Structure

Article	Citations
Gentle ions for cryo-FIB milling	123
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	117
The next decade in structural biology	98
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	63
Design of a selective peptide inhibitor targeting KDM5C demethylase activity	63
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	55
A mesophilic Argonaute from Clostridium formicaceticum with efficient DNA cleavage activity guided by small DNA	54
One bead per residue can describe all-atom protein structures	52
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	50
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1	50
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	48
Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction	46
Cryo-EM structures of prevalent gut phage PD491P1 uncover extensive disulfide stabilization and distinct structural adaptations	46
Structural insight into CD93 recognition by IGFBP7	45
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	45
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	44
Structural comparison of typical and atypical E2 pestivirus glycoproteins	43
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	42
Structures of an active type III-A CRISPR effector complex	42
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	41
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	40
Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity	38
The relationship between interfacial overlap and functional divergence in the yeast protein-protein interaction network	36
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	35
Desensitization dynamics of the AMPA receptor	35

Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	34
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP	34
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps	34
Structural insights into ZBTB20 action at the AFP promoter	33
Structural basis of selective beta-carotene binding by a soluble protein	33
TMEM55B—Jack of all trades in the endo-lysosomal system?	31
Seeing is believing—Plasmodium falciparum translation in action	30
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a	30
Computational design and improvement of a broad influenza virus HA stem targeting antibody	30
Structural basis of phage transcriptional regulation	30
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings	29
Coiled-coil-mediated phase separation of Spef1 for central-pair microtubule organization and function	29
Benchmarking AlphaFold2 on peptide structure prediction	29
Dynamics of the PAC1 receptor in apo, peptide agonist-bound, and G protein complexed states	29
PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	29
Lysozyme revisited	28
Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly	27
Structure of a type II SMC Wadjet complex from Neobacillus vireti	27
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis	27
Understanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database	27
Our authors in 2025	27
Gating mechanism of the human α1β GlyR by glycine	27
Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization	27
Nanoscale conformational dynamics of human propionyl-CoA carboxylase	26
Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii	26
Structural basis for the ligand promiscuity of the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes	25
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA	25
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging	25
Septin assemblies promote the lipid organization of membranes	24
Discovery and characterization of a pan-betacoronavirus S2-binding antibody	24
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A	24
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons	24
Structural and thermodynamic classification of amyloid polymorphs	23
Cryo-EM structures of HBV capsids from human cells at near-atomic resolution	23
Physicochemical features of subunit interfaces and their role in self-assembly across the ferritin superfamily	22
Modeling phase separation of biomolecular condensates with data-driven mass-conserving reaction-diffusion systems	22
They all rock: A systematic comparison of conformational movements in LeuT-fold transporters	22
Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump	22
Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA	22
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown	22
Memory engram synapse 3D macromolecular architecture visualized by cryoCLEM-guided cryoET	21
Cryo-EM research in India	21
Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling	21
TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins	21
One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling	21
Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease	21
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon	21
Meet the authors: Cong-Zhao Zhou and Yong-Liang Jiang	20
The pyrin domain of IFI16 forms a distinct filament structure important for IFI16-mediated enhancement of STING activation	20
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1	20

Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins	20
Human V-ATPase function is positively and negatively regulated by TLDc proteins	20
Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice	19
Near-atomic cryo-EM structure of the light-harvesting complex LH2 from the sulfur purple bacterium Ectothiorhodospira haloalkaliphila	19
Molecular insights into the initiation step of the Rcs signaling pathway	19
Intracellular tau fragment droplets serve as seeds for tau fibrils	19
Computational modeling and prediction of deletion mutants	19
Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction	19
Disorder in CENP-ACse4 tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore	18
Structural review of SARS-CoV-2 antiviral targets	18
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD	18
Capture first, then deliver!	18
We con-dense if we want to; We can’t leave AZUL outside	18
Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis	18
Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome	18
Structural elucidation of the mesothelin-mucin-16/CA125 interaction	18
Structure of a putative terminal amidation domain in natural product biosynthesis	18
Get what you want: Identifying antibodies against pre-defined epitopes on Frizzled receptors	18
Structure of the HapX:CCAAT-binding protein complex with DNA: A piece of the puzzle revealed	18
Meet the author: Constantinos Kurt Wibmer	18
Putting the brakes on endocytosis	18
Structural insights into zinc piracy by Neisseria gonorrhoeae to overcome nutritional immunity	18
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193	18
Disulfide-stabilized diabodies enable near-atomic cryo-EM imaging of small proteins: A case study of the bacterial Na+/citrate symporter CitS	18
The interconnecting hairpin extension "arm": An essential allosteric element of phytochrome activity	18
Structural insights into highly similar spatial organization of zinc-finger associated domains with a very low sequence similarity	17
Anillin-related Mid1 as an adaptive and multimodal contractile ring anchoring protein: A simulation study	17
Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms	17
Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases	17
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain	17
Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial β-oxidation trifunctional enzymes	17
PARG inhibition induces nuclear aggregation of PARylated PARP1	17
Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity	17
Geometry-aware template matching for cryo-electron tomograms in Dynamo	16
Structural changes shifting the redox potential of the outlying cluster N1a in respiratory complex I	16
Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum	16
Integrating protein sequence design and evolutionary sequence conservation to uncover spectral tuning sites in red-light photoreceptors	16
Impact of remdesivir modifications on human HINT1 binding - A structural and functional study in the remdesivir activation pathway	16
Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors	16
Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex	16
Let there be light: Targeted fluorescent labels illuminate cryo-FIB/ET of synapses	16
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor	16
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand	16
prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation	16
Pho pictures provide powerful perspectives of phosphate importing proteins	15
Chemical modulation of microtubule structure through the laulimalide/peloruside site	15
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation	15
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation	15
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor	15
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and side-chain flexibility	15
EnsembleFlex: Protein structure ensemble analysis made easy	15
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2	15
Structure and dynamics of a nucleosome core particle based on Widom 603 DNA sequence	15
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis	15
Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis	15
Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism	15
A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability	15
Discovery of tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain	15
A correlative workflow for synaptic imaging by cryo-electron tomography	15
Structural basis for the RNA binding properties of mouse IGF2BP3	15
Structural and biochemical characterization of neutralizing antibodies targeting human papillomavirus type 45	15
High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing	14
Rewiring protein binding specificity in paralogous DRG/DFRP complexes	14
A new twin expands the VirB8-like protein family	14
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif	14
Cryo-EM structure of the RfxCas13d-crRNA-off-target-RNA complex	14
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	14
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	14
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	14
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	14
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	14
Structural insights into IL-31 signaling inhibition by a neutralizing antibody	13
Mechanism of negative μ-opioid receptor modulation by sodium ions	13
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition	13
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	13
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion	13
In silico design of stable single-domain antibodies with high affinity	13
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	13
Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae	13
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus	13

Meet the authors: Ka Young Chung and Jun Xu	13
CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1	13
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook	13
Structural requirements for activity of Mind bomb1 in Notch signaling	12
Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase	12
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	12
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev	12
Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii	12
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	12
Structure determination of a DNA crystal by MicroED	12
Membrane mimetic-dependence of GPCR energy landscapes	12
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	12
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	12
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs	12
Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis	12
AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys	12
The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody	12
The ABC transporter MsbA in a dozen environments	12
Solid-state NMR studies of amyloids	12
Wolfram Saenger (1939–2026)	12
Molecular basis for pH sensing in the KDEL trafficking receptor	11
A mechanistic understanding of how KCNE1 tunes KCNQ1 channel pharmacology	11
Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism	11
Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane	11
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist	11
Rethinking what pLDDT really tells us about protein flexibility	11
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV	11
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells	11
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy	11
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser	11
AutoRNC: An automated modeling program for building atomic models of ribosome-nascent chain complexes	11
Computational microbiology of bacteria: Advancements in molecular dynamics simulations	11
Insights into the distinct membrane targeting mechanisms of WDR91 family proteins	11
Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2	11
Structures and mRNP remodeling mechanism of the TREX-2 complex	11
A glimpse into Giardia lamblia unique translational machinery	10
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4	10
Cryo-EM structures of photocomplexes from the free-living aerobic anoxygenic phototrophic bacterium Erythrobacter sanguineus	10
Triangulating variation in the population to define mechanisms for precision management of genetic disease	10
Structure of the divergent human astrovirus MLB capsid spike	10
Structural basis for the carotenoid binding and transport function of a START domain	10
Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus	10
Aberrant tau condensates as catalytic microcompartments propel tau fibrillation	10
Two heads are better than one: Cooperation of two CAPS domains in membrane binding	10
The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein	10
High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development	10
Mind the gap	10
Meet the author: Cathleen Zeymer	10
Di-His-Cu(II)-NTA spin labels for probing protein dynamics: Support from a combined crystallographic/EPR study	10
The future of integrated structural biology	10
Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding	10
SeaMoon: From protein language models to continuous structural heterogeneity	10
Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin	10
Structural characterization of the Cu(II)-NTA spin label on α-helices by X-ray crystallography and electron paramagnetic resonance	10
Addressing compressive deformation of proteins embedded in crystalline ice	10
X-rays, electrons, and neutrons as probes of atomic matter	10
Soft X-ray tomography illuminates drug-induced changes in insulin granules	10
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers	10
Fungal kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle	10
Markerauto2: A fast and robust fully automatic fiducial marker-based tilt series alignment software for electron tomography	10
Unveiling the intriguing role of FAP20 in tubulin recruitment at the doublet microtubule inner junctions	10
Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination	9
The therapeutic antibody sacituzumab induces trophoblast cell-surface antigen-2 conformational rearrangement	9
Time-resolved X-ray solution scattering observations of light-induced structural changes in sensory rhodopsin II	9
Expanding the insect defensin landscape	9
PB-GPT: An innovative GPT-based model for protein backbone generation	9
Protein model building for intermediate-resolution cryo-EM maps by integrating evolutionary and experimental information	9
REAPing the benefits of comprehensive specificity profiling for therapeutic antibody development	9
A bacteriophage tubulin forms microtubule-like assemblies with nine protofilaments	9
Structural and dynamic insights into α-synuclein dimer conformations	9
Epithelial sodium channels assemble in an orderly manner: Biology does not play dice	9
Structural insights into thermophilic chaperonin complexes	9
Structural basis of λCII-dependent transcription activation	9
The amyloid packing difference: A pairwise comparison metric for amyloid structures	9
Regulatory mechanisms of PP2A complex assembly driven by physicochemical differences in A-subunit isoforms	9
Sla2 is a core interaction hub for clathrin light chain and the Pan1/End3/Sla1 complex	9
Structural insights into an atypical histone binding mechanism by a PHD finger	9
Conformational exchange at a C2H2 zinc-binding site facilitates redox sensing by the PML protein	9
Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome	9
A liquid engine: How Spef1 droplets set the ciliary beat	8
The interactions that shape amyloid fibrils in disease	8
Nanobodies identify an activated state of the TRIB2 pseudokinase	8
Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci	8
Metal fluorides—multi-functional tools for the study of phosphoryl transfer enzymes, a practical guide	8
Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease	8
Major classes of neutralizing antibodies evaded by the SARS-CoV-2 Omicron variant	8
I shall be released: Assembly platform dynamics during type II secretion	8
Understanding cytokinesis interaction by interaction	8
Homologues not needed: Structure prediction from a protein language model	8
Ca2+-dependent lipid preferences shape synaptotagmin-1 C2A and C2B dynamics: Insights from experiments and simulations	8
Tilt-series-based joint CTF estimation for cryo-electron tomography	8
Structural biology of the human papillomavirus	8
Assessing PDB macromolecular crystal structure confidence at the individual amino acid residue level	8
Capsid structure of phage SPO1 reveals novel minor capsid proteins and insights into capsid stabilization	8
Markerfree: GPU-accelerated marker-free alignment for improved cryo-ET reconstruction	8