Structure

Article	Citations
Gentle ions for cryo-FIB milling	140
The next decade in structural biology	128
Design of a selective peptide inhibitor targeting KDM5C demethylase activity	71
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	69
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	60
Structural comparison of typical and atypical E2 pestivirus glycoproteins	60
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	56
A mesophilic Argonaute from Clostridium formicaceticum with efficient DNA cleavage activity guided by small DNA	53
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	52
Structures of an active type III-A CRISPR effector complex	50
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	50
Cryo-EM structures of prevalent gut phage PD491P1 uncover extensive disulfide stabilization and distinct structural adaptations	49
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	48
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1	47
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	47
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	45
One bead per residue can describe all-atom protein structures	45
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	44
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	43
Structural insight into CD93 recognition by IGFBP7	41
The relationship between interfacial overlap and functional divergence in the yeast protein-protein interaction network	38
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	38
Desensitization dynamics of the AMPA receptor	38
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP	37
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	37

Structural basis of phage transcriptional regulation	34
TMEM55B—Jack of all trades in the endo-lysosomal system?	34
Seeing is believing—Plasmodium falciparum translation in action	34
Computational design and improvement of a broad influenza virus HA stem targeting antibody	33
Dynamics of the PAC1 receptor in apo, peptide agonist-bound, and G protein complexed states	32
Coiled-coil-mediated phase separation of Spef1 for central-pair microtubule organization and function	32
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a	32
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps	31
PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	31
Molecular basis for the dopamine reuptake and inhibition mechanism of human dopamine transporter	31
Structural basis of selective beta-carotene binding by a soluble protein	31
Structural insights into ZBTB20 action at the AFP promoter	31
Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity	30
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA	29
Benchmarking AlphaFold2 on peptide structure prediction	29
Cryo-EM structure of the Arabidopsis thaliana ribosome in translating and non-translating states	28
Cryo-EM structures of HBV capsids from human cells at near-atomic resolution	27
Lysozyme revisited	27
Meet the author: Stephen Brohawn	27
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings	27
Structural and thermodynamic classification of amyloid polymorphs	27
Structure of a type II SMC Wadjet complex from Neobacillus vireti	26
Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization	26
Our authors in 2025	26
Gating mechanism of the human α1β GlyR by glycine	25
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A	24
Understanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database	24
Septin assemblies promote the lipid organization of membranes	24
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons	24
Nanoscale conformational dynamics of human propionyl-CoA carboxylase	24
Structural basis for the ligand promiscuity of the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes	24
Physicochemical features of subunit interfaces and their role in self-assembly across the ferritin superfamily	24
Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly	24
They all rock: A systematic comparison of conformational movements in LeuT-fold transporters	23
Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii	23
Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA	23
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis	23
Discovery and characterization of a pan-betacoronavirus S2-binding antibody	23
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging	23
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon	22
Memory engram synapse 3D macromolecular architecture visualized by cryoCLEM-guided cryoET	22
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown	22
Cryo-EM research in India	22
Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump	22
One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling	21
The pyrin domain of IFI16 forms a distinct filament structure important for IFI16-mediated enhancement of STING activation	21
Meet the authors: Cong-Zhao Zhou and Yong-Liang Jiang	21
Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling	21
Molecular insights into the initiation step of the Rcs signaling pathway	21
Intracellular tau fragment droplets serve as seeds for tau fibrils	20

Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction	20
Near-atomic cryo-EM structure of the light-harvesting complex LH2 from the sulfur purple bacterium Ectothiorhodospira haloalkaliphila	20
Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice	20
TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins	19
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1	19
Computational modeling and prediction of deletion mutants	19
Structure of a putative terminal amidation domain in natural product biosynthesis	19
Human V-ATPase function is positively and negatively regulated by TLDc proteins	19
Structural review of SARS-CoV-2 antiviral targets	19
Structural elucidation of the mesothelin-mucin-16/CA125 interaction	19
Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins	19
Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms	19
Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease	19
Modeling phase separation of biomolecular condensates with data-driven mass-conserving reaction-diffusion systems	19
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD	19
Integrating protein sequence design and evolutionary sequence conservation to uncover spectral tuning sites in red-light photoreceptors	19
PARG inhibition induces nuclear aggregation of PARylated PARP1	18
Get what you want: Identifying antibodies against pre-defined epitopes on Frizzled receptors	18
Structural insights into zinc piracy by Neisseria gonorrhoeae to overcome nutritional immunity	18
Disulfide-stabilized diabodies enable near-atomic cryo-EM imaging of small proteins: A case study of the bacterial Na+/citrate symporter CitS	18
The interconnecting hairpin extension "arm": An essential allosteric element of phytochrome activity	18
We con-dense if we want to; We can’t leave AZUL outside	18
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor	18
Capture first, then deliver!	18
Meet the author: Constantinos Kurt Wibmer	18
Putting the brakes on endocytosis	18
Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases	17
Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome	17
Impact of remdesivir modifications on human HINT1 binding - A structural and functional study in the remdesivir activation pathway	17
Anillin-related Mid1 as an adaptive and multimodal contractile ring anchoring protein: A simulation study	17
Cross-linking with diazirines: Bright sides and blind spots	17
Geometry-aware template matching for cryo-electron tomograms in Dynamo	17
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain	17
Disorder in CENP-ACse4 tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore	17
Let there be light: Targeted fluorescent labels illuminate cryo-FIB/ET of synapses	17
EnsembleFlex: Protein structure ensemble analysis made easy	16
Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum	16
prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation	16
Structural and biochemical characterization of neutralizing antibodies targeting human papillomavirus type 45	16
Structural changes shifting the redox potential of the outlying cluster N1a in respiratory complex I	16
Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity	16
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2	16
Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis	16
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation	16
A correlative workflow for synaptic imaging by cryo-electron tomography	16
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193	16
Pho pictures provide powerful perspectives of phosphate importing proteins	16
Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis	16
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation	16
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and side-chain flexibility	16
Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial β-oxidation trifunctional enzymes	16
Structural basis for the RNA binding properties of mouse IGF2BP3	15
Discovery of tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain	15
Structure and dynamics of a nucleosome core particle based on Widom 603 DNA sequence	15
Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex	15
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand	15
A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability	15
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor	15
Chemical modulation of microtubule structure through the laulimalide/peloruside site	15
Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors	15
Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism	15
Cryo-EM structure of the RfxCas13d-crRNA-off-target-RNA complex	14
Mechanism of negative μ-opioid receptor modulation by sodium ions	14
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif	14
Rewiring protein binding specificity in paralogous DRG/DFRP complexes	14
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis	14
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	14
CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1	14
High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing	14
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	14
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition	14
Wolfram Saenger (1939–2026)	13
Structural requirements for activity of Mind bomb1 in Notch signaling	13
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus	13
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	13
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	13
AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys	13
Structure determination of a DNA crystal by MicroED	13
Membrane mimetic-dependence of GPCR energy landscapes	13
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	13

In silico design of stable single-domain antibodies with high affinity	13
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	13
The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody	13
Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii	13
Meet the authors: Ka Young Chung and Jun Xu	13
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	13
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	13
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion	12
Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis	12
Structural insights into IL-31 signaling inhibition by a neutralizing antibody	12
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook	12
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	12
Computational microbiology of bacteria: Advancements in molecular dynamics simulations	12
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	12
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev	12
Solid-state NMR studies of amyloids	12
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	12
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs	12
Structures of the Xcp and Hxc T2SS endopili provide new insights into type IV pili subfamilies	12
Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae	12
Rethinking what pLDDT really tells us about protein flexibility	12
The ABC transporter MsbA in a dozen environments	12
Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase	12
The future of integrated structural biology	11
Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus	11
Molecular basis for pH sensing in the KDEL trafficking receptor	11
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser	11
Fungal kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle	11
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist	11
Meet the author: Cathleen Zeymer	11
The therapeutic antibody sacituzumab induces trophoblast cell-surface antigen-2 conformational rearrangement	11
Soft X-ray tomography illuminates drug-induced changes in insulin granules	11
Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism	11
Di-His-Cu(II)-NTA spin labels for probing protein dynamics: Support from a combined crystallographic/EPR study	11
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV	11
A mechanistic understanding of how KCNE1 tunes KCNQ1 channel pharmacology	11
AutoRNC: An automated modeling program for building atomic models of ribosome-nascent chain complexes	11
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers	11
Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2	11
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells	11
Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding	11
Structural basis of λCII-dependent transcription activation	11
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy	11
Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane	11
Insights into the distinct membrane targeting mechanisms of WDR91 family proteins	11
Markerauto2: A fast and robust fully automatic fiducial marker-based tilt series alignment software for electron tomography	11
SeaMoon: From protein language models to continuous structural heterogeneity	11
Structures and mRNP remodeling mechanism of the TREX-2 complex	11
Structural basis for the carotenoid binding and transport function of a START domain	11
Triangulating variation in the population to define mechanisms for precision management of genetic disease	11