OOIR: Observatory of International Research

Papers

(The TQCC of Inflammation Research is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
The coagulopathy, endotheliopathy, and vasculitis of COVID-19	290
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”	189
Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome	173
Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality	113
Inflammasome formation in the lungs of patients with fatal COVID-19	100
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin	73
Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms	73
Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition	72
Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation	58
Macrophage polarization in intestinal inflammation and gut homeostasis	56
The phase changes of M1/M2 phenotype of microglia/macrophage following oxygen-induced retinopathy in mice	51
Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation	40
Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation	40
RETRACTED ARTICLE: Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression	38
SARS-CoV-2-mediated inflammatory response in lungs: should we look at RAGE?	37
The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review	37
MiR-146a-5p promotes IL-1β-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway	36
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis	36
COVID-19 disrupts the blood–testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins	35
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases	34
The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind placebo-controlled phase III CORONA clinic	34
Histamine receptors and COVID-19	32
Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis	32
Molecular mechanisms of ferroptosis and relevance to inflammation	32
Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease	31

SARS-CoV-2 will continue to circulate in the human population: an opinion from the point of view of the virus-host relationship	30
The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis	30
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion	30
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy	30
CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis	30
The role of interferon-γ in cardiovascular disease: an update	30
Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction	29
The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes	29
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes	29
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19	29
Inflammasome activation in podocytes: a new mechanism of glomerular diseases	29
Notch signaling pathway in infectious diseases: role in the regulation of immune response	27
Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation	27
Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation	25
Intercellular communication and ion channels in neuropathic pain chronicization	25
Transcriptomic analysis of hidradenitis suppurativa skin suggests roles for multiple inflammatory pathways in disease pathogenesis	25
Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis	24
Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report	24
Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury	24
Adverse Ocular Events following COVID-19 Vaccination	24
Particulate matter in COPD pathogenesis: an overview	23
Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies	22
IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis	22
SARS-CoV-2 and pathological matrix remodeling mediators	21
SARS-CoV-2 will constantly sweep its tracks: a vaccine containing CpG motifs in ‘lasso’ for the multi-faced virus	20
Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults	20
LncRNA promoted inflammatory response in ischemic heart failure through regulation of miR-455-3p/TRAF6 axis	20
Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway	19
A case of reactivation of varicella–zoster virus after BNT162b2 vaccine second dose?	19
SIKIAT1/miR-96/FOXA1 axis regulates sepsis-induced kidney injury through induction of apoptosis	19
The unleashing of the immune system in COVID-19 and sepsis: the calm before the storm?	19
Methyl gallate attenuates inflammation induced by Toll-like receptor ligands by inhibiting MAPK and NF-Κb signaling pathways	19
Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus	19
Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha	19
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia	18
The role of lung macrophages in acute respiratory distress syndrome	18
TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis	18
Luteolin alleviates ulcerative colitis through SHP-1/STAT3 pathway	18
Burn injury induces elevated inflammatory traffic: the role of NF-κB	18
Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics	18
Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models	17
Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation	17
LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia	17
Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy	17
FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy	17
Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF-кB pathway	16
Changes of lipoxin levels during pregnancy and the monthly-cycle, condition the normal course of pregnancy or pathology	16
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis	16
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease	16
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)	16

Anti-inflammatory latex proteins of the medicinal plant Calotropis procera: a promising alternative for oral mucositis treatment	16
IL-33 deficiency protects mice from DSS-induced experimental colitis by suppressing ILC2 and Th17 cell responses	16
A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice	16
Severity of SARS-CoV-2 infection is linked to double-negative (CD27− IgD−) B cell subset numbers	16
Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia	15
Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells—“utilization” of ferroptosis mechanism	15
Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1β-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo	15
A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics	15
Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer	15
MicroRNA-199-3p up-regulation enhances chondrocyte proliferation and inhibits apoptosis in knee osteoarthritis via DNMT3A repression	15
Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail	15
Neuroinflammatory mediators in acquired epilepsy: an update	14
Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO/NR4A3 axis	13
Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus	13
Immunoglobulin free light chains: an inflammatory biomarker of diabetes	13
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain	13
CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro	13
Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1	13
RETRACTED ARTICLE: Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis	13
Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis	12
The role of NK cells in rheumatoid arthritis	12
Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center longitudinal study	12
Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss	12
The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19	12
The pathophysiology of immunoporosis: innovative therapeutic targets	12
LncRNA MBLN1-AS1 inhibits the progression of retinoblastoma through targeting miR-338-5p-Wnt/β-catenin signaling pathway	12
CD20+ T cells: an emerging T cell subset in human pathology	12
Immunosenescence of T cells: a key player in rheumatoid arthritis	12
Neutrophils as emerging protagonists and targets in chronic inflammatory diseases	11
COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines	11
FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages	11
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury	11
Cysteinyl leukotriene D4 (LTD4) promotes airway epithelial cell inflammation and remodelling	11
Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease	11
PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells	11
Comprehensive comparison of the prognostic value of systemic inflammation biomarkers for cancer cachexia: a multicenter prospective study	11
Protocatechuic acid supplement alleviates allergic airway inflammation by inhibiting the IL-4Rα–STAT6 and Jagged 1/Jagged2–Notch1/Notch2 pathways in allergic asthmatic mice	11
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications	11
MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer	11
Local IL-17 positive T cells are functionally associated with neutrophil infiltration and their development is regulated by mucosal microenvironment in nasal polyps	11
Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection	11
COVID-19 illness and autoimmune diseases: recent insights	11
RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis	11
MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6	10
Cellular and molecular events of inflammation induced transdifferentiation (EMT) and regeneration (MET) in mesenteric mesothelial cells	10
Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury	10
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation	10
How could perfluorocarbon affect cytokine storm and angiogenesis in coronavirus disease 2019 (COVID-19): role of hypoxia-inducible factor 1α	10
Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis	10
S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1	10
The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease	10
NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn	10
Mast cells and angiogenesis in multiple sclerosis	10
Fertility and infertility implications in rheumatoid arthritis; state of the art	10
Activated M1 macrophages suppress c-kit expression via TNF-α-mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis	10
Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects	10