OOIR: Observatory of International Research

Papers

(The median citation count of Brain Pathology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Astrocyte‐derived Interleukin‐31 causes poor prognosis in elderly patients with intracerebral hemorrhage	139
Left dural‐based mass in a 62‐year‐old female	96
A 29‐year‐old man with a right intracranial mass	94
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Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis	81
Issue Information	67
Pathologic TDP‐43 downregulates myelin gene expression in the monkey brain	67
Issue Information	61
Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1^G93A mouse model of amyotrophic later	58
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An 82‐year‐old man with a right frontal lobe rim‐enhancing lesion	45
Reply to letter by Melmed et al.	45
Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis	43
Tumor‐associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin‐2	41
Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease	41
Progress in stratified stroke characterization—associated with better diagnosis, accurate prognosis and improved treatment strategies	37
Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH‐wildtype	35
Issue Information	34
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Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy	26
RNA‐sequencing highlights differential regulated pathways involved in cell cycle and inflammation in orbitofacial neurofibromas	25
Molecular neuropathology of brain‐invasive meningiomas	25
A 55‐year‐old man with a cerebral mass	25
40‐Year‐old man with two asynchronous spinal cord tumors	25

Visualizing alpha‐synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo	25
A 76‐year‐old male with multiple enhancing brain lesions	25
Potentiating microglial efferocytosis by MFG‐E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice	24
Evaluating the performance of large language models: ChatGPT and Google Bard in generating differential diagnoses in clinicopathological conferences of neurodegenerative disorders	24
A 58‐year‐old man with B‐cell chronic lymphocytic leukemia and multiple strokes	23
The pontine diffuse midline glioma, EGFR‐subtype with ependymal features: Yet another face of diffuse midline glioma, H3K27‐altered	22
Issue Information	21
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Prognostic impact of genetic alterations and methylation classes in meningioma	21
Genomic profiling and prognostic factors of H3 K27M‐mutant spinal cord diffuse glioma	20
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Refinement of prognostication for IDH‐mutant astrocytomas using DNA methylation‐based classification	20
Embryonal and non‐meningothelial mesenchymal tumors of the central nervous system – Advances in diagnosis and prognostication	20
Epilepsy‐associated death in the Southwestern Ontario: A clinicopathological correlation study	20
Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination	20
Society News	20
Clinico‐sero‐pathological characteristics of anti‐Ha antisynthetase syndrome	19
Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain	19
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Colocalization of TDP‐43 and stress granules at the early stage of TDP‐43 aggregation in amyotrophic lateral sclerosis	18
A 2‐year‐old girl with posterior fossa mass	17
Issue Information	17
Society News	17
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Alpha‐synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain	15
LAMP‐2A ablation in hippocampal CA1 astrocytes confers cerebroprotection and ameliorates neuronal injury after global brain ischemia	15
Issue Information	15
SOCIETY NEWS	15
Primary visual cortex pathology in ALS patients with C9ORF72 expansion	15
The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis	14
Paul Kleihues (1936–2022), neuropathology innovator and entrepreneur	14
Muscle pathology of antisynthetase syndrome according to antibody subtypes	14
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NAB2::STAT6 fusions and genome‐wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors	14
Did early studies of human traumatic brain injury overlook concomitant oligodendrocyte pathology in injured white matter tracts? A comment on “Detection and verification of neurodegeneration after tra	14
Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke	13
Monomeric C‐reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction	13
A role for vessel‐associated extracellular matrix proteins in multiple sclerosis pathology	13
Brain‐specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury	13
Glycocalyx is critical for blood‐brain barrier integrity by suppressing caveolin1‐dependent endothelial transcytosis following ischemic stroke	13
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis	13
Molecular landscape of IDH‐wild type, pTERT‐wild type adult glioblastomas	12
Intracranial mesenchymal tumors with FET‐CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas	12
Dysregulation of the renin‐angiotensin system in vascular dementia	11
Multiple intracranial hemorrhages in a postmenopausal female	11
Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy	11
Issue Information	11
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Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis	10
Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy	10
Poly‐GA immunohistochemistry is a reliable tool for detecting C9orf72 hexanucleotide repeat expansions	10
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Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis	9
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease	9
Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex	9
Foxq1 activates CB2R with oleamide to alleviate POCD	9
A 4‐year‐old boy with a ventricular mass	9
Distribution of ferritin complex in the adult brain and altered composition in neuroferritinopathy due to a novel variant in the ferritin heavy chain gene FTH1 (c.409_410del; p.	9
A 24‐year‐old woman with a recurrent intracranial mass	9
An 11‐year‐old boy with a posterior fossa tumor	9
Deep learning‐based segmentation in MRI‐(immuno)histological examination of myelin and axonal damage in normal‐appearing white matter and white matter hyperintensities	9
Dendritic spine loss in epileptogenic Type II focal cortical dysplasia: Role of enhanced classical complement pathway activation	9
Single‐nucleus RNA sequencing unveils critical regulators in various hippocampal neurons for anti‐N‐methyl‐D‐aspartate receptor encephalitis	9
A vade mecum for crossing the second translational “valley of death” in brain tumor classification	9
Targeting the interaction of GABA_B receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse br	8
An unusual lymphoid lesion mimicking meningioma	8
The role of interferons type I, II and III in myositis: A review	8
Application of single cell genomics to focal epilepsies: A call to action	8
LATE‐NC in Alzheimer's disease: Molecular aspects and synergies	8
A 31‐year‐old man with recurrent blurred vision	8
Astrocytes for brain repair: More than just a neuron’s sidekick	8
Cortical iron accumulation in MAPT‐ and C9orf 72‐associated frontotemporal lobar degeneration	8
Ranking and filtering of neuropathology features in the machine learning evaluation of dementia studies	8
Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive a	8
Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP	8
Society News	8
Mitochondrial DNA variants in inclusion body myositis characterized by deep sequencing	8
Reduced neurogenesis in human hippocampus with Alzheimer's disease	8
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Understanding the pathogenic mechanisms and therapeutic effects in neurocysticercosis	7
Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction	7
Neuropathological hallmarks in autopsied cases with mitochondrial diseases caused by the mitochondrial 3243A>G mutation	7
Double‐edged effects of tamoxifen‐in‐oil‐gavage on an infectious murine model for multiple sclerosis	6
Society News	6
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Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele	6
Focal cortical dysplasia type 1	6
CHCHD2 p.Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's disease	6
Friends or foes: The mononuclear phagocyte system in ischemic stroke	6
Dynamic induction of the myelin‐associated growth inhibitor Nogo‐A in perilesional plasticity regions after human spinal cord injury	6
NanoString technology distinguishes anti‐TIF‐1γ⁺ from anti‐Mi‐2⁺ dermatomyositis patients	6
Concomitant progressive supranuclear palsy and Lewy body pathology presenting with circumscribed visual memory loss: A clinicopathological case	6
Society News	6
Issue Information	6
Differential expression of checkpoint markers in the normoxic and hypoxic microenvironment of glioblastomas	6
Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis	6
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome	5
A 3‐year‐old male with an extramedullary, intra‐ and extradural mass at T11‐L1	5
The WHO classification of tumors of the central nervous system‐finally here, and welcome!	5
A comprehensive histomolecular characterization of meningioangiomatosis: Further evidence for a precursor neoplastic lesion	5
Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume	5
Morphology‐based molecular classification of spinal cord ependymomas using deep neural networks	5
Society News	5
Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis	5
Somatostatin receptors in pituitary somatotroph adenomas as predictors of response to somatostatin receptor ligands: A pathologist's perspective	5
Quantitative magnetic resonance imaging reflects different levels of histologically determined myelin densities in multiple sclerosis, including remyelination in inactive multiple sclerosis lesions	5
Automated analysis of gray matter damage in aged mice reveals impaired remyelination in the cuprizone model	5
A 16‐year‐old female with an intrasellar mass	5
A 63‐year‐old woman with parietal scalp surface rugged	5
Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection	5
The fate of interneurons, GABA_A receptor sub‐types and perineuronal nets in Alzheimer's disease	5
A new amplicon‐based gene panel for next generation sequencing characterization of meningiomas	4
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Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies	4
Exploiting nanopore sequencing for characterization and grading of IDH‐mutant gliomas	4
Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup	4
Neuropathological stage‐dependent proteome mapping of the olfactory tract in Alzheimer's disease: From early olfactory‐related omics signatures to computational repurposing of drug candidat	4
Design and application of a customizable relational DataBase to assess clinicopathological correlations and concomitant pathology in neurodegenerative diseases	4
A tribute to John Q. Trojanowski (1946–2022), neuropathologist extraordinaire	4
TDP‐43 and tau concurrence in the entorhinal subfields in primary age‐related tauopathy and preclinical Alzheimer's disease	4
Hypothesis review: Alzheimer's overture guidelines	4
The post‐stroke young adult brain has limited capacity to re‐express the gene expression patterns seen during early postnatal brain development	3
Society News	3
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Nanoarchitecture of Ca_V2.1 channels and GABA_B receptors in the mouse hippocampus: Impact of APP/PS1 pathology	3
Acknowledgement to Reviewers	3
Society News	3
Information theory approaches to improve glioma diagnostic workflows in surgical neuropathology	3

Present and future avenues of cell‐based therapy for brain injury: The enteric nervous system as a potential cell source	3
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Studying the imaging features and infarction mechanism of vertebrobasilar dolichoectasia with high‐resolution magnetic resonance imaging	3
IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS‐associated amyotrophic lateral sclerosis	3
Enhanced Creutzfeldt‐Jakob disease surveillance in the older population: Assessment of a protocol for screening brain tissue donations for prion disease	3
The 2021 WHO Classification of Tumors of the Central Nervous System: An update on pediatric low‐grade gliomas and glioneuronal tumors	3
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Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular	2
Report two adult cases of high‐grade neuroepithelial neoplasm harbouring EP300::BCOR fusions with comprehensive molecular detection	2
Issue Information	2
The influence of HLA‐DRB115* on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter	2
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Decreased microvascular claudin‐5 levels in cerebral amyloid angiopathy associated with intracerebral haemorrhage	2
Krüppel‐like factor 7 deficiency disrupts corpus callosum development and neuronal migration in the developing mouse cerebral cortex	2
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A 7‐year‐old boy presented with temporal lobe lesion	2
Extra‐axial mass in a 72‐year‐old woman	2
Attenuation of Piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation	2
CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study	2
Recurrent TRAK1::RAF1 Fusions in pediatric low‐grade gliomas	2
Developmental delay and progressive seizures in 2‐month‐old child with diffuse MRI abnormalities	2
Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood‐cerebrospinal fluid barriers	2
The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson’s disease	2
Author Index	2
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Society News	2
Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis	2
Temporal lobe myxoid glioneuronal tumor, PDGFRA p.K385L‐mutant with DNA methylation confirmation	2
The molecular history of IDH‐mutant astrocytomas without adjuvant treatment	2
Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeos	2
Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus‐induced demyelination	1
Multiple system atrophy with hippocampal pathology	1
Issue Information	1
A 7‐month‐old boy with failure to thrive	1
Society News	1
A 71‐year‐old female with an intrasellar mass	1
Correction to “A 4‐year‐old boy with a ventricular mass”	1
Multiple system atrophy variant with severe hippocampal pathology	1
A mass in the pineal region of a young woman	1
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond	1
Nicorandil treatment improves survival and spatial learning in aged granulin knockout mice	1
A 53‐year‐old woman with a 16‐year history of epilepsy	1
Functionally distinct pericyte subsets differently regulate amyloid‐β deposition in patients with Alzheimer's disease	1
Pathology explains various mechanisms of auto‐immune inflammatory peripheral neuropathies	1
A 7‐year‐old female with hypotonia and scoliosis	1
Contribution of whole slide imaging‐based deep learning in the assessment of intraoperative and postoperative sections in neuropathology	1
Altered properties of amyloidogenic prion protein in genetic Creutzfeldt–Jakob disease with PRNP V180I mutation in response to pentosan polysulfate	1
AtypicalTDP‐43 protein expression in anALSpedigree carrying a p.Y374Xtruncation mutation inTARDBP	1
Issue Information	1
Severe histomorphological alterations in post‐mortem olfactory glomeruli in Alzheimer’s disease	1
SARS‐CoV‐2 and the brain: A review of the current knowledge on neuropathology in COVID‐19	1
Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse	1
Endoplasmic reticulum‐stress and unfolded protein response‐activation in immune‐mediated necrotizing myopathy	1
Introduction to the mini‐symposium “molecular neuropathology of meningioma”	1
Integrated genotype–phenotype analysis of long‐term epilepsy‐associated ganglioglioma	1
Meeting report of the 20th International Congress of Neuropathology (ICN) 2023 in Berlin	1
Detection and verification of neurodegeneration after traumatic brain injury in the mouse: Immunohistochemical staining for amyloid precursor protein	1
Application of deep learning to understand resilience to Alzheimer's disease pathology	1
MET fusions and splicing variants is a strong adverse prognostic factor in astrocytoma, isocitrate dehydrogenase mutant	1
A diffuse glioma with oligodendroglial‐like cells and extensive calcifications	1
Society News	1
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Perivascular phosphorylated TDP‐43 inclusions are associated with Alzheimer's disease pathology and loss of CD146 and Aquaporin‐4	1
Histamine in murine narcolepsy: What do genetic and immune models tell us?	1
Felice Giangaspero—A man of style and substance	1
Age‐related hearing loss and dementia‐related neuropathology: An analysis of the United Kingdom brains for dementia research cohort	1
A supratentorial mass in a young adult, with 25 years of follow‐up	1
Vascular endothelial growth factor‐C modulates cortical NMDA receptor activity in cortical lesions of young patients and rat model with focal cortical dysplasia	1
Variable histopathology features of neuronal dyslamination in the cerebral neocortex adjacent to epilepsy‐associated vascular malformations suggest complex pathogenesis of focal cortical dysplasia ILA	1
Aβ plaques do not protect against HSV‐1 infection in a mouse model of familial Alzheimer's disease, and HSV‐1 does not induce Aβ pathology in a model of late onset Alzheimer's di	1
Issue Information	1
Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications	1