OOIR: Observatory of International Research

Papers

(The TQCC of Inflammation Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin	116
Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition	83
Molecular mechanisms of ferroptosis and relevance to inflammation	73
The phase changes of M1/M2 phenotype of microglia/macrophage following oxygen-induced retinopathy in mice	63
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis	59
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases	46
The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind placebo-controlled phase III CORONA clinic	42
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion	40
The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes	38
COVID-19 disrupts the blood–testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins	37
Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease	37
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19	35
Histamine receptors and COVID-19	35
Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction	35
Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis	34
Particulate matter in COPD pathogenesis: an overview	33
CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis	33
Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation	33
Notch signaling pathway in infectious diseases: role in the regulation of immune response	31
Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury	30
Adverse Ocular Events following COVID-19 Vaccination	29
Neuroinflammatory mediators in acquired epilepsy: an update	29
Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy	29
The role of lung macrophages in acute respiratory distress syndrome	28
TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis	28

Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus	28
Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report	26
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease	26
Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies	26
SARS-CoV-2 and pathological matrix remodeling mediators	25
Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway	25
Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation	24
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia	24
Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics	24
Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center longitudinal study	24
Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer	22
Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia	22
Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults	22
Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models	21
Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha	21
Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells—“utilization” of ferroptosis mechanism	21
FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy	21
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)	20
CD20+ T cells: an emerging T cell subset in human pathology	20
Burn injury induces elevated inflammatory traffic: the role of NF-κB	20
Luteolin alleviates ulcerative colitis through SHP-1/STAT3 pathway	19
Severity of SARS-CoV-2 infection is linked to double-negative (CD27− IgD−) B cell subset numbers	19
A case of reactivation of varicella–zoster virus after BNT162b2 vaccine second dose?	19
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis	18
Neutrophils as emerging protagonists and targets in chronic inflammatory diseases	17
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury	17
RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis	17
Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease	17
A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics	17
Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail	17
MicroRNA-199-3p up-regulation enhances chondrocyte proliferation and inhibits apoptosis in knee osteoarthritis via DNMT3A repression	17
Immunosenescence of T cells: a key player in rheumatoid arthritis	16
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain	16
Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis	16
Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss	16
Dual role of ANGPTL4 in inflammation	16
RETRACTED ARTICLE: Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis	16
Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO/NR4A3 axis	15
MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer	15
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications	15
COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines	15
Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury	15
Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data	14
Immune response associated with ischemia and reperfusion injury during organ transplantation	14
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy	14
FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages	14
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation	14
Comprehensive comparison of the prognostic value of systemic inflammation biomarkers for cancer cachexia: a multicenter prospective study	14
LncRNA MBLN1-AS1 inhibits the progression of retinoblastoma through targeting miR-338-5p-Wnt/β-catenin signaling pathway	14
The role of NK cells in rheumatoid arthritis	14

The star target in SLE: IL-17	13
Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection	13
Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus	13
Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review	13
Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα	13
Mitophagy-promoting miR-138-5p promoter demethylation inhibits pyroptosis in sepsis-associated acute lung injury	13
The pathophysiology of immunoporosis: innovative therapeutic targets	13
Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1	13
COVID-19 illness and autoimmune diseases: recent insights	13
Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects	12
Cysteinyl leukotriene D4 (LTD4) promotes airway epithelial cell inflammation and remodelling	12
4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition	12
Ethyl pyruvate, a versatile protector in inflammation and autoimmunity	12
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis	12
Emerging perspectives on mitochondrial dysfunctioning and inflammation in epileptogenesis	12
Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies	12
Activated M1 macrophages suppress c-kit expression via TNF-α-mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis	12
NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn	12
MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6	12
The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical eviden	12
Local IL-17 positive T cells are functionally associated with neutrophil infiltration and their development is regulated by mucosal microenvironment in nasal polyps	11
Review: the role of GSDMD in sepsis	11
Inflammatory biomarkers in staging of chronic kidney disease: elevated TNFR2 levels accompanies renal function decline	11
An apoptosis inhibitor suppresses microglial and astrocytic activation after cardiac ischemia/reperfusion injury	11
PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells	11
Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases	11
Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway	11
FK506 ameliorates osteoporosis caused by osteoblast apoptosis via suppressing the activated CaN/NFAT pathway during oxidative stress	11
Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis	11
The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to air pollution	11
The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19	11
Analysis of five cases of monogenic lupus related to primary immunodeficiency diseases	10
Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways	10
S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1	10
Manifestation of lipopolysaccharide-induced tolerance in neuro-glial primary cultures of the rat afferent somatosensory system	10
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation	10
Mast cell stabilization: new mechanism underlying the therapeutic effect of intense pulsed light on rosacea	10
An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration	10
How could perfluorocarbon affect cytokine storm and angiogenesis in coronavirus disease 2019 (COVID-19): role of hypoxia-inducible factor 1α	10
Bladder mesenchymal stromal cell-derived exosomal miRNA-217 modulates bladder cancer cell survival through Hippo-YAP pathway	10
Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway	10
PAX5 activates telomerase activity and proliferation in keloid fibroblasts by transcriptional regulation of SND1, thus promoting keloid growth in burn-injured skin	10
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice	10
Are chimeric antigen receptor T cells (CAR-T cells) the future in immunotherapy for autoimmune diseases?	9
Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis	9
The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A	9
The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer	9
Albiflorin attenuates high glucose-induced endothelial apoptosis via suppressing PARP1/NF-κB signaling pathway	9
A new mouse unilateral model of diffuse alveolar damage of the lung	9
gga-miR-142-3p negatively regulates Mycoplasma gallisepticum (HS strain)-induced inflammatory cytokine production via the NF-κB and MAPK signaling by targeting TAB2	9
Mechanistic and physiological approaches of fecal microbiota transplantation in the management of NAFLD	9
A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19	9
miR-451-3p alleviates myocardial ischemia/reperfusion injury by inhibiting MAP1LC3B-mediated autophagy	9
The role of Th17 cells: explanation of relationship between periodontitis and COPD?	9
Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK	9
A spotlight on underlying the mechanism of AMPK in diabetes complications	9
Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis	9
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders	9
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration	9
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes	8
Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis	8
Tetracycline use in treating osteoarthritis: a systematic review	8
The role of adenosine A1 receptor on immune cells	8
The impact of CD4+CD28null T lymphocytes on atrial fibrillation: a potential pathophysiological pathway	8
MAIT cells and their implication in human oral diseases	8
Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection	8
Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α	8
Cancer- and cardiac-induced cachexia: same fate through different inflammatory mediators?	8
Cytokine storm: behind the scenes of the collateral circulation after acute myocardial infarction	8
A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synovium	8
Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages	8
Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis	8
Regulation of inflammation and apoptosis by GPR43 via JNK/ELK1 in acute lung injury	8