American Journal of Physiology-Lung Cellular and Molecular Physiology

Article	Citations
The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide	229
Mechanisms of cigarette smoke-induced COPD: insights from animal models	219
Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects	178
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies	152
Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles	138
The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes	133
Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension	122
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers	112
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS	111
Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function	103
Neutrophil maturation and activation determine anatomic site of clearance from circulation	99
Differentiated structure and function of cultures from human tracheal epithelium	97
Inflection points in sepsis biology: from local defense to systemic organ injury	90
Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle	88
Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstit	87
Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials	86
Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury	86
Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia	86
Caveolae from canine airway smooth muscle contain the necessary components for a role in Ca2+handling	85
New asthma biomarkers: lessons from murine models of acute and chronic asthma	84
Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace	83
Platelets in the pathogenesis of acute respiratory distress syndrome	82
Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia	82
Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins	80
Release of biologically active TGF-β from airway smooth muscle cells induces autocrine synthesis of collagen	80

Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease	79
Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis	79
Biomarkers of exposure to new and emerging tobacco delivery products	78
Hypermethylation-mediated silencing of p14ARF in fibroblasts from idiopathic pulmonary fibrosis	77
Human SP-A protein variants derived from one or both genes stimulate TNF-α production in the THP-1 cell line	77
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+entry	76
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1	75
The evolutionary continuum from lung development to homeostasis and repair	75
Intratracheal administration of clinical-grade mesenchymal stem cell-derived extracellular vesicles reduces lung injury in a rat model of bronchopulmonary dysplasia	75
Alveoli increase in number but not size from birth to adulthood in rhesus monkeys	74
Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium	74
Flavored e-cigarette liquids reduce proliferation and viability in the CALU3 airway epithelial cell line	73
Mechanical stretch-induced serotonin release from pulmonary neuroendocrine cells: implications for lung development	73
Surfactant protein A protects growing cells and reduces TNF-alpha activity from LPS-stimulated macrophages	71
Increased production of TGF-β and apoptosis of T lymphocytes isolated from peripheral blood in COPD	71
Mesenchymal stem cell-conditioned media recovers lung fibroblasts from cigarette smoke-induced damage	69
Acute exposure to e-cigarettes causes inflammation and pulmonary endothelial oxidative stress in nonsmoking, healthy young subjects	69
IL-17 enhances IL-1β-mediated CXCL-8 release from human airway smooth muscle cells	69
Alterations of lung microbiota in a mouse model of LPS-induced lung injury	69
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats	69
Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury	68
Loss of liquid from the lung lumen in labor: more than a simple “squeeze”	67
B cells in chronic obstructive pulmonary disease: moving to center stage	67
Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice	67
Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors	66
Characterization of mucins from cultured normal human tracheobronchial epithelial cells	65
Inflammation and lung maturation from stretch injury in preterm fetal sheep	65
Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide	64
Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death	64
Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension	64
Prostaglandin E2protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction	63
Mucins and their O-Glycans from human bronchial epithelial cell cultures	63
Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90	62
Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs	62
Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials	61
Development of solitary chemosensory cells in the distal lung after severe influenza injury	61
The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models	61
Stereological monitoring of mouse lung alveolarization from the early postnatal period to adulthood	61
Optical method for quantifying rates of mucus secretion from single submucosal glands	61
Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation	59
Cellular senescence in the lung across the age spectrum	58
Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers	58
Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates	57
Prophylactic treatment with MSC-derived exosomes attenuates traumatic acute lung injury in rats	56
Inflammation in fetal sheep from intra-amniotic injection of Ureaplasma parvum	56
Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury	55
Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-κB and AP-1	54
Reactive oxygen species stimulate VEGF production from C2C12skeletal myotubes through a PI3K/Akt pathway	54
Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury	54
Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells	53

Mechanical stretch stimulates macrophage inflammatory protein-2 secretion from fetal rat lung cells	53
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis	52
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension	52
Three-dimensional imaging and morphometric analysis of alveolar tissue from microfocal X-ray-computed tomography	51
Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients	50
Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants	50
Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle	50
Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells	49
Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia	48
Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment	48
TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation	48
Sustained inflation at birth did not protect preterm fetal sheep from lung injury	48
Mesenchymal stromal cell-derived exosomes improve mitochondrial health in pulmonary arterial hypertension	48
MiRNA let-7b promotes the development of hypoxic pulmonary hypertension by targeting ACE2	45
Nucleotides induce IL-6 release from human airway epithelia via P2Y2and p38 MAPK-dependent pathways	45
Pulmonary inflammation induced by low-dose particulate matter exposure in mice	44
Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1β	44
Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth	44
The LAM cell: what is it, where does it come from, and why does it grow?	43
Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome	43
Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury	42
Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?	42
Antiviral immunity is impaired in COPD patients with frequent exacerbations	42
Decreased miR-29b expression is associated with airway inflammation in chronic obstructive pulmonary disease	42
Fine airborne urban particles (PM2.5) sequester lung surfactant and amino acids from human lung lavage	42
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats	41
Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis	41
Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice	41
Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats	41
The Tcf21 lineage constitutes the lung lipofibroblast population	40
Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury	40
Tracing surfactant transformation from cellular release to insertion into an air-liquid interface	40
14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy	39
Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits	39
Sildenafil alters calcium signaling and vascular tone in pulmonary arteries from chronically hypoxic rats	38
Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis	38
Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense	37
Tomato juice prevents senescence-accelerated mouse P1 strain from developing emphysema induced by chronic exposure to tobacco smoke	37
Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix	37
Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD	37
Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs	37
Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells	36
Epidermal growth factor-like domain 7 protects endothelial cells from hyperoxia-induced cell death	36
NO protects alveolar type II cells from stretch-induced apoptosis. A novel role for macrophages in the lung	35
Oxidized α1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema	35
Ghrelin attenuates sepsis-induced acute lung injury by inhibiting the NF-κB, iNOS, and Akt signaling in alveolar macrophages	35
Cell deformation at the air-liquid interface induces Ca2+-dependent ATP release from lung epithelial cells	35
Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2	35
Protoporphyrin IX generation from δ-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation	34
Characteristics of surfactant from SP-A-deficient mice	34
Acute pulmonary effects of aerosolized nicotine	34
Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension	33
Short-chain fatty acids increase TNFα-induced inflammation in primary human lung mesenchymal cells through the activation of p38 MAPK	33
Lung inflammatory environments differentially alter mesenchymal stromal cell behavior	33
Early disruption of the alveolar-capillary barrier in a ricin-induced ARDS mouse model: neutrophil-dependent and -independent impairment of junction proteins	33
Endotracheal tube mucus as a source of airway mucus for rheological study	33
Extracellular vesicles in lung health, disease, and therapy	33
Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells	32
Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis	32
A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent	32
Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling	32
Depletion of circulating monocytes suppresses IL-17 and HMGB1 expression in mice with LPS-induced acute lung injury	32
Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension	32
A retrospective of lung morphometry: from 1963 to present	32
Animal models of pulmonary fibrosis: how far from effective reality?	31
Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice	31
HDAC8 inhibition ameliorates pulmonary fibrosis	31
GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery	31
Oxygen increases ductus arteriosus smooth muscle cytosolic calcium via release of calcium from inositol triphosphate-sensitive stores	30
Epidermal growth factor receptor paracrine upregulation in idiopathic pulmonary fibrosis fibroblasts is blocked by nintedanib	30
Disruption of the airway epithelial barrier in a murine model of respiratory syncytial virus infection	30
Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis	30
Metagenomic comparison of tracheal aspirate and mini-bronchial alveolar lavage for assessment of respiratory microbiota	30
Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice	29
Resolvin D1 attenuates mechanical stretch-induced pulmonary fibrosis via epithelial-mesenchymal transition	29
Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts	29
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension	29
GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injury	29
Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice	29