Critical Reviews in Oncology Hematology

Article	Citations
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives	233
Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence	149
ctDNA as a cancer biomarker: A broad overview	121
TMB or not TMB as a biomarker: That is the question	111
Lung cancer in never smokers: The role of different risk factors other than tobacco smoking	111
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma	86
Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles	81
Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)	73
Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives	72
Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance	68
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	67
International liquid biopsy standardization alliance white paper	66
Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis	59
Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies	59
Breast cancer, screening and diagnostic tools: All you need to know	55
CD47: the next checkpoint target for cancer immunotherapy	51
Unmet supportive care needs of people with advanced cancer and their caregivers: A systematic scoping review	50
Immunotherapy addition to neoadjuvant chemotherapy for early triple negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	49
Liquid biopsy in bladder cancer: State of the art and future perspectives	49
Emerging role of exosomes as biomarkers in cancer treatment and diagnosis	48
The main sources of circulating cell-free DNA: Apoptosis, necrosis and active secretion	47
Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis	46
Volatile organic compounds in human matrices as lung cancer biomarkers: a systematic review	45
Immunotherapy for head and neck cancer: Present and future	45
Autophagy-related MicroRNAs in chronic lung diseases and lung cancer	44

The role of epithelial-mesenchymal transition in regulating radioresistance	43
Major and minor salivary gland tumours	42
New advances in exosome-based targeted drug delivery systems	42
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	42
Immunotherapy improves efficacy and safety of patients with HPV positive and negative head and neck cancer: A systematic review and meta-analysis	41
Novel drugs targeting EGFR and HER2 exon 20 mutations in metastatic NSCLC	41
Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment	40
Comprehensive review of chromophobe renal cell carcinoma	40
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societies	40
COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature	39
Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways	39
Fathoming the link between anthropogenic chemical contamination and thyroid cancer	39
A BRAF new world	37
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	37
New rising entities in cancer of unknown primary: Is there a real therapeutic benefit?	37
Melanoma of unknown primary: New perspectives for an old story	37
Triple negative breast cancer in the era of miRNA	36
Radiomics in cervical cancer: Current applications and future potential	36
Molecular landscape of recurrent cervical cancer	35
The clinical utility of microsatellite instability in colorectal cancer	35
Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications	35
Systemic Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma- A Systematic Review and Meta-Analysis	34
PD-L1 expression and Tumor mutation burden as Pathological response biomarkers of Neoadjuvant immunotherapy for Early-stage Non-small cell lung cancer: A systematic review and meta-analysis	34
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials	34
Prevention and treatment of FGFR inhibitor-associated toxicities	34
Exercise for individuals with bone metastases: A systematic review	33
Extranodal NK/T cell lymphoma, nasal type: An updated overview	33
Efficacy and safety of ibrutinib in diffuse large B-cell lymphoma: A single-arm meta-analysis	32
Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis	32
Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review	32
First-line systemic therapy for metastatic castration-sensitive prostate cancer: An updated systematic review with novel findings	31
Gender-dependent radiotherapy: The next step in personalised medicine?	31
Health-related quality of life in curatively-treated patients with esophageal or gastric cancer: A systematic review and meta-analysis	31
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	31
Which type of cancer patients are more susceptible to the SARS-COX-2: Evidence from a meta-analysis and bioinformatics analysis	31
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review. Part 2 – Radiological features and metric markers	31
Psychosocial, behavioral, and supportive interventions for pediatric, adolescent, and young adult cancer survivors: A systematic review and meta-analysis	30
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	30
Precursor lesions of vulvar squamous cell carcinoma – histology and biomarkers: A systematic review	30
The significance of stromal collagen organization in cancer tissue: An in-depth discussion of literature	29
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review	29
Introducing immunotherapy for advanced hepatocellular carcinoma patients: Too early or too fast?	29
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer	29
Rational use of 18F-FDG PET/CT in patients with advanced cutaneous melanoma: A systematic review	29
miR-26 family and its target genes in tumorigenesis and development	29
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	29
ECCO Essential Requirements for Quality Cancer Care: Prostate cancer	28
Coronavirus infection and immune system: An insight of COVID-19 in cancer patients	28
Non-coding RNAs and macrophage interaction in tumor progression	28
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer	28

Exposure to endocrine disruptors and risk of breast cancer: A systematic review	28
The effect of liver metastasis on efficacy of immunotherapy plus chemotherapy in advanced lung cancer	27
Predictors of efficacy of androgen-receptor-axis-targeted therapies in patients with metastatic castration-sensitive prostate cancer: A systematic review and meta-analysis	27
Tumor hypoxia: The major culprit behind cisplatin resistance in cancer patients	27
Obesity and prostate cancer: A narrative review	27
Latest evidence on immune checkpoint inhibitors in metastatic colorectal cancer: A 2022 update	26
Impact of immune cells on the hallmarks of cancer: A literature review	26
The use of radiation therapy for oligoprogressive/oligopersistent oncogene-driven non small cell lung cancer: State of the art	26
Mechanisms of resistance to mTOR inhibitors	26
The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systemati	26
Characteristics of gastric cancer around the world	26
Radiomics and “radi-…omics” in cancer immunotherapy: a guide for clinicians	26
The prevalence of cancer associated systemic inflammation: Implications of prognostic studies using the Glasgow Prognostic Score	26
Preimplantation genetic testing for carriers of BRCA1/2 pathogenic variants	26
Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer	26
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	25
A user’s guide to lorlatinib	25
The application of nano-medicine to overcome the challenges related to immune checkpoint blockades in cancer immunotherapy: Recent advances and opportunities	25
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies	25
Low-risk triple-negative breast cancers: Clinico-pathological and molecular features	24
Muscle hypertrophy in cancer patients and survivors via strength training. A meta-analysis and meta-regression	24
Ischemic stroke: A paradoxical manifestation of cancer	24
Next generation sequencing for liquid biopsy based testing in non-small cell lung cancer in 2021	24
Why brain radiation therapy should take account of the individual structural and functional connectivity: Toward an irradiation “à la carte”	24
A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy	23
Toxicity profile of epidermal growth factor receptor tyrosine kinase inhibitors for patients with lung cancer: A systematic review and network meta-analysis	23
The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice: A critical review	23
The role of chemotherapy in treatment of advanced breast cancer: an overview for clinical practice	23
A comprehensive review on the diagnosis and management of intimal sarcoma of the pulmonary artery	23
Osteosarcoma, chondrosarcoma and Ewing sarcoma: Clinical aspects, biomarker discovery and liquid biopsy	23
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	23
Rechallenge of immune checkpoint inhibitors: A systematic review and meta-analysis	22
Diagnosis and treatment of early and locally advanced non-small-cell lung cancer: The 2019 AIOM (Italian Association of Medical Oncology) clinical practice guidelines	22
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications	22
Effects of mindfulness-based interventions on fatigue in cancer survivors: A systematic review and meta-analysis of randomized controlled trials	22
Cardiotoxicity in breast cancer patients treated with radiation therapy: From evidences to controversies	22
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis	22
NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy	21
Oral potentially malignant disorders: A scoping review of prognostic biomarkers	21
Immune checkpoint inhibitors in endometrial cancer	21
Gene expression signatures: A tool for analysis of breast cancer prognosis and therapy	21
Risk of thrombosis with thrombopoietin receptor agonists for ITP patients: A systematic review and meta-analysis	21
Extracellular vesicles as biomarkers in malignant pleural mesothelioma: A review	20
Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients wi	20
The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review	20
The association between antibiotics use and outcome of cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis	20
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	19
Development of asciminib, a novel allosteric inhibitor of BCR-ABL1	19
Neoadjuvant chemotherapy in hormone receptor-positive/HER2-negative early breast cancer: When, why and what?	19
Role of neutrophil-lymphocyte ratio as a predictive factor of glioma tumor grade: A systematic review	19
The impact of anthropometric parameters on colorectal cancer prognosis: A systematic review and meta-analysis	19
Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy	19
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	19
Chimeric antigen receptor T cell therapy in oncology – Pipeline at a glance: Analysis of the ClinicalTrials.gov database	19
TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis	19
The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses	19
Exploring the role of respiratory microbiome in lung cancer: A systematic review	18
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	18
A systematic review and meta-analysis of the association between circulating tumor DNA (ctDNA) and prognosis in pancreatic cancer	18
Prognostic value of platelet-related measures for overall survival in esophageal squamous cell carcinoma: A systematic review and meta-analysis	18
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance	18
Systematic review: Soluble immunological biomarkers in advanced non-small-cell lung cancer (NSCLC)	18
Natural Killer cells and monoclonal antibodies: Two partners for successful antibody dependent cytotoxicity against tumor cells	18
Adjuvant therapy for pT1a-m3/pT1b esophageal squamous cell carcinoma after endoscopic resection: Esophagectomy or chemoradiotherapy? A critical review	18
Cell signaling pathways as molecular targets to eliminate AML stem cells	18
Management of pain in colorectal cancer patients	18
Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations	18
Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy	18
Update on drug transporter proteins in acute myeloid leukemia: Pathological implication and clinical setting	18
Mantle cell lymphoma	18
Management guidelines for stage III non-small cell lung cancer	17
The evolving landscape of anatomic pathology	17
Evolving pancreatic cancer treatment: From diagnosis to healthcare management	17
Cancer management during the COVID-19 pandemic: Choosing between the devil and the deep blue sea	17
Postmastectomy radiation therapy in early breast cancer: Utility or futility?	17
Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance	17
The relationship between hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: Systematic review and meta-analysis	17
Lymphoma in the setting of autoimmune diseases: A review of association and mechanisms	17
Does nutrition for cancer patients feed the tumour? A clinical perspective	17
Nanomedicine tactics in cancer treatment: Challenge and hope	17

Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy: A systematic review	17
Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells	17
Stereotactic reirradiation for local failure of brain metastases following previous radiosurgery: Systematic review and meta-analysis	17
Diagnosis and treatment of therapy-related acute myeloid leukemia	17
PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance	17
Global frequency and distribution of head and neck cancer in pediatrics, a systematic review	17
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy	17
PD-1/PD-L1 inhibitor monotherapy or in combination with chemotherapy as upfront treatment for advanced NSCLC with PD-L1 expression ≥ 50%: Selecting the best strategy	17
Exercise and lung cancer surgery: A systematic review of randomized-controlled trials	17
Unravelling the molecular mechanisms of prostate cancer evolution from genotype to phenotype	16
Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials	16
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	16
Carotid blowout syndrome after reirradiation for head and neck malignancies: a comprehensive systematic review for a pragmatic multidisciplinary approach	16
Novel aspects on gonadotoxicity and fertility preservation in lymphoproliferative neoplasms	16
How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults	16
The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice	16
Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis	16
Outcome of patients with advanced upper tract urothelial carcinoma treated with immune checkpoint inhibitors: A systematic review and meta-analysis	16
Type I interferons in pancreatic cancer and development of new therapeutic approaches	16
Current advances in PD-1/PD-L1 axis-related tumour-infiltrating immune cells and therapeutic regimens in glioblastoma	16
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	16
In vivo sentinel lymph node identification using fluorescent tracer imaging in colon cancer: A systematic review and meta-analysis	16
Recent insights into the role of the microbiome in malignant and benign hematologic diseases	16
Considerations for interactions of drugs used for the treatment of COVID-19 with anti-cancer treatments	16
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review	16
Tumor infiltrating lymphocytes (TILs) as a predictive biomarker of response to checkpoint blockers in solid tumors: A systematic review	16
New perspectives in genetics and targeted therapy for blastic plasmacytoid dendritic cell neoplasm	16
Therapeutic potential of p53 reactivation in cervical cancer	16
State of the art of radiomic analysis in the clinical management of prostate cancer: A systematic review	16
Metabolic rewiring in melanoma drug-resistant cells	16
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target	16
Telemedicine and the current opportunities for the management of oncological patients in Peru in the context of COVID-19 pandemic	16
The Impact of Pelvic Nodal Radiotherapy on Hematologic Toxicity: A Systematic Review with Focus on Leukopenia, Lymphopenia and Future Perspectives in Prostate Cancer Treatment	16
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	15
Surgical treatment of gastric cancer liver metastases: Systematic review and meta-analysis of long-term outcomes and prognostic factors	15
Radiation recall reactions: An oncologic enigma	15
Electrolyte disorders in advanced non-small cell lung cancer patients treated with immune check-point inhibitors: A systematic review and meta-analysis	15
Hype or hope – Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?	15
Implications of COVID-19 pandemic on lung cancer management: A multidisciplinary perspective	15
MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions	15
The role of cardio-protective agents in cardio-preservation in breast cancer patients receiving Anthracyclines ± Trastuzumab: a Meta-analysis of clinical studies	15
Toxicity of extended adjuvant endocrine with aromatase inhibitors in patients with postmenopausal breast cancer: A Systemtic review and Meta-analysis	15
BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients	15
Managing side effects of immune checkpoint inhibitors in breast cancer	15
Self-expandable metal stent (SEMS) placement or emergency surgery as palliative treatment for obstructive colorectal cancer: A systematic review and meta-analysis	15
The cyclin-dependent kinases pathway as a target for prostate cancer treatment: rationale and future perspectives	15
Breast cancer: An insight into its inflammatory, molecular, pathological and targeted facets with update on investigational drugs	15
Invadopodia: A potential target for pancreatic cancer therapy	15
Serum tumour markers in germ cell tumours: From diagnosis to cure	15
Uterine carcinosarcoma: An overview	15
Osteosarcoma of the jaws: An overview of the pathophysiological mechanisms	15
Radiotherapy based management during Covid-19 pandemic – A systematic review of presented consensus and guidelines	14
The role of immune checkpoint inhibitors in the treatment sequence of advanced gastric or gastro-esophageal junction cancer: A systematic review and meta-analysis of randomized trials	14
Imaging response evaluation after neoadjuvant treatment in soft tissue sarcomas: Where do we stand?	14
Role of innate and adaptive immunity in the efficacy of anti-HER2 monoclonal antibodies for HER2-positive breast cancer	14
Current concepts and future directions for hemato-oncologic diagnostics	14
miRNA as promising theragnostic biomarkers for predicting radioresistance in cancer: A systematic review and meta‐analysis	14
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications	14
Daratumumab-based induction therapy for multiple myeloma: A systematic review and meta-analysis	14
Milestones in the treatment of hepatocellular carcinoma: A systematic review.	14
Targeting acute myeloid leukemia stem cells: Current therapies in development and potential strategies with new dimensions	14
Risk of bleeding complications and atrial fibrillation associated with ibrutinib treatment: A systematic review and meta-analysis	14
Circulating tumor cell detection methods in renal cell carcinoma: A systematic review	14
Association of periodontitis and tooth loss with liver cancer: A systematic review	13
Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis	13
Late radiation effects in survivors of head and neck cancer: State of the science	13
Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae	13
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	13
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	13
Neoadjuvant immunotherapy in head and neck cancer: Rationale, current evidence and future perspective	13
Bipolar androgen therapy in prostate cancer: Current evidences and future perspectives	13
Association between telomere length and mitochondrial copy number and cancer risk in humans: A meta-analysis on more than 300,000 individuals	13
Diet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis	13
Role of stereotactic radiosurgery for the treatment of brain metastasis in the era of immunotherapy: A systematic review on current evidences and predicting factors	13
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	13
Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: the THOCOoP cooperative group	13
Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites	13
Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials	13
Current treatment options for HER2-positive breast cancer patients with brain metastases	13
Exploring the knowledge gap of immune checkpoint inhibitors in chronic renal failure: A systematic review of the literature	13
Molecular landscape of Hereditary Melanoma	13
Magnitude of benefit of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for malignant tumor: A meta-analysis	13
Advanced and recurrent endometrial cancer: State of the art and future perspectives	12
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis	12
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma	12
A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma	12
Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach	12
Induction chemotherapy plus concomitant chemoradiotherapy in nasopharyngeal carcinoma: An updated network meta-analysis	12
Anaplastic Astrocytoma: State of the art and future directions	12
Brain metastasis formation and irradiation by stereotactic radiation therapy combined with immunotherapy: A systematic review	12
The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations	12
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	12
Targeting TRK: A fast-tracked application of precision oncology and future directions	12
Effectiveness of low level laser therapy versus cryotherapy in cancer patients with oral mucositis: Systematic review and network meta-analysis	12
TRK fusion positive cancers: From first clinical data of a TRK inhibitor to future directions	12