Bioorganic & Medicinal Chemistry

Article	Citations
Synthesis and antiproliferative activity of (−)-cleistenolide, (6S)-cleistenolide and 4-substituted cleistenolide analogues	132
Current Japanese pharmaceutical chemistry	90
Targeting prolidase. A survey of the literature data to depict a structure-activity relationship frame and to address future studies for drug development	73
Innovative synthesis and purification method of fluorescent and bifunctional substrates for self-labelling protein tags	72
Site-specific construction of triptolide-based antibody-drug conjugates	47
Sustainable electrochemical C(sp3) − H oxygenation using water as the oxygen source	46
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis	43
Exploring novel A2AAR antagonists: Design, synthesis, and evaluation of 2,6,9-trisubstituted purine derivatives as promising antifibrotic agents	42
Production and synthesis of a novel 191Pt-labeled platinum complex and evaluation of its biodistribution in healthy mice	40
Editorial Board	40
Synthesis and medicinal chemistry of tetronamides: Promising agrochemicals and antitumoral compounds	38
Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine	38
Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation	36
Graphical abstract TOC	35
RNA-templated chemical synthesis of proapoptotic L- and d-peptides	35
Design, synthesis and validation of a new Crimped Head-Piece for DNA-Encoded libraries generation	34
Contents continued	34
Crescent-shaped meta-substituted benzene derivatives as a new class of non-nucleoside ribonuclease A inhibitors	32
A DNA-encoded library special issue	32
Design, synthesis, biological activity and molecular docking studies of triazolopyridine derivatives as ASK1 inhibitors	31
Discovery of trisubstituted meta-carboranes as T cell activators by regulating CD28 cytoplasmic region and SH2 domains of Grb2 and PI3K interactions	31
Decades old glitazones still find niche in drug discoveries as PPAR-γ agonists: medicinal chemistry perspective, structure-activity relationships and therapeutic implications	30
Multiple approaches to repurposing drugs for neuroblastoma	30
Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency	29
Research progress of STAT3-based dual inhibitors for cancer therapy	28

Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling	28
Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors	28
Sulfadoxine derivatization through multicomponent reactions to obtain new antiplasmodial compounds	28
Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors	27
Design, synthesis and antibacterial evaluation of oxazolidinone derivatives containing N-methylglycyl or quaternary ammonium salts	27
Diterpenoids from the whole plants of Croton yunnanensis and their bioactivities	27
Design, synthesis and evaluation the bioactivities of novel 1,3-dimethyl-6-amino-1H-indazole derivatives as anticancer agents	26
Targeting m6A binding protein YTHDFs for cancer therapy	26
Combining CuAAC reaction enables sialylated Bi- and triantennary pseudo mannose N-glycans for investigating Siglec-7 interactions	25
Peptide-based CE-SELEX enables convenient isolation of aptamers specifically recognizing CD20-expressing cells	25
Synthesis, evaluation of anti-breast cancer activity in vitro of ICS II derivatives and summary of the structure-activity relationship	25
Current development and structure–activity relationship study of berberine derivatives	25
Pentacyclic triterpene-amino acid derivatives induced apoptosis and autophagy in tumor cells, affected the JNK and PI3K/AKT/mTOR pathway	24
More than forty years of nucleic acid structural science	23
Graphical abstract TOC	23
Design, synthesis, and antiviral activity of 1-aryl-4-arylmethylpiperazine derivatives as Zika virus inhibitors with broad antiviral spectrum	23
Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase	23
Graphical abstract TOC	23
Corrigendum to “Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction” [Bioorg. Med. Chem. 46 (2021)	22
Editorial Board	22
Contents continued	21
Graphical abstract TOC	21
Design, synthesis, and analgesia evaluation of novel Transient Receptor Potential Vanilloid 1 (TRPV1) agonists modified from Cannabidiol (CBD)	21
Assessing the rigidity of cubanes and bicyclo(1.1.1)pentanes as benzene bioisosteres	21
Oligonucleotides containing 2′-O-methyl-5-(1-phenyl-1,2,3-triazol-4-yl)uridines demonstrate increased affinity for RNA and induce exon-skipping in vitro	21
Graphical abstract TOC	21
Editorial Board	21
Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans	20
CRBN ligand expansion for hematopoietic prostaglandin D2 synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles	20
Graphical Abstract Contents Continued	20
Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors	20
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease	20
Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors	20
1,3-Disubstituted-1,2,4-triazin-6-ones with potent activity against androgen receptor-dependent prostate cancer cells	20
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulati	20
Concise synthesis of piperarborenine B	20
A pharmacophore-based approach to demonstrating the scope of alcohol dehydrogenases	20
Graphical abstract TOC	20
Discovery of tetracyclic 1,2,4-triazoline-fused dibenzo[b,f][1,4]oxazepine as a potent anti-colorectal cancer agent with good efficacy and low toxicity	20
A TNF-α blocking peptide that reduces NF-κB and MAPK activity for attenuating inflammation	19
Synthesis and biological evaluation of O4′-benzyl-hispidol derivatives and analogs as dual monoamine oxidase-B inhibitors and anti-neuroinflammatory agents	19
Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d]pyrimidines as potent HPK1 kinase inhibitors	19
Design, synthesis and biological evaluation of arylpropylamine derivatives as potential multi-target antidepressants	19
Development of novel quinoline-NO donor hybrids inducing human breast cancer cells apoptosis via inhibition of topoisomerase I	19
Design, synthesis and biological evaluation of EGFR kinase inhibitors that spans the orthosteric and allosteric sites	19
Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines	19
Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents	19
Graphical abstract TOC	18
Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure–activity relationships	17
Editorial Board	17

Hetero-aryl bromide precursor fluorine-18 radiosynthesis and preclinical evaluation of a novel positron emission tomography (PET) tracer [18F]GSK1482160	17
3-Amino-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonitrile: A fluorescent molecule that induces differentiation in PC12 cells	17
Small phenolic inhibitors of PfATP6, a Plasmodium falciparum calcium ATPase, as prototype antimalarials	17
Synthesis and mammalian cell compatibility of light-released glycan precursors for controlled metabolic engineering	17
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors	17
Design, synthesis and biological evaluation of phosphoroxy quinazoline derivatives as potential EGFRT790M/C797S inhibitors	17
Graphical abstract TOC	17
4-Arylidene curcumin derivatives in vitro inhibit α-Synuclein aggregation and disaggregate the preformed fibril	17
Editorial Board	17
The 2022 Monkeypox outbreak: How the medicinal chemistry could help us?	17
In Vivo Imaging of Tumor Hypoxia by Maintaining Green Fluorescence of 9-Aminoanthracene Under Hypoxic Conditions	17
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues	17
Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia	17
Directly arylated oligonucleotides as fluorescent molecular rotors for probing DNA single-nucleotide polymorphisms	17
In vivo imaging of fluorescent albumin modified with pyruvylated-human-type complex oligosaccharide reveals sialylation-like biodistribution and kinetics	16
Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2	16
A turn for the worse: Aβ β-hairpins in Alzheimer’s disease	16
Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display	16
Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist	16
Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A2 and B2 bound to duplex 5′-TAGTT sites	16
Ligand- and structure-based identification of novel CDK9 inhibitors for the potential treatment of leukemia	16
Inhibition of cytochrome bd oxidase in Mycobacterium tuberculosis by benzothiazole amides	16
Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model	16
Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors	16
Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile	16
Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction	16
Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for	16
Fatty acid binding protein 5 inhibitors as novel anticancer agents against metastatic castration-resistant prostate cancer	15
Graphical abstract TOC	15
Thiazolidinones and related analogues as efficient antitrypanosomal agents	15
Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds	15
(±)-Agrimonolide: Efficient synthesis and treatment of inflammatory bowel disease via JAK1/STAT3 pathway inhibition	15
Design and synthesis of phenanthridinone and phenanthridine derivatives and their radiosensitizing activity	15
Synthesis and biological evaluation of indoline derivatives as CDGSH iron sulfur domain 2 activators	15
Editorial Board	15
Graphical abstract TOC	15
ClpP-based MtPTAC technology enables targeted degradation of inner mitochondrial membrane proteins	15
Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon	15
Discovery of dual-targeted molecules based on Olaparib and Rigosertib for triple-negative breast cancer with wild-type BRCA	14
Discovery of structurally diverse diazatricyclododecenes as lysosomotropic autophagy inhibitors	14
Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents	14
Modulation of aryl hydrocarbon receptor activity by halogenated indoles	14
C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters	14
Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy	14
Dimeric 1-(1H-indol-3-yl) urea as potent STING inhibitor to alleviate cisplatin-induced acute kidney injury in mice	14
Discovery of a potent C20-oxime pachysandra alkaloid analogue promising for treatment of hepatocellular carcinoma	14
An insight into the mechanistic role of (-)-Ampelopsin F from Vatica chinensis L. in inducing insulin secretion in pancreatic beta cells	14
Design, synthesis and molecular modelling studies of bile acid-curcumin conjugates as potential antiproliferative agents for breast cancer	14
Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors	14
Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors	14
Design, synthesis and in vitro validation of bivalent binders of SARS-CoV-2 spike protein: Obeticholic, betulinic and glycyrrhetinic acids as building blocks	14
Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity	14
Contents continued	13
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors	13
Graphical abstract TOC	13
Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes	13
Recent research progress of β-carbolines as privileged scaffold in the discovery of anticancer agent (2019–2024)	13
Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease	13
Truxillic acid monoamides as fatty acid binding protein 5 inhibitors	13
Stereoisomers of cannabidiols and their pharmacological activities – A potentially novel direction for cannabinoids	13
Synthetic studies on the extracellular domain of the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) using Trt-K10 solubilizing tags	13
Graphical Abstract TOC	13
Chemical design of radioiodinated probes with a metabolizable linkage for target-selective imaging of systemic amyloidosis	13
Editorial Board	13
Graphical abstract TOC	13
PET imaging of VEGFR and integrins in glioma tumor xenografts using 89Zr labelled heterodimeric peptide	13
Rational design of AIEgens through π-bridge engineering for dual-modal photodynamic and photothermal therapy	12
Corrigendum to “Discovery of novel Quinazoline-based KRAS G12C inhibitors as potential anticancer agents” [Bioorg. Med. Chem. 71 (2022) 116962]	12
Synthesis and antibacterial properties under blue LED light of conjugates between the siderophore desferrioxamine B (DFOB) and an Iridium(III) complex	12
Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids	12
Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor: A medicinal chemistry and QTAIM study	12
FDA-approved small molecule kinase inhibitors for cancer treatment (2001–2015): Medical indication, structural optimization, and binding mode Part I	12
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy	12
Synthesis and characterization of new acid-functionalized porphyrins displaying antimicrobial activity against gram positive bacteria, yeasts and filamentous fungi with or without ultra-high irradianc	12
Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives	12
Fluorescent probes and degraders of the sterol transport protein Aster-A	12
Generation of an RNA aptamer against LipL32 of Leptospira isolated by Tripartite-hybrid SELEX coupled with in-house Python-aided unbiased data sorting	12
Synthesis and biological evaluation of novel isobenzofuran-1(3H)-one derivatives as antidepressant agents	12
Growth factors and their peptide mimetics for treatment of traumatic brain injury	12
Editorial Board	12

Editorial Board	12
Editorial Board	12
Discovery of novel hypoxia-activated, nitroimidazole constructed multi-target kinase inhibitors on the basis of AZD9291 for the treatment of human lung cancer	12
Discovery and structure-activity relationship of Morita-Baylis-Hillman adducts as larvicides against dengue mosquito vector, Aedes aegypti (Diptera: Culicidae)	12
Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis	12
Berberine improves liver injury induced glucose and lipid metabolic disorders via alleviating ER stress of hepatocytes and modulating gut microbiota in mice	12
Discovery and optimization of anthraquinone derivatives containing substituted bisbenzyloxy groups as a novel scaffold damaged endoplasmic reticulum and against hepatocellular carcinoma cells	12
Discovery and biological evaluation of novel dual PTP1B and ACP1 inhibitors for the treatment of insulin resistance	11
Graphical abstract TOC	11
Discovery of evodiamine derivatives as potent insecticide candidates	11
Target discovery of bioactive natural products with native-compound-coupled CNBr-activated Sepharose 4B beads (NCCB): Applications, mechanisms and outlooks	11
Graphical abstract TOC	11
Structure-activity relationship studies and biological properties evaluation of peptidic NRP-1 ligands: Investigation of N-terminal cysteine importance	11
Editorial Board	11
An assessment of the mutational load caused by various reactions used in DNA encoded libraries	11
Graphical abstract TOC	11
Discovery and development of small-molecule heparanase inhibitors	11
Graphical abstract TOC	11
Editorial Board	11
Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme–iron binding group	11
Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide	11
The most common linkers in bioactive molecules and their bioisosteric replacement network	11
Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity	11
Biocompatible conjugated polymer nanoparticles labeled with 225Ac for tumor endoradiotherapy	11
Dual-responsive drug release and fluorescence imaging based on disulfide-pillar[4]arene aggregate in cancer cells	11
Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction	11
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor	11
Effect of helicity and hydrophobicity on cell-penetrating ability of arginine-rich peptides	10
Evaluation of potential anticonvulsant fluorinated N-benzamide enaminones as T-type Ca2+ channel blockers	10
Elongation of N6-benzyladenosine scaffold via Pd-catalyzed C–C bond formation leads to derivatives with antiflaviviral activity	10
Potential COX-2 inhibitors modulating NF-κB/MAPK signaling pathways: Design, synthesis and evaluation of anti-inflammatory activity of Pterostilbene-carboxylic acid derivatives with an oxime ether moi	10
A special issue on artificial intelligence for drug discovery	10
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1	10
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase	10
Synthesis of 1,8-cineole derivatives and evaluation of their cytoprotective effects against cisplatin-induced HK-2 cell injury	10
Synthesis and biological evaluation of 4H-benzo[e][1,3]oxazin-4-ones analogues of TGX-221 as inhibitors of PI3Kβ	10
Natural scaffold, modern strategy: Coumarin hybrids as potential carbohydrate-digesting enzyme inhibitors-A decade of medicinal chemistry exploration (2015–2025)	10
Design of a potent and selective dual JAK1/TYK2 inhibitor	10
Discovery of acetohydroxyacid synthase inhibitors as anti-tuberculosis lead compounds from natural products	10
Synthesis of 6-ethoxyphenyl 4-fluorobenzenesulfonate-tagged thiosemicarbazones as carbonic anhydrase inhibitors: In-vitro and in silico approach	10
Design, synthesis and anti-tumor efficacy of novel phenyl thiazole/triazole derivatives as selective TrkA inhibitors	10
Design, synthesis, and pharmacological evaluation of N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potenti	10
Thiazolidinedione-based structure modification of ergosterol peroxide provides thiazolidinedione-conjugated derivatives as potent agents against breast cancer cells through a PI3K/AKT/mTOR pathway	10
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to red	10
Saturation transfer difference (STD)-NMR spectroscopy in drug discovery: A comprehensive review on identified potential hits based on natural and synthetic scaffolds against therapeutic drug targets	10
Design, synthesis, and biological evaluation of 2-arylamino-4-(piperidin-4-yloxy)pyrimidines as potent EGFRT790M/L858R inhibitors to treat non-small cell lung cancer	10
Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity	9
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies	9
Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities	9
Recent applications of seven-membered rings in drug design	9
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419	9
Graphical abstract TOC	9
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase IIα inhibitors for the therapy of small cell lung cancer	9
Design, classification, and adverse effects of NSAIDs: A review on recent advancements	9
Synthesis and evaluation of sulfonamide derivatives targeting EGFR790M/L858R mutations and ALK rearrangement as anticancer agents	9
Editorial Board	9
Editorial Board	9
Design, synthesis, and bioactivity study on Lissodendrins B derivatives as PARP1 inhibitor	9
A critical update on the strategies towards small molecule inhibitors targeting Serine/arginine-rich (SR) proteins and Serine/arginine-rich proteins related kinases in alternative splicing	9
Editorial Board	9
RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA	9
Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease	9
Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry	9
Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue	9
Advances in the development of Rho GTPase inhibitors	9
Engineered B7-H3-targeted VHH-Fc fusion antibody demonstrates rapid tumor accumulation for infrared imaging in pancreatic cancer xenograft model	9
Synthesis and biological evaluation of sulfonylpyridine derivatives as potential anti-chlamydia agents	9
Discovery, Topo I inhibitory activity and mechanism evaluation of two novel cytisine-type alkaloid dimers from the seeds of Sophora alopecuroides L	9
Graphical Abstract TOC	9
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents	9
Screening and evaluation of hydrophobic cell-penetrating peptides for antisense oligonucleotide delivery	9
Virtual screening, synthesis, optimization and anti-inflammatory activity of novel chromones as specific COX-2 inhibitors	9
Targeting the PI3K/mTOR pathway in idiopathic pulmonary fibrosis: Advances and therapeutic potential	9
Corylin induces UGT1A1 via PPARs/AhR and exerts hepatoprotection in mice	9
Design, synthesis, and biological evaluation of a potential long-acting glucagon-like peptide-1 (GLP-1) analog	9
Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents	9
Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors	9
Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin	9
Synthesis and antimicrobial studies of cadasides analogues via on-resin esterification	9
Design, in silico study, and efficient synthesis of N-acylhydrazones in deep eutectic solvents: potential anticonvulsant agents	9
Design, synthesis and anti-rheumatoid arthritis activity of target TLR4 inhibitors	9
Glutathione-responsive PROTAC for targeted degradation of ERα in breast cancer cells	9
Graphical abstract TOC	9
New phenylpiperazine-thiazolidine-2,4-dione hybrids targeting MAO inhibition: Synthesis, biological evaluation, kinetic study and in silico insights	9
Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors	9
Editorial Board	9
Contents continued	9
Graphical abstract TOC	9
Tenuistones A–H, novel flavonoid derivatives from Miliusa tenuistipitata with anti-proliferative and anti-migration activities against triple-negative breast cancer cells	9
Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease	9
Harnessing polyhydroxylated pyrrolidines as a stabilizer of acid alpha-glucosidase (GAA) to enhance the efficacy of enzyme replacement therapy in Pompe disease	9
Drug discovery targeting protein arginine methyltransferase 5 (PRMT5): an update	9
Revisiting recent unusual drug-DNA complex structures: Implications for cancer and neurological disease diagnostics and therapeutics	8
Contents continued	8
Recent achievements in molecular insights, anticancer activities, and comparative structure activity relationships of thiazolidin-4-one derivatives as EGFR inhibitors (2019-present)	8