of oncological patients in Peru in the context of COVID-19 pandemic	17
Evolving pancreatic cancer treatment: From diagnosis to healthcare management	17
Leukemic stem cells as a target for eliminating acute myeloid leukemia: Gaps in translational research	17
Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae	17
Effectiveness of low level laser therapy versus cryotherapy in cancer patients with oral mucositis: Systematic review and network meta-analysis	17
Implications of COVID-19 pandemic on lung cancer management: A multidisciplinary perspective	17
Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites	17
Side effects of using granulocyte-colony stimulating factors as prophylaxis of febrile neutropenia in cancer patients: A systematic review	17
Surgical treatment of gastric cancer liver metastases: Systematic review and meta-analysis of long-term outcomes and prognostic factors	17
Serum tumour markers in germ cell tumours: From diagnosis to cure	17
Neoadjuvant immunotherapy in head and neck cancer: Rationale, current evidence and future perspective	17

Outcome of patients with advanced upper tract urothelial carcinoma treated with immune checkpoint inhibitors: A systematic review and meta-analysis	16
Financial toxicity among adolescent and young adult cancer survivors: A systematic review of educational attainment, employment, and income	16
Imaging response evaluation after neoadjuvant treatment in soft tissue sarcomas: Where do we stand?	16
Therapeutic potential of p53 reactivation in cervical cancer	16
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target	16
The cyclin-dependent kinases pathway as a target for prostate cancer treatment: rationale and future perspectives	16
Recent therapeutic advances in urothelial carcinoma: A paradigm shift in disease management	16
Toxicity of extended adjuvant endocrine with aromatase inhibitors in patients with postmenopausal breast cancer: A Systemtic review and Meta-analysis	16
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	16
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis	16
Nano based-oncolytic viruses for cancer therapy	16
Daratumumab-based induction therapy for multiple myeloma: A systematic review and meta-analysis	16
Diet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis	16
miRNA as promising theragnostic biomarkers for predicting radioresistance in cancer: A systematic review and meta‐analysis	16
Unraveling molecular mechanisms of head and neck cancer	16
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications	16
Hype or hope – Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?	16
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma	16
Effectiveness of cognitive behavioral therapy in improving functional health in cancer survivors: A systematic review and meta-analysis	16
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor	15
The role of immune checkpoint inhibitors in the treatment sequence of advanced gastric or gastro-esophageal junction cancer: A systematic review and meta-analysis of randomized trials	15
Lung cancer organoids, a promising model still with long way to go	15
Critical review of oncology clinical trial design under non-proportional hazards	15
Radiation recall reactions: An oncologic enigma	15
Pseudoprogression in lung cancer patients treated with immunotherapy	15
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	15
Global magnitude and temporal trend of mesothelioma burden along with the contribution of occupational asbestos exposure in 204 countries and territories from 1990 to 2019: Results from the Global Bur	15
Tumor-Treating Fields: A fourth modality in cancer treatment, new practice updates	15
Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis	15
Venous thromboembolism in cancer and cancer immunotherapy	15
A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma	15
Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis	15
Milestones in the treatment of hepatocellular carcinoma: A systematic review.	14
Radiotherapy based management during Covid-19 pandemic – A systematic review of presented consensus and guidelines	14
Current treatment options for HER2-positive breast cancer patients with brain metastases	14
Metabolic disorders and gastroenteropancreatic-neuroendocrine tumors (GEP-NETs): How do they influence each other? An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Dia	14
Circulating tumor cell detection methods in renal cell carcinoma: A systematic review	14
Metaplastic breast cancer: A review	14
Effectiveness of photobiomodulation therapy in radiation dermatitis: A systematic review and meta-analysis	14
Association between telomere length and mitochondrial copy number and cancer risk in humans: A meta-analysis on more than 300,000 individuals	14
Role of stereotactic radiosurgery for the treatment of brain metastasis in the era of immunotherapy: A systematic review on current evidences and predicting factors	14
Exploring the knowledge gap of immune checkpoint inhibitors in chronic renal failure: A systematic review of the literature	14
Digital droplet PCR as a predictive tool for successful discontinuation outcome in chronic myeloid leukemia: Is it time to introduce it in the clinical practice?	14
The HER family as therapeutic targets in colorectal cancer	14
The impact of survivorship bias in glioblastoma research	14
The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review	14
The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis	14
Risk of bleeding complications and atrial fibrillation associated with ibrutinib treatment: A systematic review and meta-analysis	14
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	13
Cutaneous adverse events associated with immune checkpoint blockade: A systematic review and meta-analysis	13
Targeting TRK: A fast-tracked application of precision oncology and future directions	13
Adjuvant chemotherapy after neoadjuvant chemo-radiotherapy and surgery in locally advanced rectal cancer. A systematic review of literature with a meta-analysis of randomized clinical trials	13
Radioimmunotherapy of glioblastoma multiforme - Current status and future prospects	13
Biomarkers for predicting the outcome of various cancer immunotherapies	13
Current knowledge of immunosuppression as a risk factor for skin cancer development	13
Anti-CD19 CAR-T cells: Digging in the dark side of the golden therapy	13
Tissue and circulating PD-L2: moving from health and immune-mediated diseases to head and neck oncology	13
Long noncoding RNAs (lncRNAs) in cervical carcinogenesis: New molecular targets, current prospects	13
Application of extracellular vesicles in the diagnosis and treatment of prostate cancer: Implications for clinical practice	13
Time to rejuvenate ultra-low dose whole-body radiotherapy of cancer	13
Surgical and survival outcomes with perioperative or neoadjuvant immune-checkpoint inhibitors combined with platinum-based chemotherapy in resectable NSCLC: A systematic review and meta-analysis of ra	13
Treatment of brain metastases in ALK-positive non-small cell lung cancer	13
Induction chemotherapy plus concomitant chemoradiotherapy in nasopharyngeal carcinoma: An updated network meta-analysis	13
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	13
The current landscape of systemic therapy for recurrent glioblastoma: A systematic review of randomized-controlled trials	13
A review of HER2 overexpression and somatic mutations in cancers	13
Monoclonal antibodies in breast cancer: A critical appraisal	13
Fertility and breast cancer: A literature review of counseling, preservation options and outcomes	12
Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications	12
Immune checkpoint inhibitors rechallenge in urological tumors: An extensive review of the literature	12
Drug repositioning for cancer in the era of AI, big omics, and real-world data	12
The gut microbiome and cancer immunotherapeutics: A review of emerging data and implications for future gynecologic cancer research	12
The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis	12
The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis	12
Targeting the metabolism of cancer stem cells by energy disruptor molecules	12
Management of chemotherapy-induced alopecia (CIA): A comprehensive review and future directions	12
Management of acute spinal cord compression in multiple myeloma	12
Treatment of cancer-associated thrombosis: The evolution of anticoagulant choice and clinical insights into practical management	12
Decreasing treatment burden in HPV-related OPSCC: A systematic review of clinical trials	12
Molecular insights of metastasis and cancer progression derived using 3D cancer spheroid co-culture in vitro platform	12
Prognostic role of cell-free DNA biomarkers in pancreatic adenocarcinoma: A systematic review and meta–analysis	12
Comparing cardiovascular adverse events in cancer patients: A meta-analysis of combination therapy with angiogenesis inhibitors and immune checkpoint inhibitors versus angiogenesis inhibitors alone	12
IL-1α and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy	11
Chemotherapy is superior to checkpoint inhibitors after radical surgery for urothelial carcinoma: a systematic review and network meta-analysis of oncologic and toxicity outcomes	11
Survival and toxicity of weekly cisplatin chemoradiotherapy versus three-weekly cisplatin chemoradiotherapy for head and neck cancer: A systematic review and meta-analysis endorsed by the Italian Asso	11
Gene expression signatures in early breast cancer: Better together with clinicopathological features	11
Pancreatic neuroendocrine neoplasms: Updates on genomic changes in inherited tumour syndromes and sporadic tumours based on WHO classification	11
Risk Factors of Fluoropyrimidine Induced Cardiotoxicity among Cancer Patients: A Systematic Review and Meta-analysis	11
Inadequate health-related quality of life assessment and reporting in phase III clinical trials of immune checkpoint inhibitors in solid cancers: A systematic review	11
From preclinical efficacy to 2022 (36.7 months median follow -up) updated CROWN trial, lorlatinib is the preferred 1st-line treatment of advanced ALK+ NSCLC	11
Evidence of brain-derived neurotrophic factor in ameliorating cancer-related cognitive impairment: A systematic review of human studies	11
Prospective clinical research of radiomics and deep learning in oncology: A translational review	11
Radiotherapy and radiosensitization in breast cancer: Molecular targets and clinical applications	11
BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications	11
Efficacy of R-COMP in comparison to R-CHOP in patients with DLBCL: A systematic review and single-arm metanalysis	11