World Journal of Gastroenterology

Article	Citations
Pancreatic cancer: A review of epidemiology, trend, and risk factors	173
Gut microbiota in obesity	143
Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma	124
Gastrointestinal and hepatic manifestations of COVID-19: A comprehensive review	116
COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract	109
Liver diseases in COVID-19: Etiology, treatment and prognosis	101
Epidemiology of stomach cancer	99
Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment	98
Role of gut microbiota on intestinal barrier function in acute pancreatitis	89
Mouse models of colorectal cancer: Past, present and future perspectives	84
Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment	83
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management	80
Role of gut microbiota via the gut-liver-brain axis in digestive diseases	73
Gut microbiota, inflammatory bowel disease and colorectal cancer	73
Artificial intelligence in gastric cancer: Application and future perspectives	71
Watch and wait approach in rectal cancer: Current controversies and future directions	70
Gut microbiome in primary sclerosing cholangitis: A review	70
Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease	66
Venous thromboembolism in inflammatory bowel disease	62
Artificial intelligence applications in inflammatory bowel disease: Emerging technologies and future directions	61
High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data	58
Malignant gastric outlet obstruction: Which is the best therapeutic option?	57
Current guidelines for the management of celiac disease: A systematic review with comparative analysis	56
Pancreatic cancer in 2021: What you need to know to win	56
Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update	55

Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma	53
Helicobacter pylori infection: Beyond gastric manifestations	53
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis	53
COVID-19 pandemic: Its impact on liver disease and liver transplantation	52
Etiology and management of liver injury in patients with COVID-19	52
Helicobacter pylori: Commensal, symbiont or pathogen?	50
Management of cholelithiasis with choledocholithiasis: Endoscopic and surgical approaches	50
From hepatitis A to E: A critical review of viral hepatitis	49
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases	49
Clinical efficacy of the over-the-scope clip device: A systematic review	48
Immune checkpoint inhibitor-related hepatotoxicity: A review	47
Artificial intelligence in gastroenterology: A state-of-the-art review	47
Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning	46
Endoscopic management of gastrointestinal leaks and fistulae: What option do we have?	45
SARS-COV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant	45
Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease	45
Abnormal liver function tests associated with severe rhabdomyolysis	45
Is aggressive intravenous fluid resuscitation beneficial in acute pancreatitis? A meta-analysis of randomized control trials and cohort studies	44
Liver injury in the era of COVID-19	44
Chinese guidelines on the management of liver cirrhosis (abbreviated version)	44
Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults	44
Shared decision-making in the management of patients with inflammatory bowel disease	43
Oral microbiome and pancreatic cancer	42
Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects	42
Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats	42
Antimicrobial peptides and the gut microbiome in inflammatory bowel disease	42
Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model	41
Gastroparesis: New insights into an old disease	40
Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome	40
Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study	40
Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation	40
Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection	39
Construction of a convolutional neural network classifier developed by computed tomography images for pancreatic cancer diagnosis	39
BRCA mutated pancreatic cancer: A change is coming	39
Diet in neurogenic bowel management: A viewpoint on spinal cord injury	39
Cirrhotic portal hypertension: From pathophysiology to novel therapeutics	39
Secondary causes of inflammatory bowel diseases	38
Ever-increasing diversity of drug-induced pancreatitis	38
Artificial intelligence in the diagnosis and management of colorectal cancer liver metastases	38
Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review	38
Blood-based biomarkers for early detection of esophageal squamous cell carcinoma	37
New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism	37
Artificial intelligence based real-time microcirculation analysis system for laparoscopic colorectal surgery	37
Macrophages in metabolic associated fatty liver disease	36
Molecular overview of progressive familial intrahepatic cholestasis	36
Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer	36
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome	35
Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer	35
Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways	35
Radiomics and machine learning applications in rectal cancer: Current update and future perspectives	35

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma	35
Metastatic pattern in esophageal and gastric cancer: Influenced by site and histology	34
Prognostic role of artificial intelligence among patients with hepatocellular cancer: A systematic review	34
Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold	34
Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease	33
Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19	33
Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?	33
Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions	33
Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma	33
Impact of mobile health and medical applications on clinical practice in gastroenterology	32
Therapeutic advances in non-alcoholic fatty liver disease: A microbiota-centered view	32
Viral hepatitis update: Progress and perspectives	32
COVID-19-associated diarrhea	32
Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China	32
COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms	32
Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review	32
Non-robotic minimally invasive gastrectomy as an independent risk factor for postoperative intra-abdominal infectious complications: A single-center, retrospective and propensity score-matched analysi	32
Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease	32
COVID-19 and the gastrointestinal tract: source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?	32
Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis	31
Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients	31
Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease	31
Association between non-alcoholic fatty liver disease and obstructive sleep apnea	31
Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application	31
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship	31
Early-onset colorectal cancer: A review of current knowledge	31
Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy	31
Global whole family based-Helicobacter pylori eradication strategy to prevent its related diseases and gastric cancer	31
Prevention of vertical transmission of hepatitis B virus infection	30
Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy	30
Intratumoral heterogeneity of hepatocellular carcinoma: From single-cell to population-based studies	30
Gut microbiota in various childhood disorders: Implication and indications	30
Machine learning models and over-fitting considerations	29
Artificial intelligence-assisted colonoscopy: A review of current state of practice and research	29
Viral hepatitis: Past, present, and future	29
Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence	29
Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients	29
Update on the management of sigmoid diverticulitis	29
Metabolomics profile in gastrointestinal cancers: Update and future perspectives	28
Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review	28
Metabolic complications of hepatitis C virus infection	28
Imaging-based algorithmic approach to gallbladder wall thickening	28
Effectiveness of very low-volume preparation for colonoscopy: A prospective, multicenter observational study	28
Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening	27
Artificial intelligence-assisted esophageal cancer management: Now and future	27
Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients	27
Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives	27
Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations	27
Intestinal epithelial barrier and neuromuscular compartment in health and disease	27
Development and validation of a prediction model for microvascular invasion in hepatocellular carcinoma	27
Local ablation of pancreatic tumors: State of the art and future perspectives	27
Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions	27
Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer	26
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells	26
Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota	26
Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan, China	26
Ultrasound liver elastography beyond liver fibrosis assessment	26
Multiphase convolutional dense network for the classification of focal liver lesions on dynamic contrast-enhanced computed tomography	26
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies	26
Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link	26
Role of bile acids in liver diseases mediated by the gut microbiome	26
Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice	26
Ursodeoxycholic acid as a means of preventing atherosclerosis, steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease	26
Nutrition in alcohol-related liver disease: Physiopathology and management	26
T cells in pancreatic cancer stroma	25
Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?	25
Update on the management and treatment of viral hepatitis	25
Toward a new era of hepatitis B virus therapeutics: The pursuit of a functional cure	25
Potential applications of artificial intelligence in colorectal polyps and cancer: Recent advances and prospects	25
Neuromechanism of acupuncture regulating gastrointestinal motility	25
Identification of differentially expressed genes in ulcerative colitis and verification in a colitis mouse model by bioinformatics analyses	25
Invasive fungal infection before and after liver transplantation	25
Non-invasive tests for the prediction of primary hepatocellular carcinoma	25
Advances in traction methods for endoscopic submucosal dissection: What is the best traction method and traction direction?	25
Medical management of metabolic and cardiovascular complications after liver transplantation	24
Diabetes and pancreatic cancer: Exploring the two-way traffic	24
Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment	24
Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort	24
How to manage inflammatory bowel disease during the COVID-19 pandemic: A guide for the practicing clinician	24
Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments	24

Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps: A meta-analysis and meta-regression with single arm analysis	24
Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells	24
Risk of malignancy in Caroli disease and syndrome: A systematic review	24
Abdominal and gastrointestinal manifestations in COVID-19 patients: Is imaging useful?	24
G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment	24
Use of artificial intelligence in improving adenoma detection rate during colonoscopy: Might both endoscopists and pathologists be further helped	24
Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population: Meta-analysis	24
Gastrointestinal complications after kidney transplantation	24
Prediction of different stages of rectal cancer: Texture analysis based on diffusion-weighted images and apparent diffusion coefficient maps	24
Review of inflammatory bowel disease and COVID-19	24
Predictors of early and late hepatocellular carcinoma recurrence	24
Review of primary sclerosing cholangitis with increased IgG4 levels	23
Interaction between hepatitis B virus and SARS-CoV-2 infections	23
Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients	23
Roles of G protein-coupled receptors in inflammatory bowel disease	23
Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine	23
Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy: A debate near the end	23
Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review	23
Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients	23
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities	23
Human hepatitis viruses-associated cutaneous and systemic vasculitis	23
Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management	22
Nonalcoholic fatty liver disease in lean subjects: Prognosis, outcomes and management	22
Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis	22
Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease	22
Torque teno virus in liver diseases: On the way towards unity of view	22
Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer: Focus on short and long-term outcomes	22
Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology	22
Microbiota revolution: How gut microbes regulate our lives	22
Combining protein arginine methyltransferase inhibitor and anti-programmed death-ligand-1 inhibits pancreatic cancer progression	22
Role of alcohol in pathogenesis of hepatitis B virus infection	22
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα	22
Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome	22
Celiac disease: From genetics to epigenetics	22
Emerging use of artificial intelligence in inflammatory bowel disease	21
Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review	21
Viral hepatitis and hepatocellular carcinoma: From molecular pathways to the role of clinical surveillance and antiviral treatment	21
Circulating microRNAs as non-invasive biomarkers for hepatitis B virus liver fibrosis	21
Hepatocellular carcinoma locoregional therapies: Outcomes and future horizons	21
New advances in radiomics of gastrointestinal stromal tumors	21
Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study	21
Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease	21
Efficacy and safety of anti-hepatic fibrosis drugs	21
Liver dysfunction and SARS-CoV-2 infection	21
Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study	20
Gut mucosal microbiota profiles linked to colorectal cancer recurrence	20
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats	20
Updates on global epidemiology, risk and prognostic factors of gastric cancer	20
Radiomics of rectal cancer for predicting distant metastasis and overall survival	20
Repurposing metformin for the treatment of gastrointestinal cancer	20
Radiomics model based on preoperative gadoxetic acid-enhanced MRI for predicting liver failure	20
Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases: A cross-sectional and longitudinal analysis	20
Neurological and psychiatric effects of hepatitis C virus infection	20
Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface an	20
Comparative study on artificial intelligence systems for detecting early esophageal squamous cell carcinoma between narrow-band and white-light imaging	20
Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art	20
Preoperative albumin levels predict prolonged postoperative ileus in gastrointestinal surgery	20
Viral hepatitis: Milestones, unresolved issues, and future goals	20
Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors	20
Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?	20
Role of γδT cells in liver diseases and its relationship with intestinal microbiota	20
High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients	20
Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review	20
Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study	20
Artificial intelligence technique in detection of early esophageal cancer	20
Coronavirus disease–2019 and the intestinal tract: An overview	20
Acute liver failure and death predictors in patients with dengue-induced severe hepatitis	19
Impact of Helicobacter pylori infection on gut microbiota	19
Differentiation of atypical hepatic hemangioma from liver metastases: Diagnostic performance of a novel type of color contrast enhanced ultrasound	19
Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications	19
New role for ceramide in hypoxia and insulin resistance	19
Gut microbiome in acute pancreatitis: A review based on current literature	19
Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma	19
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation	19
Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review	19
Risk of hepatocellular carcinoma after hepatitis C virus cure	19
Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care	19
Potential risk factors for constipation in the community	19
Endoscopic management of difficult common bile duct stones: Where are we now? A comprehensive review	19
Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years	19
Non-alcoholic fatty liver and chronic kidney disease: Retrospect, introspect, and prospect	19
DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p	19
Acute kidney injury and hepatorenal syndrome in cirrhosis	19
International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: A joinpoint regression analysis	19
Textbook outcomes in hepatobiliary and pancreatic surgery	19
Development of a computed tomography-based radiomics nomogram for prediction of transarterial chemoembolization refractoriness in hepatocellular carcinoma	19
Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients	19
Microbiota shaping — the effects of probiotics, prebiotics, and fecal microbiota transplant on cognitive functions: A systematic review	19
Current understanding of the impact of COVID-19 on gastrointestinal disease: Challenges and openings	18
Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?	18
Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence	18
Gut microbiota mediated molecular events and therapy in liver diseases	18
MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer	18
Gastrointestinal mucosal immunity and COVID-19	18
Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion	18