Structure

Article	Citations
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	88
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	85
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	76
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	76
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	72
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	67
The next decade in structural biology	60
Gentle ions for cryo-FIB milling	55
A mesophilic Argonaute from Clostridium formicaceticum with efficient DNA cleavage activity guided by small DNA	49
Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction	48
The hitchhiker's guide to the periplasm: Unexpected molecular interactions of polymyxin B1 in E. coli	46
Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state	44
Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs	44
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	43
Structural insight into CD93 recognition by IGFBP7	40
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	39
Structures of an active type III-A CRISPR effector complex	39
One bead per residue can describe all-atom protein structures	38
Structural comparison of typical and atypical E2 pestivirus glycoproteins	38
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	38
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	38
High-resolution crystal structures of transient intermediates in the phytochrome photocycle	35
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP	35
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	35
Computational design and improvement of a broad influenza virus HA stem targeting antibody	34

PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	33
Structural basis of selective beta-carotene binding by a soluble protein	33
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	33
Structural basis of phage transcriptional regulation	33
Macromolecular refinement of X-ray and cryoelectron microscopy structures with Phenix/OPLS3e for improved structure and ligand quality	32
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA	31
Desensitization dynamics of the AMPA receptor	31
Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges	31
Benchmarking AlphaFold2 on peptide structure prediction	31
Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump	30
Super-resolution imaging reveals cytoskeleton-dependent organelle rearrangement within platelets at intermediate stages of maturation	30
Gating mechanism of the human α1β GlyR by glycine	30
Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii	30
The respiratory supercomplex from C. glutamicum	29
Binding of Ca2+-independent C2 domains to lipid membranes: A multi-scale molecular dynamics study	29
Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization	29
Septin assemblies promote the lipid organization of membranes	28
Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly	28
Lysozyme revisited	28
They all rock: A systematic comparison of conformational movements in LeuT-fold transporters	28
Understanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database	28
Discovery and characterization of a pan-betacoronavirus S2-binding antibody	28
Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA	27
Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel	27
Physicochemical features of subunit interfaces and their role in self-assembly across the ferritin superfamily	26
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A	26
Structural basis for the ligand promiscuity of the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes	26
Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice	25
Open, engage, bind, translocate: The multi-level dynamics of bacterial protein translocation	25
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown	25
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis	25
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons	25
TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins	25
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings	25
PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry	24
Near-atomic cryo-EM structure of the light-harvesting complex LH2 from the sulfur purple bacterium Ectothiorhodospira haloalkaliphila	24
Molecular insights into the initiation step of the Rcs signaling pathway	24
Cryo-EM research in India	24
Structural study of the N-terminal domain of human MCM8/9 complex	23
Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction	23
Structural elucidation of the mesothelin-mucin-16/CA125 interaction	23
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon	23
Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium	23
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1	23
Human V-ATPase function is positively and negatively regulated by TLDc proteins	22
Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins	22
One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling	22
A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF	22
Intracellular tau fragment droplets serve as seeds for tau fibrils	22
Structural review of SARS-CoV-2 antiviral targets	21

Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling	21
Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease	21
Computational modeling and prediction of deletion mutants	21
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor	21
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193	20
Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases	20
Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity	20
We con-dense if we want to; We can’t leave AZUL outside	20
Structure of the HapX:CCAAT-binding protein complex with DNA: A piece of the puzzle revealed	19
Anillin-related Mid1 as an adaptive and multimodal contractile ring anchoring protein: A simulation study	19
The interconnecting hairpin extension "arm": An essential allosteric element of phytochrome activity	19
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain	19
PARG inhibition induces nuclear aggregation of PARylated PARP1	19
Structural insights into highly similar spatial organization of zinc-finger associated domains with a very low sequence similarity	18
Disulfide-stabilized diabodies enable near-atomic cryo-EM imaging of small proteins: A case study of the bacterial Na+/citrate symporter CitS	18
Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms	18
B-Raf autoinhibition in the presence and absence of 14-3-3	18
CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP	18
Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis	18
NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD	18
Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis	18
Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial β-oxidation trifunctional enzymes	18
Disorder in CENP-ACse4 tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore	18
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis	17
Get what you want: Identifying antibodies against pre-defined epitopes on Frizzled receptors	17
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and side-chain flexibility	17
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation	17
Pho pictures provide powerful perspectives of phosphate importing proteins	17
Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum	17
Computational and biochemical analysis of type IV pilus dynamics and stability	17
Structure of a putative terminal amidation domain in natural product biosynthesis	17
Chemical modulation of microtubule structure through the laulimalide/peloruside site	16
Protein structure prediction using residue-resolved protection factors from hydrogen-deuterium exchange NMR	15
Structural basis for the RNA binding properties of mouse IGF2BP3	15
The molecular basis of allostery in a facilitated dissociation process	15
Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism	15
Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors	15
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand	15
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor	15
A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability	14
Rewiring protein binding specificity in paralogous DRG/DFRP complexes	14
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	14
Force-induced unfolding of an antibiotic-bound outer-membrane protein	14
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition	14
New beginnings	14
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2	14
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation	14
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	14
A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization	14
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro	14
Structure and dynamics of a nucleosome core particle based on Widom 603 DNA sequence	14
Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex	14
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states	14
A new twin expands the VirB8-like protein family	14
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	14
One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike	13
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion	13
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	13
Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III	13
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus	13
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	13
Unveiling the polarity of actin filaments by cryo-electron tomography	13
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev	13
Structural basis of bacteriophage lambda capsid maturation	13
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	13
Mechanism of negative μ-opioid receptor modulation by sodium ions	13
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook	13
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	13
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	13
Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase	13
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	13
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	13
Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii	13
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs	13
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	13
The to and fro of Rho	13
Solid-state NMR studies of amyloids	12
Structure determination of a DNA crystal by MicroED	12
Structural requirements for activity of Mind bomb1 in Notch signaling	12
Exploring protein-protein interactions at the proteome level	12

The structural heterogeneity of α-synuclein is governed by several distinct subpopulations with interconversion times slower than milliseconds	12
Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae	12
Computational microbiology of bacteria: Advancements in molecular dynamics simulations	12
Membrane mimetic-dependence of GPCR energy landscapes	12
AutoRNC: An automated modeling program for building atomic models of ribosome-nascent chain complexes	11
Insights into the distinct membrane targeting mechanisms of WDR91 family proteins	11
Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2	11
Structures and mRNP remodeling mechanism of the TREX-2 complex	11
Molecular basis for pH sensing in the KDEL trafficking receptor	11
Structural determinants of multimerization and dissociation in 2-Cys peroxiredoxin chaperone function	11
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser	11
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain	11
Markerauto2: A fast and robust fully automatic fiducial marker-based tilt series alignment software for electron tomography	11
Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1	11
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers	11
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins	11
The ABC transporter MsbA in a dozen environments	11
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy	11
Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus	11
Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane	11
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist	10
Mechanism of negative membrane curvature generation by I-BAR domains	10
Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex	10
eIF4A inhibitors PatA and RocA stack the deck against translation	10
Addressing compressive deformation of proteins embedded in crystalline ice	10
Structural basis for the carotenoid binding and transport function of a START domain	10
High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development	10
Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism	10
Structural interactions define assembly adapter function of a type II secretion system pseudopilin	10
Triangulating variation in the population to define mechanisms for precision management of genetic disease	10
Structure, dynamics, and function of PsDef2 defensin from Pinus sylvestris	10
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM	10
The future of integrated structural biology	10
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks	10
DNA ligase and PCNA: Double-ring down to seal a break in DNA	10
Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin	9
Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy	9
Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination	9
Two heads are better than one: Cooperation of two CAPS domains in membrane binding	9
Unveiling the intriguing role of FAP20 in tubulin recruitment at the doublet microtubule inner junctions	9
A glimpse into Giardia lamblia unique translational machinery	9
Llamanade: An open-source computational pipeline for robust nanobody humanization	9
Structural basis of λCII-dependent transcription activation	9
A model of full-length RAGE in complex with S100B	9
Monitoring the antibiotic darobactin modulating the β-barrel assembly factor BamA	9
Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis	9
Mind the gap	9
Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies	9
How do antiporters exchange substrates across the cell membrane? An atomic-level description of the complete exchange cycle in NarK	9
Aberrant tau condensates as catalytic microcompartments propel tau fibrillation	9
Eye lens β-crystallins are predicted by native ion mobility-mass spectrometry and computations to form compact higher-ordered heterooligomers	9
Structure of the divergent human astrovirus MLB capsid spike	9
X-rays, electrons, and neutrons as probes of atomic matter	9
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4	9
Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding	9
Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome	9