OOIR: Observatory of International Research

Papers

(The TQCC of Inflammation Research is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
News	272
IL10/AMPK pathway was associated with the hippocampal anti-inflammatory response to high-sugar and high-fat diet withdrawal	193
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression	147
Association of risk of incident acne and treatment with systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis	83
Paradoxical expression of NRP1 in decidual stromal and immune cells reveals a novel inflammation balancing mechanism during early pregnancy	77
Kinin B1 receptor and TLR4 interaction in inflammatory response	64
Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection	63
Inhibition of glycolytic reprogramming suppresses innate immune-mediated inflammation in experimental amyotrophic lateral sclerosis	62
Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling	62
Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2	60
The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target	58
From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases	55
CD20+ T cells: an emerging T cell subset in human pathology	49
Tissue-resident immune cells in the pathogenesis of multiple sclerosis	48
Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNβ1 transcription during macrophage activation	47
Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation	47
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis	47
The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases	46
Beyond CYP2C19: inflammation and angiogenesis gene variants drive clopidogrel resistance in CAD patients	45
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease	43
Clinical outcomes of anti-inflammatory therapies inhibiting the NLRP3/IL-1β/IL-6/CRP pathway in coronary artery disease patients: a systemic review and meta-analysis of 37,056 individuals from 32 rand	42
Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis	42
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia	41
Single-cell hdWGCNA reveals a novel diagnostic model and signature genes of macrophages associated with chronic obstructive pulmonary disease	40
The role of dietary fibre in lung inflammation: microbiota, metabolites, and immune crosstalk	39

HMGB1: key mediator in digestive system diseases	38
Internalization of benzylisoquinoline alkaloids by resting and activated bone marrow-derived mast cells utilizes energy-dependent mechanisms	37
The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress	36
Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway	34
A suitable model to investigate acute neurological consequences of coronavirus infection	33
Infliximab modifies CD74-mediated lymphatic abnormalities and adipose tissue alterations in creeping fat of Crohn’s disease	33
LncGBP9 knockdown alleviates myocardial inflammation and apoptosis in mice with acute viral myocarditis via suppressing NF-κB signaling pathway	33
Immune response associated with ischemia and reperfusion injury during organ transplantation	32
Treg plasticity and human diseases	32
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination	32
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury	30
IL-1 receptor antagonist: etiological and drug delivery systems overview	30
Acute lung injury: a view from the perspective of necroptosis	30
Annexin A1 is crucial during Toxoplasma gondii infection promoting the modulation of inflammation and intestinal and central nervous system barrier functions	29
Navigating the complex landscape of DPP4 inhibition in inflammation: from novel mechanisms to unresolved translational challenges	29
Successful treatment of refractory erythrodermic pemphigus foliaceus with low-dose rituximab and intravenous immunoglobulin	28
A pain from the nose to the head: neurological commitment during long COVID	28
Antigen-specific reduced IgG inhibits cellular response in rat basophilic leukemia cells activated with multivalent antigen	26
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis	25
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues	25
Identification of RRM2 as a key ferroptosis-related gene in sepsis	25
Mitochondrial proteomics reveals the impact of Estrogen in enhancing energy metabolism of patient-derived fibroblast-like synoviocytes in rheumatoid arthritis	25
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice	24
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis	24
Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice	24
Alleviated NCOA4-mediated ferritinophagy protected RA FLSs from ferroptosis in lipopolysaccharide-induced inflammation under hypoxia	24
Disulfidptosis-related genes RPN1 inhibits the progression of hepatocellular carcinoma by regulating cell cycle, may be a new therapeutic targets	23
Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K/AKT signaling pathway	23
Dog allergen-induced asthma in mice: a relevant model of T2low severe asthma with airway remodelling	22
Identification of ferroptosis-related genes and potential drugs in osteoarthritis	22
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders	21
Characterization of immune landscape and development of a novel N7-methylguanine-related gene signature to aid therapy in recurrent aphthous stomatitis	21
Inflammation, coagulation, and cellular injury in heat-induced shock	21
Prolonged effects of DPP-4 inhibitors on steato-hepatitic changes in Sprague–Dawley rats fed a high-cholesterol diet	21
Genetic correlations, shared risk genes and immunity landscapes between COVID-19 and venous thromboembolism: evidence from GWAS and bulk transcriptome data	20
Retraction Note: Knockdown of long non‑coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA‑15a and repressing ROCK1 expression	20
Treatment with lipoxin A4 improves influenza A infection outcome, induces macrophage reprogramming, anti-inflammatory and pro-resolutive responses	20
Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype	20
Prospective study of an adalimumab combined with partial enteral nutrition in the induction period of Crohn’s disease	20
USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis	20
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome	20
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells	20
The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer	19
Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study	19
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis	19
Human antimicrobial/host defense peptide LL-37 may prevent the spread of a local infection through multiple mechanisms: an update	19
Roquin-1 interaction with Regnase-1 inhibits the progression of rheumatoid arthritis via suppressing FGF2 expression and NF-κB pathway	19
SRY-related high-mobility group box 9 (SOX9) alleviates cigarette smoke extract (CSE)-induced inflammatory injury in human bronchial epithelial cells by suppressing stromal interaction molecule 1 (STI	18
Monogenic autoinflammatory disease-associated cardiac damage	18
Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer’s disease treatment	18

STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model	18
Chronic ethanol exposure decreases H3K27me3 in the Il6 promoter region of macrophages and generates persistent dysfunction on neutrophils during fungal infection	18
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model	17
IL-35 promotes IL-35+IL-10+ Bregs and Conventional LAG3+ Tregs in the lung tissue of OVA-Induced Asthmatic Mice	17
Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia	17
Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice	17
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma	17
The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review	17
The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A	17
CD8 + T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia	17
The star target in SLE: IL-17	16
Enhancing effect of sodium butyrate on phosphatidylserine–liposome-induced macrophage polarization	16
Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis	16
Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia–reperfusion injury	16
COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines	16
Molecular biology of the novel anticancer medications: a focus on kinases inhibitors, biologics and CAR T-cell therapy	16
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration	16
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models	16
Mechanosensitive ion channels and inflammation: key links in cellular signal transduction	16
Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1	15
Influence of homocysteine on regulating immunothrombosis: mechanisms and therapeutic potential in management of infections	15
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression	15
Correction to: Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes	15
Environmental and inflammatory factors influencing concurrent gut and lung inflammation	15
Interlukin-23 inhibitors as an induction and maintenance therapy for moderate to severe ulcerative colitis: a systematic review and meta‑analysis of randomized controlled trials	15
5-oxoETE promote thrombosis in antiphospholipid syndrome by triggering NETs formation through PLC/PKC/ERK pathway	15
Retraction Note: Emerging protective roles of shengmai injection in septic cardiomyopathy in mice by inducing myocardial mitochondrial autophagy via caspase-3/Beclin-1 axis	15
The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients	15
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis	15
Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice	15
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation	15
Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults	15
Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease	14
Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D	14
Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser alleviates rosacea by improving lymphatic vessel dysfunction	14
Bioinformatics analysis for identifying micro-RNAs, long noncoding RNAs, transcription factors, and immune genes regulatory networks in diabetic cardiomyopathy using an integrated bioinformatics analy	14
Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications	14
Multimodal data-driven prognostic model for predicting new-onset ST-elevation myocardial infarction following emergency percutaneous coronary intervention	14
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33	14
MitoQ alleviates mitochondria damage in sepsis-acute lung injury in a citrate synthase dependent manner	14
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming	14
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis	14
Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction	14
The potential roles of Th17 cells in the pathogenesis of oral lichen planus	14
Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease	14
Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis	13
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation	13
Aryl hydrocarbon receptor (AhR) alleviates the LPS-induced inflammatory responses in IPEC-J2 cells by activating PINK1/Parkin-mediated mitophagy	13
Retraction Note to: Suppressors of cytokine signalling (SOCS)‑1 inhibits neuroinflammation by regulating ROS and TLR4 in BV2 cells	13
Mediation of macrophage M1 polarization dynamics change by ubiquitin-autophagy-pathway regulated NLRP3 inflammasomes in PD-1 inhibitor-related myocardial inflammatory injury	13
Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro	13
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis	13
Histamine regulates the activity and the expression of the Na+/H+ exchanger (NHE)3 in human epithelial HK-2 cells	13
Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS)	13
Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy	13
The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity	13
STING deficiency protects against wasp venom-induced acute kidney injury	13
Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement	13
Biological attributes of zinc-dependent endopeptidases in endothelial dysfunction associated with sepsis: a narrative review	12
Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model	12
Pentoxifylline in COVID-19 and considerations for its research in long COVID	12
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19	12
An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration	12
ADAM10-a “multitasker” in sepsis: focus on its posttranslational target	12
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis	12
Transcriptomic profiling reveals a dramatic inflammatory shift in osteal macrophages during colitis-induced osteoporosis	12
Causal role of myeloid cells in Parkinson’s disease: Mendelian randomization study	12
Lipoxin alleviates oxidative stress: a state-of-the-art review	12
Serine metabolism in macrophage polarization	12
Calycosin inhibited MIF-mediated inflammatory chemotaxis of macrophages to ameliorate ischemia reperfusion-induced acute kidney injury	12
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19	12
Decoy oligonucleotides targeting NF-κB: a promising therapeutic approach for inflammatory diseases	12
Screening inflammatory protein biomarkers on premature infants with necrotizing enterocolitis	12
Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation	12
Comprehensive analysis of single cell and bulk RNA sequencing reveals the heterogeneity of melanoma tumor microenvironment and predicts the response of immunotherapy	12
Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis	12
Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine	12