Critical Reviews in Oncology Hematology

Papers
(The median citation count of Critical Reviews in Oncology Hematology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting373
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials242
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm155
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app119
Comparative efficacy of first-line therapies for PD-L1-negative advanced NSCLC: A network meta-analysis with reconstructed survival curves114
From immunohistochemistry to machine learning-based patient stratification by tumour proliferation characteristics in head and neck cancer87
Beyond the blood-brain barrier: Intranasal vaccines in cancer immunotherapy87
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?86
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy85
Real-world analysis of primary central nervous system diffuse large B-cell lymphoma81
A systematic review and meta-analysis of blood-based biomarkers in anal squamous cell cancer treated with chemoradiotherapy68
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches66
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer66
Novel bioengineered drugs with immunotherapies for malignant pleural effusion: Remodulate tumor immune microenvironment and activate immune system65
When immunity backfires: Meta-analysis on sarcoidosis reactivation in cancer patients treated with immune checkpoint inhibitors64
Navigating management of localized prostate cancer in the geriatric population61
Immunotherapy advancements in high-grade serous ovarian cancer: From promise to practice59
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics59
Cytokine-based NK cell engineering for cancer immunotherapy58
Salivary phosphate: A promising non-invasive biomarker for oral and systemic disease screening53
Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications52
The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy51
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment51
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II48
Beyond monospecificity: The modular revolution of bispecific immunotherapeutics48
Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials47
Systemic immune-inflammation index as a predictor of survival in non-small cell lung cancer patients undergoing immune checkpoint inhibition: A systematic review and meta-analysis46
Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies45
Epidermal growth factor receptor (EGFR) atypical mutations in non-small-cell lung cancer (NSCLC): ‘Where the streets have no name’45
Novel insight into the Warburg effect: Sweet temptation44
Targeted doublet therapy with encorafenib and cetuximab for BRAF V600E-mutant metastatic colorectal cancer: A systematic review and meta-analysis44
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models43
Current status of locally advanced rectal cancer therapy and future prospects43
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review43
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth42
The BCL-2–tumor microenvironment axis: Mechanisms of immune suppression, resistance, and pathways to therapeutic reprogramming42
Stereotactic body radiotherapy as an alternative to brachytherapy in cervical cancer (SCORE): A systematic review and meta-analysis42
Bidirectional role of neutrophils in lung cancer: Mechanisms and therapeutic implications41
Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis41
Microbiome dynamics in breast cancer: Mechanisms, therapeutic impacts and research gaps41
Spatial multiomics of the breast tumour microenvironment: State of the field, advancements and clinical implementation promises39
Surface-Enhanced Raman Scattering (SERS) combined with machine learning enables accurate diagnosis of cervical cancer: From molecule to cell to tissue level39
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review39
The hidden hand of endoplasmic reticulum stress in anticancer drug resistance38
Editorial Board38
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions38
Targeting hypoxia-inducible factor pathways in sporadic and Von Hippel-Lindau syndrome-related kidney cancers38
Editorial Board37
Comparative analysis of systemic treatment with or without immune checkpoint inhibitors for advanced or recurrent endometrial cancer: A systematic review and meta-analysis of randomized controlled tri35
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy34
cGAS–STING signaling pathway in urogenital oncology: Regulation, resistance, and routes to response34
Comment on “The risk of breast cancer and gynecologic malignancies after ovarian stimulation: Meta-analysis of cohort study”34
Proton beam therapy versus photon therapy for multiple malignancies: An umbrella systematic review and meta-analysis34
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology34
Adjuvant immunotherapy in high-risk renal cell carcinoma: Indications, limitations, and perspectives. A consensus statement from the GIOTTO uro-oncology group32
Androgen receptor as a prognostic biomarker in breast cancer: A systematic review and meta-analysis32
TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?32
KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics31
Prognostic value of HER2 discordance between primary and metastatic or recurrent breast cancer: A systematic review and meta-analysis31
Optimal treatment strategy for central nervous system non-germinomatous germ cell tumors: A systematic review and meta-analysis31
Antibody-Drug Conjugates in urothelial, prostate, and renal cell cancers: A review of current and emerging therapies30
Next-generation immunotherapy in relapsed/refractory multiple myeloma: Strategies to achieve sustained MRD negativity30
Impact of adding immune checkpoint inhibitors to standard therapies in non-small cell lung cancer: A systematic review of efficacy outcomes30
The biology and treatment of leiomyosarcomas29
MAIT Cells in Tumor Contexts: Functional Diversity and Regulatory Hierarchies29
Trastuzumab deruxtecan: Redefining precision oncology across HER2-driven cancers29
The critical role of epithelial-mesenchymal transition (EMT) in colorectal cancer progression and therapeutic outcomes29
The role of GPI-anchored LY6/uPAR family proteins in connecting membrane microdomains with immune regulation and diseases29
Predictive factors for return to work among cancer survivors in Europe: A systematic review29
Histopathological ultrastaging of mesocolic lymph nodes after colon cancer resection: A systematic review and meta-analysis29
Thrombosis and cachexia in cancer: Two partners in crime?29
Immunotherapy in OSCC: Current trend and challenges29
Predictive models for immune checkpoint inhibitor response in cancer: A review of current approaches and future directions29
UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?28
First-line treatments for advanced or recurrent endometrial cancer: Systematic literature review of clinical evidence28
Clinical trials for patients with salivary gland cancers: A systematic review of worldwide registers and an evaluation of current challenges28
Chemotherapy, immunotherapy, and targeted therapy for osteosarcoma: Recent advancements28
Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative28
Neoadjuvant therapy for muscle-invasive bladder cancer: Current clinical scenario, future perspectives, and unsolved questions28
Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance28
Efficacy of stereotactic radiosurgery as single or combined therapy for brain metastasis: A systematic review and meta-analysis27
The peripheral tumor neuro-microenvironment: Deciphering neural landscape and mechanistic insights for therapeutic innovation27
Unraveling molecular mechanisms of head and neck cancer27
Editorial Board27
The safety and effectiveness of hypofractionated radiotherapy for localized prostate cancer: A systematic review and meta-analysis27
Minimal residual disease testing for classical Hodgkin lymphoma: A comprehensive review27
Targeted cancer therapy: A comprehensive review of strategies in drug development27
Liposomal nanocarriers in precision oncology: Advances and prospects27
The role and clinical significance of tumor-draining lymph nodes in tumor progression and immunotherapy27
Evaluating quality of life in thoracic malignancy trials: A scoping review on ESMO-MCBS quality of life checklist adherence and concordance with progression-free and overall survival26
The role of liquid biopsy in epithelial ovarian cancer: State of the art26
CRISPR-mediated cancer therapies: Approaches to direct tumor targeting26
Efficacy and safety of targeted therapy and immunotherapy in advanced vulvar squamous cell carcinoma: A scoping review26
Neoadjuvant therapy in ovarian cancer: Emerging paradigms and therapeutic frontiers26
Trispecific antibodies: From challenges to integration in cancer therapy26
Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways26
Antibody-oligonucleotide conjugates in cancer therapy: Potential and Promise25
Challenges facing CAR T-cell immunotherapy in multiple myeloma25
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors25
A comprehensive review on targeting diverse immune cells for anticancer therapy: Beyond immune checkpoint inhibitors25
DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review25
Synergistic effects of immunotherapy and adjunctive therapies in prostate cancer management25
Personalized neoantigen cancer vaccines: Why clinical benefit remains inconsistent25
The role of central nervous system (CNS) prophylaxis in preventing DLBCL patients from CNS relapse: A network meta-analysis24
Editorial Board24
Epigenetic mechanisms of PARP inhibitor resistance in ovarian cancer: A systematic review with bioinformatic analysis of clinically actionable genes24
Application of mRNA Vaccines in Head and Neck Cancer Immunotherapy: Current Progress and Challenges24
Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma24
RNA N4-acetylcytidine modification in gastrointestinal cancer: Novel functions, mechanisms, and therapeutic implications24
CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology – A comprehensive analysis of clinical trials24
Editorial Board24
Corrigendum to “A review of relative dose intensity and survival in patients with metastatic solid tumors” [Crit. Rev. Oncol. Hematol. 93 (2015) 203–210]24
From G12C To pan-RAS: The expanding therapeutic landscape of KRAS-mutant NSCLC23
Epigenetic-modifying agents: The potential game changers in the treatment of hematologic malignancies23
The novel roles of RNA 5-methylcytosine modification in gastrointestinal tract cancers23
Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors23
Bridging the translational gap in HNSCC immunotherapy: From resistance mechanisms to high-fidelity preclinical models23
Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials23
Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer22
« Augmented radiotherapy » in the management of high-risk prostate cancer (PCa): A systematic review22
Plasmonic surgery: SERS-active smart nanotools reshaping intraoperative decision-making and precision therapy22
The pH perspective of cancer: From warburg's misconception to therapeutic targeting of pH regulating proteins22
Pathology, immunosuppression and NK cell immunotherapy of non-small cell lung cancer22
Role of radiation in chimeric antigen receptor T-cell therapy for patients with relapsed/refractory non-Hodgkin lymphoma: Current studies and future prospects22
Safety and efficacy of liposomal irinotecan as the second-line treatment for advanced pancreatic cancer: A systematic review and meta-analysis22
Recent development in bispecific antibody immunotherapy for hematological malignancies22
Targeting TIME in advanced hepatocellular carcinoma: Mechanisms of drug resistance and treatment strategies22
Strategies to overcome chemoresistance in epithelial ovarian cancer: Navigating beyond challenges22
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors22
Facing the climate change: Is radiotherapy as green as we would like? A systematic review22
Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer22
Revolutionizing immunotherapy: The next frontier in CAR T-cell engineering22
Advances in intravesical therapy for non-muscle-invasive bladder cancer21
Unlock the code of MHC II-enabled Cancer immunotherapy21
Towards a new approach in pleural mesothelioma: Perioperative immunotherapy and its implications21
Comprehensive review of signaling pathways and therapeutic targets in gastrointestinal cancers21
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature21
Recent advances and research progress in biomarkers for chronic graft versus host disease21
NRG1 fusions:The potential targeted treatment in non-small cell lung cancer(NSCLC)21
Sialylated glycoproteins and sialyltransferases in digestive cancers: Mechanisms, diagnostic biomarkers, and therapeutic targets21
Advancing CAR-T cell manufacturing in Latin America: Current landscape, future directions, and challenges20
Microbiota and esophageal cancer: From dysbiosis to carcinogenesis20
The impact of survivorship bias in glioblastoma research20
Artificial intelligence in NSCLC management for revolutionizing diagnosis, prognosis, and treatment optimization: A systematic review20
Cardio-oncology concerns in radiotherapy: Heart and cardiac substructure toxicities from modern delivery techniques20
Shaping immunotherapy through the tumor microenvironment: Translational perspectives20
Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma20
The association between paraneoplastic neurological syndromes (PNS) and urothelial carcinoma – A review of the literature20
Next-Generation models of Gallbladder Carcinoma: Linking biological insights to precision medicine20
Androgen annihilation versus advanced androgen blockage as first line treatment for metastatic castration resistant prostate cancer: A systematic review and meta-analysis20
Is it a new era for intrahepatic cholangiocarcinoma?19
Anticancer mechanisms and applications based on γδ T cells in cancer immunotherapy19
Current landscape of hypoxia in thyroid cancer pathogenesis and treatment19
Biomarkers in blood and saliva to screen fragile patients with solid tumors: A systematic review of the literature19
Elucidating the mechanistic role of ovarian cancer biomarkers: Lessons learnt from affinity-proteomics19
Symptomatologic outcomes of gut microbiota modifiers (probiotics, prebiotics and synbiotics) in cancer care: A scoping review of randomized controlled trials19
Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling19
Co-localization analysis of spatial transcriptomics in ligand-receptor pairs from tumor microenvironment19
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis19
Rare histotypes of epithelial biliary tract tumors: A literature review19
Molecular oncology of iodine refractory thyroid cancer current therapies and perspective19
Radiotherapy of high-grade gliomas: dealing with a stalemate19
IHC-based molecular classification in muscle-invasive urothelial bladder carcinoma: Prognostic and predictive value toward a clinically applicable IHC marker panel – A systematic review19
Chemoimmunotherapy efficacy in patients with and without liver metastases: A systematic review and meta-analysis19
Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma19
Targeting breast cancer stem cells through retinoids: A new hope for treatment19
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy19
Navigating chemotherapy and immunotherapy in early-stage lung cancer. A critical review and statements from INTERACTION group19
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis19
Prognostic value of CD49d in CLL: Systematic review and meta-analysis19
Uncovering the bookshelves of CRISPR-based libraries: Advances and applications in cancer studies19
Multidisciplinary therapy managements in endometrial and renal cancer patients treated with pembrolizumab and lenvatinib: a virtuous circle between oncologists and organ specialists19
Circular RNAs: A key modulator of established cancer hallmarks19
N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential19
Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities18
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer18
Radiosensitization strategies for hepatocellular carcinoma: Mechanisms, therapeutic advances, and clinical perspectives18
Evidence-based recommendations for induction and maintenance treatment of newly diagnosed transplant-ineligible multiple myeloma patients18
Management of patients with extensive small-cell lung cancer in the immunotherapy era: An Italian consensus through a Delphi approach18
Immune checkpoint inhibitors as a threat to reproductive function: A systematic review18
The diagnostic accuracy of single-item scales in detecting fatigue in patients with cancer: A systematic review and meta-analysis18
Delta-like ligand 3 in small cell lung cancer: Potential mechanism and treatment progress18
Endometrial cancer in the elderly: Characteristics, prognostic and risk factors, and treatment options18
The educational contribution of the college of the European school of oncology (ESCO): A survey analysis of the first three years18
Role of innate immunity in tumor microenvironment of HPV-associated anal cancer: The hypothetical beneficial role of γδ T cells.18
Evaluation of clinical decision support systems in oncology: An updated systematic review18
Incidence of antibody–drug conjugates-related pneumonitis in patients with solid tumors: A systematic review and meta-analysis18
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver18
Editorial Board18
Editorial Board18
Effect of non-pharmacological interventions on symptoms and quality of life in patients with hematological malignancies – A systematic review17
TRAIL-functionalized nanoparticles in cancer therapy: Molecular mechanisms and translational opportunities17
Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma: a narrative review17
Pseudogenes in breast cancer pathogenesis and their clinical utility17
Radioprotective agents against the ionizing radiation-induced hematopoietic stem and progenitor cell injury; Foundation review17
A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms17
Novel insights into UDP-glucuronosyltransferase 1A1 dysfunction and Gilbert’s syndrome on estrogen metabolism and breast cancer17
Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments17
The role of the SIX family in cancer development and therapy: Insights from foundational and cutting-edge research17
Immunotherapy failure in glioblastoma: A systematic review and meta-analysis of randomized controlled trials17
The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review17
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part I17
The impact of PARP inhibitors in the whole scenario of ovarian cancer management: A systematic review and network meta-analysis17
The roles of immune cells and non-immune cells in pre-metastatic niche of breast cancer17
Chimeric antigen receptor T cell immunotherapy for gynecological malignancies17
Additions and subtractions of radiotherapy in patients with oligometastatic non-small cell lung cancer under the era of immunotherapy17
mRNA vaccines in gastrointestinal cancers: Mechanistic basis, translational challenges, and emerging therapeutic strategies17
Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer17
Standardized molecular pathology workflow for ctDNA-based ESR1 testing in HR+/HER2- metastatic breast cancer16
Venetoclax and ibrutinib: Two partners for the front-line treatment of chronic lymphocytic leukemia16
Extrachromosomal DNA in cancer: Molecular mechanisms underlying oncogene amplification and tumor heterogeneity16
Safety assessment of antibody-drug conjugates: Nonclinical toxicology, non-active ingredients, and environmental risk considerations16
Profile of treatment-related adverse events of PD-1 blockade-based therapies in advanced esophageal cancer: A systematic review and meta-analysis16
KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)16
Spread through air spaces in lung cancer: From controversy to consensus16
Status of breast cancer in Latin American: Results of the breast cancer revealed initiative16
Which is the best treatment for melanoma brain metastases? A Bayesian network meta-analysis and systematic review16
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review16
Stereotactic body radiotherapy boost as an alternative to brachytherapy for cervical cancer: A scoping review16
Cardiovascular safety outcomes of chronic lymphocytic leukemia treatments: A systematic and targeted literature review16
Prognostic impact of CT-defined sarcopenia and prognostic nutritional index in immune checkpoint inhibitor–treated head and neck squamous cell carcinoma: A systematic review and meta-analysis16
Polyploid giant cancer cells: Underlying mechanisms, signaling pathways, and therapeutic strategies16
Dynamic interplay of neuroendocrine signaling and immuno-surveillance in tumor niche remodeling16
Neoadjuvant endocrine therapy for luminal breast tumors: State of the art, challenges and future perspectives16
Non-coding RNAs and liquid biopsies: Emerging biomarkers for cervical cancer16
Spatial transcriptomics in pancreatic cancer: Advances, prospects and challenges16
Epigenetics in advanced renal cell carcinoma: Potential new targets15
Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy15
Targeting metabolic reprogramming in multiple myeloma: Molecular mechanisms and potential therapeutic targets15
WEE1 inhibition in cancer therapy: Mechanisms, synergies, preclinical insights, and clinical trials15
Fatty acid in the tumor microenvironment: Perspectives for immunotherapy15
Venous thromboembolism in cancer and cancer immunotherapy15
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis15
Long non-coding RNAs as immune landscape regulators in cancer: A spotlight on HEIH in immuno-oncology15
Harnessing synergy: Innovative combinations to overcome PARP inhibitor resistance in cancer treatment15
Metaplastic breast cancer: A review15
Exploring the molecular interactions between ferroptosis and the Wnt/β-catenin signaling pathway: Implications for cancer and disease therapy15
The gut-tumor metabolic axis: A comprehensive exploration of bidirectional crosstalk in cancer immunotherapy15
The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic st15
Cardiac and vascular toxicity of amivantamab in non-small cell lung cancer (NSCLC): A systematic review15
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”15
Erratum to “Beyond the blood-brain barrier: Intranasal vaccines in cancer immunotherapy” [Crit. Rev. Oncol./Hematol. 216C (2025) 104938]15
Neural stem cells and glioblastoma stem cells: Redefining concepts15
Somatic and germline ATM variants in non-small-cell lung cancer: Therapeutic implications15
Evolving treatment for advanced non-small cell lung cancer harbouring common EGFR activating mutations15
Corrigendum to “Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers” [Crit. Rev. Oncol./Hematol. 196 (2024) 104275]14
From diagnosis and treatment to prognosis: Clinical prospects of artificial intelligence in multimodal research of hepatocellular carcinoma14
Patients’ selection and trial matching in early-phase oncology clinical trials14
How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on14
International consensus on the initial diagnostic workup of cancer of unknown primary14
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