OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Lung Cellular and Molecular Physiology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-07-01 to 2026-07-01.)

Article	Citations
Simple model of pulmonary hypertension secondary to left heart pressure overload induced by partial intravascular occlusion of the ascending aorta	47
Feeling good: welcoming the new editorial team for American Journal of Physiology-Lung Cellular and Molecular Physiology	46
A proinflammatory long noncoding RNA Lncenc1 regulates inflammasome activation in macrophage	44
Rat bronchoalveolar lavage proteome changes following e-cigarette aerosol exposures	44
ARDS in the time of corona: context and perspective	42
Computer model-based injury prediction and evaluation of lung function in mice with acute and ventilator-induced lung injuries	41
A personal appreciation of Mary Ellen Avery for World Prematurity Day	39
Endothelial knockdown of the tumor suppressor, WWOX , increases inflammation in ventilator-induced lung injury	37
A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury	37
PTPα promotes fibroproliferative responses after acute lung injury	32
Publisher’s note	32
Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced bySaccharopolyspora rectivirgula	32
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells	31
The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease	29
Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma	29
Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation	29
Increased exploration and hyperlocomotion in a cigarette smoke and LPS-induced murine model of COPD: linking pulmonary and systemic inflammation with the brain	29
COPD susceptibility gene HHIP regulates repair genes in airway epithelial cells and repair within the epithelial-mesenchymal trophic unit	29
Role of STIM1 in stretch-induced signaling in human airway smooth muscle	27
Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model	27
Electronic cigarette exposure disrupts airway epithelial barrier function and exacerbates viral infection	27
Dynamic driving pressure predicts ventilator-induced lung injury in mice with and without endotoxin-induced acute lung injury	26
Role of transient receptor potential vanilloid 4 in therapeutic antifibrotic effects of pirfenidone	26
High-fat diet obesity exacerbates acute lung injury-induced dysregulation of fatty acid oxidation in alveolar epithelial type 2 cells	26
Activation of platelets and the complement system in mice with Schistosoma-induced pulmonary hypertension	26

CFTR as a therapeutic target for severe lung infection	25
Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension	25
Functional modulation of retrotrapezoid neurons drives fentanyl-induced respiratory depression	25
Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury	25
Biomarkers of alveolar epithelial injury and endothelial dysfunction are associated with scores of pulmonary edema in invasively ventilated patients	24
β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation	24
T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4^−/−)-deficient rats in basal and stress conditions	23
Editorial Board	23
Inflammatory and antiviral responses to influenza A virus infection are dysregulated in pregnant mice with allergic airway disease	22
Call for Papers: “Alveolar biology, pulmonary surfactant, and beyond”: a tribute to Dr. John Allen Clements on his 100th birthday	22
A comprehensive map of proteoglycan expression and deposition in the pulmonary arterial wall in health and pulmonary hypertension	22
Fibroblast cross talk promotes mucin synthesis by COPD-derived airway epithelial cells	22
Nicotinic receptors in airway disease	21
Effects of glial-derived neurotrophic factor on remodeling and mitochondrial function in human airway smooth muscle cells	21
Role of voltage-gated Ca ²⁺ channels and Ano1 Ca ²⁺ -activated Cl ⁻	21
The impact of hyperoxia and antibiotics on lung mesenchymal cells in experimental bronchopulmonary dysplasia	20
Endothelin-1 depletion of cartilage oligomeric matrix protein modulates pulmonary artery superoxide and iron metabolism-associated mitochondrial heme biosynthesis	20
FGF2 is secreted in extracellular vesicles from lung cells	20
Obese adipocytes induce fibroblast-to-myofibroblast transition through TGF-β1 signaling: implications in asthma pathogenesis	20
The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice	19
Pseudomonas aeruginosa exoenzyme Y activity inhibits exoenzyme S-induced caspase activation in pulmonary microvascular endothelial cells	19
Mesenchymal stromal cell extracellular vesicles reduce Pseudomonas biofilm formation, and let-7b-5p loading confers additional anti-inflammatory effects	19
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma	19
IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats	19
Good things: announcing the next round of the American Journal of Physiology-Lung Cellular and Molecular Physiology Editorial Board Fellowship Program	18
Predominant lung cDC2 phenotype in cigarette smoke-exposed mice favors polarization of IL-17-producing CD4 ⁺ T cells	18
Cross-journal Call for Papers on “Opioids and Respiratory Depression”	18
Biological sex influences immune response to influenza infection in juvenile outbred mice	18
Effect of physical activity in lymphocytes senescence burden in patients with COPD	17
Editorial Board	17
Circulating biomarker analyses in a longitudinal cohort of patients with IPF	17
SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury	17
Role of ZIP kinase in development of myofibroblast differentiation from HPMCs	16
Maternal diabetes and lung health: an unexplored risk factor for COPD?	16
M₄ muscarinic receptors mediate acetylcholine-induced suppressant effects on the cough reflex in the caudal nucleus tractus solitarii of the rabbit	16
A new Anticalin protein for IL-23 inhibits non-type 2 allergen-driven mouse lung inflammation and airway hyperresponsiveness	16
Surfactant Protein-A and its immunomodulatory roles in infant respiratory syncytial virus infection: a potential for therapeutic intervention?	16
Epinephrine evokes shortening of human airway smooth muscle cells following β₂adrenergic receptor desensitization	16
Roles of peripheral and central µ ₁ -opioid receptors in the fentanyl-induced cardiorespiratory responses	16
Living with lung disease: experimental models to assess the long-term effects of prematurity	16
Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia	16
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions	15
Changes in intestinal homeostasis and immunity in a cigarette smoke- and LPS-induced murine model for COPD: the lung-gut axis	15
Contribution of transient receptor potential canonical channels in human and experimental pulmonary arterial hypertension	15
Acute vaping in a golden Syrian hamster causes inflammatory response transcriptomic changes	15
Stem cells, cell therapies, and bioengineering in lung biology and disease 2021	15
Menthol in electronic cigarettes causes biophysical inhibition of pulmonary surfactant	15
Nicotine affects mitochondrial structure and function in human airway smooth muscle cells	15
Dietary influence on lung injury and immune modulation in cadmium-exposed mice	14
Every breath you take: exploring macrophages and environmental exposures in the lung—a tribute to Dr. Joseph Brain’s legacy	14

Targeted stereology: sampling heterogeneously distributed structures and lesions in the lung	14
Short-chain fatty acids improve inflamm-aging and acute lung injury in old mice	14
T cell and airway smooth muscle interaction: a key driver of asthmatic airway inflammation and remodeling	14
ENaC contributes to macrophage dysfunction in cystic fibrosis	14
High-altitude pulmonary edema: the intercellular network hypothesis	14
The pontine Kölliker-Fuse nucleus is important for reduced postinspiratory airflow elicited by stimulation of the ventral respiratory parafacial region	14
Reply to Myslivecek	13
Wnt5a/β-catenin axis is involved in the downregulation of AT2 lineage by PAI-1	13
Culture conditions differentially regulate the inflammatory niche and cellular phenotype of tracheobronchial basal stem cells	13
Pulmonary-delivered Anticalin Jagged-1 antagonists reduce experimental airway mucus hyperproduction and obstruction	13
Mitoquinone mesylate attenuates pathological features of lean and obese allergic asthma in mice	13
Understanding the role of placental pathophysiology in the development of bronchopulmonary dysplasia	13
Coal dust complexes host cell iron to impact metal homeostasis and pneumoconiosis	13
Analysis of the alveolar shape in 3-D	13
Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus	13
Muscarinic receptors in the nucleus tractus solitarii	13
cUMP elicits interendothelial gap formation during Pseudomonas aeruginosa infection	13
Corrigendum for Audi et al., volume 323, 2022, p. L410–L422	13
Particulate matter increases bone morphogenetic protein 2 in lung fibroblasts	12
Use of patient-derived organoids for pleural mesothelioma 3-D modeling	12
Sensitive physiological readouts to evaluate countermeasures for lipopolysaccharide-induced lung alterations in mice	12
Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures	12
Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions	12
Congenital heart disease-associated pulmonary dysplasia and its underlying mechanisms	12
Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx	12
The pyruvate kinase activator etavopivat (FT-4202) limits pulmonary and systemic sequelae of sepsis in a mouse LPS model	11
Inference of alveolar capillary network connectivity from blood flow dynamics	11
Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension	11
Lung pericytes as mediators of inflammation	11
Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture	11
Enhanced glycolysis causes extracellular acidification and activates acid-sensing ion channel 1a in hypoxic pulmonary hypertension	11
Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis	11
MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis	11
An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa	11
AlveolEye: rapid and precise lung morphometry guided by computer vision	11
LMTK2 switches on canonical TGF-β1 signaling in human bronchial epithelial cells	11
Bioenergetics and metabolism of the pulmonary endothelium. Scientific session I: ReSPIRE 2025	11
cAMP-enriched extracellular vesicles improve outcomes in pulmonary hypertension	11
Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia	11
Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease	11
CFTR modulators: a new class of antimicrobials in lung infection?	11
Chronic hyperglycemia aggravates lung function in a Scnn1b-Tg murine model	11
Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia	11
TLR9-mediated innate immune signaling contributes to acetaminophen-induced injury in the developing lung	10
Red blood cells function as reservoirs of tumor DNA	10
The matricellular protein CCN3 supports lung endothelial homeostasis and function	10
Sorted-cell proteomics reveals an AT1-associated epithelial cornification phenotype and suggests endothelial redox imbalance in human bronchopulmonary dysplasia	10
Prolonged, physiologically relevant nicotine concentrations in the airways of smokers	10
A proteomics approach to identify COPD-related changes in lung fibroblasts	10
Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α	10
Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33	10
Divergent ventilatory responses during opioid-induced respiratory depression in response to repeated fentanyl use	10
PMN recruitment in inflammatory lung injury models follows classical transendothelial migration paradigms requiring PECAM-1 and CD99	10
Combining innovative methodologies with deep personal connections to further physiology research: lessons from Joseph D. Brain, ScD	10
LncRNA HOTAIR contributes to cigarette smoke-induced pro-inflammatory responses in human airway epithelial cells	10
Distribution, composition, and activity of airway-associated adipose tissue in the porcine lung	10
Regulation of inflammatory lung injury and repair by transforming growth factors	10
Involvement of ryanodine receptors in the contraction of small pulmonary veins	10
Stereological analysis of the naked mole-rat Heterocephalus glaber lung provides evidence of altered surfactant function and late alveolarization	10
Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia	9
Identification of FGFR4 as a regulator of myofibroblast differentiation in pulmonary fibrosis	9
Are alveolar type 2 cells “oversaturated” in obesity and ARDS?	9
Piezo channels modulate human lung fibroblast function	9
Intravascular hemolysis aggravates ventilator-induced lung injury in mice	9
Optimizing miRNA transfection for screening in precision cut lung slices	9
GPx3 deficiency exacerbates maladaptive right ventricular remodeling in experimental pulmonary artery banding	9
Differential effects of α7nAChR activation in a murine model of asthma	9
Obesity elicits a unique metabolomic signature in human airway smooth muscle cells	9
Metabolic profiling of in vivo right ventricular function and exercise performance in pulmonary arterial hypertension	9
The differential roles of the two NO-GC isoforms in adjusting airway reactivity	9
Early-life pulmonary viral infection leads to long-term functional and lower airway structural changes in the lungs	9
BALF gene expression profiling reveals a fibrosis associated innate immune activation bias in persistent post-COVID-19 ILD	9
Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx	9
Multicompartmental analysis of the murine pulmonary immune response by spectral flow cytometry	9
Low tidal volume ventilation facilitates spontaneous increase in bronchoconstriction and air trapping that can be resolved by deep inspiration and bronchodilator	9
Intrauterine inflammation-induced neonatal lung injury via succinic acid-mediated alveolar epithelial E-cadherin downregulation	9
Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury	9
Sex chromosomes and gonadal sex interactions in airway and immune responses to allergen challenge	9