OOIR: Observatory of International Research

Papers

(The TQCC of Inflammation Research is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
News	335
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression	221
Inhibition of glycolytic reprogramming suppresses innate immune-mediated inflammation in experimental amyotrophic lateral sclerosis	171
Paradoxical expression of NRP1 in decidual stromal and immune cells reveals a novel inflammation balancing mechanism during early pregnancy	114
Kinin B1 receptor and TLR4 interaction in inflammatory response	96
Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNβ1 transcription during macrophage activation	92
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis	89
Beyond CYP2C19: inflammation and angiogenesis gene variants drive clopidogrel resistance in CAD patients	76
Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation	68
Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2	68
Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling	60
Association of risk of incident acne and treatment with systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis	59
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia	59
CD20+ T cells: an emerging T cell subset in human pathology	57
Tissue-resident immune cells in the pathogenesis of multiple sclerosis	56
The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target	50
Single-cell hdWGCNA reveals a novel diagnostic model and signature genes of macrophages associated with chronic obstructive pulmonary disease	50
From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases	47
IL10/AMPK pathway was associated with the hippocampal anti-inflammatory response to high-sugar and high-fat diet withdrawal	46
The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases	46
Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis	45
Clinical outcomes of anti-inflammatory therapies inhibiting the NLRP3/IL-1β/IL-6/CRP pathway in coronary artery disease patients: a systemic review and meta-analysis of 37,056 individuals from 32 rand	44
HMGB1: key mediator in digestive system diseases	44
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease	44
Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection	41

The role of dietary fibre in lung inflammation: microbiota, metabolites, and immune crosstalk	40
IL-1 receptor antagonist: etiological and drug delivery systems overview	39
A suitable model to investigate acute neurological consequences of coronavirus infection	39
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues	38
Navigating the complex landscape of DPP4 inhibition in inflammation: from novel mechanisms to unresolved translational challenges	37
Mitochondrial proteomics reveals the impact of Estrogen in enhancing energy metabolism of patient-derived fibroblast-like synoviocytes in rheumatoid arthritis	37
Annexin A1 is crucial during Toxoplasma gondii infection promoting the modulation of inflammation and intestinal and central nervous system barrier functions	34
A pain from the nose to the head: neurological commitment during long COVID	33
Successful treatment of refractory erythrodermic pemphigus foliaceus with low-dose rituximab and intravenous immunoglobulin	33
Antigen-specific reduced IgG inhibits cellular response in rat basophilic leukemia cells activated with multivalent antigen	32
LncGBP9 knockdown alleviates myocardial inflammation and apoptosis in mice with acute viral myocarditis via suppressing NF-κB signaling pathway	32
Infliximab modifies CD74-mediated lymphatic abnormalities and adipose tissue alterations in creeping fat of Crohn’s disease	32
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination	31
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury	30
The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress	29
Immune response associated with ischemia and reperfusion injury during organ transplantation	28
Treg plasticity and human diseases	28
Acute lung injury: a view from the perspective of necroptosis	28
Disulfidptosis-related genes RPN1 inhibits the progression of hepatocellular carcinoma by regulating cell cycle, may be a new therapeutic targets	27
Dog allergen-induced asthma in mice: a relevant model of T2low severe asthma with airway remodelling	27
Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K/AKT signaling pathway	27
Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway	27
Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice	26
Identification of ferroptosis-related genes and potential drugs in osteoarthritis	25
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis	24
Identification of RRM2 as a key ferroptosis-related gene in sepsis	24
Inflammation, coagulation, and cellular injury in heat-induced shock	24
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice	24
Alleviated NCOA4-mediated ferritinophagy protected RA FLSs from ferroptosis in lipopolysaccharide-induced inflammation under hypoxia	24
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis	23
Characterization of immune landscape and development of a novel N7-methylguanine-related gene signature to aid therapy in recurrent aphthous stomatitis	22
Prolonged effects of DPP-4 inhibitors on steato-hepatitic changes in Sprague–Dawley rats fed a high-cholesterol diet	22
Genetic correlations, shared risk genes and immunity landscapes between COVID-19 and venous thromboembolism: evidence from GWAS and bulk transcriptome data	22
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders	22
Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study	21
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells	21
The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer	21
Retraction Note: Knockdown of long non‑coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA‑15a and repressing ROCK1 expression	21
Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype	21
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome	20
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis	20
Prospective study of an adalimumab combined with partial enteral nutrition in the induction period of Crohn’s disease	20
Roquin-1 interaction with Regnase-1 inhibits the progression of rheumatoid arthritis via suppressing FGF2 expression and NF-κB pathway	20
Human antimicrobial/host defense peptide LL-37 may prevent the spread of a local infection through multiple mechanisms: an update	20
USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis	20
Treatment with lipoxin A4 improves influenza A infection outcome, induces macrophage reprogramming, anti-inflammatory and pro-resolutive responses	20
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression	19
Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice	19
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration	19
STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model	19

Mechanosensitive ion channels and inflammation: key links in cellular signal transduction	19
Chronic ethanol exposure decreases H3K27me3 in the Il6 promoter region of macrophages and generates persistent dysfunction on neutrophils during fungal infection	19
Molecular biology of the novel anticancer medications: a focus on kinases inhibitors, biologics and CAR T-cell therapy	19
IL-35 promotes IL-35+IL-10+ Bregs and Conventional LAG3+ Tregs in the lung tissue of OVA-Induced Asthmatic Mice	19
Monogenic autoinflammatory disease-associated cardiac damage	19
Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer’s disease treatment	19
Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1	19
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models	19
The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review	19
5-oxoETE promote thrombosis in antiphospholipid syndrome by triggering NETs formation through PLC/PKC/ERK pathway	18
Interlukin-23 inhibitors as an induction and maintenance therapy for moderate to severe ulcerative colitis: a systematic review and meta‑analysis of randomized controlled trials	18
Influence of homocysteine on regulating immunothrombosis: mechanisms and therapeutic potential in management of infections	18
CD8 + T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia	18
Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice	18
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model	18
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma	18
Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia–reperfusion injury	18
Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis	18
The star target in SLE: IL-17	18
The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A	18
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis	18
Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia	18
Correction to: Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes	17
The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients	17
Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications	17
Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction	17
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis	17
Environmental and inflammatory factors influencing concurrent gut and lung inflammation	17
Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D	17
Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser alleviates rosacea by improving lymphatic vessel dysfunction	17
Multimodal data-driven prognostic model for predicting new-onset ST-elevation myocardial infarction following emergency percutaneous coronary intervention	16
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33	16
MitoQ alleviates mitochondria damage in sepsis-acute lung injury in a citrate synthase dependent manner	16
Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease	16
Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease	16
Retraction Note: Emerging protective roles of shengmai injection in septic cardiomyopathy in mice by inducing myocardial mitochondrial autophagy via caspase-3/Beclin-1 axis	16
Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro	16
Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults	16
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation	16
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming	16
Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis	16
The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity	15
Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy	15
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation	15
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis	15
Histamine regulates the activity and the expression of the Na+/H+ exchanger (NHE)3 in human epithelial HK-2 cells	15
Aryl hydrocarbon receptor (AhR) alleviates the LPS-induced inflammatory responses in IPEC-J2 cells by activating PINK1/Parkin-mediated mitophagy	15
Mediation of macrophage M1 polarization dynamics change by ubiquitin-autophagy-pathway regulated NLRP3 inflammasomes in PD-1 inhibitor-related myocardial inflammatory injury	14
Biological attributes of zinc-dependent endopeptidases in endothelial dysfunction associated with sepsis: a narrative review	14
Decoy oligonucleotides targeting NF-κB: a promising therapeutic approach for inflammatory diseases	14
STING deficiency protects against wasp venom-induced acute kidney injury	14
Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS)	14
Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis	14
Lipoxin alleviates oxidative stress: a state-of-the-art review	14
The potential roles of Th17 cells in the pathogenesis of oral lichen planus	14
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis	14
Serine metabolism in macrophage polarization	14
Pentoxifylline in COVID-19 and considerations for its research in long COVID	14
Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model	13
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo	13
Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund’s adjuvant-induced paw inflammation model	13
Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement	13
ADAM10-a “multitasker” in sepsis: focus on its posttranslational target	13
Causal role of myeloid cells in Parkinson’s disease: Mendelian randomization study	13
Retraction Note to: Suppressors of cytokine signalling (SOCS)‑1 inhibits neuroinflammation by regulating ROS and TLR4 in BV2 cells	13
Comprehensive analysis of single cell and bulk RNA sequencing reveals the heterogeneity of melanoma tumor microenvironment and predicts the response of immunotherapy	13
5-Methoxytryptophan ameliorates endotoxin-induced acute lung injury in vivo and in vitro by inhibiting NLRP3 inflammasome-mediated pyroptosis through the Nrf2/HO-1 signaling pathway	13
Screening inflammatory protein biomarkers on premature infants with necrotizing enterocolitis	13
Calycosin inhibited MIF-mediated inflammatory chemotaxis of macrophages to ameliorate ischemia reperfusion-induced acute kidney injury	13
Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation	13
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19	13
Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti-inflammatory iNKT10 cells in the brain	13
PI3Kγ controls IL-17A expression and attenuates alveolar bone loss in an experimental periodontitis model	13
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19	13
Transcriptomic profiling reveals a dramatic inflammatory shift in osteal macrophages during colitis-induced osteoporosis	13