Critical Reviews in Oncology Hematology

Article	Citations
Trastuzumab deruxtecan in breast cancer	150
Research update for ferroptosis and cholangiocarcinoma	111
Evaluation of first-line and salvage therapies for unresectable malignant mesothelioma: A systematic review and network meta-analysis	109
Perioperative chemotherapy versus adjuvant chemotherapy in patients with resectable gastric cancer: A systematic review with meta-analysis	98
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting	77
Treatment of melanoma brain metastases with radiation and immunotherapy or targeted therapy: A systematic review with meta-analysis	68
Genomic biology and therapeutic strategies of liver metastasis from gastric cancer	67
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer	62
Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities	61
Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review	59
Impact of molecular testing on the surgical management of advanced epithelial ovarian cancer	59
Management of acute spinal cord compression in multiple myeloma	55
Treatment strategies for locally advanced non-small cell lung cancer in elderly patients: Translating scientific evidence into clinical practice	54
Epigenetics in advanced renal cell carcinoma: Potential new targets	53
The applications of plasma cell-free DNA in cancer detection: Implications in the management of breast cancer patients	50
Hurrying up but not rushing, acting and not reacting, good sense and not common sense: Open thoughts and reasonable doubts on COVID-19 vaccination strategies in cancer patients	50
Adjuvant chemotherapy after neoadjuvant chemo-radiotherapy and surgery in locally advanced rectal cancer. A systematic review of literature with a meta-analysis of randomized clinical trials	49
Current status of locally advanced rectal cancer therapy and future prospects	47
Targeting androgen receptor in glioblastoma	45
Application of molecular imaging in immune checkpoints therapy: From response assessment to prognosis prediction	45
Diagnosis and treatment of therapy-related acute myeloid leukemia	43
Comprehensive approach to cancer immunotherapy – Simultaneous targeting of myeloid-derived suppressor cells and cancer cells with AFP conjugates	43
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II	42
Immune checkpoint inhibitors therapy as the game-changing approach for pediatric lymphoma: A brief landscape	42
Filgrastim biosimilar (EP2006): A review of 15 years’ post-approval evidence	42

International consensus on the initial diagnostic workup of cancer of unknown primary	41
Geriatric predictors of response and adverse events in older patients with cancer treated with immune checkpoint inhibitors: A systematic review	38
Daratumumab-based induction therapy for multiple myeloma: A systematic review and meta-analysis	36
Progress and prospects of flattening filter free beam technology in radiosurgery and stereotactic body radiotherapy	35
Dose and volume de-escalation of radiotherapy in head and neck cancer	35
The management of oligometastatic disease in colorectal cancer: Present strategies and future perspectives	35
Recent strategies to overcome breast cancer resistance	35
Overcoming barriers to timely recognition and treatment of cancer cachexia: Sharing Progress in Cancer Care Task Force Position Paper and Call to Action	34
A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin’s Lymphoma	34
Theragnostic strategies harnessing the self-renewal pathways of stem-like cells in the acute myeloid leukemia	34
Comprehensive review of solid tumor bone marrow metastasis	34
Circular RNAs and thyroid cancer: Closed molecules, open possibilities	33
The 2022 Assisi Think Tank Meeting: White paper on optimising radiation therapy for breast cancer	32
Potential therapeutic targets in myeloid cell therapy for overcoming chemoresistance and immune suppression in gastrointestinal tumors	32
How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults	31
Standard Operating Procedures (SOPs) for non-invasive multiple biomarkers detection in an academic setting: A critical review of the literature for the RENOVATE study protocol	31
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials	31
High dose chemotherapy followed by autologous hematopoietic stem cell transplantation for advanced germ cell tumors: State of the art and a single-center experience	30
The intestinal microbiota in colorectal cancer metastasis – Passive observer or key player?	29
Thrombotic microangiopathy (aHUS/iTTP) reported so far in Covid-19 patients: The virus alone or an omnium gatherum of mechanisms and etiologies?	29
Thoracic re-irradiation with 3D-conformal or more advanced techniques: A systematic review of treatment safety by the Re-irradiation Study Group of the Italian Association of Radiation and Oncology AI	29
C-reactive protein (CRP) as a prognostic biomarker in patients with urothelial carcinoma: A systematic review and meta-analysis	29
BCMA CAR-T induces complete and durable remission in plasmablastic lymphoma synchronous transformation of chronic lymphocytic leukemia: Case report and literature review	28
A meta-analysis of palifermin efficacy for the management of oral mucositis in patients with solid tumours and haematological malignancy	28
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment	28
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications	28
KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies	27
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy	27
Navigating management of localized prostate cancer in the geriatric population	27
The prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis	27
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions	26
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches	26
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance	25
Considerations on antimicrobial prophylaxis in patients with lymphoproliferative diseases: A SEIFEM group position paper	25
Enhancing breast cancer surgery outcomes: A comprehensive review of oncoplastic techniques, surgical planning, and aesthetic considerations	25
Nrf2--a hidden bridge linking cancer stem cells to ferroptosis	24
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app	24
Patient reported outcomes in the daily practice in clinical oncology: A systematic review	24
Dynamics of eligibility criteria for central nervous system metastases in non-small cell lung cancer randomized clinical trials over time: A systematic review	24
Recommendation for the contouring of limbic system in patients receiving radiation treatment: A pictorial review for the everyday practice and education	24
Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates	24
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review	23
Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors	23
Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated myelodysplastic syndrome: A systematic review and meta-analysis	23
Working tables on Hormone Receptor positive (HR+), Human Epidermal growth factor Receptor 2 negative (HER2-) early stage breast cancer: Defining high risk of recurrence	22
Potential agnostic role of BRCA alterations in patients with several solid tumors: One for all, all for one?	22
DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy	22
Editorial Board	22
Maintenance strategies after anti-EGFR-based induction in metastatic colorectal cancer: A systematic review and bayesian network meta-analysis	22
Preoperative treatments in borderline resectable and locally advanced pancreatic cancer: Current evidence and new perspectives	21

Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis	21
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?	21
Editorial Board	21
Editorial Board	21
Editorial Board	21
Editorial Board	21
Network meta-analysis of palliative treatments in patients with esophageal cancer	21
Integrating hereditary breast and ovarian cancer genetic counselling and testing into mainstream clinical practice: Legal and ethical challenges	21
Editorial Board	20
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”	20
Open issues in the therapeutic management of unresectable stage III NSCLC in the immunotherapy era	20
Factor Xa inhibitors versus low molecular weight heparin for the treatment of cancer associated venous thromboembolism; A meta-analysis of randomized controlled trials and non-randomized studies	20
Postoperative treatment of intermediate-risk early stage cervical cancer: results of a survey from the Gynecology Study Group in the AIRO Gyn and MITO Groups	20
Editorial Board	20
A bone paradigm challenging the standard model of myeloma oncogenesis	19
Real-world insights into the efficacy and safety of tyrosine kinase inhibitors against thyroid cancers	19
Molecular biomarkers in prostate cancer tumorigenesis and clinical relevance	19
Editorial Board	19
Recent approaches for the treatment of uveal melanoma: Opportunities and challenges	19
Brain metastases and next-generation anticancer therapies: a survival guide for clinicians	19
Navigating immune cell immunometabolism after liver transplantation	19
Clinical evidence and adverse event management update of patients with RET- rearranged advanced non-small-cell lung cancer (NSCLC) treated with pralsetinib	19
Letter to the Editor regarding the article “Prognostic significance of SF3B1 mutations in patients with myelodysplastic syndromes: A meta-analysis”	18
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis	18
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	18
Nano based-oncolytic viruses for cancer therapy	18
Editorial Board	18
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm	18
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma	18
Editorial Board	18
Neoadjuvant immunotherapy in head and neck cancer: Rationale, current evidence and future perspective	18
Novel insights of acute myeloid leukemia with CEBPA deregulation: Heterogeneity dissection and re-stratification	18
What is the role of physical exercise in the era of cancer prehabilitation? A systematic review	17
Management of bone disease with concurrent chimeric antigen receptor T-cell therapy for multiple myeloma	17
Tumor budding is a prognostic factor in head and neck squamous cell carcinoma: A comprehensive meta-analysis and trial sequential analysis	17
Faecal immunochemical tests can improve colonoscopy triage in patients with iron deficiency: A systematic review and meta-analysis	17
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis	17
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	17
Survival and toxicity of weekly cisplatin chemoradiotherapy versus three-weekly cisplatin chemoradiotherapy for head and neck cancer: A systematic review and meta-analysis endorsed by the Italian Asso	17
Multigenic panels in breast cancer: Clinical utility and management of patients with pathogenic variants other than BRCA1/2	17
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	17
Recent insights into the role of the microbiome in malignant and benign hematologic diseases	17
Hematopoietic stem cell stretches and moves in its bone marrow niche	16
BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications	16
Patients’ selection and trial matching in early-phase oncology clinical trials	16
The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses	16
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth	16
Inhibition of acetylation, is it enough to fight cancer?	16
Neoadjuvant chemotherapy in hormone receptor-positive/HER2-negative early breast cancer: When, why and what?	16
The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice	16
Gut and local microbiota in patients with cancer: increasing evidence and potential clinical applications	16
Gene expression signatures in older patients with breast cancer: A systematic review	16
Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies	16
The role of PARP inhibitors in gastrointestinal cancers	16
Targeted immunotherapy to cancer stem cells: A novel strategy of anticancer immunotherapy	16
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies	16
Cell signaling pathways as molecular targets to eliminate AML stem cells	16
From preclinical efficacy to 2022 (36.7 months median follow -up) updated CROWN trial, lorlatinib is the preferred 1st-line treatment of advanced ALK+ NSCLC	15
Paraneoplastic syndromes review: The great forgotten ones	15
Comparison of the efficacy and safety of first-line treatments based on clinicopathological characteristics for patients with advanced epidermal growth factor receptor mutated non-small-cell lung canc	15
The application of cancer stem cell model in malignant mesothelioma	15
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	15
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review	15
Effectiveness of low level laser therapy versus cryotherapy in cancer patients with oral mucositis: Systematic review and network meta-analysis	15
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer	15
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target	15
Donor-derived and off-the-shelf allogeneic anti-CD19 CAR T-cell therapy for R/R ALL and NHL: A systematic review and meta-analysis	15
cGAS-STING at the crossroads in cancer therapy	15
Colorectal cancer with BRAF V600E mutation: Trends in immune checkpoint inhibitor treatment	14
Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy	14
Lymph node metastasis in cancer: Clearing the clouds to see the dawn	14
Thrombosis and cachexia in cancer: Two partners in crime?	14
Outcomes in randomized controlled trials of therapeutic interventions for multiple myeloma: A systematic review	14
Current management of cervical cancer in women living with HIV	14
The role of hyperthermia in the treatment of tumor	14
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics	14
Corrigendum to “Prevalence of treatment-related adverse events (TRAEs) with antibody-drug conjugates in metastatic breast cancer patients: A systematic review and meta-analysis” [Crit. Rev. Oncol./Hem	14
A clinical evaluation of robotic-assisted radical prostatectomy (RARP) in located prostate cancer: A systematic review and network meta-analysis	14
Corrigendum to “Navigating the complexity of PI3K/AKT pathway in HER-2 negative breast cancer: Biomarkers and beyond” [Crit. Rev. Oncol./Hematol. 200C (2024) 104404]	14
Third-line treatment and beyond in metastatic colorectal cancer: What do we have and what can we expect?	14

Blood-based liquid biopsy in advanced prostate cancer	13
Therapeutic sequencing in advanced renal cell carcinoma: How to choose considering clinical and biological factors	13
Understanding mechanisms of resistance to FLT3 inhibitors in adult FLT3-mutated acute myeloid leukemia to guide treatment strategy	13
Diagnosis and treatment of cholangiocarcinoma in Italy: A Delphi consensus statement	13
The biology and treatment of leiomyosarcomas	13
Incidence of antibody–drug conjugate-related fatigue in patients with breast cancer: A systematic review and meta-analysis	13
Update on drug transporter proteins in acute myeloid leukemia: Pathological implication and clinical setting	13
Comprehensive review of chromophobe renal cell carcinoma	13
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology	13
Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach	13
Bacteria-driven cancer therapy: Exploring advancements and challenges	13
Editorial Board	13
Predictors of response to neoadjuvant therapy in urothelial cancer	13
Circulating tumor cell detection methods in renal cell carcinoma: A systematic review	13
Risk of thrombosis with thrombopoietin receptor agonists for ITP patients: A systematic review and meta-analysis	13
Efficacy and safety of first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) combined with chemotherapy or antiangiogenic therapy as first-line treatment in patien	13
Live European School of Oncology e-Sessions (e-ESO)	13
Long non-coding RNA and the tumor microenvironment: Prospects for clinical applications in breast cancer	12
The optimal timing between neoadjuvant therapy and surgery of breast cancer: A brief systematic review of the literature	12
Immunologic disparities in prostate cancer between American men of African and European descent	12
Managing side effects of immune checkpoint inhibitors in breast cancer	12
Editorial Board	12
Chronic pain management in sickle cell disease: A systematic scoping review of controlled trials	12
Comparative effectiveness and safety of eribulin in advanced or metastatic breast cancer: a systematic review and meta-analysis	12
Primary neuroendocrine neoplasms of the vulva: A review of the MITO rare cancer group	12
An empirical review on the resistance mechanisms of epidermal growth factor receptor inhibitors and predictive molecular biomarkers in colorectal cancer	12
New options and open issues in the management of unresectable stage III and in early-stage NSCLC: A report from an expert panel of Italian medical and radiation oncologists – INTERACTION group	12
Puzzling out iron complications in cancer drug resistance	12
Current mRNA-based vaccine strategies for glioma treatment	11
Can inflammasomes promote the pathophysiology of glioblastoma multiforme? A view about the potential of the anti-inflammasome therapy as pharmacological target	11
Effectiveness and safety of immune checkpoint inhibitors in combination with palliative radiotherapy in advanced melanoma: A systematic review	11
Prognostic factors in salvage surgery for recurrent head and neck cancer: A systematic review and meta-analysis	11
Chemotherapy is superior to checkpoint inhibitors after radical surgery for urothelial carcinoma: a systematic review and network meta-analysis of oncologic and toxicity outcomes	11
UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?	11
Long noncoding RNA expression in acute lymphoblastic leukemia: A systematic review	11
ESO's career development program (2002-2021): Presentation and evaluation	11
Perioperative imaging predictors of tumor progression and pseudoprogression: A systematic review	11
Tumor-associated macrophages in non-small-cell lung cancer: From treatment resistance mechanisms to therapeutic targets	11
Impact of immune cells on the hallmarks of cancer: A literature review	11
Clinical implications of the Drug-Drug Interaction in Cancer Patients treated with innovative oncological treatments	11
Predictive factors for return to work among cancer survivors in Europe: A systematic review	11
Editorial Board	11
Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis	11
Digestive MiNENs: Could histological classification and molecular characterization drive clinical outcome and therapeutic approach?	11
Targeting pediatric solid tumors in the new era of RNA therapeutics	11
Inadequate health-related quality of life assessment and reporting in phase III clinical trials of immune checkpoint inhibitors in solid cancers: A systematic review	11
Exploring pulmonary function and physical function in childhood cancer: A systematic review	11
Improving the efficiency of immune checkpoint inhibitors for metastatic pMMR/MSS colorectal cancer: Options and strategies	11
Total neoadjuvant therapy in rectal cancer: the evidence and expectations	11
Targeting TRK: A fast-tracked application of precision oncology and future directions	11
Special features of sarcomas developed in patients with Lynch syndrome: A systematic review	11
Exploring biological heterogeneity and implications on novel treatment paradigm in BRAF-mutant metastatic colorectal cancer	11
Surrogate endpoints in phase III randomized trials of advanced gastroesophageal cancer: A systematic review and meta-analysis	10
Safety of immune checkpoint inhibitors: An updated comprehensive disproportionality analysis and meta-analysis	10
Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma	10
Thromboembolic risk in prostate cancer patients treated with PARP inhibitors: A systematic review and meta-analysis	10
Editorial Board	10
Editorial Board	10
Clinical pharmacology and drug-drug interactions of lenvatinib in thyroid cancer	10
Salivary gland cancer in the setting of tumor microenvironment: Translational routes for therapy	10
A systematic review and meta-analysis of adjuvant chemotherapy after chemoradiation for locally advanced cervical cancer	10
Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy	10
Efficacy and safety profile of avelumab monotherapy	10
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis	10
Unlocking Hope: Anti-VEGFR inhibitors and their potential in glioblastoma treatment	10
Editorial Board	10
Biopsychosocial factors related to transition among adolescents and young adults with sickle cell disease: A systematic review	10
Association of PD-L1 expression with survival benefit from PD-1/PD-L1 inhibitors in advanced cancer: Systematic review and meta-analysis of phase III randomized clinical trials	10
TEMPORARY REMOVAL: Role of the International Society of Liquid Biopsy (ISLB) in establishing quality control frameworks for clinical integrat	10
Severe infections in patients with chronic lymphocytic leukemia included in trials investigating BTK and BCL2 inhibitors	10
NTRK fusions in thyroid cancer: Pathology and clinical aspects	10
Fertility counseling in women with hereditary cancer syndromes	10
Immune checkpoint inhibitors combined with HER-2 targeted therapy in HER-2 positive gastroesophageal cancer	10
Cancer-related fatigue in childhood cancer survivors: A systematic scoping review on contributors of fatigue and how they are targeted by non-pharmacological interventions	10
Editorial Board	10
Potential role of cGAS/STING pathway in regulating cancer progression	10
Hype or hope – Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?	10
Comparing cardiovascular adverse events in cancer patients: A meta-analysis of combination therapy with angiogenesis inhibitors and immune checkpoint inhibitors versus angiogenesis inhibitors alone	9
Editorial Board	9
Patient reported outcome measure domains and tools used among adolescents and young adults with cancer: A scoping review	9
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	9
Killing two birds with one stone: Abscopal effect mechanism and its application prospect in radiotherapy	9
Uncommon targets in non-small cell lung cancer: Everyone wants a slice of cake	9
Risk Factors of Fluoropyrimidine Induced Cardiotoxicity among Cancer Patients: A Systematic Review and Meta-analysis	9
Systematic review of randomised clinical trials and observational studies for patients with RAS wild-type or BRAF-mutant metastatic and/or unresectable colorectal cancer	9
Differentiation therapy: Unlocking phenotypic plasticity of hepatocellular carcinoma	9
Bladder-sparing treatment for muscle-invasive bladder carcinoma using immune checkpoint inhibitors	9
Brain metastasis: An insight into novel molecular targets for theranostic approaches	9
Folate, folic acid, and chemotherapy-induced toxicities: A systematic literature review	9
In vivo sentinel lymph node identification using fluorescent tracer imaging in colon cancer: A systematic review and meta-analysis	9
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	9
Cutaneous adverse events associated with immune checkpoint blockade: A systematic review and meta-analysis	9
Cellular and molecular mechanisms implicated in the dual role of ROR2 in cancer	9
HER2-low breast cancer: Novel detections and treatment advances	9
The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations	9