World Journal of Gastroenterology

Article	Citations
Pancreatic cancer: A review of epidemiology, trend, and risk factors	181
Gut microbiota in obesity	152
Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma	128
Gastrointestinal and hepatic manifestations of COVID-19: A comprehensive review	117
COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract	111
Epidemiology of stomach cancer	109
Liver diseases in COVID-19: Etiology, treatment and prognosis	101
Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment	100
Role of gut microbiota on intestinal barrier function in acute pancreatitis	95
Mouse models of colorectal cancer: Past, present and future perspectives	88
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management	86
Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment	85
Gut microbiota, inflammatory bowel disease and colorectal cancer	77
Role of gut microbiota via the gut-liver-brain axis in digestive diseases	75
Gut microbiome in primary sclerosing cholangitis: A review	73
Watch and wait approach in rectal cancer: Current controversies and future directions	71
Artificial intelligence in gastric cancer: Application and future perspectives	71
Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease	66
Artificial intelligence applications in inflammatory bowel disease: Emerging technologies and future directions	63
Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma	61
High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data	58
Malignant gastric outlet obstruction: Which is the best therapeutic option?	58
Pancreatic cancer in 2021: What you need to know to win	58
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis	58
Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update	57

Helicobacter pylori infection: Beyond gastric manifestations	56
Current guidelines for the management of celiac disease: A systematic review with comparative analysis	56
Management of cholelithiasis with choledocholithiasis: Endoscopic and surgical approaches	53
COVID-19 pandemic: Its impact on liver disease and liver transplantation	52
Etiology and management of liver injury in patients with COVID-19	52
Helicobacter pylori: Commensal, symbiont or pathogen?	51
Immune checkpoint inhibitor-related hepatotoxicity: A review	51
From hepatitis A to E: A critical review of viral hepatitis	50
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases	50
Artificial intelligence in gastroenterology: A state-of-the-art review	49
Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease	48
Clinical efficacy of the over-the-scope clip device: A systematic review	48
Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning	46
Endoscopic management of gastrointestinal leaks and fistulae: What option do we have?	46
Chinese guidelines on the management of liver cirrhosis (abbreviated version)	46
SARS-COV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant	45
Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults	45
Liver injury in the era of COVID-19	44
Shared decision-making in the management of patients with inflammatory bowel disease	43
Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats	42
Oral microbiome and pancreatic cancer	42
Gastroparesis: New insights into an old disease	42
Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects	42
BRCA mutated pancreatic cancer: A change is coming	42
Antimicrobial peptides and the gut microbiome in inflammatory bowel disease	42
Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model	41
Construction of a convolutional neural network classifier developed by computed tomography images for pancreatic cancer diagnosis	41
Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation	41
Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study	41
Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome	41
Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection	40
Cirrhotic portal hypertension: From pathophysiology to novel therapeutics	40
Blood-based biomarkers for early detection of esophageal squamous cell carcinoma	39
Diet in neurogenic bowel management: A viewpoint on spinal cord injury	39
Ever-increasing diversity of drug-induced pancreatitis	38
Artificial intelligence in the diagnosis and management of colorectal cancer liver metastases	38
Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review	38
Secondary causes of inflammatory bowel diseases	38
Artificial intelligence based real-time microcirculation analysis system for laparoscopic colorectal surgery	37
New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism	37
Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer	37
Early-onset colorectal cancer: A review of current knowledge	37
Molecular overview of progressive familial intrahepatic cholestasis	37
Metastatic pattern in esophageal and gastric cancer: Influenced by site and histology	36
Viral hepatitis update: Progress and perspectives	36
Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?	36
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome	36
Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways	36
Radiomics and machine learning applications in rectal cancer: Current update and future perspectives	36
Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions	36

Macrophages in metabolic associated fatty liver disease	36
Machine learning models and over-fitting considerations	35
Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma	35
Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19	35
Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer	35
Prognostic role of artificial intelligence among patients with hepatocellular cancer: A systematic review	34
Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review	34
Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold	34
Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma	34
Therapeutic advances in non-alcoholic fatty liver disease: A microbiota-centered view	33
COVID-19-associated diarrhea	33
Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease	33
COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms	33
Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives	32
Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy	32
Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application	32
Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis	32
Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China	32
Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions	32
Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease	32
COVID-19 and the gastrointestinal tract: source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?	32
Impact of mobile health and medical applications on clinical practice in gastroenterology	32
Gut microbiota in various childhood disorders: Implication and indications	31
Intratumoral heterogeneity of hepatocellular carcinoma: From single-cell to population-based studies	31
Association between non-alcoholic fatty liver disease and obstructive sleep apnea	31
Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence	31
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship	31
Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients	31
Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease	31
Imaging-based algorithmic approach to gallbladder wall thickening	30
Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link	30
Artificial intelligence-assisted colonoscopy: A review of current state of practice and research	30
Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy	30
Prevention of vertical transmission of hepatitis B virus infection	30
Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review	29
Viral hepatitis: Past, present, and future	29
Metabolomics profile in gastrointestinal cancers: Update and future perspectives	29
Update on the management of sigmoid diverticulitis	29
Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients	29
Intestinal epithelial barrier and neuromuscular compartment in health and disease	28
Diabetes and pancreatic cancer: Exploring the two-way traffic	28
Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan, China	28
Metabolic complications of hepatitis C virus infection	28
Effectiveness of very low-volume preparation for colonoscopy: A prospective, multicenter observational study	28
Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer	27
Artificial intelligence-assisted esophageal cancer management: Now and future	27
Ursodeoxycholic acid as a means of preventing atherosclerosis, steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease	27
Development and validation of a prediction model for microvascular invasion in hepatocellular carcinoma	27
Local ablation of pancreatic tumors: State of the art and future perspectives	27
Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients	27
Multiphase convolutional dense network for the classification of focal liver lesions on dynamic contrast-enhanced computed tomography	27
Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations	27
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies	27
Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review	27
T cells in pancreatic cancer stroma	26
Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice	26
How to manage inflammatory bowel disease during the COVID-19 pandemic: A guide for the practicing clinician	26
Non-invasive tests for the prediction of primary hepatocellular carcinoma	26
Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota	26
Role of bile acids in liver diseases mediated by the gut microbiome	26
Toward a new era of hepatitis B virus therapeutics: The pursuit of a functional cure	26
Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?	26
Use of artificial intelligence in improving adenoma detection rate during colonoscopy: Might both endoscopists and pathologists be further helped	26
Review of primary sclerosing cholangitis with increased IgG4 levels	26
Ultrasound liver elastography beyond liver fibrosis assessment	26
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells	26
Potential applications of artificial intelligence in colorectal polyps and cancer: Recent advances and prospects	26
Nutrition in alcohol-related liver disease: Physiopathology and management	26
Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort	25
Neuromechanism of acupuncture regulating gastrointestinal motility	25
Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population: Meta-analysis	25
Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment	25
Invasive fungal infection before and after liver transplantation	25
Update on the management and treatment of viral hepatitis	25
Identification of differentially expressed genes in ulcerative colitis and verification in a colitis mouse model by bioinformatics analyses	25
Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps: A meta-analysis and meta-regression with single arm analysis	25
Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy: A debate near the end	25
Advances in traction methods for endoscopic submucosal dissection: What is the best traction method and traction direction?	25
Predictors of early and late hepatocellular carcinoma recurrence	25
Medical management of metabolic and cardiovascular complications after liver transplantation	25

Gastrointestinal complications after kidney transplantation	25
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα	24
Human hepatitis viruses-associated cutaneous and systemic vasculitis	24
Hepatocellular carcinoma locoregional therapies: Outcomes and future horizons	24
Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients	24
Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells	24
Prediction of different stages of rectal cancer: Texture analysis based on diffusion-weighted images and apparent diffusion coefficient maps	24
Review of inflammatory bowel disease and COVID-19	24
G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment	24
Interaction between hepatitis B virus and SARS-CoV-2 infections	24
Risk of malignancy in Caroli disease and syndrome: A systematic review	24
Abdominal and gastrointestinal manifestations in COVID-19 patients: Is imaging useful?	24
Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments	24
Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art	23
Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology	23
Microbiota revolution: How gut microbes regulate our lives	23
Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine	23
Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis	23
Updates on global epidemiology, risk and prognostic factors of gastric cancer	23
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities	23
Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients	23
Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer: Focus on short and long-term outcomes	22
Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases: A cross-sectional and longitudinal analysis	22
Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome	22
New advances in radiomics of gastrointestinal stromal tumors	22
Viral hepatitis and hepatocellular carcinoma: From molecular pathways to the role of clinical surveillance and antiviral treatment	22
Acute liver failure and death predictors in patients with dengue-induced severe hepatitis	22
International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: A joinpoint regression analysis	22
Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface an	22
Celiac disease: From genetics to epigenetics	22
Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease	22
Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management	22
Nonalcoholic fatty liver disease in lean subjects: Prognosis, outcomes and management	22
Efficacy and safety of anti-hepatic fibrosis drugs	22
Torque teno virus in liver diseases: On the way towards unity of view	22
Combining protein arginine methyltransferase inhibitor and anti-programmed death-ligand-1 inhibits pancreatic cancer progression	22
Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease	21
Development of a computed tomography-based radiomics nomogram for prediction of transarterial chemoembolization refractoriness in hepatocellular carcinoma	21
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats	21
Impact of Helicobacter pylori infection on gut microbiota	21
Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study	21
Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review	21
Gut microbiome in acute pancreatitis: A review based on current literature	21
Endoscopic management of difficult common bile duct stones: Where are we now? A comprehensive review	21
Microbiota shaping — the effects of probiotics, prebiotics, and fecal microbiota transplant on cognitive functions: A systematic review	21
Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study	21
Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study	21
Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?	21
Liver dysfunction and SARS-CoV-2 infection	21
Radiomics of rectal cancer for predicting distant metastasis and overall survival	21
Emerging use of artificial intelligence in inflammatory bowel disease	21
Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review	20
Repurposing metformin for the treatment of gastrointestinal cancer	20
Viral hepatitis: Milestones, unresolved issues, and future goals	20
Neurological and psychiatric effects of hepatitis C virus infection	20
Gut microbiota mediated molecular events and therapy in liver diseases	20
New role for ceramide in hypoxia and insulin resistance	20
Comparative study on artificial intelligence systems for detecting early esophageal squamous cell carcinoma between narrow-band and white-light imaging	20
Novel drug delivery systems for inflammatory bowel disease	20
Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease	20
Artificial intelligence technique in detection of early esophageal cancer	20
Gut mucosal microbiota profiles linked to colorectal cancer recurrence	20
Role of γδT cells in liver diseases and its relationship with intestinal microbiota	20
Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care	20
Coronavirus disease–2019 and the intestinal tract: An overview	20
Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors	20
Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?	20
Risk of hepatocellular carcinoma after hepatitis C virus cure	20
High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients	20
Gastrointestinal mucosal immunity and COVID-19	20
Acute kidney injury and hepatorenal syndrome in cirrhosis	19
Potential risk factors for constipation in the community	19
Short- and long-term outcomes associated with enhanced recovery after surgery protocol vs conventional management in patients undergoing laparoscopic gastrectomy	19
Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma	19
Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients	19
Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells	19
Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications	19
Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients	19
Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years	19
Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions	19
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation	19
Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients	19
Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review	19
Textbook outcomes in hepatobiliary and pancreatic surgery	19
Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence	19
Artificial intelligence technologies for the detection of colorectal lesions: The future is now	19
Non-alcoholic fatty liver and chronic kidney disease: Retrospect, introspect, and prospect	19
DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p	19
Hepatitis B virus infection and hepatocellular carcinoma in sub-Saharan Africa: Implications for elimination of viral hepatitis by 2030?	19
Autoimmune liver diseases in systemic rheumatic diseases	18
Ischemic bowel disease in 2021	18
MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer	18
Promising xenograft animal model recapitulating the features of human pancreatic cancer	18
Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion	18
Evaluation of 177Lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors	18