Structure

Article	Citations
A standard data format for 3DED/MicroED	72
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	71
Meet the authors: Dr. Eva Huber, Dr. Michael Groll, and Dr. Eric Ortlund	65
Structure-guided insights into TIR-mediated bacterial and eukaryotic immunity	59
Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan	53
Structural insights into polyisoprenyl-binding glycosyltransferases	53
NMR Structure and Dynamics Studies of Yeast Respiratory Supercomplex Factor 2	50
The cards you have been dealt: How an intertidal green macroalga absorbs blue-green light	47
Structural and functional properties of different types of siphonous LHCII trimers from an intertidal green alga Bryopsis corticulans	47
Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction	46
The accuracy of protein structures in solution determined by AlphaFold and NMR	45
Structural comparison of typical and atypical E2 pestivirus glycoproteins	45
Gentle ions for cryo-FIB milling	39
Structural and functional characterization of the N-terminal acetyltransferase Naa50	38
Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation	37
Opening the Door to Better Aspirin	34
Mapping structural and dynamic divergence across the MBOAT family	34
Structural insights from G-protein-coupled receptor complexes enable the rational engineering of improved light-activated designer receptors	34
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro	32
Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state	32
Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins	31
Conformational changes and CO2-induced channel gating in connexin26	31
Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions	31
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	31
Recent advances in small-angle scattering and its expanding impact in structural biology	30

Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism	30
Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding	29
Ordering the disordered	29
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling	28
Mechanism of ceramide synthase inhibition by fumonisin B1	28
Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain	28
Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9	27
Catalytic cycling of human mitochondrial Lon protease	27
Propelling COPII vesicle biogenesis at the endoplasmic reticulum	26
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	26
Chaperoning the major facilitator superfamily at single-molecule level	25
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	25
Force-induced unfolding of an antibiotic-bound outer-membrane protein	25
Cullin(g) glutamate dehydrogenase: Insights into multivalent CRL3KLHL22 substrate recognition	25
A new visual design language for biological structures in a cell	25
Scaling up cryo-EM for biology and chemistry: The journey from niche technology to mainstream method	25
A new twin expands the VirB8-like protein family	25
Structural basis of bacteriophage lambda capsid maturation	24
Polysaccharide assemblies in fungal and plant cell walls explored by solid-state NMR	24
Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae	24
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response	24
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states	24
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	23
Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein	22
Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs	22
Chemical probing provides insight into the native assembly state of a bacterial microcompartment	22
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase	22
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	22
Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM	21
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs	21
Conformational response of αIIbβ3 and αVβ3 integrins to force	21
Cryo-EM structure of flagellotropic bacteriophage Chi	21
Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction	21
New beginnings	20
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	20
Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex	20
Trading in catalytic power for sensing	20
Evolving cryo-EM structural approaches for GPCR drug discovery	20
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development	19
Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions	19
Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax	19
Simplified quality assessment for small-molecule ligands in the Protein Data Bank	19
Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX	19
Soft X-ray tomography to map and quantify organelle interactions at the mesoscale	19
Cryo-EM and artificial intelligence visualize endogenous protein community members	19
Structure-guided optimization of light-activated chimeric G-protein-coupled receptors	18
Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition	18
Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization	18
Cryo-EM structure of the cytosolic AhR complex	18
Insights into substrate coordination and glycosyl transfer of poplar cellulose synthase-8	18

Ping, pong, and freeze: Structural insights into the inhibition of ceramide synthase by Fumonisin B1	18
Molecular structures of human ACAT2 disclose mechanism for selective inhibition	18
A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization	18
The hitchhiker's guide to the periplasm: Unexpected molecular interactions of polymyxin B1 in E. coli	17
Structural and biochemical insights into the mechanism of the anti-CRISPR protein AcrIE3	17
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	17
Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase	17
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	17
Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography	17
Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms	17
The next decade in structural biology	17
Protein translocation through α-helical channels and insertases	17
Mechanism of negative μ-opioid receptor modulation by sodium ions	16
Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964	16
Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane	16
Multiple masks of a Shigella podophage	16
Structural insight into CD93 recognition by IGFBP7	16
Mechanistic insight into light-dependent recognition of Timeless by Drosophila Cryptochrome	16
Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O	16
One bead per residue can describe all-atom protein structures	16
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	16
Slow conformational dynamics of the human A2A adenosine receptor are temporally ordered	15
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	15
Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target	15
Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III	15
Protein language-model embeddings for fast, accurate, and alignment-free protein structure prediction	15
Compressed sensing for electron cryotomography and high-resolution subtomogram averaging of biological specimens	15
Structures of an active type III-A CRISPR effector complex	15
Structural characterization of the POTRA domains from A. baumannii reveals new conformations in BamA	14
Mechanism of phospho-Ubls’ specificity and conformational changes that regulate Parkin activity	14
Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules	14
Rewiring protein binding specificity in paralogous DRG/DFRP complexes	14
Extracellular Fe(III) reductase structure reveals a modular organization enabling S-layer insertion and electron transfer to insoluble substrates	14
Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures	14
Lys716 in the transmembrane domain of yeast mitofusin Fzo1 modulates anchoring and fusion	14
Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly	14
Structure, function, surf, repeat: A week at Lorne Proteins 2024	13
Treatment of noise caused by radiation damage during cryo-EM data collection	13
Advances in the field of RNA 3D structure prediction and modeling, with purely theoretical approaches, and with the use of experimental data	13
An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation	13
Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?	13
A finger that gets in the way: When binding isn’t just about the bound state	13
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	12
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	12
EncoMPASS: An encyclopedia of membrane proteins analyzed by structure and symmetry	12
Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae	12
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	12
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	12
Structural insights into human ABCA7-mediated lipid transport	12
Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization	12
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	12
Structural dissection of the CMP-pseudaminic acid synthetase, PseF	12
A novel interleukin-10 antibody graft to treat inflammatory bowel disease	12
Structural insights into the bifunctional enzyme human FAD synthase	12
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	12
Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity	11
The to and fro of Rho	11
Exploring protein-protein interactions at the proteome level	11
Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding	11
Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs	11
LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates	11
Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation	11
The roles of FUS-RNA binding domain and low complexity domain in RNA-dependent phase separation	11
Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins	11
Structure-based prediction of Ras-effector binding affinities and design of “branchegetic” interface mutations	11
Cooperative mechanics of PR65 scaffold underlies the allosteric regulation of the phosphatase PP2A	11
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	11
Progress toward automated methyl assignments for methyl-TROSY applications	11
Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain	11
Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core	11
Membrane mimetic-dependence of GPCR energy landscapes	11
Kenneth C. Holmes (1934–2021)	11
How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view	11
De novo design of SARS-CoV-2 main protease inhibitors with characteristic binding modes	11
High-resolution cryo-EM of a small protein complex: The structure of the human CDK-activating kinase	11
How CEP164 ciliopathy mutations impair ciliogenesis	11
Two steps, one ligand: How PPARγ binds small-molecule agonists	11
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion	11
Molecular rules governing the structural polymorphism of amyloid fibrils in neurodegenerative diseases	10
The solution structure of human leptin reveals a conformational plasticity important for receptor recognition	10

Molecular mechanism of contactin 2 homophilic interaction	10
A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3	10
Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor	10
It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors	10
HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases	10
Architecture of the bacteriophage lambda tail	10
Structural requirements for activity of Mind bomb1 in Notch signaling	10
One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike	10
Metal fluorides—multi-functional tools for the study of phosphoryl transfer enzymes, a practical guide	10
The hidden (degron) truth behind the degradation of DHFR disease-associated variants	10
Structural insights into a functional unit from an immunogenic mollusk hemocyanin	10
Cryo-EM structure of a Shigella podophage reveals a hybrid tail and novel decoration proteins	10
Structure and assembly of the human IL-12 signaling complex	10
Tails don’t tell the whole story	10
The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis	10
Functional dynamics and allosteric modulation of TRPA1	9
Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC	9
Structure of V-ATPase from citrus fruit	9
Disease-associated patterns of acetylation stabilize tau fibril formation	9
Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2	9
Structure of an inactive conformation of GTP-bound RhoA GTPase	9
GPCRana: A web server for quantitative analysis of GPCR structures	9
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker	9
Structural insights into the role and targeting of EGFRvIII	9
Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS	9
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies	9
Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop	9
Transient association between proteins elicits alteration of dynamics at sites far away from interfaces	9
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev	9
Host receptor binding induces conformational changes in a PfEMP1 protein	9
The structural heterogeneity of α-synuclein is governed by several distinct subpopulations with interconversion times slower than milliseconds	9
An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants	9
Inherent backbone dynamics fine-tune the functional plasticity of Tudor domains	9
Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes	9
An engineered construct of cFLIP provides insight into DED1 structure and interactions	8
The accuracy of NMR protein structures in the Protein Data Bank	8
Solid-state NMR studies of amyloids	8
RCSB Protein Data Bank resources for structure-facilitated design of mRNA vaccines for existing and emerging viral pathogens	8
PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	8
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins	8
Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM	8
Unveiling the polarity of actin filaments by cryo-electron tomography	8
Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation	8
In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution	8
Quantitative mining of compositional heterogeneity in cryo-EM datasets of ribosome assembly intermediates	8
Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges	8
High-resolution crystal structures of transient intermediates in the phytochrome photocycle	8
Desensitization dynamics of the AMPA receptor	8
Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor	8
Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1	8
Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives	8
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	7
Structure of the Extracellular Region of the Bacterial Type VIIb Secretion System Subunit EsaA	7
Computational microbiology of bacteria: Advancements in molecular dynamics simulations	7
Antigen presentation by MHC-II is shaped by competitive and cooperative allosteric mechanisms of peptide exchange	7
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	7
CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain	7
Probing hot spots of protein-protein interactions mediated by the safety-belt region of REV7	7
Structural insights into the evolutionary simplification of human ClpP activators	7
Macromolecular refinement of X-ray and cryoelectron microscopy structures with Phenix/OPLS3e for improved structure and ligand quality	7
Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM	7
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme	7
Structural basis of selective beta-carotene binding by a soluble protein	7
Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses	7
Transmembrane dimers of type 1 receptors sample alternate configurations: MD simulations using coarse grain Martini 3 versus AlphaFold2 Multimer	7
Benchmarking AlphaFold2 on peptide structure prediction	7
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	7
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook	7
Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design	6
Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase	6
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings	6
Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets	6
Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing	6
Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family	6
Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System	6
Cobalamin decyanation by the membrane transporter BtuM	6
Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors	6
Finding the sweet spot of the insect gustatory receptor	6
Computational design and improvement of a broad influenza virus HA stem targeting antibody	6
Cartwheels create symmetry and asymmetry	6
Cross-linking and mass spectrometry as a tool for studying the structural biology of ribonucleoproteins	6
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA	6
Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1	6
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	6
Bilayer lipids modulate ligand binding to atypical chemokine receptor 3	6
Biochemical and structural characterization of the DNA-binding properties of human TRIP4 ASCH domain reveals insights into its functional role	6
Go big and go home: A bulky extension makes promiscuous ligands settle down	6
Molecular mechanism of N-terminal acetylation by the ternary NatC complex	6
Charting the molecular landscape of the cell	6
Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications	6
DEER experiments reveal fundamental differences between calmodulin complexes with IQ and MARCKS peptides in solution	6
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser	6
Structure determination of a DNA crystal by MicroED	6
Structural basis of phage transcriptional regulation	6
αMI-domain of integrin Mac-1 binds the cytokine pleiotrophin using multiple mechanisms	6