Brain Pathology

Article	Citations
cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading	349
cIMPACT‐NOW update 7: advancing the molecular classification of ependymal tumors	158
Neuropathologic features of four autopsied COVID‐19 patients	140
B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis	73
SARS‐CoV‐2 and the brain: A review of the current knowledge on neuropathology in COVID‐19	70
COVID‐19‐related neuropathology and microglial activation in elderly with and without dementia	70
Pathology, diagnostics, and classification of medulloblastoma	66
The 2021 WHO Classification of Tumors of the Central Nervous System: An update on pediatric low‐grade gliomas and glioneuronal tumors	66
Loss of capillary pericytes and the blood–brain barrier in white matter in poststroke and vascular dementias and Alzheimer’s disease	58
Brain ischemic injury in COVID‐19‐infected patients: a series of 10 post‐mortem cases	54
The microbiota–microglia axis in central nervous system disorders	50
Classification of adult‐type diffuse gliomas: Impact of the World Health Organization 2021 update	47
Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions	45
The role of interferons type I, II and III in myositis: A review	43
Intracranial mesenchymal tumor with FET‐CREB fusion—A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma‐like neoplasms	40
Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy	37
Mediators of cerebral hypoperfusion and blood‐brain barrier leakiness in Alzheimer’s disease, vascular dementia and mixed dementia	36
Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology	35
MiR‐1253 exerts tumor‐suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7‐H3)	35
IL‐1β/IL‐1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha‐Synuclein pathology in the olfactory bulb, substantia nigra and striatum	35
Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer’s disease	35
Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease	31
Interaction of microglia with infiltrating immune cells in the different phases of stroke	30
Genomic mechanisms in Alzheimer's disease	29
The spectrum of rare central nervous system (CNS) tumors with EWSR1‐non‐ETS fusions: experience from three pediatric institutions with review of the literature	28

TERT promoter mutations in primary and secondary WHO grade III meningioma	27
Biology and grading of pleomorphic xanthoastrocytoma—what have we learned about it?	27
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond	27
Tumor cell and immune cell profiles in primary human glioblastoma: Impact on patient outcome	27
Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives	26
MRI and muscle imaging for idiopathic inflammatory myopathies	25
Prognostic impact of genetic alterations and methylation classes in meningioma	25
Glycocalyx is critical for blood‐brain barrier integrity by suppressing caveolin1‐dependent endothelial transcytosis following ischemic stroke	25
Limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change and microvascular pathologies in community‐dwelling older persons	24
Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease	24
Postmortem neuropathology in COVID‐19	24
Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP	23
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation	23
Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex	22
Infective myositis	22
Role of mTOR‐regulated autophagy in spine pruning defects and memory impairments induced by binge‐like ethanol treatment in adolescent mice	21
Toward a refined genotype–phenotype classification scheme for the international consensus classification of Focal Cortical Dysplasia	21
Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer’s disease and other tauopathies	20
A Zika virus primary isolate induces neuroinflammation, compromises the blood‐brain barrier and upregulates CXCL12 in adult macaques	19
Isoform‐specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias	19
Denser brain capillary network with preserved pericytes in Alzheimer's disease	19
The use and limitations of single‐cell mass cytometry for studying human microglia function	18
Unfolded protein response activation in C9orf72 frontotemporal dementia is associated with dipeptide pathology and granulovacuolar degeneration in granule cells	18
Distinct circular RNA expression profiles in pediatric ependymomas	17
Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease	17
Hypothesis review: Alzheimer's overture guidelines	17
Pediatric meningioma: a clinicopathologic and molecular study with potential grading implications	17
Accumulation of cellular prion protein within β‐amyloid oligomer plaques in aged human brains	17
TREM2‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology	17
PKR kinase directly regulates tau expression and Alzheimer's disease‐related tau phosphorylation	17
Ependymoma‐like tumor with mesenchymal differentiation harboring C11orf95‐NCOA1/2 or ‐RELA fusion: A hitherto unclassified tumor related to ependymoma	16
Endothelium‐targeted overexpression of Krüppel‐like factor 11 protects the blood‐brain barrier function after ischemic brain injury	16
Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications	15
Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor‐initiating cells	15
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration	15
Mitochondrial DNA variants in inclusion body myositis characterized by deep sequencing	15
Inflammatory features in sporadic late‐onset nemaline myopathy are independent from monoclonal gammopathy	15
Diverse changes in microglia morphology and axonal pathology during the course of 1 year after mild traumatic brain injury in pigs	15
A deep learning‐based model for prediction of hemorrhagic transformation after stroke	14
Neuropathological profile of long‐duration amyotrophic lateral sclerosis in military Veterans	14
Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup	14
Integrated genotype–phenotype analysis of long‐term epilepsy‐associated ganglioglioma	14
An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB‐fused broadening the spectrum of tumor entities in comparison with their soft tiss	14
Multiple system atrophy variant with severe hippocampal pathology	14
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three‐dimensional matrix	14
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid	13
Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non‐motor dysfunction	13
Proteomic analysis of human hippocampal subfields provides new insights into the pathogenesis of Alzheimer’s disease and the role of glial cells	13
Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis	13
Molecular diagnostics in drug‐resistant focal epilepsy define new disease entities	13

Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases	13
Edematous myositis: a clinical presentation first suggesting dermatomyositis diagnosis	13
Congenital tumors of the central nervous system: an institutional review of 64 cases with emphasis on tumors with unique histologic and molecular characteristics	13
Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases	12
Differential diagnosis of vacuolar myopathies in the NGS era	12
Mini‐symposium in medulloblastoma genomics in the modern molecular era	12
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease	12
Downregulated GPR30 expression in the epileptogenic foci of female patients with focal cortical dysplasia type IIb and tuberous sclerosis complex is correlated with 18F‐FDG PET‐CT values	12
Effect of olfactory bulb pathology on olfactory function in normal aging	12
Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non‐cell autonomous developmental mechanisms	12
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome	11
Focal cortical dysplasia type 1	11
A novel temporal‐predominant neuro‐astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS‐TDP	11
Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders	11
RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies	11
Neuropathology of COVID‐19: where are the neuropathologists?	11
Oligodendrocyte‐specific deletion of FGFR2 ameliorates MOG35‐55‐induced EAE through ERK and Akt signalling	11
Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse	11
Region‐specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1	11
The molecular etiology of Alzheimer’s disease	11
NanoString technology distinguishes anti‐TIF‐1γ+ from anti‐Mi‐2+ dermatomyositis patients	11
High‐dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy	11
Considerations for integrative multi‐omic approaches to explore Alzheimer's disease mechanisms	11
Expanding the spectrum of EWSR1‐PATZ1 rearranged CNS tumors: An infantile case with leptomeningeal dissemination	11
Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress	10
Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies	10
Glial activation in prion diseases is selectively triggered by neuronal PrPSc	10
The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson’s disease	10
Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology	10
Intracranial mesenchymal tumors with FET‐CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas	10
Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease	10
Evaluating the performance of large language models: ChatGPT and Google Bard in generating differential diagnoses in clinicopathological conferences of neurodegenerative disorders	10
Molecular neuropathology of brain‐invasive meningiomas	10
Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer’s disease	10
Use of advanced neuroimaging and artificial intelligence in meningiomas	10
Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era	9
Stimulation of retrotrapezoid nucleus Phox2b‐expressing neurons rescues breathing dysfunction in an experimental Parkinson’s disease rat model	9
Motor neuron involvement expands the neuropathological phenotype of late‐onset ataxia in RFC1 mutation (CANVAS)	9
Alleviation of extensive visual pathway dysfunction by a remyelinating drug in a chronic mouse model of multiple sclerosis	9
Cognitive decline in amyotrophic lateral sclerosis: Neuropathological substrate and genetic determinants	9
Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer’s disease	9
Does etiology really matter for epilepsy surgery outcome?	9
Targeting the interaction of GABAB receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse br	9
CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study	9
Overexpression of the ubiquitin‐editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation	9
Medullary tyrosine hydroxylase catecholaminergic neuronal populations in sudden unexpected death in epilepsy	9
Epithelioid glioblastoma with microglia features: potential for novel therapy	9
Molecular landscape of IDH‐wild type, pTERT‐wild type adult glioblastomas	8
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies	8
Applying gene‐editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer’s disease	8
Brain‐specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury	8
Epigenome‐wide association studies in Alzheimer’s disease; achievements and challenges	8
Automated and unbiased discrimination of ALS from control tissue at single cell resolution	8
Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety‐like behaviors in mice	7
Application of single cell genomics to focal epilepsies: A call to action	7
Variable histopathology features of neuronal dyslamination in the cerebral neocortex adjacent to epilepsy‐associated vascular malformations suggest complex pathogenesis of focal cortical dysplasia ILA	7
lncRNA MEG3 restrained the M1 polarization of microglia in acute spinal cord injury through the HuR/A20/NF‐κB axis	7
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease	7
Embryonal and non‐meningothelial mesenchymal tumors of the central nervous system – Advances in diagnosis and prognostication	7
Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive a	7
ZFTA‐YAP1 fusion‐positive ependymoma can occur in the spinal cord: Letter to the editor	7
Muscle pathology of antisynthetase syndrome according to antibody subtypes	7
Ependymoma relapse goes along with a relatively stable epigenome, but a severely altered tumor morphology	7
IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature	7
Clinical implementation of integrated molecular‐morphologic risk prediction for meningioma	7
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits	7
Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures	6
Prognostic relevance of adding MRI data to WHO 2016 and cIMPACT‐NOW updates for diffuse astrocytic tumors in adults. Working toward the extended use of MRI data in integrated glioma diagnosis	6
Endoplasmic reticulum‐stress and unfolded protein response‐activation in immune‐mediated necrotizing myopathy	6
Iron accumulation in the choroid plexus, ependymal cells and CNS parenchyma in a rat strain with low‐grade haemolysis of fragile macrocytic red blood cells	6
Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP	6
CHCHD2 p.Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's disease	6
Progression of phosphorylated α‐synuclein in Macaca fuscata	6
Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology	5
Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke	5
Reduction in miR‐219 expression underlies cellular pathogenesis of oligodendrocytes in a mouse model of Krabbe disease	5
Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination	5
Detection of endophenotypes associated with neuropsychiatric deficiencies in a mouse model of tuberous sclerosis complex using diffusion tensor imaging	5
The presence of TIM‐3 positive cells in WHO grade III and IV astrocytic gliomas correlates with isocitrate dehydrogenase mutation status	5
A new amplicon‐based gene panel for next generation sequencing characterization of meningiomas	5

Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus‐induced demyelination	5
Myxoid glioneuronal tumor, PDGFRA p.K385L‐mutant, arising in midbrain tectum with multifocal CSF dissemination	5
Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction	5
The neurovasculature as a target in temporal lobe epilepsy	5
No evidence of aberrant amyloid β and phosphorylated tau expression in herpes simplex virus‐infected neurons of the trigeminal ganglia and brain	5
Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic later	5
Application of deep learning to understand resilience to Alzheimer's disease pathology	5
An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden	5
Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study	5
Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities	5
Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent	5
TDP‐43 and tau concurrence in the entorhinal subfields in primary age‐related tauopathy and preclinical Alzheimer's disease	5
Genomic profiling and prognostic factors of H3 K27M‐mutant spinal cord diffuse glioma	4
Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors	4
Brachial plexus lipomatosis with perineurial pseudoonion bulb formation: Result of a mosaic PIK3CA mutation in the para‐axial mesoderm state	4
Role of VAPB and vesicular profiles in α‐synuclein aggregates in multiple system atrophy	4
Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD	4
LAMP‐2A ablation in hippocampal CA1 astrocytes confers cerebroprotection and ameliorates neuronal injury after global brain ischemia	4
Double‐edged effects of tamoxifen‐in‐oil‐gavage on an infectious murine model for multiple sclerosis	4
Dendritic spine loss in epileptogenic Type II focal cortical dysplasia: Role of enhanced classical complement pathway activation	4
Enhanced expression of autophagy‐related p62 without increased deposits of neurodegeneration‐associated proteins in glioblastoma and surrounding tissue – An autopsy‐based study	4
Histamine in murine narcolepsy: What do genetic and immune models tell us?	4
Aβ plaques do not protect against HSV‐1 infection in a mouse model of familial Alzheimer's disease, and HSV‐1 does not induce Aβ pathology in a model of late onset Alzheimer's di	4
Cerebellar developmental deficits underlie neurodegenerative disorder spinocerebellar ataxia type 23	4
The influence of HLA‐DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter	4
Information theory approaches to improve glioma diagnostic workflows in surgical neuropathology	4
Primary age‐related tauopathy (PART) in the general autopsy setting: Not just a disease of the elderly	4
Innate immune activation without immune cell infiltration in brains of murine models of Aicardi‐Goutières Syndrome	3
Expression pattern of mitochondrial respiratory chain enzymes in skeletal muscle of patients with mitochondrial myopathy associated with the homoplasmic m.14674T>C variant	3
Fra‐1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury	3
Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease	3
Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis	3
Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington’s chorea	3
Pathology explains various mechanisms of auto‐immune inflammatory peripheral neuropathies	3
	3
AtypicalTDP‐43 protein expression in anALSpedigree carrying a p.Y374Xtruncation mutation inTARDBP	3
Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy	3
Quantitative magnetic resonance imaging reflects different levels of histologically determined myelin densities in multiple sclerosis, including remyelination in inactive multiple sclerosis lesions	3
A 2‐year‐old girl with posterior fossa mass	3
Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult	3
Exploiting nanopore sequencing for characterization and grading of IDH‐mutant gliomas	3
Studying the imaging features and infarction mechanism of vertebrobasilar dolichoectasia with high‐resolution magnetic resonance imaging	3
Temporal lobe myxoid glioneuronal tumor, PDGFRA p.K385L‐mutant with DNA methylation confirmation	2
Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice	2
The myeloid side of the CNS	2
Present and future avenues of cell‐based therapy for brain injury: The enteric nervous system as a potential cell source	2
Monomeric C‐reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction	2
Developmental delay and progressive seizures in 2‐month‐old child with diffuse MRI abnormalities	2
Alpha‐synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain	2
Attenuation of Piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation	2
Report two adult cases of high‐grade neuroepithelial neoplasm harbouring EP300::BCOR fusions with comprehensive molecular detection	2
Cortical iron accumulation in MAPT‐ and C9orf 72‐associated frontotemporal lobar degeneration	2
Design and application of a customizable relational DataBase to assess clinicopathological correlations and concomitant pathology in neurodegenerative diseases	2
Detection and verification of neurodegeneration after traumatic brain injury in the mouse: Immunohistochemical staining for amyloid precursor protein	2
The WHO classification of tumors of the central nervous system‐finally here, and welcome!	2
Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α‐syn co‐pathology	2
Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume	2
Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis	2
Hispano‐American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders	2
Plasma mid‐regional pro‐adrenomedullin: A biomarker of the ischemic penumbra in hyperacute stroke	2
Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator	2
Severe histomorphological alterations in post‐mortem olfactory glomeruli in Alzheimer’s disease	2
An H3F3A K27M‐mutation in a sonic hedgehog medulloblastoma	2
Leigh syndrome is the main clinical characteristic of PTCD3 deficiency	2