OOIR: Observatory of International Research

Papers

(The median citation count of Critical Reviews in Clinical Laboratory Sciences is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Data analytics for error detection in clinical laboratories	69
Lipoprotein(a): a genetically determined risk factor for Cardiovascular disease	62
The dual roles of microorganisms in inflammatory diseases: initiators and regulators	55
The anion gap as a predictive tool for morbidity and mortality	52
Aptamer-based biosensing strategies for influenza virus detection: a systematic and critical review of electrochemical and optical platforms	52
Deep learning algorithms and Raman spectroscopy in the clinical laboratory setting	39
Advances and challenges in the measurement of 1,25-dihydroxyvitamin D: a comprehensive review	38
Machine learning-based error detection in the clinical laboratory: a critical review	35
Human telomere length detected by quantitative fluorescent in situ hybridization: overlooked importance and application	34
Single cell mechanodeformation signatures as early biomarkers for hematological malignancies	33
Copeptin as a surrogate marker for arginine vasopressin: analytical insights, current utility, and emerging applications	30
Transthyretin mutagenesis: impact on amyloidogenesis and disease	28
Clinical utility of human epididymis protein 4	27
Comparison of liquid biopsy-based technologies for cancer screening	26
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology	26
Beyond newborn screening: the role of reverse cascade testing in familial disease detection	24
Cardiovascular disease lipids and lipoproteins biomarker standardization	23
Indirect methods for the verification of reference intervals in laboratory medicine	23
Guidance for securing approvals for new biomarkers: from discovery to clinical implementation	23
Mid-regional pro-atrial natriuretic peptide in managing cardiovascular and cerebrovascular diseases	22
KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker	22
Development of next-generation reference interval models to establish reference intervals based on medical data: current status, algorithms and future consideration	21
One health and laboratory medicine: challenges and perspectives for antimicrobial resistance, emerging infections, and food/water security	21
Blood biomarkers for the diagnosis of chorioamnionitis following preterm premature rupture of membranes: a systematic review and meta-analysis of studies since 2020	19
It’s in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19	19

Challenges of insulin-like growth factor-1 testing	17
Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID	17
Association of inflammatory biomarkers with morbidity and mortality risk in patients with peripheral artery disease: a systematic review and meta-analysis	16
Stage-specific circulating transcriptomic and proteomic biomarkers and regulators in colorectal cancer: bridging affordable diagnostics and translational therapeutics	16
Analytical and clinical considerations of synovial fluid calprotectin in diagnosing periprosthetic joint infections	16
Emerging applications of machine learning in genomic medicine and healthcare	15
The intersection of the laboratory and transgender care	14
Pleural fluid biomarkers for the diagnosis and management of malignant pleural effusions: a clinical review	13
Therapeutic biomarkers in metastatic castration-resistant prostate cancer: does the state matter?	13
Methodological and conceptual challenges to the flow cytometric classification of leukemic lymphoproliferative disorders	12
Insight into metabolic dysregulation of polycystic ovary syndrome utilizing metabolomic signatures: a narrative review	12
General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis	12
Guidelines for diagnosing and differentiating infection with antifungal-resistant Trichophyton indotineae from other dermatophytoses	12
Circulating tumor DNA (ctDNA): can it be used as a pan-cancer early detection test?	12
Diagnostic stewardship monitoring systems: institutional and system-level approaches	12
Glycation and disease: a systematic review of the analytical methods and applications of advanced glycation end products (AGEs) as biomarkers of disease	12
From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure	11
Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)	11
Advances in internal quality control	11
DNA/RNA-based electrochemical nanobiosensors for early detection of cancers	11
The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects	11
Diagnostic performance and heterogeneity of validated flow cytometry scores: a systematic review	11
Free thyroxine measurement in clinical practice: how to optimize indications, analytical procedures, and interpretation criteria while waiting for global standardization	10
Point of care blood glucose devices in the hospital setting	10
Establishing, evaluating and monitoring analytical quality in the traceability era	9
Genetic variants of accessory proteins and G proteins in human genetic disease	9
Erroneous potassium results: preanalytical causes, detection, and corrective actions	9
Genotype-phenotype correlation in the spectrum of frontotemporal dementia-parkinsonian syndromes and advanced diagnostic approaches	9
Estimating glomerular filtration rate with new equations: can one size ever fit all?	8
Parallelism in neurodegenerative biomarker tests: hidden errors and the risk of misconduct	8
Current practices in the diagnosis of Lyme disease	8
Pre-analytical conditions and implementation of quality control steps in liquid biopsy analysis	8
Research progress of KL-6 in respiratory system diseases	8
Omics-based novel strategies in the diagnosis of endometriosis	8
Analytical performance specifications and quality assurance of point-of-care testing in primary healthcare	8
Correction	8
From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors	7
Pathologist workload, burnout, and wellness: connecting the dots	7
Large scale implementation of DP for clinical diagnoses: experience, challenges, and lessons learned	7
Beyond the amyloid hypothesis: how current research implicates autoimmunity in Alzheimer’s disease pathogenesis	7
The current state in liquid chromatography-mass spectrometry methods for quantifying kynurenine pathway metabolites in biological samples: a systematic review	6
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer	6
Loop-mediated isothermal amplification (LAMP)-based microbial detection: a review of FDA-authorized tests and future perspectives	6
Implementation of pharmacogenomics testing for precision medicine	6
Advances in minimal residual disease monitoring in multiple myeloma	6
Unveiling Parkinson’s disease through biomarker research: current insights and future prospects	6
The role of immunophenotyping in common variable immunodeficiency: a narrative review	5
Modern techniques used in the diagnosis of autoimmune rheumatic diseases	5
Reference intervals: past, present, and future	5
The European Organisation of External Quality Assurance Providers in Laboratory Medicine (EQALM) Statement: guidelines for publishing about interlaboratory comparison studies (PubILC)	5

Machine learning models for acute kidney injury prediction and management: a scoping review of externally validated studies	5
Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome	5
Mapping the evidence: a scoping review of the impact of COVID-19 on non-communicable disease care in Sub-Saharan Africa	5
G protein-coupled receptor (GPCR) gene variants and human genetic disease	5
Current status in cellular-based therapies for prevention and treatment of COVID-19	5