Bioorganic & Medicinal Chemistry

Article	Citations
A comprehensive review on the biological interest of quinoline and its derivatives	298
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors	123
An insight into the medicinal attributes of berberine derivatives: A review	76
Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells	74
Application of marine natural products in drug research	71
Structural modification aimed for improving solubility of lead compounds in early phase drug discovery	66
The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors	60
Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens	60
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase	60
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors	60
Recent advances on synthesis and biological activities of aurones	59
Pyridine alkaloids with activity in the central nervous system	56
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity	55
Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer	49
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer’s disease	49
[1,2,4]Triazolo[4,3-c]quinazoline and bis([1,2,4]triazolo)[4,3-a:4′,3′-c]quinazoline derived DNA intercalators: Design, synthesis, in silico ADMET profile, molecular docking and anti-proliferative eva	47
Indole acrylonitriles as potential anti-hyperglycemic agents: Synthesis, α-glucosidase inhibitory activity and molecular docking studies	46
Covalent peptides and proteins for therapeutics	43
The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity	42
Boron-Containing heterocycles as promising pharmacological agents	38
Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases	38
Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells	36
Recent progress in covalent warheads for in vivo targeting of endogenous proteins	35
Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models	35
Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol	34

Bioorthogonal strategies for the in vivo synthesis or release of drugs	33
MCC950, a NLRP3 inhibitor, ameliorates lipopolysaccharide-induced lung inflammation in mice	33
The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR opti	32
Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro	29
Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study	29
SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases	28
Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents	27
Azaindole therapeutic agents	27
Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects	26
Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR	26
Novel 4-(piperazin-1-yl)quinolin-2(1H)-one bearing thiazoles with antiproliferative activity through VEGFR-2-TK inhibition	26
Potential inhibitors interacting in Neuropilin-1 to develop an adjuvant drug against COVID-19, by molecular docking	26
Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability	26
Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease	26
Assays for the identification and quantification of sialic acids: Challenges, opportunities and future perspectives	26
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy	25
Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold	25
Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study	25
Discovery, development, chemical diversity and design of isoxazoline-based insecticides	25
Progress in the development of small molecular inhibitors of the Bruton’s tyrosine kinase (BTK) as a promising cancer therapy	25
Design, synthesis biological activity, and docking of novel fluopyram derivatives containing guanidine group	25
A review upon medicinal perspective and designing rationale of DPP-4 inhibitors	25
Thiacalixarene based quaternary ammonium salts as promising antibacterial agents	25
Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential	25
Structure-based designing and synthesis of 2-phenylchromone derivatives as potent tyrosinase inhibitors: In vitro and in silico studies	25
Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies	24
CYPlebrity: Machine learning models for the prediction of inhibitors of cytochrome P450 enzymes	24
Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection	24
Natural spirocyclic alkaloids and polyphenols as multi target dementia leads	24
Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies	24
Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2	24
Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment	24
Effects of data quality and quantity on deep learning for protein-ligand binding affinity prediction	23
In vitro and in vivo evaluation of 211At-labeled fibroblast activation protein inhibitor for glioma treatment	23
Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor	23
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation	23
Synthetic approaches to the 2015–2018 new agrochemicals	22
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer’s disease	22
Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors	22
Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review	22
Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactate transport inhibitors	22
Anti-inflammatory activity of naturally occuring diarylheptanoids – A review	22
Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates	21
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry	21
New BODIPYs for photodynamic therapy (PDT): Synthesis and activity on human cancer cell lines	21
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro	21
Large screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation	21
Dismantling the bacterial glycocalyx: Chemical tools to probe, perturb, and image bacterial glycans	21
COVID-19 therapy: What weapons do we bring into battle?	21
Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain	20

Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer’s disease	20
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease	20
Design concepts for DNA-encoded library synthesis	20
Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI)	20
Recent applications of seven-membered rings in drug design	20
Developments of small molecules as inhibitors for carbonic anhydrase isoforms	19
Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT)	19
Berberine improves liver injury induced glucose and lipid metabolic disorders via alleviating ER stress of hepatocytes and modulating gut microbiota in mice	19
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2	19
Xanthones for melanogenesis inhibition: Molecular docking and QSAR studies to understand their anti-tyrosinase activity	19
Sophorolipids: Anti-cancer activities and mechanisms	19
Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents	19
Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2	19
In vivo organic synthesis by metal catalysts	19
Druggable targets from coronaviruses for designing new antiviral drugs	19
Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects	19
A network pharmacology-integrated metabolomics strategy for clarifying the action mechanisms of Schisandrae Chinensis Fructus for treating drug-induced liver injury by acetaminophen	19
Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library	18
Methods to generate site-specific conjugates of antibody and protein	18
A brief overview on recent advances in spiro[chromane-2,4′-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research	18
Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study	18
On the design of lead-like DNA-encoded chemical libraries	18
Biotin and glucose co-modified multi-targeting liposomes for efficient delivery of chemotherapeutics for the treatment of glioma	18
Mitochondria-localizing curcumin-cryptolepine Zn(II) complexes and their antitumor activity	18
Next generation quorum sensing inhibitors: Accounts on structure activity relationship studies and biological activities	18
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies	18
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase	17
Genetic code expansion in mammalian cells: A plasmid system comparison	17
Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis	17
Diversity-oriented synthesis as a tool to expand the chemical space of DNA-encoded libraries	17
Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells	17
Design and synthesis of acrylate and acrylamide substituted pyrimidinediones as potential PPO herbicides	17
Junctions in DNA: underexplored targets for therapeutic intervention	17
Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain	17
Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling	17
Antiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach	17
Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment	17
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis	17
Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding	17
Recent progress and challenges for polymeric microsphere compared to nanosphere drug release systems: Is there a real difference?	17
The chemistry and biology of phosphatidylinositol 4-phosphate at the plasma membrane	17
Novel 2-amino-1,4-naphthoquinone hybrids: Design, synthesis, cytotoxicity evaluation and in silico studies	16
Thioether-linked dihydropyrrol-2-one analogues as PqsR antagonists against antibiotic resistant Pseudomonas aeruginosa	16
Efficient delivery of VEGFA mRNA for promoting wound healing via ionizable lipid nanoparticles	16
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction	16
Novel penta-1,4-diene-3-one derivatives containing quinazoline and oxime ether fragments: Design, synthesis and bioactivity	16
Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors	16
Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors	16
Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer	16
Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus	16
Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic	16
Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities	16
Isolation and biological activity of azocine and azocane alkaloids	15
Discovery of a polysubstituted phenyl containing novel N-phenylpyrazole scaffold as potent ryanodine receptor activator	15
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry	15
DNA-encoded C H functionality via photoredox-mediated hydrogen atom transformation catalysis	15
Sinomenine inhibits hypoxia induced breast cancer side population cells metastasis by PI3K/Akt/mTOR pathway	15
Synthetic approaches to unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles and their MAO-B inhibitory activity. A review	15
Carbon nanomaterials as emerging nanotherapeutic platforms to tackle the rising tide of cancer – A review	15
De novo design with deep generative models based on 3D similarity scoring	15
pH-responsive Mannose-modified ferrocene Metal-Organic frameworks with rare earth for Tumor-targeted synchronous Chemo/Chemodynamic therapy	15
The subgroup of 2′-hydroxy-flavonoids: Molecular diversity, mechanism of action, and anticancer properties	15
Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones	15
Self-assembly of photosensitive and radiotherapeutic peptide for combined photodynamic-radio cancer therapy with intracellular delivery of miRNA-139-5p	15
Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives	14
Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies	14
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site	14
Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent	14
Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids	14
Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus	14
Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189	14
Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors	14
Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss	14
A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens	14
Novel arylcarbamate-N-acylhydrazones derivatives as promising BuChE inhibitors: Design, synthesis, molecular modeling and biological evaluation	14
Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis	14
Design, synthesis, and antitumor activity evaluation of steroidal oximes	14
Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction	14
Synthesis and anticancer potential of novel 5,6-oxygenated and/or halogenated steroidal d-homo lactones	14
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer’s disease	14

Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase	14
A versatile toolbox for investigating biological processes based on quinone methide chemistry: From self-immolative linkers to self-immobilizing agents	14
An assessment of the mutational load caused by various reactions used in DNA encoded libraries	14
Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532	14
Synthesis and evaluation of enantiomers of hydroxychloroquine against SARS-CoV-2 in vitro	14
Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells	14
Ximaoglaucumins A − F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum	14
Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311	14
Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents	14
Discovery of 4-amino-1H-pyrazolo[3,4-d]pyrimidin derivatives as novel discoidin domain receptor 1 (DDR1) inhibitors	13
Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies	13
Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors	13
Dual-responsive drug release and fluorescence imaging based on disulfide-pillar[4]arene aggregate in cancer cells	13
1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β	13
Targeting mycobacterial membranes and membrane proteins: Progress and limitations	13
Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors	13
Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents	13
Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents	13
Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission	13
Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives	13
Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents	13
Berberine and folic acid co-modified pH-sensitive cascade-targeted PTX-liposomes coated with Tween 80 for treating glioma	13
A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism	13
Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: Synthesis, in vitro and in vivo studies	13
Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors	13
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity	13
JNK selective inhibitor, IQ-1S, protects the mice against lipopolysaccharides-induced sepsis	13
A beginner’s guide to current synthetic linker strategies towards VHL-recruiting PROTACs	13
Nitrile-based peptoids as cysteine protease inhibitors	13
Discovery of florylpicoxamid, a mimic of a macrocyclic natural product	13
Ligand- and structure-based identification of novel CDK9 inhibitors for the potential treatment of leukemia	13
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants	13
Synthesis and evaluation of new mixed “2 + 1” Re, 99mTc and 186Re tricarbonyl dithiocarbamate complexes with different monodentate ligands	12
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer	12
Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents	12
A minimally-masked inactive prodrug of panobinostat that is bioorthogonally activated by gold chemistry	12
Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays	12
Antitumor and toxicity study of mitochondria-targeted triptolide derivatives using triphenylphosphine (TPP+) as a carrier	12
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs	12
Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy	12
Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition	12
Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation	12
Designed, synthesized and biological evaluation of proteolysis targeting chimeras (PROTACs) as AR degraders for prostate cancer treatment	12
Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents	12
Soloxolone methyl, as a 18βH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells	12
Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome	12
Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C	12
Synthesis of estrone selenocyanate Compounds, anti-tumor activity evaluation and Structure-activity relationship analysis	12
S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation	12
Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis	12
Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines	12
Design, synthesis and biological evaluation of KRASG12C-PROTACs	12
Discovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors	12
Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors	12
The most common linkers in bioactive molecules and their bioisosteric replacement network	12
Synthesis and evaluation of glycosylated quercetin to enhance neuroprotective effects on cerebral ischemia-reperfusion	12
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay	12
Biosynthesis of vanillic acid by Ochrobactrum anthropi and its applications	12
Synthesis of six-membered carbocyclic ring α,α-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide	12
Synthesis of naturally occurring β-l-arabinofuranosyl-l-arabinofuranoside structures towards the substrate specificity evaluation of β-l-arabinofuranosidase	12
Exploring a combined Escherichia coli-based glycosylation and in vitro transglycosylation approach for expression of glycosylated interferon alpha	11
Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation	11
Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models	11
Systematic evaluation of structure–property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride	11
A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities	11
Isolation, synthesis and bioactivity evaluation of isoquinoline alkaloids from Corydalis hendersonii Hemsl. against gastric cancer in vitro and in vivo	11
Concise solid-phase synthesis enables derivatisation of YEATS domain cyclopeptide inhibitors for improved cellular uptake	11
Synthesis and biological evaluation of tetrahydroisoquinoline-derived antibacterial compounds	11
Insights into non-peptide small-molecule inhibitors of the PD-1/PD-L1 interaction: Development and perspective	11
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer	11
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors	11
Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents	11
Alkaloids of Delphinium grandiflorum and their implication to H2O2-induced cardiomyocytes injury	11
Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease	11
The natural anthraquinone dye purpurin exerts antibacterial activity by perturbing the FtsZ assembly	11
Chemical generation of small molecule-based bispecific antibody-drug conjugates for broadening the target scope	11
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway	11
Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities	11
Hetero-aryl bromide precursor fluorine-18 radiosynthesis and preclinical evaluation of a novel positron emission tomography (PET) tracer [18F]GSK1482160	11
Synthesis, antitumor activity and structure-activity studies of novel pyridoxine-based bioisosteric analogs of estradiol	11
Isolation and biological activity of natural chalcones based on antibacterial mechanism classification	11
Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A	11
Design, synthesis, and biological activity of novel semicarbazones as potent Ryanodine receptor1 inhibitors of Alzheimer’s disease	11
Loop-mediated fluorescent probes for selective discrimination of parallel and antiparallel G-Quadruplexes	11
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway	11
Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line	11
Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library	10
Fluorescent image-based high-content screening of extracts of natural resources for cell cycle inhibitors and identification of a new sesquiterpene quinone from the sponge, Dactylospongia metachromia	10
Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases	10
Design, synthesis and biological evaluation of vortioxetine derivatives as new COX-1/2 inhibitors in human monocytes	10
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases	10
Detection of N,N-diacetyllactosamine (LacdiNAc) containing free prostate-specific antigen for early stage prostate cancer diagnostics and for identification of castration-resistant prostate cancer pat	10
Comparative studies on the substrate specificity and defucosylation activity of three α-l-fucosidases using synthetic fucosylated glycopeptides and glycoproteins as substrates	10
Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors	10
Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors	10